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The relationship between cognitive function and having diabetes in patients treated with hemodialysis

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International Journal of Nursing Sciences 2020年第1期7卷 60-65页

作者： Lei Cui weixia chen Xingxing Yu Changping Ju Medical School Southeast UniversityNanjingJiangsuChina Nursing Department Zhongda HospitalNanjingJiangsuChina Nursing Department Zhongda Hospital Lishui BranchNanjingJiangsuChina

Purpose:Patients undergoing maintenance hemodialysis(MHD)have a higher prevalence of cognitive impairment and inferior cognitive performance than the general population,and those with cognitive impairment are at higher risk of death than those without cognitive *** diabetes has been associated with an increased risk of cognitive decline in end-stage kidney disease patients treated with peritoneal dialysis or kidney ***,these findings may not extend to the hemodialysis ***,we aim to investigate the relationship between having diabetes and cognitive function in MHD ***:This was a cross-sectional study.A total of 203 patients treated with MHD from two blood purification centers were enrolled as *** Chinese version of the Montreal Cognitive Assessment(MoCA)was utilized to assess cognitive ***:MHD patients with diabetes had a significantly higher prevalence of global cognitive impairment and inferior performance in global cognition,visuospatial/executive function,naming,language,abstraction and orientation tasks compared with those without *** to the multiple linear analyses,having diabetes was significantly associated with lower global cognitive function,naming,and language scores,withβcoefficients and 95%CIs of-1.30[-2.59,-0.01],-0.25[-0.47,-0.02],and-0.32[-0.58,-0.07],respectively(all P<0.05).Having diabetes could not independently predict an increased risk of global cognitive ***:In MHD patients,having diabetes is significantly associated with lower cognitive function *** staff should evaluate early and focus on the decline of cognitive function in MHD patients with diabetes,in order to achieve early diagnosis and earlv intervention.

关键词： Alzheimer disease Cognitive dysfunction Dementia Diabetes mellitus Dialysis

Transcriptome analysis of wheat grain using RNA-Seq

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Frontiers of Agricultural Science and Engineering 2014年第3期1卷 214-222页

作者： Liu WEI Zhihui WU Yufeng ZHANG Dandan GUO Yuzhou XU weixia chen Haiying ZHOU Mingshan YOU Baoyun LI Beijing Key Laboratory of Crop Genetic Improvement College of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Key Laboratory of Crop Heterosis&Utilization Ministry of EducationCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China

With the increase in consumer demand,wheat grain quality improvement has become a focus in China and *** analysis is a powerful approach to research grain traits and elucidate their genetic *** this study,two cDNA libraries from the developing grain and leaf-stem components of bread wheat cultivar,Nongda211,were sequenced using Roche/454 *** were 1061274 and 1516564 clean reads generated from grain and leaf-stem,respectively.A total of 61393 high-quality unigenes were obtained with an average length of 1456 bp after de novo *** analysis of the 61393 unigenes involved in the biological processes of the grain showed that there were 7355 differentially expressed genes upregulated in the grain *** ontology enrichment and the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that many transcription products and transcription factors associated with carbohydrate and protein metabolism were abundantly expressed in the *** results contribute to excavate genes associated with wheat quality and further study how they interact.

关键词： transcriptome analysis wheat grain differentially expressed genes enrichment analysis

Mechanism of Action of the Traditional Chinese Medicine Formula Weichang’an in the Treatment of Gastric Cancer Based on TMT Proteomics Analysis

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Chinese Medicine and Natural Products 2024年第4期4卷 173-181页

作者： Yaofei Niu weixia chen Yajie Ding Yan Xu Aiguang Zhao Department of Infection Henan Provincial People’s HospitalZhengzhouHenanChina Department of Oncology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Oncology Henan Province Hospital of TCM(The Second Affiliated Hospital of Henan University of Chinese Medicine)ZhengzhouHenanChina

Objective The aim of the study was to screen key proteins involved in the treatment of human gastric cancer subcutaneous xenografts in nude mice by the traditional Chinese medicine formula Weichang’an and to explore its mechanism of action in treating gastric *** Sixteen 7-to 8-week-old female BALB/C nude mice were used to establish a human gastric cancer subcutaneous xenograft model by bilateral axillary injection of MKN45 *** with successfully established tumors were randomly divided into the Weichang’an group and the model group,with eight mice in each *** in the Weichang’an group were orally administered 0.5mL of Weichang’an decoction,while mice in the model group were given 0.5 mL of normal saline by gavage once a day for 21 consecutive *** day 28,the animals were sacrificed by cervical dislocation,and tumors were excised to measure tumor weight and assess the tumor suppression *** mass tags(TMT)quantitative proteomics was used to analyze the tumor samples,identify differentially expressed proteins,and perform Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** Compared with the model group,the tumor weight in the Weichang’an group was significantly reduced(p<0.001),and the tumor suppression rate was 41.40%,indicating that Weichang’an can inhibit the growth of human gastric cancer subcutaneous xenografts in nude *** quantitative proteomics identified a total of 2,856 proteins,with 13 proteins showing downregulated expression and 25 proteins showing upregulated expression in the Weichang’an *** enrichment analysis revealed that differentially expressed proteins were mainly enriched in cellular components such as the cell membrane,extracellular matrix,and envelope,and participated in biological processes like negative regulation of cell adhesion hematopoiesis,and skeletal system development,with functions in cell adhesion molecule binding and molecular sensor activity

关键词： TMT proteomics Weichang’an gastric cancer differentially expressed protein

甲基丙烯酸甲酯-丙烯酰胺杯芳烃聚合物膜中残留溶剂行为的多尺度模拟

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计算机与应用化学 2009年第1期26卷 57-61页

作者：陈维霞黄民同济大学化学系上海200092

利用耗散力动力学(DPD)模拟,研究只有少量溶剂之下,甲基丙烯酸甲酯-丙烯酰胺杯芳烃聚合物膜的介观结构。溶剂包括氯仿(CHCl_3)和四氢呋喃(THF)。在DPD模拟中,聚合物和溶剂分子采用粗粒化模型。Flory-Huggins理论中的相互作用参数χ是用... 详细信息

利用耗散力动力学(DPD)模拟,研究只有少量溶剂之下,甲基丙烯酸甲酯-丙烯酰胺杯芳烃聚合物膜的介观结构。溶剂包括氯仿(CHCl_3)和四氢呋喃(THF)。在DPD模拟中,聚合物和溶剂分子采用粗粒化模型。Flory-Huggins理论中的相互作用参数χ是用计算组分之间的内聚能而求。模拟得到了不同溶剂与丙烯酰胺杯芳烃(CA)以及甲基丙烯酸甲酯(PMMA)之间的斥力参数。在DPD模拟得到的介观结构的基础上,根据溶剂、甲基丙烯酸甲酯(PMMA)及杯芳烃的浓度分布曲线,通过杂化蒙特卡罗(Hybrid Monte Carlo)方法映射,求得溶剂存在下聚合物的微观结构。通过分子力学(MM)和分子动力学(MD)计算求得径向分布函数以及溶剂的自扩散系数。

关键词：多尺度模拟杯芳烃 Material Studio软件耗散粒子动力学分子动力学

活体肝移植术后肝淤血的多层螺旋CT评价及原因分析

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临床放射学杂志 2009年第5期28卷 648-651页

作者：王小鹏陈卫霞四川大学华西医院放射科四川成都610041

目的探讨CT双期增强扫描对活体右半肝移植(LDLT)受体术后肝淤血的诊断价值,并对比供体术前CT图像分析肝淤血的原因。资料与方法回顾性分析48例不包含肝中静脉LDLT术后2～4周的CT增强扫描图像,观察原肝中静脉引流区域肝实质密度、肝中静... 详细信息

目的探讨CT双期增强扫描对活体右半肝移植(LDLT)受体术后肝淤血的诊断价值,并对比供体术前CT图像分析肝淤血的原因。资料与方法回顾性分析48例不包含肝中静脉LDLT术后2～4周的CT增强扫描图像,观察原肝中静脉引流区域肝实质密度、肝中静脉属支显影情况,并对照不同的手术方式——肝中静脉属支重建或结扎,比较两种处理方式肝淤血发生率有无差异,分析肝淤血的原因。结果16例(33.3%)显示Ⅴ/Ⅷ段肝实质密度异常。门静脉期淤血区域肝中静脉属支未见显影12例(75.0%),显影4例(25.0%)。原肝中静脉Ⅴ/Ⅷ段属支重建和结扎两种手术方式肝淤血发生率差异无统计学意义(P>0.05)。16例淤血区域肝体积为(44.75±1.6)～(126.76±1.8)cm3中位体积(84.62±1.7)cm3,移植肝总体积为(1064.81±6.9)～(1547.37±8.3)cm3中位体积(1183.14±7.5)cm3,两者之比为(5.2±2.3)%(3.1%～12.4%),1个月后复查,肝静脉属支均显影,13例淤血区基本消失,3例淤血区范围缩小。结论多层螺旋CT双期增强扫描有助于LDLT术后受体肝淤血的诊断,测量肝淤血的范围可评价淤血的程度,门静脉期淤血区肝中静脉属支显影情况与患者预后相关。

关键词：右半肝移植肝淤血体层摄影术 X线计算机

双氯芬酸钠甲基纤维素骨架片体外释药的影响因素研究

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现代医药卫生 2012年第19期28卷 2923-2924页

作者：陈炜霞镇江市第四人民医院江苏镇江212001

目的探讨影响甲基纤维素(MC)亲水凝胶骨架片体外释药的因素。方法以双氯芬酸钠(DS)为模型药物,选取MC为骨架材料,观察MC用量、黏合剂选择、压片压力大小对MC亲水凝胶骨架片体外释药的影响。结果 MC用量、压片压力对骨架片的体外释药有... 详细信息

目的探讨影响甲基纤维素(MC)亲水凝胶骨架片体外释药的因素。方法以双氯芬酸钠(DS)为模型药物,选取MC为骨架材料,观察MC用量、黏合剂选择、压片压力大小对MC亲水凝胶骨架片体外释药的影响。结果 MC用量、压片压力对骨架片的体外释药有较大影响,而黏合剂性质对骨架片的体外释药影响不显著。结论 MC可作为DS骨架片的骨架材料;MC用量、压片压力均影响骨架片的体外释放。

关键词：迟效制剂二氯酚酸甲基纤维素亲水凝胶骨架片溶出度

The Chinese Herbal Formula Weichang’an Reduces the Proliferation of Human Gastric Cancer Cells via Mitochondrial Apoptosis

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Chinese Medicine and Natural Products 2024年第3期4卷 117-125页

作者： weixia chen Yaofei Niu Bin chen Aiguang Zhao Department of Oncology Henan Province Hospital of Traditional Chinese MedicineZhengzhouHenanChina Department of Oncology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Infection Henan Provincial People’s Hospital/Zhengzhou University People’s HospitalZhengzhouHenanChina Department of Oncology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Objective The aim of the study was to investigate the effects of Chinese herbal formula Weichang’an(WCA)on the proliferation and mitochondria-mediated apoptosis of human gastric cancer *** Cell Counting Kit-8(CCK8)was used to evaluate the antiproliferative activity ofWCA on MKN45 cells;Giemsa staining was used to investigate cell colony formation;flow cytometry was used to analyze cell cycle,apoptosis rate,and caspases activation;and Hoechst staining was used to analyze the morphology of cell *** mitochondrial membrane potential was analyzed by both flow cytometric measurements and fluorescence *** blot was used to analyze the protein levels of pro-caspase-3,Bcl-2,Bax,and ***45 cells were subcutaneously injected into the right forelimb of 16 nude mice to establish the tumor xenograft model,and a total of 12 nude mouse tumor xenograft models were successfully *** nude mice were divided into the control group and the WCA-treated *** two groups received normal saline and WCA treatment at 35.49 g/kg by a single daily oral gavage for 21 *** body weight and tumor size of the nude mice were measured twice a *** ultrastructural changes of subcutaneous tumors were observed by a transmission electron *** WCA can suppress cell proliferation and colony *** can also induce changes in the mitochondrial membrane potential and increase the activities of caspases-3,caspases-8,and caspases-9 in MKN45 *** induced S-phase arrest and apoptosis in MKN45 cells,and decreased the expression levels of antiapoptotic proteins Bcl-2 and Bcl-X in MKN45 cells,while increasing the expression levels of the proapoptotic proteins Bax and pro-caspase-3 compared with the control *** inhibited the growth of a xenografted MKN45 tumor in nude mice,and the protein levels of Bax and pro-caspase-3 were significantly increased,while Bcl-X and Bcl-2 were reduced compared with the control *** differences are

关键词： gastric cancer Chinese herbal formula Weichang’an mitochondrial apoptosis

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玄麦甘桔泡腾片的质量标准研究

中国中医药现代远程教育 2012年第23期10卷 159-160页

作者：陈炜霞江苏镇江市第四人民医院镇江212003

玄麦甘桔泡腾片清热滋阴、化痰利咽,临床上用以用于阴虚火旺,虚火上浮,口鼻干燥,咽喉肿痛。处方中玄参为君药,麦冬为臣药,甘草为佐药。玄参中药效成分哈帕俄甙在药材中含量平均约为0.1%,在制剂中含量约为十万分之一;麦冬中代表药效的单... 详细信息

玄麦甘桔泡腾片清热滋阴、化痰利咽,临床上用以用于阴虚火旺,虚火上浮,口鼻干燥,咽喉肿痛。处方中玄参为君药,麦冬为臣药,甘草为佐药。玄参中药效成分哈帕俄甙在药材中含量平均约为0.1%,在制剂中含量约为十万分之一;麦冬中代表药效的单一活性成分尚不明确;甘草中甘草酸具有解毒、抗炎、镇咳、抗肿瘤、抗溃疡、抗菌等多种药理作用,是甘草的主要药效成分,故将甘草酸定为本制剂含量测定的指标成分。

关键词：玄麦甘桔泡腾片 HPLC法甘草酸

指向“幸福”的师幼交往活动审思:内涵、价值与对策

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成才之路 2022年第8期 107-109页

作者：陈蔚霞福建省龙岩市上杭县实验幼儿园福建上杭364200

指向“幸福”的师幼交往活动是指在幼儿园一日活动中,教师及幼儿通过各种轻松的、愉悦的交流与沟通让彼此都找到幸福、温暖的感觉。其有助于营造愉悦、舒适的教育氛围,有助于推动幼儿的发展,有助于强化幼儿教师的职业幸福感。文章通过... 详细信息

指向“幸福”的师幼交往活动是指在幼儿园一日活动中,教师及幼儿通过各种轻松的、愉悦的交流与沟通让彼此都找到幸福、温暖的感觉。其有助于营造愉悦、舒适的教育氛围,有助于推动幼儿的发展,有助于强化幼儿教师的职业幸福感。文章通过探究指向“幸福”的师幼交往活动的内涵、价值与对策,引导幼儿教育工作者更新教育理念,调整教育行为,用科学适宜的方式方法让幼儿体验幸福,也让自身的幼儿教育工作变得幸福而温暖。

关键词：幼儿园师幼活动幸福概念价值策略注意事项

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