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A novel biodegradable Mg-1Zn-0.5Sn alloy:Mechanical properties,corrosion behavior,biocompatibility,and antibacterial activity

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Journal of Magnesium and Alloys 2020年第2期8卷 374-386页

作者： Weikang Zhao Jingfeng Wang jiang weiyang Bo Qiao Yiyang Wang Yuling Li Dianming jiang Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China National Engineering Research Center for Magnesium Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400044PR China Department of Orthopedics Affiliated Hospital of North Sichuan Medical CollegeSichuan 637000PR China Department of Orthopedics Third A ffiliated Hospital of Chongqing Medical UniversityChongqing 401120PR China Department of Bioengineering University of CaliforniaLos AngelesCalifornia 90095-1600United States

To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated antibacterial properties was constructed.A small amount of Sn added to Mg-1Zn alloy reduces the biocorrosion rate,which can be attributed to Sn participation in outer-layer film formation,significantly reducing the biocorrosion rate and hydrogen evolution rate after implantation in *** Mg alloys,which are susceptible to degradation in the acidic bacterial microenvironment,degrade by releasing Mg,Zn and Sn,producing favorably alkaline and antibacterial *** with the composition of Mg-1Zn-0.5Sn were found to be beneficial for promoting initial cell adhesion and proliferation,resulting in improved biocompatibility and *** biocompatibility of this alloy was confirmed by the healthy behavior of animals and the absence of acute or chronic toxicity in the liver,spleen,and *** results demonstrate that Mg-1Zn-0.5Sn is safe for biological systems,enabling its efficacious use in biomedical applications.

关键词： Magnesium alloy Degradable materials Antibacterial Biosafety

羟丙基-β-环糊精/臭氧包络物氧化降解多种有机物研究

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山东化工 2024年第4期53卷 265-269页

作者：蒋维洋聂瑶唐俊辉王涛西华师范大学环境科学与工程学院四川南充637009

为延长臭氧的半衰期,保留其选择氧化性,通过羟丙基-β-环糊精与臭氧包络的方式。研究了臭氧/羟丙基-β-环糊精包络物(O_(3)/CD)的氧化特性,研究对比了两种不同液相制备方法制备包络物的氧化性能,探究了O_(3)/CD对靛蓝三磺酸盐(indigo)、... 详细信息

为延长臭氧的半衰期,保留其选择氧化性,通过羟丙基-β-环糊精与臭氧包络的方式。研究了臭氧/羟丙基-β-环糊精包络物(O_(3)/CD)的氧化特性,研究对比了两种不同液相制备方法制备包络物的氧化性能,探究了O_(3)/CD对靛蓝三磺酸盐(indigo)、2,2-联氮-双-(3-乙基-苯并噻唑啉-6-磺酸)二胺盐(ABTS)以及甲基橙(MO)的氧化特性,O_(3)/CD能够延长臭氧的半衰期,并提高其氧化性,在环糊精溶液中通入臭氧的氧化性明显优于文献报道的方式,在通入饱和臭氧下,表现出较高的氧化性能,向0.5 mmol/L的环糊精溶液中通入10 mg/L的臭氧后,对Indigo、ABTS和MO均表现出较强的持续氧化能力,为水体和土壤污染物氧化修复提供了新的路径。

关键词：臭氧氧化羟丙基-β-环糊精包络物

Multimodal Fusion of Brain Imaging Data: Methods and Applications

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Machine Intelligence Research 2024年第1期21卷 136-152页

作者： Na Luo weiyang Shi Zhengyi Yang Ming Song Tianzi jiang Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Augmented Intelligence Zhejiang LaboratoryHangzhou 311100China

Neuroimaging data typically include multiple modalities,such as structural or functional magnetic resonance imaging,dif-fusion tensor imaging,and positron emission tomography,which provide multiple views for observing and analyzing the *** lever-age the complementary representations of different modalities,multimodal fusion is consequently needed to dig out both inter-modality and intra-modality *** the exploited rich information,it is becoming popular to combine multiple modality data to ex-plore the structural and functional characteristics of the brain in both health and disease *** this paper,we first review a wide spectrum of advanced machine learning methodologies for fusing multimodal brain imaging data,broadly categorized into unsupervised and supervised learning *** by this,some representative applications are discussed,including how they help to under-stand the brain arealization,how they improve the prediction of behavioral phenotypes and brain aging,and how they accelerate the biomarker exploration of brain ***,we discuss some exciting emerging trends and important future ***,we intend to offer a comprehensive overview of brain imaging fusion methods and their successful applications,along with the chal-lenges imposed by multi-scale and big data,which arises an urgent demand on developing new models and platforms.

关键词： Multimodal fusion supervised learning unsupervised learning brain atlas cognition brain disorders

Wetting alternating with partial drying during grain filling increases lysine biosynthesis in inferior rice grain

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The Crop Journal 2024年第1期12卷 262-270页

作者： Yi jiang Wenli Tao weiyang Zhang Zhiqin Wang Jianchang Yang jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009JiangsuChina

Lysine content is a criterion of the nutritional quality of *** the process of lysine biosynthesis in early-flowering superior grain(SG)and late-flowering inferior grain(IG)of rice would advance breeding and cultivation to improve nutritional ***,little information is available on differences in lysine anabolism between SG and IG and the underlying mechanism,and whether and how irrigation regimes affect lysine anabolism in these grains.A japonica rice cultivar was grown in the field and two irrigation regimes,continuous flooding(CF)and wetting alternating with partial drying(WAPD),were imposed from heading to the mature *** content and activities of key enzymes of lysine biosynthesis,and levels of brassinosteroids(BRs)were lower in the IG than in the SG at the early grainfilling stage but higher at middle and late grain-filling *** increased activities of these key enzymes,BR levels,and contents of lysine and total amino acids in IG,but not SG relative to *** of 2,4-epibrassinolide to rice panicles in CF during early grain filling reproduced the effects of WAPD,but neither treatment altered the activities of enzymes responsible for lysine catabolism in either SG or *** and elevated BR levels during grain filling increased lysine biosynthesis in *** in lysine biosynthesis in rice should focus on IG.

关键词： Brassinosteroids Inferior grain Lysine biosynthesis Rice Wetting alternating with partial drying

The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series

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Cancer Biology & Medicine 2019年第4期16卷 811-821页

作者： jianghua Wu Wei Sun Haiyue Wang Xiaozheng Huang Xinyu Wang weiyang jiang Ling Jia Ping Wang Qin Feng Dongmei Lin Department of Pathology Peking University Cancer Hospital&InstituteKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Beijing 100142China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)***:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our ***-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were ***:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic *** TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer *** could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic ***:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC *** findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers.

关键词： Lung adenocarcinoma PD-L1 expression classical genomic aberrations molecular biomarkers

Safety Risk Analysis of Large⁃scale Complex Project based on WBS⁃RBS and Interval Numbers

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International Journal of Plant Engineering and Management 2022年第3期27卷 129-143页

作者： jiang weiyang HE Xiaoliang DU Hejia Rocket Force University of Engineering Xi′an 710025China

Safety risks are essential to the success or failure of the large⁃scale complex *** order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of work breakdown structure and risk breakdown structure(WBS⁃RBS)is proposed to identify the project *** this paper,interval numbers are used to evaluate the risk levels,weights are assigned automatically based on the complexity and risk degree of WBS to distinguish three types of nodes in WBS,and a risk assessment algorithm is designed to assess safety risk at all layers of the project.A case study is conducted to demonstrate how to apply the *** results show the practicality,robustness and efficiency of our new method,which can be applied to different kinds of large⁃scale complex projects in reality.

关键词： large⁃scale complex project risk assessment WBS⁃RBS assign weights automatically

Research of Personnel Operational Ability Evaluation of Large-scale Complex Equipment

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International Journal of Plant Engineering and Management 2019年第3期24卷 129-139页

作者： jiang weiyang HE Xiaoliang ZHAO Manyun Rocket Force University of Engineering

The level of personnel operation ability determines the expected effectiveness of large-scale complex equipment. Firstly, this paper constructs the personnel operational ability evaluation index system and analyzes the data source of index. Secondly, the weight of index is determined and the fuzzy comprehensive evaluation model is proposed. Finally, results of instance analysis show that the evaluation model is feasible and effective.

关键词： large-scale complex equipment personnel operational ability AHP fuzzy comprehensive evaluation

Survey of the Hypertention Suffered by the Middle-aged from Suburban Areas and Its Related Pathogenesis

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South China Journal of Cardiology 2007年第4期8卷 212-215页

作者： weiyang Li Fen jiang Yanping Wang Hongqi Hospital Mudanjiang Medical College Mudanjiang 157011 China

Objectives To investigate the related pathogenic factors of hypertension affecting the middle-aged in suburban areas in Mudanjiang City and further popularize health education with regard to hypertension. Methods A survey was conducted on 858 middle-aged people of 35 to 59 years old from such suburban areas as Jinglong village, Bada village and Fengshou village by adopting the hypertensive definition and classifying standard of an WHO/ISH hypertensive treatment guidance in 1999. Results Positive correlation was shown between occurrence of hypertension and such elements as diet in excess salt, drinking, obesity, smoking. Conclusions It is of great clinical significance to combat and prevent the hypertension by regulating one＇s diet and life style.

关键词： hypertension pathogeny diet habits modes of conduct

社会化服务能推动农业高质量发展吗?——来自第三次全国农业普查中粮食生产的证据

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中国农村经济 2021年第12期 109-130页

作者：钟真蒋维扬李丁中国人民大学农业与农村发展学院中国人民大学社会与人口学院

我国农业生产高度依赖于物质要素投入的时代正在"翻篇",发展社会化服务能否推动农业进入高质量发展轨道,其效果机制尚未被有效证实。为此,本文利用第三次全国农业普查的权威数据,以农业经营主体从事社会化服务对其粮食生产参与、生产规... 详细信息

我国农业生产高度依赖于物质要素投入的时代正在"翻篇",发展社会化服务能否推动农业进入高质量发展轨道,其效果机制尚未被有效证实。为此,本文利用第三次全国农业普查的权威数据,以农业经营主体从事社会化服务对其粮食生产参与、生产规模、生产方式的影响为例,深入分析了在"大国小农"背景下社会化服务与农业高质量发展"三大维度"之间的内在关系。分析结果显示,尽管全国各类农业经营主体从事农业社会化服务的比例还不高,但从事农业社会化服务总体上是"有利可图"的。发展农业社会化服务对改变农业经营主体的粮食生产参与、优化粮食生产规模、改进粮食生产方式均具有积极意义。这说明,发展农业社会化服务可以成为新时代农业经济增长的重要潜力点,不仅有助于促进农民增收、推动农业结构调整,还有助于保持和提高农业综合生产能力,并为实现农业生产绿色化转型提供更大可能。

关键词：农业社会化服务农业高质量发展粮食生产绿色化转型