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Pullulan Acetate Coated Magnetite Nanoparticles for Hyper-Thermia:Preparation,Characterization and In Vitro Experiments

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Nano Research 2010年第1期3卷 23-31页

作者： Fuping Gao Yuanyuan Cai Jing Zhou Xiaoxue Xie weiwei ouyang Yuhui Zhang Xufei Wang Xiaodong Zhang Xiaowen Wang Lingyun Zhao Jintian Tang Key Laboratory of Particle&Radiation Imaging Ministry of EducationInstitute of Medical Physics and EngineeringDepartment of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Biopharmaceutics Beijing University of Traditional Chinese MedicineBeijing 100102China Department of Oncology Xiangya Hospital of Central South UniversityChangsha 410008China

Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMNs) had spherical morphology. Dynamic light scattering (DLS) showed that the size distribution of PAMNs was unimodal,with an average diameter of 25.8 nm ± 6.1 nm. The presence of the adsorbed layer of PA on the magnetite surface was confirmed by Fourier transform infrared (FTIR) spectroscopy. Magnetic measurements revealed that the saturation magnetization of the PAMNs reached 51.9 emu/g and the nanoparticles were superparamagnetic. Thermogravimetric analysis (TGA) showed that the Fe_(3)O_(4) particles constituted 75 wt% of the PAMNs. The PAMNs had good heating properties in an alternating magnetic field. Cytotoxicity assay showed that PAMNs exhibited no significant cytotoxicity against L929 cells. TEM results showed that a large number of PAMNs were internalized into KB cells. PAMNs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia. These novel magnetic nanoparticles have great potential as magnetic hyperthermia mediators.

关键词： Magnetic nanoparticles pullulan acetate hyperthermia cytotoxicity cellular uptake

抗EGFR或VEGF机制及在EGFR突变阳性晚期非小细胞肺癌的研究进展

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中华转移性肿瘤杂志 2024年第3期7卷 271-275页

作者：黄丽曹东东欧阳伟炜耿一超卢冰贵州医科大学附属医院肿瘤科贵州医科大学附属肿瘤医院肿瘤科贵州医科大学肿瘤学教研室贵阳550004

表皮生长因子受体(EGFR)以及血管内皮生长因子(VEGF)信号通路在非小细胞肺癌(NSCLC)的发生和进展中起着重要的作用,两者具有共同的下游信号通路且具有协同促瘤作用。大部分临床试验表明抗EGFR药物联合抗VEGF单克隆抗体可以显著提高EGFR... 详细信息

表皮生长因子受体(EGFR)以及血管内皮生长因子(VEGF)信号通路在非小细胞肺癌(NSCLC)的发生和进展中起着重要的作用,两者具有共同的下游信号通路且具有协同促瘤作用。大部分临床试验表明抗EGFR药物联合抗VEGF单克隆抗体可以显著提高EGFR突变阳性进展期NSCLC患者的中位无进展生存期,但在治疗肺癌中抗EGFR及VEGF联合治疗仍需要进一步探索。本文综述了EGFR或VEGF通路治疗机制和EGFR突变阳性进展期NSCLC中联合治疗的临床前实验及临床研究。

关键词：非小细胞肺癌酪氨酸激酶抑制剂抗血管内皮生长因子抑制剂

Safety and activity of WX-0593(Iruplinalkib)in patients with ALK-or ROS1-rearranged advanced non-small cell lung cancer:a phase 1 dose-escalation and dose-expansion trial

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Signal Transduction and Targeted Therapy 2022年第2期7卷 573-582页

作者： Yuankai Shi Jian Fang Xuezhi Hao Shucai Zhang Yunpeng Liu Lin Wang Jianhua Chen Yi Hu Xiaosheng Hang Juan Li Chunling Liu Yiping Zhang Zhehai Wang Yanping Hu Kangsheng Gu Jian’an Huang Liangming Zhang Jinlu Shan weiwei ouyang Yanqiu Zhao Wu Zhuang Yan Yu Jun Zhao Helong Zhang Pei Lu Weidong Li Meimei Si Mingjing Ge Huaize Geng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs100021 BeijingP.R.China Beijing Cancer Hospital 100142 BeijingP.R.China Beijing Chest Hospital Capital Medical University101149 BeijingP.R.China The First Hospital of China Medical University 110001 ShenyangP.R.China Hunan Cancer Hospital 410000 ChangshaP.R.China Chinese PLA General Hospital 100853 BeijingP.R.China Affiliated Hospital of Jiangnan University 214062 WuxiP.R.China Sichuan Cancer Hospital 610041 ChengduP.R.China Affiliated Tumour Hospital of Xinjiang Medical University 830000 UrumqiP.R.China Zhejiang Cancer Hospital 310022 HangzhouP.R.China Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences250117 JinanP.R.China Hubei Cancer Hospital 430079 WuhanP.R.China The First Affiliated Hospital of Anhui Medical University 230022 HefeiP.R.China The First Affiliated Hospital of Soochow University 215006 SuzhouP.R.China Yantai Yuhuagding Hospital Yantai 264000P.R.China Army Medical Center of People’s Liberation Army 400042 ChongqingP.R.China Guizhou Cancer Hospital 520100 GuiyangP.R.China Henan Cancer Hospital 450008 ZhengzhouP.R.China Fujian Province Cancer Hospital 350014 FuzhouP.R.China Harbin Medical University Cancer Hospital 150081 HarbinP.R.China Tangdu Hospital of the Fourth Military Medical University 710038 Xi’anP.R.China Liuzhou People’s Hospital 545006 LiuzhouP.R.China Cancer Center of Guangzhou Medical University 510095 GuangzhouP.R.China Qilu Pharmaceutical Co. Ltd250101 JinanP.R.China

WX-0593(Iruplinalkib)is a novel,highly selective oral ALK and ROS1 tyrosine kinase inhibitor(TKI).In this study,the safety,antitumor activity,and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer(NSCLC)patients with ALK or ROS1 *** the dose-escalation phase and dose-expansion phase,patients were treated with WX-0593 until disease progression,unacceptable toxicity,or subject *** the dose-escalation phase,the primary endpoints were maximum tolerated dose(MTD),dose-limiting toxicity(DLT),and safety assessed by *** the dose-expansion phase,the primary endpoint was objective response rate(ORR)assessed by *** September 25,2017 and October 15,2018,a total of 153 patients received WX-0593 *** dose-limiting toxicities(DLTs)including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one *** was not ***,140 of the 152(92%)patients experienced treatment-related adverse events(TRAEs)and 35 of the 152(23%)patients had TRAEs≥grade *** overall ORR was 59.3%(32 of 54)for the dose-escalation phase and 56.6%(56 of 99)for the dose-expansion *** patients who were ALK-rearranged and ALK TKI naive,the ORR were 81.0%(17 of 21)in the dose-escalation phase and 76.3%(29 of 38)in the dose-expansion phase,and for patients who previously received crizotinib as the only ALK TKI,the ORR were 38.1%(8 of 21)and 45.7%(21 of 46)for the two phases,*** patients who were ROS1-rearranged,the ORR were 30.0%(3 of 10)in the dose-escalation phase and 44.4%(4 of 9)in the dose-expansion ***-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement.

关键词： patients expansion phase

Control Effects of Different Agents on Tobacco Mosaic Virus Disease

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Agricultural Biotechnology 2019年第6期8卷 27-29,63页

作者： weiwei ouyang Zhengyang ZHANG Qiuzan ZHONG Changyou SHEN Runsheng LIU Xianyi XIAO Qinggen YANG Wenping RAO Yi LIU Chenggen FAN Hai LIAN Lifang XIE Institute of Tobacco Sciences in Ganzhou City of Jiangxi Province Ganzhou 341000China Jiangxi Tobacco Company Nanchang 330025China Ruijin Branch Ganzhou Tobacco Company of Jiangxi ProvinceRuijin 342500China Ganzhou Tobacco Company of Jiangxi Province Ganzhou 341000China

[Objectives] This study was conducted to screen out suitable agents for controlling tobacco mosaic virus disease and the best control period in Zhangzhou tobacco area, providing a theoretical basis for the control of virus diseases, thereby improving the quality of flue-cured tobacco and the income of tobacco farmers. [Methods] The effects on tobacco mosaic virus disease under the interaction between different agents and different application periods were investigated. The incidence of tobacco mosaic virus disease was investigated, and its control effect was analyzed. [Results] Different agents and different application periods had different control effects on tobacco mosaic virus disease. The incidence of tobacco mosaic virus disease: At 30 and 45 d after transplanting, the incidences of A2B1 treatment were the lowest, at 0.85%, 1.71%, respectively;and at 60 d after transplanting, the incidence of A3B1 treatment was the lowest, only 10.68%. The control effect: At 30 and 45 d after transplanting, A2B1 treatment had better control effects, reaching 79.39% and 73.06%, respectively. [Conclusions] 3% hypersensitive protein sprayed at 1 d before transplanting and 7 and 15 d after transplanting achieved the best effect, followed by 10% ningnanmycin sprayed at 1 d before transplanting and 7 and 15 d after transplanting. In tobacco production, it is recommended to apply 1 000 times dilution of 3% supersensitive protein microgranules for three times(at 1 d before transplanting and 7 and 15 d after transplanting), which can effectively prevent tobacco mosaic virus disease.

关键词： Tobacco mosaic virus disease Control effect Hypersensitive protein Oligosaccharins-plant activation protein

重庆市住院医师规范化培训并轨硕士研究生培养的实践

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中华医院管理杂志 2017年第6期33卷 442-444页

作者：欧阳薇薇黄莹魏琳徐永柱重庆市卫生服务中心 404000 重庆市卫生和计划生育委员会重庆医科大学附属第一医院

介绍了重庆市住院医师规范化培训并轨研究生的培训情况，并通过对比重庆市2014年普通专科住院医师规范化培训与2015年住院医师规范化培训并轨研究生结业考核的成绩及通过率，分析其规律以及2种培养制度的差异性，提出并轨研究生培养工... 详细信息

介绍了重庆市住院医师规范化培训并轨研究生的培训情况，并通过对比重庆市2014年普通专科住院医师规范化培训与2015年住院医师规范化培训并轨研究生结业考核的成绩及通过率，分析其规律以及2种培养制度的差异性，提出并轨研究生培养工作的改进建议，如进一步健全领导机构和管理制度、严把质量控制环节、完善考核评估体系等。

关键词：重庆市住院医师规范化培训并轨硕士研究生培养

Rapid Optimization of Tension Distribution for Cable-Driven Parallel Manipulators with Redundant Cables

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Chinese Journal of Mechanical Engineering 2016年第2期29卷 231-238页

作者： ouyang Bo SHANG weiwei Department of Automation University of Science and Technology of China

The solution of tension distributions is infinite for cable-driven parallel manipulators（CDPMs） with redundant cables. A rapid optimization method for determining the optimal tension distribution is presented. The new optimization method is primarily based on the geometry properties of a polyhedron and convex analysis. The computational efficiency of the optimization method is improved by the designed projection algorithm, and a fast algorithm is proposed to determine which two of the lines are intersected at the optimal point. Moreover, a method for avoiding the operating point on the lower tension limit is developed. Simulation experiments are implemented on a six degree-of-freedom（6-DOF） CDPM with eight cables, and the results indicate that the new method is one order of magnitude faster than the standard simplex method. The optimal distribution of tension distribution is thus rapidly established on real-time by the proposed method.

关键词： cable-driven parallel manipulator tension distribution redundant cable linear programming

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鲜茧丝与干茧丝织物性能研究

丝绸 2017年第9期54卷 1-6页

作者：杨莹莹寿霜霜欧阳微微侍康妮田伟祝成炎浙江理工大学"纺织纤维材料与加工技术"国家地方联合工程实验室杭州310018

为研究鲜茧缫丝与干茧缫丝对真丝织物物理机械性能的影响,采用六个庄口的蚕茧,3个织物品种和多种经纬密度,分别将鲜茧丝和干茧丝织造成6组对比织物试样,并对织物试样的光泽度、拉伸性能、折皱回复性、抗弯刚度、悬垂性和透湿性等进行测... 详细信息

为研究鲜茧缫丝与干茧缫丝对真丝织物物理机械性能的影响,采用六个庄口的蚕茧,3个织物品种和多种经纬密度,分别将鲜茧丝和干茧丝织造成6组对比织物试样,并对织物试样的光泽度、拉伸性能、折皱回复性、抗弯刚度、悬垂性和透湿性等进行测试和分析。研究结果表明,对于不同庄口织制的各种参数织物品种,鲜茧丝织物的光泽度比干茧丝织物好;鲜茧丝织物的断裂强力和断裂伸长率比干茧丝织物高;由于鲜茧丝织物的折皱回复角、抗弯长度、静态悬垂系数均比干茧丝织物小,鲜茧丝织物的手感较柔软,抗皱性稍差;此外,鲜茧丝织物的透湿性通常比干茧丝织物好。

关键词：缫丝鲜茧丝干茧丝真丝织物光泽度力学性能织物手感

290名住院医师规范化培训质量影响因素分析

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重庆医学 2016年第4期45卷 504-507页

作者：王梅李玉霞李静欧阳薇薇徐永柱重庆医科大学公共卫生与管理学院重庆400016 重庆市卫生服务中心重庆400015

目的探讨影响住院医师规范化培训(以下简称规培)制度创新的相关因素,为进一步完善住院医师规培制度提供理论依据。方法对2013年参加规培的学员随机抽取290名进行问卷调查,对调查数据运用统计方法分析处理。结果学员基本情况与住院医师... 详细信息

目的探讨影响住院医师规范化培训(以下简称规培)制度创新的相关因素,为进一步完善住院医师规培制度提供理论依据。方法对2013年参加规培的学员随机抽取290名进行问卷调查,对调查数据运用统计方法分析处理。结果学员基本情况与住院医师规培制度的接受程度、培训效果、考核组织的科学合理性、医院开展情况等因素相互影响,培训对提高临床实践和专业技能方面有较好的作用,学员对住院医师规培的认识总体是利大于弊。结论要积极借鉴成功经验,通过宣传营造氛围,优化各类培训方案,打造优秀师资队伍,切实解决学员困难,提供优质软硬件设施,最终保障培训实施效果。

关键词：住院医师规范化培训影响因素

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喷气涡流纺羊绒/涤纶混纺纱纤维径向分布

现代纺织技术 2020年第1期28卷 31-35页

作者：欧阳微微李艳清田伟刘向东祝成炎浙江理工大学材料与纺织学院

为研究纤维规格对喷气涡流纺纱线中纤维径向分布的影响规律,将两种不同规格的羊绒纤维和同一棉型涤纶纤维分别以相同比例混纺,经喷气涡流纺纱机MVS861制备了两种羊绒/涤纶纤维混纺纱线。运用哈氏切片器切取两种混纺纱线的横截面样本,借... 详细信息

为研究纤维规格对喷气涡流纺纱线中纤维径向分布的影响规律,将两种不同规格的羊绒纤维和同一棉型涤纶纤维分别以相同比例混纺,经喷气涡流纺纱机MVS861制备了两种羊绒/涤纶纤维混纺纱线。运用哈氏切片器切取两种混纺纱线的横截面样本,借助扫描电子显微镜观察并采集纱线样品横截面的纤维分布图,结合汉密尔顿指数分析法和Onion指数法分析,得到喷气涡流纺混纺纱中羊绒纤维和涤纶纤维在纱线横截面内的内外转移趋势和分布规律。结果表明,利用喷气涡流纺纱技术制得的羊绒/涤纶混纺纱线中,羊绒纤维因其初始模量更小、长度更长有向外转移趋势,初始模量更大、长度更短的涤纶纤维则有向内转移趋势;但混纺纱的最外层纤维由纤维含量和纤维规格共同决定。该结论可帮助纺制喷气涡流纺羊绒混纺纱时根据需要来选择纤维原料的规格。

关键词：喷气涡流纺混纺纱纤维分布汉密尔顿转移指数 Onion指数