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Haemorrhage risk of brain arteriovenous malformation during pregnancy and puerperium

Stroke & Vascular Neurology 2023年第4期8卷 307-317,I0022-I0037页

作者： Junyu Liu Honghao Zhang Chun Luo Yuxin Guo Yifeng Li Dun Yuan weixi jiang Junxia Yan Department of Neurosurgery Xiangya Hospital Central South UniversityChangshaHunanChina Department of Pharmacology Kyoto University Graduate School of Medicine Faculty of MedicineKyotoJapan Department of Epidemiology and Health Statistics Central South University Xiangya School of Public HealthChangshaHunanChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South University Xiangya School of Public HealthChangshaHunanChina

Background This study aimed to assess whether pregnancy and puerperium were associated with the risk of brain arteriovenous malformation(bAVM)*** A retrospective review was conducted in Xiangya Hospital,Central South University from January 2012 to December 2021.A case-crossover design was adopted to calculate the incidence density of bAVM-related haemorrhage among female patients in risk(pregnancy and puerperium)and control(non-pregnancy and non-puerperium)periods,according to four scenarios observed in different populations scenario I:patients with haemorrhagic bAVM of all ages;scenario II:patients with haemorrhagic bAVM of all ages,with at least one previous pregnancy;scenario III:patients with haemorrhagic bAVM who are of reproductive age(15-45 years);scenario IV:patients with haemorrhagic bAVM of reproductive age(15-45 years),with at least one previous ***,a comprehensive literature aggregation(up to April 2022)was performed for evidence *** Among the 311 female patients with haemorrhagic bAVM,a significant haemorrhage risk during pregnancy and puerperium was found in Scenarios I(relative risk[RR],2.08;95%CI,1.28 to 3.39),II(RR,3.21;95%CI,1.95 to 5.31)and IV(RR,2.92;95%CI,1.73 to 4.93);however,a suggestive risk was found in scenario III(RR,1.62;95%CI,0.99 to 2.67).Evidence synthesis revealed a consistent haemorrhage risk among patients of all ages(RR,3.15;95%CI,1.93 to 5.15)and those of reproductive age(RR,1.29;95%CI,0.89 to 1.86).Conclusion Compared with most previous studies,a higher but relatively moderate risk for bAVM-related haemorrhage was identified during pregnancy and *** prevention and treatment strategies should be preferred when neurosurgeons make clinical decisions.

关键词： pregnancy malformation prevention

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Non-medical financial burden in tuberculosis care: a cross-sectional survey in rural China

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Infectious Diseases of Poverty 2016年第1期5卷 37-43页

作者： Qiang Li weixi jiang Quanli Wang Yuan Shen Jingyuan Gao Kaori D.Sato Qian Long Henry Lucas Department of Biostatistics and Epidemiology School of Public HealthXi’an Jiaotong UniversityXi’anShaanxiChina Global Health Research Center Duke Kunshan UniversityKunshanJiangsuChina Duke Global Health Institute Duke UniversityDurhamNCUSA Institute of Development Studies at the University of Sussex BrightonUK

Background:Treatment of tuberculosis(TB)in China is partially covered by national programs and health insurance schemes,though TB patients often face considerable medical *** some,especially those from poorer households,non-medical costs,such as transport,accommodation,and nutritional supplementation may be a substantial additional *** this article we aim to evaluate these non-medical costs induced by seeking TB care using data from a large scale cross-sectional ***:A total of 797 TB cases from three cities were randomly selected using a stratified cluster sampling *** medical costs,outpatient medical costs,and direct non-medical costs related to TB treatment were collected using in-person interviews by trained *** and median non-medical costs for different sub-groups were calculated and compared using Kruskal-Wallis and Mann–Whitney U *** analysis was conducted to assess the influence of different patient characteristics on total non-medical ***:The median non-medical cost was RMB 1429,with interquartile range RMB 424–*** median non-medical costs relating to inpatient treatment,outpatient treatment,and additional nutrition supplementation were RMB 540,91,and 900,*** the 797 cases,20%reported catastrophic expenditure on non-medical *** significant differences were detected between different cities,age groups,geographical locations,inpatient/outpatient care,education levels and family income ***:Non-medical costs relating to TB treatment are a serious financial burden for many TB *** assistance that can limit this burden is urgently needed during the treatment period,especially for the poor.

关键词： Non-medical cost Financial burden Tuberculosis China

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PDGFRB mutation causes intracranial aneurysm

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Journal of Genetics and Genomics 2024年第9期51卷 978-981页

作者： Junyu Liu Chunling Wang Enyu Huang Luming Wang Chengchao Wu weixi jiang Mei Wu Xiuru Zhang Junxia Yan Yeqi Wang Jingjing Zhang Department of Neurosurgery XiangYa HospitalCentral South UniversityChangshaHunan 410008China Department of Pharmacology Kyoto University Graduate School of MedicineKyoto 606-8501Japan Key Laboratory for Biorheological Science and Technology of Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044China Affiliated Hospital of Guangdong Medical University&Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease Guangdong Medical UniversityZhanjiangGuangdong 524001China Department of Epidemiology and Health Statistics XiangYa School of Public HealthCentral South UniversityChangshaHunan 410006China Hunan Provincial Key Laboratory of Clinical Epidemiology XiangYa School of Public HealthCentral South UniversityChangshaHunan 410006China

Intracranial aneurysm(IA)is characterized by defects in the middle muscular layer and pathological dilatation of cerebral *** rupture of IA,resulting in aneurysmal subarachnoid hemorrhage,poses a substantial public health problem,especially in developed countries,due to its high mortality,morbidity,and socioeconomic burden(Bakker and Ruigrok,2021).Understanding the risk factors for IA is critical for disease *** numerous studies(Yan et al.,2015;Santiago-Sim et al.,2016;Barak et al.,2021;Liu et al.,2021)have highlighted familial aggregation of IA and identified candidate genes such as ADAMTS15,THSD1,ANK3,and PPIL4,the mechanisms underlying IA formation and rupture remain unclear.

关键词： aneurysm rupture

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ACUPUNCTURE CREDIBILITY SCALE SCORES ASSOCIATED WITH TCM ACUPUNCTURE VERSUS A SHAM ACUPUNCTURE PROCEDURE:IMPLICATION FOR CLINICAL TRIAL DESIGN

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Journal of Integrative Medicine 2014年第3期 311-312页

作者： weixi jiang Wunian Chen Remy Coeytaux Duke University University of North Carolina

Objective: To compare self-reported perceptions of the credibility of traditional Chinese medicine(TCM) acupuncture and a shallowneedling sham procedure, and to explore whether study subjectscan distinguish between real acupuncture and sham acupuncture in controlled clinical trials for headache when they are exposed to ***: Thirty-seven patients with frequent headaches and no prior experience with acupuncture received both a TCM acupuncture treatment and a sham acupuncture procedure in random *** participants were not informed that one of the treatments was intended to be a sham *** main outcome measure was patient-perceived credibility of each procedure as assessed by the Acupuncture Credibility ***: The TCM acupuncture treatment was associated with mean credibility scale scores of 21.2(SD=4.0), whereas the sham acupuncture procedure was associated with a mean scale score of 19.6(SD=4.6).The difference in mean scores associated with the two protocols was 1.6(95% CI: 0.6-2.6; P=0.002).Mean credibility scale scores increased from the first to second treatment for TCM acupuncture, but decreased for the sham acupuncture ***: The clinical significance of a 1.6-point difference on a 30-point scale is unclear, but the observation that study participants may be able to distinguish between TCM and sham acupuncture protocols after a single exposure to each provides support for the policy of excluding patients with prior experience with acupuncture from participation in clinical trials that involve a sham acupuncture control.

关键词： TCM

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Signal intensity of magnetic resonance imaging of pituitary adenoma reflects its collagen content

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Neural Regeneration Research 2006年第6期1卷 533-536页

作者： Hui Wang Xianrui Yuan weixi jiang Department of Neurosurgery Third Hospital Affiliated to Sun Yat-sen University Guangzhou 510630 Guangdong Province China Department of Neurosurgery Xiangya Hospital Central South University Changsha 410008 Hunan Province China

BACKGROUND ： At present, results of a few studies demonstrate that preoperative magnetic resonance imaging （MRI） examination reveals the texture of pituitary adenoma, i.e. on the T2 -weighted image, solid pituitary adenoma shows weak signal and soft one shows strong signal. Also, solid pituitary adenoma is caused by fibrosis, which is confirmed. However, some key problems are still in question and disputation, such as how to exactly quantize MRI signal intensity, which signal is used as prediction index, and the relationship of MRI signal and collagen content which reflects the texture of pituitary adenoma, and so on. OBJECTIVE： To observe the relationship of MRI signal intensity of different textures of pituitary adenoma and its collagen content, and investigate the best prediction index of the texture of pituitary adenoma. DESIGN ： Case-control observation SETTING： Department of Neurosurgery, Third Hospital Affiliated to Sun Yat-sen University; Department of Neurosurgery, Xiangya Hospital, Central South University. PARTICIPANTS ： Fifty-seven patients with pituitary adenoma, including 32 males and 25 females, aged 20 to 65 years, who received treatment in the Department of Neurosurgery, Xiangya Hospital, Central South University during June 2003 to January 2004. The involved patients were all diagnosed by MRI and confirmed by pathological resection. Informed consents were obtained from all the patients. The samples of above-mentioned patients resected by operation were fixed with 40 g/L formaldehyde for sirius red staining. METHODS ：（1） According to the texture of pituitary adenoma observed in the operation： The 57 samples of pituitary adenoma were divided into 2 groups： non-fibrosis group （n =49） and fibrosis group （n =8）. In the non-fibrosis group, the texture of pituitary adenoma was soft, Le. pituitary adenoma tissue automatically flew out, and could be aspirated by aspirater or erased by curette, and the superior part of saddle could fall in the sad

关键词：垂体肿瘤/病理学磁共振成像/方法胶原/分析腺瘤/病理学成年人老年人男(雄)性女(雌)性人类中年人

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信息增收的行为阶梯——一项基于城市“相对贫困”人群信息使用的研究

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南京社会科学 2021年第5期 53-62页

作者：叶明睿蒋文茜中国传媒大学电视学院北京100024 中国传媒大学科研创新与社会服务研究中心

后脱贫时代背景下,处于"相对贫困"的群体成为社会研究领域接续关注的重要人群,因此,在数字经济推动业态转型的浪潮中保障这一人群的发展利益,具有重大的经济意义和社会意义。通过田野调查,从信息鸿沟和相对贫困视角出发,对相对贫困人群... 详细信息

后脱贫时代背景下,处于"相对贫困"的群体成为社会研究领域接续关注的重要人群,因此,在数字经济推动业态转型的浪潮中保障这一人群的发展利益,具有重大的经济意义和社会意义。通过田野调查,从信息鸿沟和相对贫困视角出发,对相对贫困人群信息增收行为路径做出四段式阶梯划分,即感知、筹划、行动和评估。研究发现,信息能力和现存瓶颈在信息增收实际中的制约性影响主要表现为拟态环境构建存在偏差、认知缺乏结构系统性、社会资本现实转化的"耦合困境"以及自我评价中的情绪化归因。此外,与增收难点相对应的现有保障体系中的现有信息平台与服务也无法在技能帮扶和专业研判等方面为增收个体提供有效帮助。研究认为,正是信息能力和社会资本等制约因素形成连锁效应制约了现阶段城市中低收入人群信息增收的行动效果。

关键词：信息增收相对贫困信息素养数字鸿沟后脱贫时代

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多功能纳米粒干预肿瘤细胞膜转运蛋白相关性耐药的研究进展

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中国医学科学院学报 2021年第4期43卷 620-627页

作者：江唯希任建丽重庆医科大学超声影像学研究所超声分子影像重庆市重点实验室重庆400016 重庆医科大学附属第二医院超声科重庆400016

肿瘤多药耐药(MDR)是指肿瘤细胞在多种机制的介导下,失去对传统化疗药物的敏感性,导致化疗疗效降低。研究认为,包括细胞膜转运蛋白介导的药物外排、肿瘤组织中特殊的微环境、细胞DNA自我修复及抗凋亡、上皮-间质细胞转化等在内的多种因... 详细信息

肿瘤多药耐药(MDR)是指肿瘤细胞在多种机制的介导下,失去对传统化疗药物的敏感性,导致化疗疗效降低。研究认为,包括细胞膜转运蛋白介导的药物外排、肿瘤组织中特殊的微环境、细胞DNA自我修复及抗凋亡、上皮-间质细胞转化等在内的多种因素均可能是导致MDR形成的原因。细胞膜转运蛋白介导的药物外排是指由于肿瘤细胞膜表面ATP结合盒转运蛋白表达上调,导致经由该通道“泵出”细胞外的抗肿瘤药物量增加,降低细胞中的药物浓度从而形成细胞耐药。采取有效的方法抑制由细胞膜转运蛋白过表达引起的药物外泵可能是逆转MDR的关键。多功能纳米粒子作为一种具有良好的应用前景的药物递送系统,已经在抗肿瘤治疗中呈现出诸多优势。此外,经合理设计的纳米粒子还可以结合多种策略协同化疗克服肿瘤多药耐药。本文详细综述运用多功能纳米给药系统结合不同MDR逆转策略,如药物共递送、外界响应及靶点修饰等干预细胞膜转运蛋白外排作用的相关研究,为纳米给药系统下一步的开发以及逆转手段的制定提供参考。

关键词：多药耐药 ATP结合盒转运蛋白 P-糖蛋白药物递送系统

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剪切波弹性成像技术评估非酒精性脂肪性肝病研究进展

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中国介入影像与治疗学 2018年第10期15卷 637-640页

作者：江唯希冉海涛重庆医科大学附属第二医院超声科重庆400010 重庆医科大学超声影像学研究所超声分子影像重庆市重点实验室重庆400010

近年来,非酒精性脂肪性肝病(NAFLD)的患病率在我国日益升高,已成为仅次于乙型病毒性肝炎的第2大慢性肝病。弹性成像技术已广泛用于诊断乳腺、甲状腺、前列腺等部位病变,在诊断肝纤维化等方面也得到应用。本文针对三种不同剪切波弹性成... 详细信息

近年来,非酒精性脂肪性肝病(NAFLD)的患病率在我国日益升高,已成为仅次于乙型病毒性肝炎的第2大慢性肝病。弹性成像技术已广泛用于诊断乳腺、甲状腺、前列腺等部位病变,在诊断肝纤维化等方面也得到应用。本文针对三种不同剪切波弹性成像技术评估NAFLD进展程度的研究现状进行综述。

关键词：弹性成像技术非酒精性脂肪性肝病肝纤维化

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预适应与后适应联合干预对脑缺血/再灌注损伤的保护作用

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中南大学学报（医学版） 2014年第1期39卷 30-35页

作者：姜维喜刘庆袁贤瑞中南大学湘雅医院神经外科中南大学神经外科研究所长沙410008

目的:探讨缺血预适应联合缺血后适应对大鼠脑缺血/再灌注(I/R)损伤的保护作用及可能的机制。方法:60只SD大鼠随机均分为假手术组,脑I/R组(模型组),脑I/R+预适应(预适应组),脑I/R+后适应组(后适应组),脑I/R+预适应与后适应联合干预组(联... 详细信息

目的:探讨缺血预适应联合缺血后适应对大鼠脑缺血/再灌注(I/R)损伤的保护作用及可能的机制。方法:60只SD大鼠随机均分为假手术组,脑I/R组(模型组),脑I/R+预适应(预适应组),脑I/R+后适应组(后适应组),脑I/R+预适应与后适应联合干预组(联合干预组)。采用线栓法制作大鼠脑I/R损伤模型,预适应在造模24 h和1 h前采用3个循环的大脑中动脉阻闭15 s/再通30 s的方法诱导,后适应于再灌注前采用3个循环的再灌注30 s/缺血15 s的方法诱导。造模后48 h,分别检测大鼠脑梗死体积,脑组织氧化应激指标及p-Akt与p-ERK1/2蛋白的表达。结果:预适应组与后适应组间脑梗死灶体积比较差异无统计学意义(P>0.05),但均明显小于模型组,大于联合干预组(均P0.05),但p-Akt表达轻度上调、p-ERK1/2表达明显上调(P<0.05,P<0.01),后适应组脑组织氧化应激水平明显降低(均P<0.01),且p-Akt表达明显上调和p-ERK1/2表达轻度上调(P<0.01,P<0.05)。联合干预组脑组织氧化应激水平降低程度及p-Akt与p-ERK1/2表达上调程度均明显强于预适应组或后适应组(均P<0.01)。结论:预适应与后适应联合干预对脑缺I/R损伤的保护作用强于单独的预适应或后适应,可能与预适应与后适应的抗I/R损伤的机制不同且互补有关。

关键词：脑缺血再灌注损伤缺血预处理缺血后处理

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教育家精神引领下大学教师专业发展的伦理诉求与实现

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大学教育科学 2024年第3期 4-11页

作者：李洪修蒋维西天津师范大学教育学部天津300387

教育家精神具有深刻的伦理意蕴,其在目的论上蕴含“至善”的伦理归旨,过程论上体现“从善”的德性实践。它的提出为大学教师专业发展提供了伦理遵循。教育家精神引领下的大学教师专业发展具有三重伦理诉求:学术研究向度体现为从克己他... 详细信息

教育家精神具有深刻的伦理意蕴,其在目的论上蕴含“至善”的伦理归旨,过程论上体现“从善”的德性实践。它的提出为大学教师专业发展提供了伦理遵循。教育家精神引领下的大学教师专业发展具有三重伦理诉求:学术研究向度体现为从克己他律的被动约束到多种语境下的修身自为;教学育人向度体现为从单向的知识传输到师生人伦关系的情感重构;社会服务向度体现为从自我中心的身份取向到融入共同体的家国情怀。这需要大学教师追求学术实践的价值理性,达成“主体责任”与“自由意志”的契合;秉持学生主体立场的道德倾向,发挥公正的育人效力;挖掘教师身份的“社会价值”,实现公共与个体间的意义澄明。

关键词：教育家精神教师专业发展伦理诉求学术研究向度教学育人向度社会服务向度

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