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Combined experimental and simulation study on corrosion behavior of B10 copper-nickel alloy welded joint under local turbulence

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Journal of Iron and Steel Research(International) 2023年第8期30卷 1598-1612页

作者： Da-lei Zhang Ran liul Ying-shuang liul Shao-hua Xing Zong-hao He Yao Qian Jin-zeng Liu Xiao-hui Dou Xin-wei Zhang School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266237ShandongChina

The corrosion behavior of B10 copper-nickel alloy welded joints in seawater pipeline system was analyzed under local turbulence induced by weld residual *** corrosion behavior was evaluated by array electrode technology,mor-phology and elemental characterization,and COMSOL Multiphysics *** results provide a theoretical basis for the corrosion and leakage of B10 alloy in seawater pipeline under the action of *** results show that residual height-induced turbulence exhibits a significant effect on the corrosion behavior in different areas of welded joints in B10 *** can damage some surfaces,causing polarity deflection followed by acceleration of corrosion,or it is easier to form a protective film to slow down *** Multiphysics results show that the shear rate and turbulent kinetic energy increase linearly with the increase in residual height and *** corrosion behavior of alloy surface is influenced by controlling the mass transfer rate and surface state.

关键词： Array electrode technology Welded joint Corrosion COMSOL Multiphysics simulation Seawater

Effect of stabilizing treatment on microstructure and stress rupture properties of phosphorus microalloyed Inconel 706 alloy

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Journal of Iron and Steel Research(International) 2023年第8期30卷 1613-1621页

作者： Sha Zhang Yu-chao Wu Yu Lil Zhong-pei Dail Dan Jia Yan-fei Xu Guang-sheng Zeng Zhi-ming Guo Jian liul College of Mechanical&Electrical Engineering Changsha UniversityChangsha 410022HunanChina Hunan Engineering Research Center of Research and Development of Degradable Materials and Molding Technology Changsha UniversityChangsha 410022HunanChina Changsha Kaiple Technology Co. Ltd.Changsha 410114HunanChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The microstructure and stress rupture properties of Inconel 706 alloy microalloyed with phosphorus are examined under stabilizing and unstabilizing heat treatment *** was found that applying the stabilizing treatment resulted in a 98% increment in the stress rupture life and a 215% increment in the elongation tested at 650℃/690 MPa for the alloy compared to that under the unstabilizing heat treatment *** stabilizing treatment led to the precipitation of rod-shaped and needle-shaped n phases at the grain *** of γ'-γ" co-precipitates in the grain interior were noncompact form and compact form for the alloy under unstabilizing and stabilizing heat treatment conditions,*** on the microstructure characterizations,the improvement of stress rupture properties by the stabilizing treatment was attributed to the precipitation of n phases at the grain boundaries,which can hinder cracks initiation and propagation and relieve the stress concentration.

关键词： Superalloy Stabilization ηphase γ'-γ"co-precipitate Stress rupture property

Two Retroviruses Packaged in One Cell Line can Combined Inhibit the Replication of HIV-1 in TZM-bl Cells

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Virologica Sinica 2012年第6期27卷 339-344页

作者： Zhipin Liang Zhiyuan Guo Xin Wang Xiaohong Kong Chang liul School of Medicine Nankai University Tianjin 300071 China Tianjin Centers for Disease Control and Prevention Tianjin 300171 China

The cellular protein tetherin tethers the HIV-1 viral particles on the cellular membrane to inhibit the replication of ***,the HIV-1 accessory protein Vpu counteracts the antiviral function of *** this study,two retroviral vector plasmids were *** inhibited the vpu gene expression;the other one over-expressed the *** retroviral vector plasmids could be packaged in the packaging cell line PT67 to obtain the corresponding *** retroviral vector plasmids' functions of tetherin over-expression or vpu-RNAi were detected at the cell *** vector plasmids were transfected to PT67 cells at different ratios from 0T3V to 3T0V,and then mixed retroviruses were *** antiviral functions of mixed retroviruses were detected in HIV-1 infected TZM-bl *** results showed that packaged mixed retroviruses could repress the replication of HIV-1 in TZM-bl cells.

关键词：逆转录病毒载体 HIV-1 细胞系复制抗病毒功能封装载体质粒 RNAi技术

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Salvia miltiorrhiza monomer IH764-3 induces hepatic stellate cell apoptosis via caspase-3 activation

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World Journal of Gastroenterology 2002年第3期8卷 515-519页

作者： ZhanXL liul 等 DepartmentofGastroenterology TheSecondHospitalofHebeiMedicalUniversityShijiazhuang05000HebeiProvinceChina DepartmentofGastroenterology TheSecondHospitalofHebeiMedicalUniversityShijiazhuang05000He

AIM: To investigate the effects of IH764-3 on HSC apoptosis,and the expression of caspase-3 protein in HSC ***: HSCs were cultured in medium with differentIH764-3 doses ( 10 μg@ mL-1 , 20 μg@ mL-1 , 30 μg@ mL-1,40μg @mL-1) and without IH764-3, and HSC proliferation wasquantitatively measured by 3 H-thymidine incorporation. Themorphological changes of HSCs were observed withtransmission electron microscope after exposure to the doseof 40 μg@ mL-1 of IH764-3 for 48 hr, The apoptosis rates weredetected by annexin V/PI and TdT-mediated dUTP nick endlabeling (TUNEL). The expression of caspase-3 protein wasdetermined by flow ***: (1) HSC proliferation rates induced with differentIH764-3 doses ( 10 μg@ mL-1 , 20 μg@ mL-1 , 30 μg@ mL-1 , 40 μg@mL-1) were significantly reduced compared with that of thecontrol group ( P＜ 0.01). (2)With the doses above, IH764-3dose-dependently produced HSC apoptosis rates of 6.7 %(9.4%),9.3 %(21.6 %),15.1%(27.2 %) and 19.0 %(28.4 %)respectively, by annexin V and PI-labeled flow cytometry assay(or TUlE L), while it was only 2.3 %(6.7 %) in the control. (3)The expression of caspase-3 protein in IH764-3 groups wassignificantly higher than that of the cortrol (P＜0.05).CONCLUSION: Within the dose range used in present study,IH764-3 can inhibit HSC proliferation, as well as enhance HSCapoptosis. Furthermore, IH764-3 can significantly increasethe caspase-3 protein expression.

关键词：丹参肝星状细胞细胞凋亡 IH764-3 Caspase-3蛋白表达

Complete chloroplast genome sequences of Schisandra chinensis:genome structure,comparative analysis,and phylogenetic relationship of basal angiosperms

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Science China(Life Sciences) 2017年第11期60卷 1286-1290页

作者： Haojie Guo Jiushi liul Li Luo Xueping Wei Jin Zhang Yaodong Qi Bengang Zhang Haitao Liu Peigen Xiao Instiute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Institute of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830011China

Dear Editor,Schisandra chinensis(Turcz.)*** to family *** fruit called"Wu Wei Zi"in Chinese is a well-known medicinal material,which is used to treat chronic cough and dyspnea,nocturnal emission,enuresis,etc.(National Pharmacopoeia Committee,2015).Except for ***,many species of Schisandraceae,such as ***,*** and ***,are used as the original plants of folk *** these species have similar traditional effects,modern

关键词： Schisandra chloroplast medicines basal phylogenetic belongs cough SSRs nocturnal fruit

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Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages

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第二军医大学学报 2006年第3期27卷 243-243页

作者： LongF WangYX liul ZhouJ CuiRY JiangCL DepartmentofNauticalMedicine SecondMilitaryMedicalUniversityShanghai200433China

Traditionally, steroid hormone effects have been described as a result of the modulation of nuclear transcription, thus triggering genomic events that are responsible for physiological effects. Despite early observations of rapid steroid effects that were incompatible with this theory, nongenomic steroid effects have been widely recognized only recently. However, the nongenomic effect of glucocorticoid (GC) on anti-inflammation and immunosuppression has not been reported. Macrophages play important roles in inflammation and the immune response. The present experiment selected macrophages as experimental cells to explore the nongenomic effects and possible mechanisms of GCs on phagocytosis and superoxide anion production. Phagocytosis by macrophages was detected by the neutral red uptake assay. The superoxide anions were measured by cytochrome C reduction assay. It was found that both 10^-4 and 10^-5 mol/L corticosterone (CORT) rapidly inhibited uptake of neutral red by macrophages in less than 30 min, and the inhibition by the former was stronger than that of the latter. CORT (10^-4 to 10^-10 mol/L) rapidly inhibited superoxide anion production by macrophages in less than 30 min. The above-mentioned effects were insensitive to the GC-receptor antagonist mifepristone (RU486) and the translation inhibitor actidione. CORT coupled to bovine serum albumin (BSA-CORT) was able to mimic the rapid inhibitory effects of CORT. The results indicated that CORT could rapidly inhibit phagocytosis and superoxide anion production by mouse peritoneal macrophages in vitro in less than 30 rain by a rapid, nongenomic mechanism, which contributes to the anti-inflammatory and immunosuppressive actions of GCs. These data shed a new light on the clinical application of GCs.

关键词：超氧化物类/代谢巨噬细胞/药物作用巨噬细胞/代谢巨噬细胞/免疫学糖皮质激素类/药理学吞噬作用/药物作用细胞培养的动物小鼠

MXene Ti_3C_2T_x saturable absorber for pulsed laser at 1.3 μm

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Chinese Physics B 2018年第9期27卷 124-127页

作者：王聪彭倩倩范秀伟梁维源张峰刘杰张晗 Shandong Provincial Key Laboratory of Optics and Photonic Device School of Physics and Electronics Shandong Normal University SZU-NUS Collaborative Innovation Centre for Optoelectronic Science & Technology and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education Institute of Data Science and Technology Shandong Normal University

The excellent optical properties of MXene provide new opportunities for short-pulse lasers. A diode-pumped passively Q-switched laser at 1.3 μm wavelength with MXene Ti3C2Tx as saturable absorber was achieved for the first time. The stable passively Q-switched laser has 454 ns pulse width and 162 kHz repetition rate at 4.5 W incident pumped power. The experimental results show that the MXene Ti3C2Tx saturable absorber can be used as an optical modulator to generate short pulse lasers in a solid-state laser field.

关键词： MXene Ti3C2Tx passively Q-switched lasers 1.3 μm diode-pumped lasers

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艾迪注射液联合一线化疗用于NSCLC的快速卫生技术评估

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中国药房 2023年第10期34卷 1247-1251页

作者：许聪聪黄柳绿唐姣刘盈韩永龙上海交通大学医学院附属第六人民医院药剂科上海201306

目的评价艾迪注射液联合一线化疗用于非小细胞肺癌(NSCLC)的有效性、安全性和经济性,为临床用药和决策提供循证依据。方法计算机检索PubMed、Embase、the Cochrane Library、中国知网、万方数据、维普网及国内外卫生技术评估(HTA)机构... 详细信息

目的评价艾迪注射液联合一线化疗用于非小细胞肺癌(NSCLC)的有效性、安全性和经济性,为临床用药和决策提供循证依据。方法计算机检索PubMed、Embase、the Cochrane Library、中国知网、万方数据、维普网及国内外卫生技术评估(HTA)机构官方网站,收集艾迪注射液联合一线化疗用于NSCLC的HTA报告、系统评价/Meta分析和药物经济学研究,检索时限均为建库起至2022年8月。资料提取和质量评价后,对纳入研究的结果进行描述性分析。结果共纳入16篇文献,其中1篇系统评价,13篇Meta分析,2篇药物经济学研究。与一线化疗相比,艾迪注射液联合一线化疗可提高NSCLC患者的有效率和疾病控制率,延长生存时间,改善生存质量,降低恶心呕吐、白细胞减少、血小板降低发生率,提高免疫功能,但对肝肾功能的影响存在争议。以2019年全国人均国内生产总值设定支付阈值,艾迪注射液联合一线化疗具有经济性。结论艾迪注射液联合一线化疗用于NSCLC的疗效和安全性均较好,且具有一定的经济性,但鉴于纳入的药物经济学研究较少,因此所得经济学结论需谨慎解读。

关键词：艾迪注射液化疗非小细胞肺癌快速卫生技术评估药物经济学

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Phonon-assisted upconversion in twisted two-dimensional semiconductors

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Light(Science & Applications) 2023年第1期12卷 89-98页

作者： Yuchen Dai Pengfei Qi Guangyi Tao Guangjie Yao Beibei Shi Zhixin liul Zhengchang Liu Xiao He Pu Peng Zhibo Dang Liheng Zheng Tianhao Zhang Yongji Gong Yan Guan Kaihui Liu Zheyu Fang School of Physics State Key Laboratory for Mesoscopic PhysicsAcademy for Advanced Interdisciplinary StudiesCollaborative Innovation Center of Quantum MatterNano-optoelectronics Frontier Center of Ministry of EducationPeking University100871 BeijingChina Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and Technology300350 TianjinChina Photonics Research Center School of PhysicsMOE Key Lab of Weak-Light Nonlinear Photonicsand Tianjin Key Lab of Photonics Materials and Technology for Information ScienceNankai University300071 TianjinChina School of Materials Science and Engineering Beihang University100191 BeijingChina Center for Physicochemical Analysis and Measurements in ICCAS Analytical Instrumentation CenterPeking University100871 BeijingChina

Phonon-assisted photon upconversion(UPC)is an anti-Stokes process in which incident photons achieve higher energy emission by absorbing *** letter studies phonon-assisted UPC in twisted 2D semiconductors,in which an inverted contrast between UPC and conventional photoluminescence(PL)of WSe2 twisted bilayer is emergent.A 4-fold UPC enhancement is achieved in 5.5°twisted bilayer while PL weakens by *** interlayer exciton conversion efficiency driven by lattice relaxation,along with enhanced pump efficiency resulting from spectral redshift,lead to the rotation-angle-dependent UPC *** counterintuitive phenomenon provides a novel insight into a unique way that twisted angle affects UPC and light-matter interactions in 2D ***,the UPC enhancement platform with various superimposable means offers an effective method for lighting bilayers and expanding the application prospect of 2D stacked van der Waals devices.

关键词： twisted semiconductors relaxation