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Partial response to Chinese patent medicine Kangliu pill for adult glioblastoma: A case report and review of the literature

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World Journal of Clinical Cases 2021年第12期9卷 2845-2853页

作者： Ge Sun Wei zhuang Qing-Tang Lin Lei-Ming Wang Yu-Hang Zhen Sheng-Yan Xi Xiao-Lan Lin Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Traditional Chinese Medicine School of Medicine and Cancer Research CenterXiamen UniversityXiamen 361102Fujian ProvinceChina

BACKGROUND Glioblastoma is the most common type of brain tumor and is invariably fatal,with a mean survival time of 8-15 mo for recently diagnosed tumors,and a 5-year survival rate of only 7.2%.The standard treatment for newly diagnosed glioblastoma includes surgery followed by concurrent chemoradiotherapy and further adjuvant ***,the prognosis remains poor and longterm survival is *** report aimed to demonstrate a new therapeutic strategy for the treatment of *** SUMMARY A patient was referred to the Department of Neurosurgery with an intracranial space-occupying lesion with a maximum diameter of approximately 5 *** tumor was compressing functional areas,and the patient accordingly underwent partial resection and concurrent *** imaging and pathological findings were consistent with a diagnosis of glioblastoma with oligodendroglioma differentiation(World Health Organization IV).The patient was finally diagnosed with ***,the patient discontinued treatment due to intolerable side effects,and was prescribed Kangliu pill(KLP)7.5 g three times/d,which he has continued to *** shrinkage of the tumor(maximum diameter reduced from about 3.5 to about 2 cm)was found after 3 mo of KLP therapy,and the tumor was further reduced to about 1 cm after 3 *** patient’s symptoms of headache,limb weakness,and left hemiplegia were relieved,with no side *** KLP has been a successful intervention for glioblastoma, and the current caseindicates that traditional Chinese medicine may offer effective alternativetherapies for glioblastoma.

关键词： Glioblastoma Kangliu pill Traditional Chinese medicine Therapeutic effect Adjunct therapy Chinese patent medicine Case report

基于自编码多层感知器的电力负荷管理终端运行故障诊断方法

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电力需求侧管理 2024年第2期26卷 113-118页

作者：朱亮亮滕姗姗徐辰冠庄重段梅梅苏慧玲国网电力科学研究院武汉能效测评有限公司武汉430074 国网电力科学研究院有限公司南京211106 国网江苏省电力有限公司营销服务中心南京210000

针对现有电力负荷管理终端运行故障辨识率低问题,提出一种基于自编码多层感知器的电力负荷管理终端运行故障诊断方法。首先,分析负荷管理终端运行状态指标与故障;其次,阐述自编码多层感知器电力负荷管理终端运行的故障诊断模型及其实现... 详细信息

针对现有电力负荷管理终端运行故障辨识率低问题,提出一种基于自编码多层感知器的电力负荷管理终端运行故障诊断方法。首先,分析负荷管理终端运行状态指标与故障;其次,阐述自编码多层感知器电力负荷管理终端运行的故障诊断模型及其实现方法,通过终端运行技术指标时序数据的等间隔式滑动窗口,操作获取表征终端运行状态特征候选集合,采用自编码器AE特征选择子模型,提取最优特征子集,借助多层感知器MLP故障诊断辨识子模型,实现终端运行故障分类诊断;最后,通过实验验证所提方法有效性。结果表明所提方法能提升电力负荷管理终端运行故障辨识精确率、召回率和辨识效率,实现电力负荷管理终端运行故障的精细化诊断。

关键词：故障诊断特征选择自动编码器多层感知机电力负荷管理终端

Synthesis,spectroscopic and electrochemical property of an unsymmetrical porphyrin and its Zn compound

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Chinese Chemical Letters 2010年第7期21卷 769-773页

作者： Chang Fu zhuang Yu Jing Zhang Ai Qing Xia Wen Hui Lian Yun Fang Wang Ping Zhang Tong Shun Shi College of Chemistry Jilin UniversityChangchun 130023China

In this article,a new 5-（p-maleicaminophenyl）-10,15,20-triphenylporphyrin（H_2P） and relative zinc compound（ZnP） were synthesized and characterized by means of elemental analyses,UV-vis,IR,MS and 1H NMR ***,we have investigated the fluorescence spectroscopy of these *** oxidation and reduction properties of the compounds were studied by the cyclic voltarnmetry,the oxidation-reduction potentials were obtained.

关键词： Synthesis Porphyrin Cyclic voltammetry Fluorescence

Degradation of Microcystin-RR by Combination of UV/H_2O_2 Technique

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Chinese Chemical Letters 2005年第9期16卷 1271-1274页

作者： Rui Ping QIAO Yong Min MA Xin Hua QI Nan LI Xiang Can JIN Qi Shan WANG Yuan Yi zhuang College of Environmental Science and Engineering Nankai University Tianjin 300071 2Centers of Disease Control and Prevention of Tianjin Tianjin 300011 Centers of Disease Control and Prevention of Tianjin Tianjin 300011 Chinese Research Academy of Environmental Sciences Beijing 100012

The experiments were performed to investigate the degradation of microcystins in order to assess the effectiveness and feasibility of UV/H2O2 system for the disinfection of water polluted by microcystins. The influence factors such as H2O2, pH and UV light intensities were investigated respectively. Degradation of microcystin-RR （MC-RR） could be fitted by either the pseudo-first-order or second-order rate equations. This homogenous system could significantly enhance the degradation rate due to the synergetic effect between UV and H2O2. The degradation mainly followed the mechanism of direct photolysis and .OH oxidation reactions. Experimental results showed that 94.83% of MC-RR was removed under optimal experimental conditions and the UV/H2O2 system provided an alternative to promote the removal of microcystins in drinking water supplies.

关键词： Microcystin-RR degradation kinetics UV/H2O2 photo-oxidation

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新型石膏混凝土复合外墙板的恢复力模型研究

天津大学学报（自然科学与工程技术版） 2018年第9期51卷 977-987页

作者：姜南梁壮天津大学建筑工程学院天津300072 滨海土木工程结构与安全教育部重点实验室(天津大学) 天津300072

以一组新型石膏混凝土复合外墙板在低周反复水平荷载作用下的抗震性能试验为基础,推导了在整个受力过程中不同极限状态下该墙板的顶点位移公式,构建了新型石膏混凝土复合外墙板的骨架曲线模型.通过选择合理的参数组合形式,提出了一种双... 详细信息

以一组新型石膏混凝土复合外墙板在低周反复水平荷载作用下的抗震性能试验为基础,推导了在整个受力过程中不同极限状态下该墙板的顶点位移公式,构建了新型石膏混凝土复合外墙板的骨架曲线模型.通过选择合理的参数组合形式,提出了一种双参数地震损伤模型.利用该双参数地震损伤模型,考虑捏缩效应以及在卸载顶点处的侧向荷载骤降现象,提出了相应的滞回规则.最终得到基于损伤的恢复力模型,并进行了数值分析.研究表明,本文提出的恢复力模型与试验曲线较为吻合,为结构非线性分析提供了依据.

关键词：新型石膏混凝土复合外墙板地震损伤模型恢复力模型

基于改进成本收入比法的DRG成本核算模式探索与实践

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医院管理论坛 2024年第3期41卷 79-86页

作者：张运奎刘国华庄娟崔宗晴李云霞济南市儿童医院

成本收入比法以病案首页的费用分类划分服务单元,进行成本收入归集,存在一定缺陷,通过对成本收入比法进行优化,将服务单元细化为作业中心,引入作业成本费率作为分摊参数,构建DRG成本核算模型,为DRG成本核算方法的应用提供参考。结果显示... 详细信息

成本收入比法以病案首页的费用分类划分服务单元,进行成本收入归集,存在一定缺陷,通过对成本收入比法进行优化,将服务单元细化为作业中心,引入作业成本费率作为分摊参数,构建DRG成本核算模型,为DRG成本核算方法的应用提供参考。结果显示,改进的成本收入比法可以快速、有效地核算DRG成本,核算结果更为精细,对帮助医院实现多维度精细化管理具有重要作用。

关键词：医院按疾病诊断相关分组成本核算成本收入比法

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中心城区紧凑型住宅的内部平面尺度解析

同济大学学报（自然科学版） 2011年第4期39卷 517-523页

作者：庄宇张莹同济大学建筑与城市规划学院上海200092 同济大学建筑设计研究院(集团)有限公司上海200092

以核心家庭为例,探讨紧凑型住宅平面尺度的两个主要影响因素:家庭生活行为的细分对尺度变化的要求,现代家居产品的尺度导致的空间尺度变化.通过家庭生活行为的解析、行为单元的尺度分析以及行为的组合三个渐进的分析步骤,探求面向核心... 详细信息

以核心家庭为例,探讨紧凑型住宅平面尺度的两个主要影响因素:家庭生活行为的细分对尺度变化的要求,现代家居产品的尺度导致的空间尺度变化.通过家庭生活行为的解析、行为单元的尺度分析以及行为的组合三个渐进的分析步骤,探求面向核心家庭的中心城区紧凑型住宅平面不同层次的尺度要求.

关键词：中心城区紧凑型住宅平面尺度核心家庭

Comparison of Abbott and Da-an real-time PCR for quantitating serum HBV DNA

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World Journal of Gastroenterology 2014年第33期20卷 11762-11769页

作者： Ning Qiu Rui Li Jian-Guo Yu Wen Yang Wei Zhang Yong An Tong Li Xue-En Liu Hui zhuang Department of Microbiology and Infectious Disease Center School of Basic Medical Sciences Peking University Health Science Center Department of Internal Medicine Liver Disease Center No. 88 Hospital of People’s Liberation Army

AIM: To compare the performance of the Da-an real-time hepatitis B virus (HBV) DNA assay and Abbott RealTime HBV assay.

关键词： Hepatitis B virus Hepatitis B virus DNA quantitation Real-time polymerase chain reaction Chronic hepatitis B Antiviral therapy

Qishen Taohong Granule as Adjuvant Therapy for Improving Cardiac Function and Quality of Life in Patients with Chronic Heart Failure:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第1期28卷 12-19页

作者： LI Xing-xing WU Yang FAN Zong-jing CUI Jie LI Dong LIN Quan zhuang Rui YAN Rong-kun LIN Qian LI Yan Department of Graduate School Beijing University of Chinese MedicineBeijing(100029)China Department of Cardiology Dongfang HospitalBeijing University of Chinese MedicineBeijing(100078)China Department of Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China

Objective:To confirm the improvement of cardiac function and quality of life(QoL)in patients with chronic heart failure(CHF)via Chinese medicine(CM)Qishen Taohong Granule(QTG).Methods:This study was a single-center,prospective,randomized,controlled clinical ***-six patients from 27 to 84 years old diagnosed with CHF New York Heart Association(NYHA)classⅡorⅢin stage C were enrolled and randomly assigned at a 1:1 ratio to receive QTG or trimetazidine(TMZ),in addition to their standard medications for the treatment of *** study period was 4 *** primary outcomes included cardiac function evaluated by NYHA classification and left ventricular ejection fraction(LVEF),as well as QoL evaluated by CHF Integrated Chinese and Western Medicine Survival Scale(CHFQLS).The secondary outcomes included 6-min walking test(6 MWT),CM syndrome score,symptom and sign scores and N-terminal pro-B-type natriuretic peptide level(NT-proBNP).All indices were measured at baseline and the end of the ***:At the 4-week follow-up period,the effective rate according to NYHA classification in the QTG group was better than that in the TMZ group(74.29%vs.54.29%,P0.05).The CHFQLS scores improved by 13.82±6.04 vs.7.49±2.28 in the QTG and TMZ groups,respectively(P<0.05).Subgroup analysis of the CHFQLS results showed that physiological function,role limitation and vitality were significantly higher in the QTG group than in the TMZ group(15.76±7.85 vs.7.40±3.36,P<0.05;16.00±8.35 vs.10.53±4.64,P<0.05;15.31±8.09 vs.7.89±4.60,P<0.05).Compared with TMZ group,treatment with QTG also demonstrated superior performance with respect to 6 MWT,CM syndrome,shortness of breath,fatigue,gasping,general edema and NT-proBNP *** significant adverse reactions or adverse cardiac events occurred during treatment in either ***:In addition to conventional treatments,the use of QTG a

关键词： chronic heart failure Chinese medicine Qishen Taohong Granule cardiac function quality of life