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非齐次马尔可夫LPV系统的H_∞异步控制

系统工程与电子技术 2020年第5期42卷 1152-1159页

作者：孙维阳刘雨哈尔滨工业大学航天学院控制科学与工程系黑龙江哈尔滨150001

针对存在外界干扰的情况,对一类离散时间非齐次马尔可夫线性变参数(linear parameter-varying,LPV)系统的H∞异步控制问题进行了研究。由于实际非齐次马尔可夫系统的系统模态难以直接获得,考虑了控制器模态和系统模态不一致的异步问题,... 详细信息

针对存在外界干扰的情况,对一类离散时间非齐次马尔可夫线性变参数(linear parameter-varying,LPV)系统的H∞异步控制问题进行了研究。由于实际非齐次马尔可夫系统的系统模态难以直接获得,考虑了控制器模态和系统模态不一致的异步问题,并用一个非齐次隐马尔可夫模型建模。非齐次马尔可夫系统和非齐次隐马尔可夫链的时变特性分别由分段齐次状态转移概率矩阵和分段齐次条件概率矩阵描述,且受同一个高层齐次马尔可夫链支配。针对上述问题,完成了对闭环非齐次马尔可夫LPV系统的稳定性分析、H∞性能分析和H∞异步控制器设计,使系统在受到外界干扰和控制器模态与系统模态存在异步现象的情况下满足给定的H∞性能指标。最后通过对直流电机的仿真实验验证了利用非齐次信息得到理论的有效性和优越性。

关键词：非齐次马尔可夫跳跃系统非齐次隐马尔可夫链时变转移概率分段齐次转移概率 H∞异步控制

Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway

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Virologica Sinica 2023年第1期38卷 119-127页

作者： Chaoxiang Lv Yuanguo Li Tiecheng Wang Qiqi Zhang Jing Qi Mingwei Sima Entao Li Tian Qin Zhuangzhuang Shi Fangxu Li Xuefeng Wang weiyang sun Na Feng Songtao Yang Xianzhu Xia Ningyi Jin Yifa Zhou Yuwei Gao College of Life Sciences Northeast Normal UniversityChangchunJilin130021China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences.Changchun130122China College of Animal Medicine Jilin UniversityChangchun130000China College of Basic Medicine Changchun University of Chinese MedicineChangchun130117China College of Animal Science and Technology Jilin Agricultural UniversityChangchun130033China College of Life Sciences Shandong Normal UniversityJinan250014China

Taurolidine(TRD),a derivative of taurine,has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls,endotoxins and exotoxins to inhibit the adhesion of ***,its application in antiviral therapy is seldom ***,we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration(EC_(50))of 34.45μg/***,the drug inhibited the amplification of the cytokine storm effect and improved the survival rate of mice lethal challenged with H5N1(protection rate was 86%).Moreover,TRD attenuated virus-induced lung damage and reduced virus titers in mice *** of TRD reduced the number of neutrophils and increased the number of lymphocytes in the blood of H5N1 virus-infected ***,the drug regulated the NF-κB signaling pathway by inhibiting the separation of NF-κB and IκBa,thereby reducing the expression of inflammatory *** conclusion,our findings suggested that TRD could act as a potential anti-influenza drug candidate in further clinical studies.

关键词： Influenza viruses H5N1 Taurolidine(TRD) Cytokine storms Inflammatory response NF-κB signaling pathway

CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation

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Cellular & Molecular Immunology 2023年第12期20卷 1457-1471页

作者： Huasong Chang Peili Hou Xuefeng Wang Aibiao Xiang Hao Wu Wenjing Qi Rukun Yang Xue Wang Xingyu Li Wenqi He Guimin Zhao weiyang sun Tiecheng Wang Daniel Chang He Hongmei Wang Yuwei Gao Hongbin He Ruminant Diseases Research Center College of Life SciencesShandong Normal UniversityJinanShandong250014China Department of Preventive Veterinary Medicine College of Veterinary MedicineShandong Agricultural UniversityTaianShandong271018China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchunJilin130122China Key Laboratory of Zoonosis Research Ministry of EducationCollege of Veterinary MedicineJilin UniversityChangchunJilin130062China The College of Arts and Sciences University of North Carolina at Chapel HillChapel HillNC27599USA

The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in ***,its function in the antiviral innate immune response remains to be *** this study,we report that CD97 inhibits virus-induced type-I interferon(IFN-I)release and enhances RNA virus replication in cells and ***97 was identified as a new negative regulator of the innate immune receptor RIG-I,and RIG-1 degradation led to the suppression of the IFN-I signaling ***,overexpression of CD97 promoted the ubiquitination of RIG-I,resulting in its degradation,but did not impact its mRNA ***,CD97 upregulates RNF125 expression to induce RNF125-mediated RIG-I degradation via K48-linked ubiquitination at Lys181 after RNA virus *** importantly,CD97-deficient mice are more resistant than wild-type mice to RNA virus *** also found that sanguinarine-mediated inhibition of CD97 effectively blocks VSV and SARS-CoV-2 *** findings elucidate a previously unknown mechanism through which CD97 negatively regulates RIG-I in the antiviral innate immune response and provide a molecular basis for the development of new therapeutic strategies and the design of targeted antiviral agents.

关键词： CD97 RNA virus IFN-l Ubiquitination RIG-1

The Application of a Safe Neutralization Assay for Ebola Virus Using Lentivirus-Based Pseudotyped Virus

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Virologica Sinica 2021年第6期36卷 1648-1651页

作者： Zengguo Cao Hongli Jin Gary Wong Ying Zhang Cuicui Jiao Na Feng Fangfang Wu Shengnan Xu Hang Chi Yongkun Zhao Tiecheng Wang weiyang sun Yuwei Gao Songtao Yang Xianzhu Xia Hualei Wang Key Laboratory of Zoonosis Research Ministry of EducationCollege of Veterinary MedicineJilin UniversityChangchun 130062China Key Laboratory of Jilin Province for Zoonosis Prevention and Control Institute of Military VeterinaryAcademy of Military Medical SciencesChangchun 130122China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China Département de Microbiologie-Infectiologie Et D'immunologie UniversitéLavalQuébecQC G1V 0A6Canada Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose Yangzhou UniversityYangzhou 225009China

Dear Editor,Zaire Ebola virus(EBOV)is a negative-sense singlestranded RNA virus that is capable of causing acute hemorrhagic fever with a frightening fatality rate that can reach up to 90%.Due to its high lethality and frequent recurrence,EBOV is a substantial threat to public *** about live EBOV is restricted to BSL-4 laboratories;therefore,conventional serological detection methods do not provide a safe way to evaluate neutralizing activity,resulting in a bottleneck in antibody-based detection of viruses such as ***,we aim to develop and apply a neutralization assay for EBOV using a generated lentivirus-based pseudotyped EBOV bearing GP on its surface.

关键词： Ebola acute hemorrhagic

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双光互注入半导体激光器混沌同步通信研究

激光与光电子学进展 2019年第21期56卷 121-125页

作者：孙巍阳胡宝洁王航中国洛阳电子信息装备试验中心

将双光互注入半导体激光器作为混沌光发射源,构建了受环境影响较小、稳定性较好的全光纤型混沌同步通信系统,并从延时特征的隐藏、接收与发射激光器的互相关性及输出混沌光带宽三方面研究该系统的同步通信能力。使用自相关函数及互信息... 详细信息

将双光互注入半导体激光器作为混沌光发射源,构建了受环境影响较小、稳定性较好的全光纤型混沌同步通信系统,并从延时特征的隐藏、接收与发射激光器的互相关性及输出混沌光带宽三方面研究该系统的同步通信能力。使用自相关函数及互信息函数等数学工具仿真计算该系统外腔反馈延时特征峰值、发射与接收激光器的互信息函数峰值及系统输出混沌光带宽。研究表明,通过适当调整参数使发射与接收激光器高度同步,双光互注入系统外腔反馈延时特征峰值可减小至0.1899,比相同条件下单光互注入的延时特征峰值降低了0.1696,接收和发射激光器最大互相关系数为0.9113。此外,21GHz的中心频率失谐能将输出光带宽展宽到3.319GHz。经实验验证,双光互注入系统产生的混沌载波能很好地隐藏实验用的正弦波信号,并且能够在接收端成功解调。

关键词：激光器双光互注入半导体激光器混沌同步通信

A　quasi－three－dimensional　numerical　prediction　model　of　salinity　structure　in　Bohai　Sea　and　Huanghai　Sea

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Acta Oceanologica Sinica 1994年第4期13卷 485-494页

作者： sun weiyang and Wang Zongshan (Department of Geological Sciences, Columbia University, New York 10964, U. S. A. First institute of Oceanography, State Oceanic Administration, Qingdao 266003, China)

The vertical salinity structure in the Bohai As and the Huanghai Sea have typical self-similar characters. However, horizontal salinity distribution is influenced by advection, horizontal diffusion, river discharge,etc. By using observed sea salinity data, a similarity function of vertical salinity profiles of the Bohai Sea and the Huanghai Sea has been constructed. On the basis of vertical integrated equations of motion and equation of continuity, and governing equations about the distribution of 3 characteristic factors (surface salinity Ss, bottom salinity SH, and thickness of upper homogeneous layer h), and combined with the similarity function, a quasithree-dimensional numerical model of salinity structure bas ben developed. In the model, the comprehensive effects of sea surface wind stress and heat influx, advection, diffusion, entrainment, bottom as well as lateral eddy mixture are taken into consideration. It is shown that the numerical model is more practical and the results of the trial prediction are satisfactory

关键词： salinity model prediction Bohai

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一种大型矿用自卸车自动称重系统的设计

船电技术 2010年第8期30卷 53-56页

作者：孙卫阳湘电重型装备股份有限公司湘潭411101

大型矿用自卸车装设自动称重系统可以帮助驾驶员和调度管理部门及时了解车辆的载荷情况,以防止车辆超载,从而延长车辆和轮胎使用寿命、减少车辆维修时间,并减少车辆维护运行成本。本文介绍了SF33900大型矿用自卸车自动称重系统的组成、... 详细信息

大型矿用自卸车装设自动称重系统可以帮助驾驶员和调度管理部门及时了解车辆的载荷情况,以防止车辆超载,从而延长车辆和轮胎使用寿命、减少车辆维修时间,并减少车辆维护运行成本。本文介绍了SF33900大型矿用自卸车自动称重系统的组成、工作原理及其应用,并分析了引起系统测量误差的原因。

关键词：矿用自卸车称重系统车辆信息管理电力传动

Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses

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Biosafety and Health 2019年第3期1卷 159-161页

作者： Jing Liu Tiecheng Wang Ying Xie Yuanguo Li Jian He Xinghai Zhang weiyang sun Na Feng Chuan Qin Yuwei Gao Xianzhu Xia Comparative Medicine Center Peking Union Medical College(PUMC)and Institute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)Beijing 100021China Key Laboratory of Jilin Province for Zoonosis Institute of Military VeterinaryAcademy of Military Medical SciencesChangchun 130122China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Nanjing 225009China

Antibodies are ideal for controlling the influenza A virus,but their effect on newly emerging strains is ***,we assessed the neutralization activity of the humanized monoclonal antibodies(mAbs)F10,H98 and H40 against circulating influenza viruses(H5N1,H1N1,H3N2 and H7N7 and new subtypes viruses H5N6 and H7N9).The results showed that all the three humanized mAbs(F10,H98 and H40)displayed different degrees of virus neutralization activities when encountered with different subtypes of influenza ***,the humanized monoclonal antibody F10 produced higher and broader neutralization titers(range 25–1.56μg/ml)than those of the other two humanized mAbs(H98(range 50–3.12μg/ml),H40(range 50–5.56μg/ml))to against the viruses H5N1,H1N1,H3N2,H7N7,H5N6 and *** mAb may represent a new class of heterosubtypic neutralizing humanized mAb that could replace vaccines and chemical drugs.

关键词： Influenza A virus humanized antibodies Neutralization activity New subtypes of influenza viruses

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我国罕见病药品价格水平和可负担性研究

中国药房 2021年第8期32卷 897-903页

作者：朱楚玉孙维阳常峰路云中国药科大学国际医药商学院南京211198

目的:评估我国罕见病药品价格水平及可负担性情况,提出改善罕见病治疗药品可负担性的政策建议,以期为政府主管部门的相关决策提供依据。方法:基于《第一批罕见病目录》和《罕见病诊疗指南(2019年版)》选择罕见病药品,采用中位价格比值法... 详细信息

目的:评估我国罕见病药品价格水平及可负担性情况,提出改善罕见病治疗药品可负担性的政策建议,以期为政府主管部门的相关决策提供依据。方法:基于《第一批罕见病目录》和《罕见病诊疗指南(2019年版)》选择罕见病药品,采用中位价格比值法(MPR)评估药品价格水平,用药品年治疗费用和城乡居民年均可支配收入的倍数评估药品可负担性以及价格管理政策对药品价格和可负担性的影响。结果与结论:共纳入罕见病药品71种,其MPR中位数为0.83,其中原研药的MPR中位数为1.13、仿制药的MPR中位数为0.37。71种罕见病药品年均费用相当于2020年我国城镇居民年均收入的0.001~178.43倍,农村居民年均收入的0.003~456.57倍,分别有21和28种药品年均费用超过城镇和农村居民年均收入。对其中14种罕见病药品实施医保准入谈判或集中带量采购后,相关药品的MPR中位数从1.71下降到0.46,费用超过城镇居民年收入的药品数由8种降为0种,农村居民由10种降为5种。总体上,我国罕见病药品价格水平略低于国际参考价格,但原研药价格水平整体高于国际参考价格,部分药品费用远超过居民支付能力。建议加强原研药价格管理,促进优质仿制药临床替代,建立健全高负担罕见病药品支付保障体系。

关键词：罕见病药品药品价格中位价格比可负担性