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区域经济、农业与物流业耦合协调发展时空演化研究——以长江经济带为例

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湖南工业大学学报（社会科学版） 2024年第1期29卷 40-47页

作者：梁雯殷伟伟安徽大学商学院安徽合肥230039

运用耦合协调度模型、空间自相关模型和灰色预测模型,对2011—2020年长江经济带11个省市的区域经济、农业与物流业的综合发展水平、耦合协调度、空间相关性进行了分析,并对三系统2021—2030年的耦合协调发展水平进行了预测。结果表明,... 详细信息

运用耦合协调度模型、空间自相关模型和灰色预测模型,对2011—2020年长江经济带11个省市的区域经济、农业与物流业的综合发展水平、耦合协调度、空间相关性进行了分析,并对三系统2021—2030年的耦合协调发展水平进行了预测。结果表明,长江经济带区域经济、农业、物流业三个子系统综合指数和总体综合指数大致呈增长趋势;三系统耦合协调度逐年上升,上游、中游、下游地区的耦合协调水平依次增高;三系统耦合协调度在空间上呈现出正向关系,空间聚集性逐渐增强;2021—2030年,预测长江经济带耦合协调水平将不断增大,发展速度也将逐年递增,预计到2030年达到良好协调状态。据此,建议政府加大对农业与物流业的投入,分区域制定相关政策,各区域加强合作力度,培养专业化人才,以共同促进长江经济带的高效协调发展。

关键词：区域经济农业物流业耦合协调发展时空演化长江经济带

Series-parallel Hybrid Vehicle Control Strategy Design and Optimization Using Real-valued Genetic Algorithm

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Chinese Journal of Mechanical Engineering 2009年第6期22卷 862-868页

作者： XIONG weiwei yin Chengliang ZHANG Yong ZHANG Jianlong Institute of Automotive Engineering Shanghai Jiao Tong University Shanghai 200240 China

Despite the series-parallel hybrid electric vehicle inherits the performance advantages from both series and parallel hybrid electric vehicle, few researches about the series-parallel hybrid electric vehicle have been revealed because of its complex co nstruction and control strategy. In this paper, a series-parallel hybrid electric bus as well as its control strategy is revealed, and a control parameter optimization approach using the real-valued genetic algorithm is proposed. The optimization objective is to minimize the fuel consumption while sustain the battery state of charge, a tangent penalty function of state of charge（SOC） is embodied in the objective function to recast this multi-objective nonlinear optimization problem as a single linear optimization problem. For this strategy, the vehicle operating mode is switched based on the vehicle speed, and an ＂optimal line＂ typed strategy is designed for the parallel control. The optimization parameters include the speed threshold for mode switching, the highest state of charge allowed, the lowest state of charge allowed and the scale factor of the engine optimal torque to the engine maximum torque at a rotational speed. They are optimized through numerical experiments based on real-value genes, arithmetic crossover and mutation operators. The hybrid bus has been evaluated at the Chinese Transit Bus City Driving Cycle via road test, in which a control area network-based monitor system was used to trace the driving schedule. The test result shows that this approach is feasible for the control parameter optimization. This approach can be applied to not only the novel construction presented in this paper, but also other types of hybrid electric vehicles.

关键词： series-parallel hybrid electric vehicle control strategy design optimization real-valued genetic algorithm

肺结核患者血清PGRN、LCN2水平及其与病情严重程度的相关性

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东南大学学报（医学版） 2024年第4期43卷 610-615页

作者：印薇薇胡小芳姜艳萍无锡市第五人民医院呼吸与危重症医学科江苏无锡214000 无锡市第五人民医院结核科江苏无锡214000

目的:探讨肺结核(PTB)患者血清颗粒蛋白前体(PGRN)、脂质运载蛋白2(LCN2)水平及其与病情严重程度的相关性。方法:选取2020年2月至2023年2月于本院就诊的127例肺结核患者,根据病情严重程度将其分为轻症组(n=78)和重症组(n=49),另选取同... 详细信息

目的:探讨肺结核(PTB)患者血清颗粒蛋白前体(PGRN)、脂质运载蛋白2(LCN2)水平及其与病情严重程度的相关性。方法:选取2020年2月至2023年2月于本院就诊的127例肺结核患者,根据病情严重程度将其分为轻症组(n=78)和重症组(n=49),另选取同期体检健康者72例作为对照组。采用酶联免疫吸附法测定各组血清PGRN和LCN2水平;Spearman法分析血清PGRN和LCN2水平与Bandim结核病(TB)评分之间的相关性;多因素Logistic回归分析重症PTB发生的影响因素;绘制受试者工作特征(ROC)曲线分析血清PGRN和LCN2水平对重症PTB的诊断价值。结果:重症组血清PGRN和LCN2水平明显高于轻症组和对照组(P<0.05);重症组糖尿病史占比,Bandim TB评分,IL-10、IFN-γ、PCT、CRP水平明显高于轻症组(P<0.05);血清PGRN和LCN2水平与Bandim TB评分均呈正相关(r_(s)值分别为0.428、0.420,均P<0.001);PGRN(OR=1.576,95%CI:1.112~2.234)和LCN2(OR=2.163,95%CI:1.320~3.545)为重症PTB发生的危险因素(P<0.05);血清PGRN和LCN2水平联合诊断重症PTB的曲线下面积(AUC)为0.943,敏感度为91.84%,二者联合优于各自单独诊断(Z_(二者联合-PGRN)=2.327,P=0.020;Z_(二者联合-LCN2)=2.061,P=0.039)。结论:PTB患者血清PGRN和LCN2水平与Bandim TB评分呈正相关,二者血清水平与患者病情严重程度密切相关。

关键词：颗粒蛋白前体脂质运载蛋白2 肺结核病情严重程度

A practical strategy to subcutaneous administered in-situ gelling co-delivery system of arsenic and retinoic acid for the treatment of acute promyelocytic leukemia

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 633-642页

作者： Xiao Liu weiwei yin Andy Samuel Widjaya Yueying Yang Yunhu Liu Yanyan Jiang Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201023China

Arsenic trioxide(ATO) combined with all trans retinoic acid(ATRA) is the first choice for the treatment of low and medium risk acute promyelocytic leukemia(APL). Clinical studies reported that the combination of ATO and ATRA could achieve a significant curative effect. However, the retinoic acid syndrome, serious drug resistance and the short half-life in vivo which lead to frequent and large dose administration limit the application of ATRA. In addition, the preparations of arsenic are conventional injections and tablets in clinic, which has poor patients’ compliance caused by frequent long-term administration and serious side effects. In order to overcome the above limitations, a phospholipid phase separation gel(PPSG) loaded with ATO and ATRA was developed. ATO + ATRA-PPSG(AAP), as a biodegradable sustained-release delivery system, was the first achievement of co-delivery of hydrophilic ATO and lipophilic ATRA with high drug loading which is the main problem in the application of nano preparation. The prepared PPSG displayed high safety and biocompatibility. The drug in PPSG was released slowly and continuously in vivo and in vitro for up to 10 d, which could reduce the side effects caused by the fluctuation of blood drug concentration and solve the problem of the long treatment cycle and frequent administration. In vivo pharmacokinetics depicted that PPSG could improve the bioavailability, decrease the peak concentration, and prolong the t 1/2 of ATO and ATRA. Particularly, AAP significantly inhibited the tumor volume, extended the survival period of tumor-bearing mice, and promoted the differentiation of APL cells into normal cells. Therefore, ATO + ATRA-PPSG not only could co-load hydrophilic ATO and lipophilic ATRA according to the clinical dosage, but also possessed the sustained-release and long-acting treatment effect which was expected to reduce administration time and ameliorate compliance of patients. Thus, it had great potential for clinical transforma

关键词： Arsenic trioxide All trans retinoic acid Phospholipid phase separation gel Sustained-release Bioavailability Compliance

机械合金化+放电等子烧结FeCrAl/La_(2)Zr_(2)O_(7)复合材料高温氧化行为研究

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中国腐蚀与防护学报 2024年第4期44卷 965-971页

作者：张帮彦吴洪斌胡雪刚董家键郑世杰尹蔚蔚张方宇田礼熙刘光明南昌航空大学材料科学与工程学院南昌330063

采用机械合金化+放电等离子烧结技术制备了Fe-Cr-x Al/La_(2)Zr_(2)O_(7)(x=4、8和10,质量分数,%)复合材料,结合扫描电子显微镜(SEM)、能谱仪(EDS)、X射线衍射仪(XRD)和氧化增重等方法研究了复合材料中Al含量对其高温氧化行为的影响。... 详细信息

采用机械合金化+放电等离子烧结技术制备了Fe-Cr-x Al/La_(2)Zr_(2)O_(7)(x=4、8和10,质量分数,%)复合材料,结合扫描电子显微镜(SEM)、能谱仪(EDS)、X射线衍射仪(XRD)和氧化增重等方法研究了复合材料中Al含量对其高温氧化行为的影响。结果表明:氧化初期,复合材料氧化速率随着Al含量的升高而逐渐增大,而氧化稳定阶段3种复合材料氧化速率接近;氧化过程中,含Al量为4%的复合材料氧化产物保持为生长缓慢的稳定α-Al_(2)O_(3);含Al量为8%和10%的复合材料中析出了FeAl相,使其表面在氧化初期产生生长较快的亚稳θ-Al_(2)O_(3),加快了氧化,且含Al量越高则析出的FeAl相越多,氧化加速越明显;氧化时间延长后,θ-Al_(2)O_(3)逐渐转变为α-Al_(2)O_(3),3种复合材料氧化行为接近。

关键词： FeCrAl/La_(2)Zr_(2)O_(7)复合材料穿孔顶头高温氧化氧化动力学

经颅多普勒联合经胸超声心动图发泡试验对偏头痛患者脑血流特征的评估

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中风与神经疾病杂志 2024年第10期41卷 898-903,F0003页

作者：阴玮伟闫灵娟金京兰程洪瑜王佳空军军医大学第二附属医院超声科陕西西安710038

目的联合应用经颅多普勒发泡试验(cTCD)和经胸超声心动图声学造影(cTTE)技术,评估不同分级卵圆孔未闭(PFO)伴偏头痛患者之间脑血流动力学参数的变化。方法选取空军军医大学第二附属医院的偏头痛患者85名,联合应用cTCD和cTTE判断受检者... 详细信息

目的联合应用经颅多普勒发泡试验(cTCD)和经胸超声心动图声学造影(cTTE)技术,评估不同分级卵圆孔未闭(PFO)伴偏头痛患者之间脑血流动力学参数的变化。方法选取空军军医大学第二附属医院的偏头痛患者85名,联合应用cTCD和cTTE判断受检者是否存在PFO导致的右向左分流(PFO-RLS)并根据分级标准进行分流程度分级(0、Ⅰ、Ⅱ、Ⅲ级)。同时应用TCD分别观察Valsalva动作(VM)前后大脑中动脉(MCA)收缩期峰值血流速度(Vs)、平均血流速度(Vm)、舒张期峰值血流速度(Vd)、阻力指数(RI)和搏动指数(PI)等超声参数的特征,并对比分析PFO-RLS 0级与PFO-RLSⅠ、Ⅱ、Ⅲ级患者之间以上超声参数的差异。结果85例受检者中,偏头痛伴PFO-RLS 0级患者13例,偏头痛伴PFO-RLSⅠ级患者34例,偏头痛伴PFO-RLSⅡ级患者17例,偏头痛伴PFO-RLSⅢ级患者21例。结果显示VM前偏头痛伴PFO-RLSⅡ级患者比偏头痛伴PFO-RLS 0级患者的Vs、Vm、Vd血流速度增快,差异有统计学意义(P<0.05);VM后偏头痛伴PFO-RLSⅢ级者比偏头痛伴PFO-RLS 0级患者的Vm、Vd增快,差异有统计学意义(P<0.05)。结论不同分级PFO-RLS伴偏头痛患者之间脑血流变化趋势不同,根据脑血流特征性变化,可为偏头痛患者的病因诊断及治疗提供一定的临床理论依据。

关键词：经颅多普勒发泡试验右心声学造影偏头痛脑血流速度

重度颈动脉狭窄患者颈动脉内膜剥脱术后认知功能、颈动脉血流速度的侧别差异及其相关性分析

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实用心脑肺血管病杂志 2024年第3期32卷 54-57页

作者：闫灵娟阴玮玮金京兰王佳空军军医大学第二附属医院超声科陕西省西安市710038

目的分析重度颈动脉狭窄患者颈动脉内膜剥脱术(CEA)后认知功能、颈动脉血流速度的侧别差异及其相关性。方法选取2019年1月—2022年1月在空军军医大学第二附属医院接受CEA并进行认知功能评估的重度颈动脉狭窄患者120例为研究对象,其中... 详细信息

目的分析重度颈动脉狭窄患者颈动脉内膜剥脱术(CEA)后认知功能、颈动脉血流速度的侧别差异及其相关性。方法选取2019年1月—2022年1月在空军军医大学第二附属医院接受CEA并进行认知功能评估的重度颈动脉狭窄患者120例为研究对象,其中左侧病变58例、右侧病变62例。比较左侧病变患者和右侧病变患者一般资料及CEA后认知功能[神经行为认知状态检查(NCSE)量表、额叶功能评定量表(FAB)评分]、患侧颈动脉血流速度指标[收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、搏动指数(PI)]。分析左、右侧病变患者CEA后NCSE量表、FAB评分与颈动脉血流速度指标间的相关性。结果右侧病变患者CEA后NCSE量表、FAB评分高于左侧病变患者(P0.05)。左侧病变患者CEA后NCSE量表、FAB评分与EDV、PI呈正相关(P0.05);右侧病变患者CEA后NCSE量表、FAB评分与EDV呈正相关(P0.05)。结论左侧重度颈动脉狭窄患者CEA后认知功能差于右侧重度颈动脉狭窄患者,但二者的颈动脉血流速度无差异;左侧重度颈动脉狭窄患者CEA后认知功能与颈动脉EDV、PI呈正相关,右侧重度颈动脉狭窄患者CEA后认知功能与颈动脉EDV呈正相关。

关键词：颈动脉狭窄颈动脉内膜剥脱术认知颈动脉血流速度

SWG: an architecture for sparse weight gradient computation

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Science China(Information Sciences) 2024年第2期67卷 302-321页

作者： weiwei WU Fengbin TU Xiangyu LI Shaojun WEI Shouyi yin School of Integrated Circuits Tsinghua University Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology

On-device training for deep neural networks(DNN) has become a trend due to various user preferences and scenarios. The DNN training process consists of three phases, feedforward(FF), backpropagation(BP), and weight gradient(WG) update. WG takes about one-third of the computation in the whole training process. Current training accelerators usually ignore the special computation property of WG and process it in a way similar to FF/BP. Besides, the extensive data sparsity existing in WG, which brings opportunities to save computation, is not well explored. Nevertheless, exploiting the optimization opportunities would meet three underutilization problems, which are caused by(1) the mismatch between WG data dimensions and hardware parallelism,(2) the full sparsity, i.e., the sparsity of feature map(Fmap),error map(Emap), and gradient, and(3) the workload imbalance resulting from irregular sparsity. In this paper, we propose a specific architecture for sparse weight gradient(SWG) computation. The architecture is designed based on hierarchical unrolling and sparsity-aware(HUSA) dataflow to exploit the optimization opportunities of the special computation property and full data sparsity. In HUSA dataflow, the data dimensions are unrolled hierarchically on the hardware architecture. A valid-data trace(VDT) mechanism is embedded in the dataflow to avoid the underutilization caused by the two-sided input sparsity. The gradient is unrolled in PE to alleviate the underutilization induced by output sparsity while maintaining the data reuse opportunities. Besides, we design an intra-and inter-column balancer(IIBLC) to dynamically tackle the workload imbalance problem resulting from the irregular sparsity. Experimental results show that with HUSA dataflow exploiting the full sparsity, SWG achieves a speedup of 12.23× over state-of-the-art gradient computation architecture, Train Ware. SWG helps to improve the energy efficiency of the state-of-the-art training accelerator LNPU from

关键词： CNN training gradient computation sparsity architecture

Deep structure of the Southeast Asian curved subduction system and its dynamic process

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Journal of Oceanology and Limnology 2024年第3期42卷 701-704页

作者： weiwei DING Key Laboratory of Submarine Geoscience&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China

The deep structure,material circulation,and dynamic processes in the Southeast Asia have long been an elusive scientific puzzle due to the lack of systematic scientific observations and recognized theoretical *** on the deep seismic tomography using long-period natural earthquake data,in this study,the deep structure and material circulation of the curved subduction system in Southeast Asia was studied,and the dynamic processes since 100 million years ago was *** is pointed out that challenges still exist in the precise reconstruction of deep mantle structures of the study area,the influence of multi-stage subduction on deep material exchange and shallow magma activity,as well as the spatiotemporal evolution and coupling mechanism of multi-plate *** work should focus on high-resolution land-sea joint 3-D seismic tomography imaging of the curved subduction system in the Southeast Asia,combined with geochemical analysis and geodynamic modelling works.

关键词： curved subduction system deep structure material recycling dynamic process Southeast Asia