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Acta Pharmaceutica Sinica B 2020年第11期10卷 2125-2139页

作者： Wei Shi weiwei jin Linghui Xia Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Fred Hutchinson Cancer Research Center SeattleWA 98109-1024USA Department of Cardiovascular Optical Valley School DistrictHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Hubei Province Academy of Traditional Chinese Medicine Wuhan 430074China

Relapse remains the worst life-threatening complications after allogeneic hematopoietic stem cell transplantation(allo-HSCT)in patients with acute myeloid leukemia(AML),whose prognosis has been historically *** the rapid development of genomics and immunotherapies,the interference strategies for AML recurrence have been changing these *** and more novel targeting agents that have received the *** and Drug Administration(FDA)approval for de novo AML treatment have been administrated in the salvage or maintenance therapy of post-HSCT *** strategies that regulate the immune microenvironment of and optimize the graft versus leukemia(GVL)effect of immune cells are gradually *** agents not only have been proven to achieve clinical benefits from a single drug,but if combined with classic therapies,can significantly improve the poor prognosis of AML patients who relapse after *** review will focus on currently available and promising upcoming agents and also discuss the challenges and limitations of targeted therapies in the allogeneic hematopoietic stem cell transplantation community.

关键词： AML Targeted therapy Relapse Immune microenvironment Allogeneic hematopoietic stem cell transplantation Oncogenic effectors Metabolism Surface markers

Repetitive sequence analysis and karyotyping reveal different genome evolution and speciation of diploid and tetraploid Tripsacum dactyloides

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The Crop Journal 2016年第4期4卷 247-255页

作者： Qilin Zhu Zexi Cai Qilin Tang weiwei jin National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic Improvement Coordinated Research Center for Crop Biology China Agricultural University Maize Research Institute Sichuan Agricultural University

In the subtribe Maydeae, Tripsacum and Zea are closely related genera. Tripsacum is a horticultural crop widely used as pasture forage. Previous studies suggested that Tripsacum might play an important role in maize origin and evolution. However, our understanding of the genomics and the evolution of Tripsacum remains limited. In this study, two diploids,T. dactyloides var. meridionale(2n = 36, MR) and T. dactyloides(2n = 36, DD), and one tetraploid,T. dactyloides(2n = 72, DL) were sequenced by low-coverage genome sequencing followed by graph-based cluster analysis. The results showed that 63.23%, 59.20%, and 61.57% of the respective genome of MR, DD, and DL were repetitive DNA sequence. The proportions of different repetitive sequences varied greatly among the three species. Fluorescence in situ hybridization(FISH) analysis of mitotic metaphase chromosomes with satellite repeats as the probes showed that the FISH signal patterns of DL were more similar to that of DD than to that of MR. Comparative analysis of the repeats also showed that DL shared more common repeat families with DD than with MR. Phylogenetic analysis of internal transcribed spacer region sequences further supported the evolutionary relationship among the three species. Repetitive sequences comparison showed that Tripsacum shared more repeat families with Zea than with Coix and Sorghum. Our study sheds new light on the genomics of Tripsacum and differential speciation in the Poaceae family.

关键词： Tripsacum Low-coverage sequencing Repetitive sequence Karyotype Phylogenetic analysis

Striking a growth–defense balance:Stress regulators that function in maize development

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Journal of Integrative Plant Biology 2024年第3期66卷 424-442页

作者： Shiyi Xie Hongbing Luo Wei Huang weiwei jin Zhaobin Dong Maize Engineering and Technology Research Center of Hunan Province College of AgronomyHunan Agricultural UniversityChangsha 410128China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingChina Agricultural UniversityBeijing 100193China Tianjin Key Laboratory of Intelligent Breeding of Major Crops Fresh Corn Research Center of BTHCollege of Agronomy&Resources and EnvironmentTianjin Agricultural UniversityTianjin 300384China

Maize(Zea mays)cultivation is strongly affected by both abiotic and biotic stress,leading to reduced growth and *** has recently become clear that regulators of plant stress responses,including the phytohormones abscisic acid(ABA),ethylene(ET),and jasmonic acid(JA),together with reactive oxygen species(ROS),shape plant growth and *** their well established functions in stress responses,these molecules play crucial roles in balancing growth and defense,which must be finely tuned to achieve high yields in crops while maintaining some level of *** this review,we provide an in-depth analysis of recent research on the developmental functions of stress regulators,focusing specifically on *** unraveling the contributions of these regulators to maize development,we present new avenues for enhancing maize cultivation and growth while highlighting the potential risks associated with manipulating stress regulators to enhance grain yields in the face of environmental challenges.

关键词： stress regulators maize development ABA ET JA ROS

Laparoscopic pancreaticoduodenectomy for pancreatic cancer:a hope or hype?

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 388-390页

作者： weiwei jin Tom Tan To Cheung Yiping Mou Department of Gastroenterology and Pancreatic Surgery Zhejiang Provincial People's Hospitaland Key Laboratory of Gastroenterology of Zhejiang ProvinceHangzhou 310014China Department of Surgery Mary HospitalUniversity of Hong KongHong KongChina

Pancreaticoduodenectomy(PD)is the optimal treatment for resectable pancreatic head *** the development of laparoscopic skills,laparoscopic PD(LPD)has been considered safe and feasible with advantages of the minimally ... 详细信息

关键词： Laparoscopic cancer feasible

Comparative genome research between maize and rice using genomic in situ hybridization

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Chinese Science Bulletin 2001年第8期46卷 656-658,706页

作者： Shunbin Ning weiwei jin Ling Wang Yi Ding Yunchun Song Wuhan Univ Key Lab MOE Plant Wuhan 430072 Peoples R China

Using the genomic DNAs of maize and rice as probes respectively, the homology of maize and rice genomes was assessed by genomic in situ hybridization. When rice genomic DNAs were hybridized to maize, all chromosomes displayed many multiple discrete regions, while each rice chromosome delineated a single consecutive chromosomal region after they were hybridized with maize genomic DNAs. The results indicate that the genomes of maize and rice share high homology, and confirm the proposal that maize and rice are diverged from a common ancestor.

关键词： maize rice genome homology comparative cytogenetics genomic in situ hybridization.

Amino acid permease 6 regulates grain protein content in maize

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The Crop Journal 2022年第6期10卷 1536-1544页

作者： Tianyi Wang Yunfei Li Yumin Huang Xiaoming Zhao Zhaobin Dong weiwei jin Wei Huang State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement Center of ChinaBeijing Key Laboratory of Crop Genetic ImprovementKey Laboratory of Crop Heterosis and UtilizationMinistry of EducationChina Agricultural UniversityBeijing 100193China College of Agronomy&Resources and Environment Tianjin Agricultural UniversityTianjin 300384China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China Sanya Institute of China Agricultural University Sanya 572025HainanChina

Grain protein content(GPC)is an indicator of cereal nutritional *** of genes involved in the regulation of GPC provides targets for molecular breeding for crop protein *** characterized a maize gene encoding the putative amino acid transporter ZmAAP6,a gene expressed mainly in immature seeds,especially in the basal endosperm transfer *** protein and zein contents were decreased in ZmAAP6 null mutants and increased in ZmAAP6 overexpression(OE)lines,consistent with their changed in the size of protein *** and transcriptomic analysis supported the regulatory role of ZmAAP6 in amino acid *** results suggest that ZmAAP6 functions as a positive regulator of GPC in maize,shedding new light on the genetic basis of GPC regulation.

关键词： Grain protein content Amino acid Maize Amino acid permease

Simulation study on delay of end-to-end data communication for protective relaying in substations

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Frontiers of Electrical and Electronic Engineering in China 2008年第2期3卷 246-250页

作者： Huisheng GAO weiwei jin Guang LIU School of Electrical and Electronic Information Engineering North China Electric Power UniversityBaoding 071003China

The end-to-end delay of protective relaying data flow in a substation was studied by dynamic simulation modeling *** distribution characteristics of protective relaying data flow and the constitution of the end-to-end delay of messages were *** simulation model for digital communication between pro-tective relaying equipment and monitoring equipment of interval layer was *** end-to-end delay of pro-tective relaying data flow in different network configurations was *** is found that the size and interval of the data frame,utilization of the link background and protocols of higher layer are key factors of real-time *** analysis results are presented.A proposal for network configuration is suggested to reduce end-to-end delay of pro-tective relaying data flow.

关键词： protective relaying OPNET network simu-lation delay

Fabrication of telechelic DNA-bridged food emulsion gel as edible ink for 3D printing

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Food Quality and Safety 2024年第1期8卷 158-165页

作者： Ruyuan Zhang Hao Huang Rong Ai Dong Li Yanqun Xu weiwei jin Zisheng Luo College of Biological Chemical Sciences and Engineering Jiaxing UniversityJiaxingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina College of Ecology Lishui UniversityLishuiChina Ningbo Innovation Center Zhejiang UniversityNingboChina Wenzhou Academy of Agriculture Science Liuhongqiao Road 1000WenzhouChina Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs Zhejiang Key Laboratory for Agri-Food ProcessingHangzhouChina

Objectives:Interdroplet interactions affect the properties and textures of *** this study,we creatively introduced telechelic DNA to link oil droplets directly at molecular scale to further improve the viscoelastic properties of *** and Methods:A stable emulsion with 70%oil fraction was prepared by adding 40 mg/mL of whey protein isolate and peach gum polysaccharide complex(WPI–PGP complex).The addition of telechelic DNA(0.125–0.375μmol/L)made the emulsion change from a cream-like state to a self-supporting ***:Rheological experiments confirmed that the telechelic DNA could improve the yield stress,storage modulus/loss modulus(Gʹ/Gʹʹ)and apparent viscosity of the emulsion gel in a concentration-dependent manner(0–0.375μmol/L).Inverted fluorescence images clearly showed the interdroplet network of the emulsion gel linked by telechelic *** 3D printing,the emulsion gel with a higher concentration(0.375μmol/L)of telechelic DNA displayed better surface quality and dimensional resolution,indicating improved ***:This study successfully designed a novel telechelic DNA-bridged emulsion gel,which showed great potential as edible ink for 3D printing.

关键词： Telechelic DNA WPI-PGP complex emulsion gel interdroplet interactions 3D printing.

Radical cascade cyclization for the green and simple synthesis of silylated indolo[2,1-a]isoquinoline derivatives via visible light-mediated Si–H bonds activation

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Chinese Chemical Letters 2024年第1期35卷 243-249页

作者： Zhenkai Lei Fei Xue Bin Wang Shijie Wang Yu Xia Yonghong Zhang weiwei jin Chenjiang Liu State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources Key Laboratory of Oil and Gas Fine ChemicalsMinistry of Education&Xinjiang Uygur Autonomous RegionUrumqi Key Laboratory of Green Catalysis and Synthesis TechnologyCollege of ChemistryXinjiang UniversityUrumqi 830017China College of Future Technology Institute of Materia Medic1Xinjiang UniversityUrumqi 830017China Xinjiang Uygur Autonomous Region Product Quality Supervision and Inspection Institute Urumqi 830011China

Photocatalytic and photoinduced silyl radicals cascade cyclization procedures for the green and simple preparation of fused tetracyclic skeleton silylated indolo[2,1-a]isoquinoline-6(5H)-ones from 2-aryl-N-acryloyl indoles with hydrosilanes are *** photocatalytic reaction is carried out with 9,10-dicyanoanthracene(DCA)as an organophotocatalyst and 3-acetoxyquinuclidine as hydrogen atom transfer(HAT)catalyst at room temperature under metal-and oxidant-free *** keys to the success of photoredox-catalytic conversion include(1)the reductive quenching of DCA^(*)[E_(1/2)(*P/P^(-))=+1.97 V *** in MeCN]by 3-acetoxyquinuclidine(E_(p)=+1.22 V *** in MeCN),and(2)the thermodynamic feasibility of hydrogen atom abstraction from hydridic Si-H bond by electrophilic N^(+·).Particularly,the simple photoinduced cascade cyclization using(TMS)3SiH with 2-aryl-N-acryloyl indoles was exploited via an electron-donor-acceptor(EDA)complex under visible light irradiation.

关键词： Indolo[2,1-a]isoquinolines Silyl radicals Green photocatalytic Simple photoinduced Silylated Hydrogen atom transfer EDA complex

Determination of copy number for 5S rDNA and centromeric sequence RCS2 in rice by Fiber-FISH

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Chinese Science Bulletin 2002年第3期47卷 214-217页

作者： Zongyun Li Siluo Huang weiwei jin Shunbin Ning Yunchun Song Lijia Li Wuhan Univ Key Lab Minist Educ Plant Dev Biol Wuhan 430072 Peoples R China

The copy number of 5S rDNA and centromerie sequence RCS2 was determined by extended DNA fiber based fluorescence in situ hybridization (Fiber-FISH) in rice (Oryza sativa ssp. indica cv. Guangluai No. 4) genome. In order to determine the copy number, it is necessary to know the basepair number that a given length DNA fiber contains under a microscope. Therefore, the length of two DNA frag-ments, in which the basepair number had been already known, was measured. The insert sequence of the tested BAC 38D17 was 136 kb and its extended DNA was 56.4 μm long, 2.41 kb/μm on average, while that of the tested BAC 44B4 was 144.5 kb in total and 55.7 μm long, 2.60 kb/μm on average under the microscope. They were very close to the theoretical value of B-DNA in the Watson-Crick DNA model, which is 2.97 kb/μm. According to the average value of basepair number per μm of the two samples mentioned above, that is, 2.51 kb/μm, it could be estimated that the copy number was about 686 for 5S rDNA and 286-1121 for the

关键词： centromeric DNA sequence 5S rDNA copy number fiber based fluorescence in situ hybridization (Fiber-FISH) rice.