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Portable hydrogel-based tri-channel fluorescence sensor array for visual detection of multiple explosives

Nano Research 2024年第7期17卷 6483-6492页

作者： Wenxing Gao Wenfeng Liu Saijin Huang Lin wang Yingying Jian Yutong Li weiwei Wu Li Shang State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China School of Advanced Materials and Nanotechnology Xidian UniversityXi'an 710126China Honors College Northwestern Polytechnical UniversityXi'an 710119China

The identification and detection of various types of explosives are essential for human health and environmental ***-based sensing approach offers significant advantages in detecting multi-analytes simultaneously,thereby holding great potential in identifying multiple ***,we report a tri-channel fluorescence array composed of three distinct fluorescence probes based on gold nanoclusters and nicotinamide adenine dinucleotide with well-separated emission *** the specific interactions of explosives with different fluorescent probes and the yielded response patterns,seven explosives can be successfully distinguished with 100%*** particular,the sensor array exhibits excellent performance in the quantitative analysis of individual explosive and the differentiation of multiple explosive *** facilitate the field detection towards practical application,the tri-channel fluorescence array was further integrated with polymer *** fabricated portable hydrogel-based array sensors can not only visually identify seven different explosives by their distinct fluorescence color change,but also enable quantitative detection based on linear discriminant analysis(LDA)together with a *** study illustrates the great potential of hydrogel-based fluorescence sensor array as robust sensors for explosives,which also holds significant promise for the development of portable explosive devices towards practical application.

关键词： sensor array gold nanoclusters explosives fluorescence hydrogels

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dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing

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Regenerative Biomaterials 2024年第2期3卷 100-113页

作者： Ju Zhang Ruijuan Si Yu Gao Hui Shan Qi Su Zujian Feng Pingsheng Huang Deling Kong weiwei wang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China School of Nursing Qingdao UniversityNingde RoadShinan DistrictQingdaoShandong266071China Cancer Hospital of Tianjin Medical University North Huanhu West RoadTianjinChina The Affliated Hospital of Qingdao University 16 Jjiangsu RoadShinan DistrictQingdaoChina 5NankaiUniver aniin300071.China

Due to its highly insidious and rapid progression,deep tissue pressure injury(DTPI)is a clinical *** previous study found that DTPI may be a skeletal muscle injury dominated by macrophage immune dysfunction due to excessive iron *** extracellular matrix(dECM)hydrogel promotes skeletal muscle injury ***,its role in po-larizing macrophages and regulating iron metabolism in DTPI remains ***,porcine dECM hydrogel was prepared,and its therapeutic function and mechanism in repairing DTPI were *** stimulus of dECM hydrogel toward RAW264.7 cells resulted in a significantly higher percentage of CD2o6+macrophages and notably decreased intracellular divalent iron *** mice DTPI model,dECM hydrogel treatment promoted M1 to M2 macrophage conversion,improved iron metabolism and reduced oxidative stress in the early stage of *** the remodeling phase,the dECM hydrogel remarkably enhanced revascularization and accelerated skeletal muscle ***,the immunomodulation of dEcM hydrogels in vivo was mainly involved in the P13k/Akt signaling pathway,as revealed by GO and KEGG pathway analysis,which may ameliorate the iron deposition and promote the healing of *** findings indicate that dECM hydrogel is promising in skeletal muscle repair,inflammation resolution and tissue injury healing by effectively restoring macrophage immune homeostasis and normalizing iron metabolism.

关键词： Deep tissue pressure injury hydrogel immunomodulation tissue repair

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***:A Julia package for micromagnetic and atomistic simulations with GPU support

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Chinese Physics B 2024年第10期33卷 70-79页

作者： weiwei wang Boyao Lyu Lingyao Kong Hans Fangohr Haifeng Du Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Anhui Province Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230031China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China University of Southampton Southampton SO171BJUnited Kingdom

*** is an open-source Julia package for micromagnetic and atomistic *** the features of the Julia programming language,*** supports CPU and various GPU platforms,including NVIDIA,AMD,Intel,and Apple ***,*** supports Monte Carlo simulations for atomistic models and implements the nudged-elastic-band method for energy barrier *** built-in support for double and single precision modes and a design allowing easy extensibility to add new features,*** provides a versatile toolset for researchers in micromagnetics and atomistic simulations.

关键词： micromagnetic simulations atomistic simulations graphics processing units

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Observing the collapse of super-Bloch oscillations in strong-driving photonic temporal lattices

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Advanced Photonics 2024年第4期6卷 14-24页

作者： Xinyuan Hu Shulin wang Chengzhi Qin Chenyu Liu Lange Zhao Yinglan Li Han Ye weiwei Liu Stefano Longhi Peixiang Lu Bing wang Huazhong University of Science and Technology School of PhysicsWuhan National Laboratory for OptoelectronicsWuhanChina Wuhan Institute of Technology Hubei Key Laboratory of Optical Information and Pattern RecognitionWuhanChina Politecnico di Milano Dipartimento di FisicaMilanoItaly IFISC(UIB-CSIC) Instituto de Fisica Interdisciplinary Sistemas ComplejosPalma de MallorcaSpain

Super-Bloch oscillations(SBOs)are amplified versions of direct current(dc)-driving Bloch oscillations realized under the detuned dc-and alternating current(ac)-driving electric fields.A unique feature of SBOs is the coherent oscillation inhibition via the ac-driving renormalization effect,which is dubbed as the collapse of ***,previous experimental studies on SBOs have only been limited to the weak ac-driving regime,and the collapse of SBOs has not been ***,by harnessing a synthetic temporal lattice in fiber-loop systems,we push the ac-field into a strong-driving regime and observe the collapse of SBOs,which manifests as the oscillation-trajectory localization at specific ac-driving amplitudes and oscillation-direction flip by crossing collapse *** adopting arbitrary-wave ac-driving fields,we also realize generalized SBOs with engineered collapse ***,we exploit the oscillation-direction flip features to design tunable temporal beam routers and *** initiate and demonstrate the collapse of SBOs,which may feature applications in coherent wave localization control for optical communications and signal processing.

关键词： super-Bloch oscillations band collapse ac-driving renormalization effect photonic temporal lattices strong-driving regime

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Design and preparation of a crosslinkable,oil-resistant,and bio-based elastomer from fumarate

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Science China Chemistry 2024年第2期67卷 622-631页

作者： Hui Yang Haijun Ji Xinxin Zhou Shihan Yang Liwei Li Chaoying Sun weiwei Lei Runguo wang Liqun Zhang Beijing State Key Laboratory of Organic-Inorganic Composites&Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing100029China Hubei Key Laboratory of Polymer Materials Faculty of Materials Science and EngineeringHubei UniversityWuhan430062China

Poly(diethyl fumarate-co-methoxyethyl acrylate-co-vinyl chloroacetate)(PDEFMV),a novel bio-based elastomer with a saturated structure,was synthesized via redox emulsion *** glass-transition temperatures of PDEFMV,adjusted through the variation of the diethyl fumarate-to-methoxyethyl acrylate feeding ratio,ranged from-36.1 to-14.8 ℃.The number-average molecular weights of PDEFMV ranged from 384,000 to 46,000 g/*** designing the molecular structure,vinyl chloroacetate was used to provide active sites for subsequent vulcanization and *** active chlorine groups within the PDEFMV chain reacted with the crosslinking agent trithiocyanuric acid under high temperature and pressure to form a nonsulfur crosslinked three-dimensional network *** achieve the desired properties,carbon black(CB,N330) was incorporated to reinforce PDEFMV,leading to the formation of PDEFMV/CB composites.A comprehensive study was conducted on the high-temperature oil resistance of PDEFMV/CB *** immersion in IRM903 oil at temperatures of 150 and 200 ℃ for 72 h,the mass and volume changes in PDEFMV/CB were lower than those observed in commercially available acrylate rubber(AR)/CB,indicating that PDEFMV exhibited superior oil ***,the aging characteristics and mechanisms of oil resistance in the PDEFMV/CB and AR/CB composites were investigated at different temperatures(150,200,and 250 ℃).The results provide insights into the operational temperature ranges suitable for PDEFMV/CB and offer valuable guidance for potential industrial applications.

关键词： diethyl fumarate molecular design bio-based elastomer solvent-free synthetic route high-temperature oil resistance

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Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

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Research 2024年第1期2023卷 281-299页

作者： Bitao Lu Enling Hu weiwei Ding Wenyi wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China Division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital ***,multiple hemostatic strategies are critical for treating large bleeding *** this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug *** aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug *** ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally *** novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

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Isolation and microbial transformation of tea sapogenin from seed pomace of Camellia oleifera with anti-inflammatory effects

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Chinese Journal of Natural Medicines 2024年第3期22卷 280-288页

作者： SHEN Pingping JIANG Xuewa ZHANG Jingling wang Jiayi Raj Richa LI Guolong GE Haixia wang weiwei YU Boyang ZHANG Jian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi&Education Ministry Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation ResearchShaanxi University of Chinese MedicineXianyang 712046China School of Life Sciences Huzhou UniversityHuzhou 313000China Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nanjing 210046China Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical UniversityNanjing 211198China

In the current study,tea saponin,identified as the primary bioactive constituent in seed pomace of Camellia oleifera Abel.,was meticulously extracted and hydrolyzed to yield five known sapogenins:16-O-tiglogycamelliagnin B(a),camelliagnin A(b),16-O-angeloybarringtogenol C(c),theasapogenol E(d),theasapogenol F(e).Subsequent biotransformation of compound a facilitated the isolation of six novel metabolites(a1−a6).The anti-inflammatory potential of these compounds was assessed using pathogenassociated molecular patterns(PAMPs)and damage-associated molecular patterns molecules(DAMPs)-mediated cellular inflammation ***,compounds b and a2 demonstrated significant inhibitory effects on both lipopolysaccharide(LPS)and high-mobility group box 1(HMGB1)-induced inflammation,surpassing the efficacy of the standard anti-inflammatory agent,***,compounds d,a3,and a6 selectivity targeted endogenous HMGB1-induced inflammation,showcasing a pronounced *** results underscore the therapeutic promise of *** seed pomace-derived compounds as potent agents for the management of inflammatory diseases triggered by infections and tissue damage.

关键词： Camellia oleifera Seed pomace Tea sapogenin Microbial transformation Damage-associated molecular patterns and Pathogen-associated molecular patterns Anti-inflammatory activity

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Age and fluid source constraints of the Haoyaoerhudong orogenic gold deposit,North China:Evidence from geochronology and noble gas isotopes

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Geoscience Frontiers 2024年第4期15卷 176-195页

作者： Chenglong Fan Jingwen Mao Huishou Ye Yitian wang Junchen Liu Wei Jian Xuyang Meng Wenhao Tang weiwei Chao Peng wang School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China MNR Key Laboratory for Exploration Theory&Technology of Critical Mineral Resources China University of GeosciencesBeijing 100083China Ministry of Natural Resources(MNR)Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of Resources by the Province and Ministry Guilin University of TechnologyGuilin 541004China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013JiangxiChina School of Earth Sciences and Spatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China

The Haoyaoerhudong gold deposit,located in the northwestern part of the North China craton(NCC),has produced over 120 metric tonnes(t)of gold since *** has a total reserve of>240 t at average gold grade of 0.62 g/t,making it one of the largest open pit gold mines in *** steeply dipping,large-tonnage,low-grade,vein-or veinlet-type gold orebodies are hosted in strongly-deformed Mesoproterozoic carbonaceous schist of the Bayan Obo *** laminated/boudinaged veins/veinlets in the sinistral ductile-brittle shear zones are dominated by quartz,biotite,gold-bearing löllingite,pyr-rhotite,(arseno)pyrite,with minor native gold,titanite and *** this paper,we present new in situ U-Pb geochronological data on magmatic zircon from the preore dikes,on metamorphic and hydrothermal xenotime,and on hydrothermal titanite from the hydrothermally altered carbonaceous schist and auriferous quartzsulfides veins/veinlets,as well as He-Ar isotopic analysis on gold-bearing(arseno)pyrite in the syn-ore *** metamorphic xenotime U-Pb age of 426±6.0 Ma(2σ)records a regional metamorphic event,possibly related to the accretion of the Bainaimiao arc onto the *** pre-ore andesitic dikes yielded similar emplacement ages at~278 Ma constrained by laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS)U-Pb zircon *** xenotime grains from the altered carbonaceous schist and auriferous quartz-sulfides veins yielded U-Pb ages of 256.0±4.1 Ma(2σ)and 254.4±2.1 Ma(2σ),respectively,overlapping with that of the hydrothermal titanite at 255.4±0.8 Ma(2σ)from the laminated quartz-sulfides *** indicates that the gold mineralization occurred at ca.255 ***~255 Ma gold mineralization age is much younger than the previously reported Early-Middle Permian regional magmatic activity(ca.291 Ma to 268 Ma),and may be associated with the regional sinistral strike-slip event in the late orogenic cycle related to the collision between the Siberian craton

关键词： Xenotime Titanite In situ U-Pb dating Noble gas Orogenic gold deposit North China Craton

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The Expansion of the Kernels for 3D Elastic Fast Multipole BEM

The Expansion of the Kernels for 3D Elastic Fast Multipole B...

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The second Asia-Pacific International Conference on Computational Methods in Engineering（ICOME2006）

作者： Yiming Chen 1 weiwei wang 1 Guangxian Shen 2 Hailian Gui 1 Lamei Tong 1 1 College of Science Yanshan University Qinhuangdao 066004 China 2 College of Mechanical Engineering Yanshan University Qinhuangdao 066004 China

In comparision with finite element method （FEM）,the boundary element method （BEM） has unique advantages of dimension reduction and high accuracy. But the conventional BEM is not efficient for large scale problems because of the dense and nonsymmetric matrix formed by BEM. Moreover,for a conventional calculation,O（N3）or O（N2） operations O（N2）memory are required,where N is the number of degrees of freedom （DOF）. However,both can be reduced for the Fast Multipole Element Method （FM-BEM）.Since the FM-BEM is suitable for large scale problems,the FM-BEM has been investigated by many researchers recently. We further the research production of Shen Guangxian’s research group in Yanshan University,that is,the 3D elastic FM-BEM,the program-pattern multipole BEM for frictional contact,the multipole BEM for 3D elasto-plastic contact with friction,and the 3D multipole BEM for potential problems. The above-mentioned methods have been developed,the theorical methods and experimentation results can be obtained,the FM-BEM has been applied to large scale engineering problems successfully. Firstly,we give the BEM formulation for 3D elasticity problems,also give the formulation of stress in the domain,and relevant basic kernels. Secondly,we introduce the basic solutions for 3D elasticity problems,and give the fast multipole method （FMM） expansions of the basic solutions,which have been used for 3D elasticity problems and rolling problems. Finally,we use the mathematical method of the FM-BEM for 3D elasticity problems,and the knowledge of the partial differential coefficient derive the FMM expansions of the kernels for 3D elastic FM-BEM,and complete the mathematical methods of the FM-BEM for 3D elasticity problems. We can obtain that the FMM expansions of kernels for 3D elasticity problems,this FMM expansions can be written as the form of 1/ R ,hence,we can use the mathematical methods of the FM-BEM for 3D elasticity problems,and the computation of the kernels can be simplied,the comput

关键词： Fast Muotipole Boundary Element Method 3D elasticity problems kernels

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CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4059-4072页

作者： Xiaoyu Wu Zijun Bai Hui wang Hanqing wang Dahai Hou Yunzhu Xu Guanqun Wo Haibo Cheng Dongdong Sun weiwei Tao Department of Surgical Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China School of Integrated Medicine Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjing 210023China School of Pharmacology Nanjing University of Chinese MedicineNanjing 210023China School of Pharmacology Ningxia Medical UniversityYinchuan 750004China

Copper-based nanomaterials demonstrate promising potential in cancer *** efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione,initiating chemical dynamic therapy(CDT)and ***,a newly identified cell death modality that represents a great prospect in cancer therapy,is ***,active homeostatic systems rigorously keep copper levels within cells exceptionally low,which hinders the application of cooper nanomaterials-based ***,a novel strategy of CRISPR-Cas9 RNP nanocarrier to deliver cuprous ions and suppress the expression of copper transporter protein ATP7A for maintaining a high level of copper in cytoplasmic fluid is *** Cu2O and organosilica shell would degrade under the high level of glutathione and weak acidic environment,further releasing RNP and *** liberated Cut triggered a Fenton-like reaction for CDT and partially transformed to Cu2t,consuming intracellular GSH and initiating cuproptosis and ferroptosis ***,the release of RNP effectively reduced the expression of copper transporter ATP7A,subsequently increasing the accumulation of cooper and enhancing the efficacy of CDT,cuproptosis,and *** tumor microenvironment responsive multimodal nanoplatform opens an ingenious avenue for colorectal cancer therapy based on gene editing enhanced synergistic cuproptosis/CDT/ferroptosis.

关键词： GSH-and pH-responsive Effective copper delivery CRISPR-Cas9 ATP7A Cuproptosis Chemodynamic Ferroptosis Synergistic therapy

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