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Ultracompact meta-imagers for arbitrary all-optical convolution

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Light(Science & Applications) 2022年第4期11卷 595-607页

作者： weiwei fu Dong Zhao Ziqin Li Songde Liu Chao Tian Kun Huang Department of Optics and Optical Engineering University of Science and Technology of ChinaHefeiAnhui 230026China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui 230088China. Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefeiAnhui 230026China

Electronic digital convolutions could extract key features of objects for data processing and information identification in artificial intelligence,but they are time-cost and energy consumption due to the low response of *** massless photons enable high-speed and low-loss analog convolutions,two existing all-optical approaches including Fourier fItering and Green's function have either limited functionality or bulky volume,thus restricting their applications in smart ***,we report aloptical convolutional computing with a metasurface-singlet or-doublet imager,considered as the third approach,where its point spread function is modified arbitrarily via a complex-amplitude meta-modulator that enables functionality-unlimited *** one-and two-dimensional spatial differentiation,we demonstrate real-time,parallel,and analog convolutional processing of optical and biological specimens with challenging pepper-salt denoising and edge enhancement,which significantly enrich the toolkit of all-optical *** meta-imager approach bridges multi-functionality and high-integration in all-optical convolutions,meanwhile possessing good architecture compatibility with digital convolutional neural networks.

关键词： convolution enable arbitrary

GGVD:A goat genome variation database for tracking the dynamic evolutionary process of selective signatures and ancient introgressions

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Journal of Genetics and Genomics 2021年第3期48卷 248-256页

作者： weiwei fu Rui Wang Jiantao Yu Dexiang Hu Yudong Cai Junjie Shao Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

Understanding the evolutionary history and adaptive process depends on the knowledge that we can acquire from both ancient and modern genomic *** the availability of a deluge of whole-genome sequencing data from ancient and modern goat samples,a user-friendly database making efficient reuse of these important resources is ***,we use the genomes of 208 modern domestic goats,24 bezoars,46 wild ibexes,and 82 ancient goats to present a comprehensive goat genome variation database(GGVD).GGVD hosts a total of~41.44 million SNPs,~5.14 million indels,6,193 selected loci,and 112 introgression *** can freely visualize the frequency of genomic variations in geographical maps,selective sweeps in interactive tables,Manhattan plots,or line charts,as well as the heatmap patterns of the SNP *** data can be shown in haplotypes to track the state of genetic variants of selection and introgression events in the early,middle,and late *** facilitating access to sequence features,the UCSC Genome Browser,BLAT,BLAST,Lift Over,and pcadapt are also integrated into *** will be a convenient tool for population genetic studies and molecular marker designing in goat breeding programs,and it is publicly available at http://***/Goat Var.

关键词： Goat Genetic structure Variation Selective signature Introgression Database

Free-ranging Sichuan snub-nosed monkeys Rhinopithecus roxellana： Neophobia, neophilia, or both？

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Current Zoology 2013年第3期59卷 311-316页

作者： weiwei fu Dapeng ZHAO Xiaoguang QI Songtao GUO Wei WEI Baoguo LI College of Life Sciences Northwest University Xi'an 710069 China College of Life Sciences Tianjin Normal University Tianjin 300387 China Institute of Zoology Shaanxi Academy of Sciences Xi'an 710032 China

We studied the responsiveness of the Sichuan snub-nosed monkey Rhinopithecus roxellana, an arboreal Old World monkey, to the presence of novel stimuli associated with familiar food. We also determined differences in responses by age and sex. Results showed that monkeys exhibited neophilia and neophobia simultaneously when facing novel stimuli. Age affected the response to novel stimuli significantly, with immature individuals responding to novel stimuli most frequently and infants least frequently. No significant differences were observed for sex, although females were more responsive to the novel object than were males. Our results support the ＂readiness to eat＂ hypothesis that the presence of a novel object can increase latencies to consume familiar food .

关键词： Rhinopithecus roxellana Neophobia Age Sex differences

Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity

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Science China(Life Sciences) 2022年第6期65卷 1075-1090页

作者： Han Feng Xiaohong Zhao Jenny Xie Xue Bai weiwei fu Hairong Chen Hong Tang Xiaohu Wang Chen Dong Institute for Immunology Tsinghua UniversityBeijing 100084China Discovery Immunology Bristol Myers SquibbPrinceton NJ 08543USA Department of Gastroenterology Peking University Third HospitalBeijing 100191China CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of ScienceBeijing 100101China CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200025China Pasteurien College Suzhou UniversitySuzhou 215123China Shanghai Immune Therapy Institute Shanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200127China

T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center *** cell plasticity,especially with regard to their expression of effector Th cytokines,has been described,but lacks in-depth analysis with genetic *** this study,we systemically compared transcriptomic profiles of Tfh cells derived from various types of immune responses and found gene clusters corresponding to effector Th cells were differentially induced in response to pathogens or immune *** special interest,a subset of Tfh cells producing IFN-γwas generated in an influenza virus infection,partially dependent on the innate cytokine ***-tracing mouse model revealed unique developmental regulation of IFN-γ~+Tfh cells,while selective ablation of these cells impaired the induction of Ig G2c~+germinal center B cells and the control of influenza *** results indicate that pathogen-associated Tfh cell plasticity is necessary for host immunity,which has implications in vaccine design.

关键词： T follicular helper(Tfh)cell plasticity influenza infection IFN-γ IgG2

Short Term Efficacy of Entecavir in the Treatment of Decompensated Chronic Hepatitis B Cirrhosis

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Proceedings of Anticancer Research 2020年第6期4卷 53-56页

作者： weiwei fu Third People's Hospital of Zhenjiang City Zhenjiang 212001Jiangsu ProvinceChina

Objective:To explore the effect of entecavir on patients with decompensated chronic hepatitis B ***:From October 2007 to December 2019,100 patients with decompensated chronic hepatitis B cirrhosis who were treated in our hospital were selected to carry out this *** clinical data of the patients were *** to whether entecavir treatment was carried out,100 patients were divided into two groups,50 cases in the control group and 50 cases in the observation *** control group was treated with conventional drugs,and the observation group was treated with *** function indexes,liver fibrosis indexes,HBV-DNA negative conversion rate and incidence of adverse reactions were compared between the two ***:Compared with the control group,the liver function indexes of the observation group were lower,P***:Entecavir can not only improve the liver function,but also enhance the shortterm treatment effect,without increasing adverse reactions,and has high safety,which is worthy of recommendation.

关键词： Decompensated stage of chronic hepatitis B cirrhosis Entecavir Treatment effect Negative rate of HBV-DNA

BGVD:An Integrated Database for Bovine Sequencing Variations and Selective Signatures

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 186-193页

作者： Ningbo Chen weiwei fu Jianbang Zhao Jiafei Shen Qiuming Chen Zhuqing Zheng Hong Chen Tad S.Sonstegard Chuzhao Lei Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China College of Information Engineering Northwest A&F UniversityYangling 712100China Recombinetics St PaulMN55104USA

Next-generation sequencing has yielded a vast amount of cattle genomic data for global characterization of population genetic diversity and identification of genomic regions under natural and artificial ***,efficient storage,querying,and visualization of such large datasets remain ***,we developed a comprehensive database,the Bovine Genome Variation Database(BGVD).It provides six main functionalities:gene search,variation search,genomic signature search,Genome Browser,alignment search tools,and the genome coordinate conversion *** contains information on genomic variations comprising^60.44 M SNPs,~6.86 M indels,76,634 CNV regions,and signatures of selective sweeps in 432 samples from modern cattle *** can quickly retrieve distribution patterns of these variations for 54 cattle breeds through an interactive source of breed origin map,using a given gene symbol or genomic region for any of the three versions of the bovine reference genomes(ARS-UCD1.2,UMD3.1.1,and Btau5.0.1).Signals of selection sweep are displayed as Manhattan plots and Genome Browser *** further investigate and visualize the relationships between variants and signatures of selection,the Genome Browser integrates all variations,selection data,and resources,from NCBI,the UCSC Genome Browser,and Animal ***,all these features make the BGVD a useful archive for in-depth data mining and analyses of cattle biology and cattle breeding on a global *** is publicly available at http://***/BosVar.

关键词： Bovine Sequence variation Selective signatures QTL Database

Bovine HSD17B8 gene and its relationship with growth and meat quality traits

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Science Bulletin 2015年第18期60卷 1617-1621页

作者： Yun Ma Ningbo Chen Fen Li weiwei fu Yapeng Han Yanlin Chang Xiangxiang Jiang Junya Li Yueyu Bai Xuxin Tan College of Life Sciences Xinyang Normal University Institute of Animal Science Chinese Academy of Agricultural Sciences Henan Institute of Animal Health Supervision Henan Center of Animal Products Quality Monitoring and Test

17 β-Hydroxysteroid dehydrogenase type 8 （HSD17B8） is an important regulator of lipid and steroid metabolism. In the present study, we aimed to assess the effects of HSD17B8 on growth and meat quality traits in cattle. Transcription profile analysis showed that HSD17B8 was primarily expressed in the salpinx, liver, and testis. Meanwhile, we identified three SNPs （SNPI： intron 1-A91G; SNP2： exon 1-A90G; and SNP3： intron 8-A86G） of the bovine HSD17B8 gene and investigated its haplotype frequencies and linkage disequilibrium. The detected SNPs were found associated with growth traits （body weight, body length, height at withers, heart girth, hip width, and average daily gain） in native cattle populations （Nanyang and Jiaxian） as well as the meat quality traits （Warner- Bratzler shear force, rib area, dressing percentage, carcass weight, and backfat thickness） in commercial breeds （Angus, Hereford, Limousin, Luxi, Simmental, and Jinnan）. Our results provided evidence that polymorphisms in the HSD17B8 gene were associated with growth traits and meat quality traits. Moreover, our findings might be used for marker-assisted selection in beef cattle breeding program

关键词： HSD17B8. Polymorphisms Growthand meat quality traits Native Chinese cattle

Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data

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Science China(Life Sciences) 2020年第5期63卷 750-763页

作者： Xiaomeng Tian Ran Li weiwei fu Yan Li Xihong Wang Ming Li Duo Du Qianzi Tang Yudong Cai Yiming Long Yue Zhao Mingzhou Li Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China

Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs ***,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference *** a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as *** the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European *** sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid *** flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference *** supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for exploration of genetic diversity and promote pig breeding and biomedical research.

关键词： pan-genome pig reference genome 3D chromatin structure presence-absence variation

Tissue expression, polymorphism identification of HSD17B8 gene and their relationship with growth and meat quality traits in cattle

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Tissue expression, polymorphism identification of HSD17B8 ge...