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Removal of pharmaceutical in a biogenic/chemical manganese oxide system driven by manganese-oxidizing bacteria with humic acids as sole carbon source

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Journal of Environmental Sciences 2023年第4期126卷 734-741页

作者： Tingming Ye Huijuan Liu weixiao qi Jiuhui Qu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100049China

Bioaugmented sand filtration has attracted considerable attention because it can effectively remove contaminants in drinking water without additional chemical reagent addition.In this study,a synthesized chemical manganese dioxide (MnO_(2)) -coated quartz sand(MnQS) and biogenic manganese oxide (BioMnOx) composite system was proposed to simultaneously remove typical pharmaceutical contaminants and Mn_(2)+.We demonstrated a manganese-oxidizing bacterium,Pseudomonas sp.QJX-1,could oxidize Mn_(2)+to generate BioMnOxusing humic acids (HA) as sole carbon source.The coaction of MnQS,QJX-1,and the generated BioMnOxin simultaneously removing caffeine and Mn_(2)+in the presence of HA was evaluated.We found a synergistic effect between them.MnQS and BioMnOxtogether significantly increased the caffeine removal efficiency from 32.8%(MnQS alone) and 21.5%(BioMnOxalone) to 61.2%.Meanwhile,Mn_(2)+leaked from MnQS was rapidly oxidized by QJX-1 to regenerate reactive BioMnOx,which was beneficial for continuous contaminant removal and system stability.Different degradation intermediates of caffeine oxidized by MnQS and BioMnOxwere detected by LC-QTOF-MS analysis,which implied that caffeine was oxidized by a different pathway.Overall,this work promotes the potential application of bioaugmented sand filtration in pharmaceutical removal in the presence of natural organic matter in drinking water.

关键词： Bioaugmentation MnO_(2)-coated quartz sand Manganese-oxidizing bacteria Humic acid Caffeine

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Mixing regime shapes the community assembly process,microbial interaction and proliferation of cyanobacterial species Planktothrix in a stratified lake

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Journal of Environmental Sciences 2022年第5期34卷 103-113页

作者： Junwen Chen Huacong Liu Yaohui Bai Jing qi weixiao qi Huijuan Liu Jianfeng Peng Jiuhui Qu Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Lake mixing influences aquatic chemical properties and microbial community composition,and thus,we hypothesized that it would alter microbial community assembly and interac-tion.To clarify this issue,we explored the community assembly processes and cooccurrence networks in four seasons at two depths(epilimnion and hypolimnion)in a mesotrophic and stratified lake(Chenghai Lake),which formed stratification in the summer and turnover in the winter.During the stratification period,the epilimnion and hypolimnion went through contrary assembly processes but converged to similar assembly patterns in the mixing pe-riod.In a highly homogeneous selection environment,species with low niche breadth were filtered,resulting in decreased species richness.Water mixing in the winter homogenized the environment,resulting in a simpler microbial cooccurrence network.Interestingly,we observed a high abundance of the cyanobacterial genus Planktothrix in the winter,proba-bly due to nutrient redistribution and Planktothrix adaptivity to the winter environment in which mixing played important roles.Our study provides deeper fundamental insights into how environmental factors influence microbial community structure through community assembly processes.

关键词： Stratified lake Water mixing Microbial community assembly Microbial interaction Planktothrix

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Microbial responses to the use of NaClO in sediment treatment

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Frontiers of Environmental Science & Engineering 2022年第2期16卷 25-38页

作者： Kun Li Tingming Ye Wang Zhang Jianfeng Peng Yaohui Bai weixiao qi Huijuan Liu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100049China China University of Mining&Technology Beijing 100083China

Chlorine is often used in algal removal and deodorization of landscape waters,and occasionally used as an emergency treatment of heavily polluted sediments.However,the ecological impact of this practice has not been fully studied and recognized.In this study,NaClO at 0.1 mmol/g based on dry weight sediment was evenly mixed into the polluted sediment,and then the sediment was incubated for 150 days to evaluate its microbial effect.Results showed that NaClO addition enhanced the release of TOC,TN,Cr and Cu from the sediment.The microbial richness in the examined sediment decreased continuously,and the Chao1 index declined from 4241 to 2731,in 150 days.The microbial community composition was also changed.The abundance of Proteobacteria and Bacteroidetes increased to 54.8%and 4.2%within 7 days compared to the control,and linear discriminant analysis(LDA)showed gram-negative bacteria and aerobic bacteria enriched after chlorination.The functional prediction with PICRUSt2 showed the functions of the microbial community underwent major adjustments,and the metabolic-related functions such as carbon metabolism,including pyruvate and methane metabolisms were significantly inhibited;besides,15 out of 22 analyzed key enzymes involved in C cycling and 6 out of 12 key enzymes or genes involved in N cycling were strongly impacted,and the enzymes and genes involved in carbon degradation and denitrification showed remarkable downregulation.It can be concluded that chlorination posed a seriously adverse effect on microbial community structure and function.This study deepens the understanding of the ecological effects of applying chlorine for environmental remediation.

关键词： Sediment chlorination Substance mobility Microbial response Community composition Function

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The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

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Science China Life Sciences 2024年

作者： weixiao Yan Xiaotong Wang Wenjing Wang qi Guo Na Huang Hao Chen Xingjie Liang Yu Han Dandan Liu Jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationCollege of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei Province Hebei University CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

Cancer stem cells(CSCs) play an important role in metastasis development, tumor recurrence, and treatment resistance, and are essential for the eradication of cancer. Currently, therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape, which leads to enhanced aggressive behaviors compared with CSCs that have never been treated. However, the underlying mechanisms regulating the therapeutic escape remain unknown. To this end, we established a model to isolate the therapeutic escaped CSCs(TSCSCs) from breast CSCs and performed the transcription profile to reveal the mechanism. Mechanistically, we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway, resulting in TSCSCs exhibiting enhanced motility and metastasis. Notably,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo, which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and N-cadherin.The obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

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Defect-enhanced photocatalytic removal of dimethylarsinic acid over mixed-phase mesoporous TiO2

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Journal of Environmental Sciences 2020年第5期32卷 35-42页

作者： Jingjing Dong Chengzhi Hu weixiao qi Xiaoqiang An Huijuan Liu Jiuhui Qu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Much attention has been paid to the pollutant dimethylarsenic acid(DMA),because of its high toxicity even at very low doses.Although TiO2 photocatalytic oxidation(PCO)is one of the few effective methods for treating DMA-containing water,the efficient decomposition of DMA and simultaneous removal of toxic arsenic species remains a significant but challenging task.Here,defective mesoporous TiO2 with mixed-phase structure was synthesized and used as both photocatalyst and adsorbent for DMA removal.Due to the reduced band-gap and enhanced separation of photogenerated charge carriers,the oxygen-deficient TiO2 nanostructures exhibited 4.2 times higher PCO efficiency than commercial TiO2(P25).More importantly,the high surface area of the mesoporous TiO2 provided sufficient active sites for in-situ adsorption and reaction,resulting in the efficient removal of as-formed As(V).Combining the experimental and characterization results,the different roles of reactive species during PCO reactions were clarified.In the presence of hole(h+)as the dominant oxidation species,DMA was demethylated and transformed into MMA.Thereafter,MMA was subsequently reduced to As(Ⅲ)by photo-generated electrons.Superoxide radicals(O2·-)played a significant role in oxidizing As(Ⅲ)into As(Ⅴ),which was finally adsorptively removed by the mesoporous TiO2.

关键词： Mesoporous TiO2 Dimethylarsinic acid Adsorption Photocatalysis Oxygen vacancy

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污水厂尾水对受纳水体中消毒副产物(DBPs)时空分布特征的影响

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环境科学学报 2024年第3期44卷 105-116页

作者：刘菲李翀聂中林黄适尔徐赫姝吴涵陈亚松张驰齐维晓中国长江三峡集团长江生态环境工程研究中心北京100038 清华大学环境学院清华大学水质与水生态研究中心北京100084 桂林理工大学环境科学与工程学院桂林541004

以保障污水厂尾水补水安全为目的,通过分析长江中下游城镇污水厂尾水及受纳水体的水质、溶解性有机质与消毒副产物(DBPs)的时空分布特征,评估污水厂尾水DBPs对受纳水体的生态风险.结果表明,污水厂尾水中溶解性有机碳(DOC)含量低,排入受... 详细信息

以保障污水厂尾水补水安全为目的,通过分析长江中下游城镇污水厂尾水及受纳水体的水质、溶解性有机质与消毒副产物(DBPs)的时空分布特征,评估污水厂尾水DBPs对受纳水体的生态风险.结果表明,污水厂尾水中溶解性有机碳(DOC)含量低,排入受纳水体后下游较上游断面DOC含量有所下降;空间上总氮(TN)浓度沿程呈先上升后下降趋势,季节上冬季>夏季>春季.4种三卤甲烷(THM)与4种卤乙腈(HANs)的浓度范围分别为0.16~26.46μg·L^(-1)与0.007~14.08μg·L^(-1),随着受纳水体的输移呈先升高后降低的趋势;冬季THMs浓度高于夏季与春季,春季HANs浓度高于冬季与夏季.夏季的C/N-DBPs对受纳水体基本无生态风险,冬季与春季时三氯甲烷(TCM)与二氯乙腈(DCAN)为高风险物质,需重点关注.本文对长江中下游典型污水厂尾水排入受纳水体的迁移过程进行系统研究,为该地区污水中DBPs的风险控制提供了重要科学依据.

关键词：污水厂尾水受纳水体消毒副产物生态风险

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经典名方柴胡桂枝干姜汤的关键信息考证与临床运用分析

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中国实验方剂学杂志 2024年第12期30卷 136-146页

作者：王雪洁梁绿圆曹佳蕾刘澜李维笑王艺萍魏炳琦马丙祥史文丽河南中医药大学儿科医学院郑州450046 河南中医药大学中医学院郑州450000 河南中医药大学第一附属医院郑州450000

柴胡桂枝干姜汤临床疗效确切,自汉代至今广为流传记载,是一首被历代医家推崇的柴胡类方,已被收录于2023年8月国家中医药管理局公布的《古代经典名方目录(第二批)——汉族医药》。笔者采用文献计量学的方法,搜集并纳入明确记载方名及药... 详细信息

柴胡桂枝干姜汤临床疗效确切,自汉代至今广为流传记载,是一首被历代医家推崇的柴胡类方,已被收录于2023年8月国家中医药管理局公布的《古代经典名方目录(第二批)——汉族医药》。笔者采用文献计量学的方法,搜集并纳入明确记载方名及药物组成的柴胡桂枝干姜汤相关古籍文献数据共有37处,涉及中医古籍34部。该文从柴胡桂枝干姜汤的方源方名、组成、药物基原、剂量、制法用法、古今主治功效及临床应用分析等方面进行梳理考证。考证结果显示柴胡桂枝干姜汤出自汉代张仲景所著《伤寒论》,药物基原古今基本一致,古籍中药物剂量大多数与《伤寒论》所载用量一致,柴胡桂枝干姜汤功效为和解少阳,温化水饮。主治病证范围广泛,但总以太阳少阳枢机不利为主。该方现代应用范围涉及消化系统、呼吸系统、皮肤科、神经系统等,对于疑难杂症亦有良效。通过对柴胡桂枝干姜汤古籍文献的挖掘梳理,确定其关键信息,以期为经典名方的临床应用及新药研发提供科学参考。

关键词：柴胡桂枝干姜汤经典名方文献考证古今应用

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长江重点江段枯水期药物及个人护理品(PPCPs)的空间分布特征及来源

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环境科学学报 2022年第2期42卷 164-173页

作者：胡烨徐辉王殿常王旭曾超怡边睿齐维晓刘会娟桂林理工大学环境科学与工程学院桂林541004 清华大学环境学院清华大学水质与水生态研究中心北京100084 中国长江三峡集团有限公司北京100038 东北师范大学环境学院长春130117

药物及个人护理品(PPCPs)由于潜在的生态效应引起广泛关注,近年来在长江流域中也被普遍检出.本文研究了长江攀枝花、宜宾、泸州、重庆、涪陵、三峡、岳阳、武汉、九江和南京共计10个重点江段枯水期表层水中57种PPCPs及部分代谢产物的分... 详细信息

药物及个人护理品(PPCPs)由于潜在的生态效应引起广泛关注,近年来在长江流域中也被普遍检出.本文研究了长江攀枝花、宜宾、泸州、重庆、涪陵、三峡、岳阳、武汉、九江和南京共计10个重点江段枯水期表层水中57种PPCPs及部分代谢产物的分布和来源,为长江流域的污染管控提供了科学支撑.结果表明,长江表层水中57种PPCPs均有不同程度检出,其中磺胺甲恶唑(SMX)、甲氧苄氨嘧啶(TMP)、土霉素(OTC)、环丙沙星(CIP)、诺氟沙星(NFX)、咖啡因(CF)、碘普罗胺(IPM)等物质的检出频率在70%以上.表层水中ΣPPCPs平均浓度为90.0~409.3 ng·L^(-1),咖啡因(平均值76.9 ng·L^(-1))、碘普罗胺(平均值20.1 ng·L^(-1))浓度相对较高.10个江段中,ΣPPCPs平均浓度相对较高的江段有泸州江段(409.3 ng·L^(-1))、九江江段(277.7 ng·L^(-1))和南京江段(306.9 ng·L^(-1)).除了上游的泸州江段,整体上长江下游的PPCPs污染程度要高于上游和中游.通过咖啡因空间差异的指示结果,长江上游江段可能有较多未经处理的污水排入,或受农业面源污染较大;中下游江段中PPCPs主要来源于污水处理厂的排放.

关键词：药物及个人护理品长江流域浓度水平空间分布特征来源枯水期

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山东、安徽省村镇饮用水源中碘化物的分布、来源及存在的健康风险

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环境科学学报 2022年第12期42卷 104-113页

作者：黄适尔边睿郭加汛谢煜齐维晓刘会娟李艳红桂林理工大学环境科学与工程学院桂林541004 清华大学环境学院清华大学水质与水生态研究中心北京100084 东北师范大学环境学院长春130117

村镇中小型饮用水源是中国农村饮用水的主要类型,对该类水源中碘化物分布特征的研究较少.为探明山东、安徽村镇饮用水源中碘化物的分布、来源及存在的饮用健康风险,于2021年10—11月对该区域97个代表性村镇饮用水源(湖库、河流、地下水... 详细信息

村镇中小型饮用水源是中国农村饮用水的主要类型,对该类水源中碘化物分布特征的研究较少.为探明山东、安徽村镇饮用水源中碘化物的分布、来源及存在的饮用健康风险,于2021年10—11月对该区域97个代表性村镇饮用水源(湖库、河流、地下水)进行调研和样品采集,综合水化学分析、统计学和风险评价等方法进行分析.结果表明,研究区水体中碘化物的浓度为0.1~294.5μg·L^(-1),其中15%的点位为高碘型水源,集中在山东菏泽和安徽北部的地下水源,50%的点位为缺碘型水源,以地表水源为主.碘化物浓度与水化学类型密切相关,Ca^(2+)·HCO_(3)^(-)型水源中74%为缺碘型,Na^(+)·HCO_(3)^(-)型水源中45%为高碘型.岩石风化的空间异质性导致水化学类型存在差异,水岩作用下的阳离子交换使沉积岩中的碘释放到水中,蒸发浓缩使水中的碘化物富集.健康风险评价表明,2%的水源(菏泽郓城县、淮北濉溪县)的儿童风险熵大于1,成人的高碘饮用水健康风险较低.

关键词：村镇饮用水源碘化物分布来源健康风险

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岸滤系统中磺胺甲恶唑、咖啡因和卡马西平的厌氧转化模拟研究

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环境科学学报 2018年第9期38卷 3573-3581页

作者：莫小妤齐维晓李静河北工业大学土木与交通学院天津300401 中国科学院生态环境研究中心北京100085

为了探究药品和个人护理用品(PPCPs)在岸滤系统中的转化过程及其影响因素,采集了不同类型的河床岸滤土壤,模拟岸滤系统中的反硝化和硫还原过程,探究该过程中磺胺甲恶唑(Sulfamethoxazole,SMX)及两种共存PPCPs(咖啡因、卡马西平)的转化... 详细信息

为了探究药品和个人护理用品(PPCPs)在岸滤系统中的转化过程及其影响因素,采集了不同类型的河床岸滤土壤,模拟岸滤系统中的反硝化和硫还原过程,探究该过程中磺胺甲恶唑(Sulfamethoxazole,SMX)及两种共存PPCPs(咖啡因、卡马西平)的转化过程及中间产物的生成.批次培养实验结果显示,至培养周期第87 d时SMX的生物降解率达到100%,反硝化过程中SMX自第5 d开始转化为两种衍生物—D-SMX及4-nitro-SMX,反硝化反应结束两种衍生物再次还原为SMX.SMX的转化率因有机质的不同而产生差异,添加乙酸钠有机质时SMX的转化率整体高于添加富里酸有机质的转化率;硫还原条件下SMX则完全降解;咖啡因(Caffeine,CFE)的生物降解率高于50%,不同河床土壤的理化性质差异及微生物的分布差异造成CFE的吸附及降解效果有很大差异,投加潮白河沉积物样品中CFE生物降解率高于投加密云水库沉积物样品;卡马西平(Carbamazepine,CMZ)的降解率范围在20%~35%,CMZ在岸滤系统中不易发生降解.

关键词：岸滤系统磺胺甲恶唑(SMX) 咖啡因(CFE) 卡马西平(CMZ) 厌氧转化

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