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中国式教育现代化背景下高校“三全育人”落实机制研究

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内蒙古师范大学学报（教育科学版） 2024年第1期37卷 1-6,19页

作者：徐伟侠西北工业大学教育基金会陕西西安710072

“三全育人”是建设中国式教育现代化的重要途径,对于构建高质量思想政治工作体系和高水平人才培养体系具有支撑性、保障性作用。在全面建设社会主义现代化强国的新征程中,高校应以中国式教育现代化的方向目标为引领,深化“三全育人”... 详细信息

“三全育人”是建设中国式教育现代化的重要途径,对于构建高质量思想政治工作体系和高水平人才培养体系具有支撑性、保障性作用。在全面建设社会主义现代化强国的新征程中,高校应以中国式教育现代化的方向目标为引领,深化“三全育人”综合改革,健全“三全育人”工作体系,筑牢立德树人主阵地。提升新时代高校“三全育人”改革实效性,需要探究中国式教育现代化与高校“三全育人”的内在关联,从高校“三全育人”实践中归纳成效、理清问题,明晰主导精神、优化实现路径、完善落实机制,从而打造育人过程贯通、育人资源共享、育人力量汇聚的育人新格局。

关键词：高校 “三全育人” 中国式教育现代化立德树人

All-stage targeted therapy for the brain metastasis from triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2023年第1期13卷 359-371页

作者： Zimiao Luo Sunyi Wu Jianfen Zhou weixia xu Qianzhu xu Linwei Lu Cao Xie Yu Liu Weiyue Lu Department of Pharmaceutics School of PharmacyKey Laboratory of Smart Drug DeliveryFudan UniversityShanghai 201203China Department of Integrative Medicine Huashan HospitalInstitutes of Integrative Medicine of Fudan UniversityShanghai 200041China Minhang Branch Zhongshan Hospital and Institute of Fudan-Minghang Academic Health SystemMinghang HospitalFudan UniversityShanghai 201199China State Key Laboratory of Medical Neurobiology Collaborative Innovation Center for Brain ScienceFudan UniversityShanghai 200032China

Brain metastasis is a common and serious complication of breast cancer,which is commonly associated with poor survival and *** particular,the treatment of brain metastasis from triplenegative breast cancer(BM-TNBC)has to face the distinct therapeutic challenges from tumor heterogeneity,circulating tumor cells(CTCs),blood-brain barrier(BBB)and blood-tumor barrier(BTB),which is in unmet clinical ***,combining with the advantages of synthetic and natural targeting moieties,we develop a“Y-shaped”peptide pVAP-decorated platelet-hybrid liposome drug delivery system to address the all-stage targeted drug delivery for the whole progression of *** from the activated platelet,the hybrid liposomes still retain the native affinity toward ***,the peptide-mediated targeting to breast cancer cells and transport across BBB/BTB are demonstrated in vitro and in *** resultant delivery platform significantly improves the drug accumulation both in orthotopic breast tumors and brain metastatic lesions,and eventually exhibits an outperformance in the inhibition of BM-TNBC compared with the free ***,this work provides a promising prospect for the comprehensive treatment of BMTNBC,which could be generalized to other cell types or used in imaging platforms in the future.

关键词： Breast cancer Brain metastasis from breast cancer Platelet-hybrid liposome pVAP peptide Nanocrystal Cabazitaxel Targeted drug delivery Drug delivery system

A Bayesian validation approach to practical boson sampling

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Science China(Physics,Mechanics & Astronomy) 2020年第5期63卷 39-46页

作者： Zhe Dai Yong Liu Ping xu weixia xu xueJun Yang JunJie Wu Institute for Quantum Information&State Key Laboratory of High Performance Computing College of Computer National University of Defense TechnologyChangsha 410073China

Boson sampling is a promising candidate for demonstrating quantum supremacy. The validation that involves judging whether a quantum setup outputs photons following the boson sampling model is an essential task in the experiments. However, the current validation methods may result in an incorrect conclusion being reached in realistic experiments, in which no ideally identical photons exist. Accordingly, this study proposes a slope-based approach, which is an extended Bayesian validation, to model the degree of photon indistinguishability. Through numerical simulations and performance evaluations, we demonstrate that the proposed approach can correctly validate boson sampling against the distribution of classical particles. In addition to offering a useful approach for validation, our research indicates that physicists should pay more attention to the quality of photon indistinguishability in boson sampling experiments.

关键词： boson sampling quantum supremacy Bayesian validation photon indistinguishability

Hybrid hierarchy storage system in MilkyWay-2 supercomputer

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Frontiers of Computer Science 2014年第3期8卷 367-377页

作者： weixia xu Yutong LU Qiong LI Enqiang ZHOU Zhenlong SONG Yong DONG Wei ZHANG Dengping WEI Xiaoming ZHANG Haitao CHEN Jianying XING Yuan YUAN State Key Laboratory of High Performance Computing Changsha 410073 China College of Computer National University of Defense Technology Changsha 410073 China

With the rapid improvement of computation capability in high performance supercomputer system, the imbalance of performance between computation subsystem and storage subsystem has become more and more serious, especially when various big data are produced ranging from tens of gigabytes up to terabytes. To reduce this gap, large-scale storage systems need to be designed and implemented with high performance and scalability. MilkyWay-2 （TH-2） supercomputer system with peak performance 54.9 Props, definitely has this kind of requirement for storage system. This paper mainly introduces the storage system in MilkyWay-2 supercomputer, including the hardware architecture and the parallel file system. The storage system in MilkyWay-2 supercomputer exploits a novel hybrid hierarchy storage architecture to enable high scalability of I/O clients, I/O bandwidth and storage capacity. To fit this architecture, a user level virtualized file system, named H^2FS, is designed and implemented which can cooperate local storage and shared storage together into a dynamic single namespace to optimize I/O performance in IO-intensive applications. The evaluation results show that the storage system in MilkyWay-2 supercomputer can satisfy the critical requirements in large scale supercomputer, such as performance and scalability.

关键词： supercomputer storage system file system,MilkyWay-2 hybrid hierarchy

论课程思政与思政课程协同育人的战略思维考量

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漳州职业技术学院学报 2023年第4期25卷 37-43页

作者：许伟虾漳州职业技术学院经济管理学院福建漳州363000 厦门大学公共事务学院福建厦门361005

基于战略思维视角,课程思政与思政课程协同有着立德树人价值指向协同、内驱力外逼力助推协同、辩证统一思维推进协同的内在逻辑。在对协同育人战略目标思维、战略判断思维、战略决策思维、战略实施思维、战略评价思维等要素进行分析的... 详细信息

基于战略思维视角,课程思政与思政课程协同有着立德树人价值指向协同、内驱力外逼力助推协同、辩证统一思维推进协同的内在逻辑。在对协同育人战略目标思维、战略判断思维、战略决策思维、战略实施思维、战略评价思维等要素进行分析的基础上,提出优化系统举措,保障协同育人的规范性;把握教师和课程两大战略核心,实现协同育人的实效性和超越性;注重结果复盘,增强协同发展的全局性等育人协同策略。

关键词：课程思政思政课程协同育人战略思维

结合多解码器与两阶段通道选择的异常检测方法

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计算机工程 2023年第3期49卷 37-48页

作者：王禹博陈利锋许卫霞复旦大学计算机科学技术学院上海200433

异常检测是发现数据集中不符合明确定义的模式(或样本)的过程。目前流行的异常检测方法通常只对合群点进行建模,忽视了潜藏在无标记数据中的丰富信息,导致出现过拟合、阈值依赖等问题。此外,部分现有方法同等地处理正常类和异常类,与异... 详细信息

异常检测是发现数据集中不符合明确定义的模式(或样本)的过程。目前流行的异常检测方法通常只对合群点进行建模,忽视了潜藏在无标记数据中的丰富信息,导致出现过拟合、阈值依赖等问题。此外,部分现有方法同等地处理正常类和异常类,与异常检测的目的相矛盾。提出一种结合多解码器与两阶段通道选择的异常检测方法,采用一种全新的重构-选择模型代替重构-排序-拒绝模型,并分别对合群点和离群点进行解码建模,构造一个无须阈值的选择器以区分两者,降低阈值确定过程中产生的人为误差和计算开销。通道选择器以两阶段的方式为样本分配通道,在第一阶段使用注意力选择器为无标记样本选择最佳匹配的离群点通道,在第二阶段使用竞争式选择器在合群点通道和最佳离群点通道中选择更适合的一个作为目标通道。两阶段选择器的结构能避免出现局部极值点,并可以利用直接引入的监督信息对选择结果进行修正。实验结果表明,与U-Std、ARAE、AnoGAN等流行方法相比,该方法的检测性能更好,在MNIST、Fashion-MNIST、CIFAR-10数据集上的AUROC值分别为99.3%、96.9%和90.5%。

关键词：异常检测非对称建模数据增强数据集清理免阈值

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类脑处理器异步片上网络架构

计算机研究与发展 2023年第1期60卷 17-29页

作者：杨智杰王蕾石伟彭凌辉王耀徐炜遐国防科技大学计算机学院长沙410073

类脑处理器较深度学习处理器具有能效优势.类脑处理器的片上互连一般采用具有可扩展性高、吞吐量高和通用性高等特点的片上网络.为了解决采用同步片上网络面临的全局时钟树时序难以收敛的问题以及采用异步片上网络面临的链路延迟匹配、... 详细信息

类脑处理器较深度学习处理器具有能效优势.类脑处理器的片上互连一般采用具有可扩展性高、吞吐量高和通用性高等特点的片上网络.为了解决采用同步片上网络面临的全局时钟树时序难以收敛的问题以及采用异步片上网络面临的链路延迟匹配、缺乏电子设计自动化工具实现和验证的问题,提出了一种异步片上网络架构——NosralC,用于构建全局异步局部同步(global asynchronous local synchronous,GALS)的多核类脑处理器.NosralC采用异步链路和同步路由器实现.实验表明,NosralC较同步基线,在4个类脑应用数据集下展现出37.5%~38.9%的功耗降低、5.5%~8.0%的平均延迟降低和36.7%~47.6%的能效提升,同时增加不多于6%的额外资源以及带来较小的性能开销(吞吐量降低0.8%~2.4%).NosralC在现场可编程门阵列(FPGA)上得到了验证,证明了该架构的可实现性.

关键词：类脑处理器片上网络异步电路全局异步局部同步脉冲神经网络

Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by *** understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were *** rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate *** isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid *** on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely *** the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier ***,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise