检索结果-南通市图书馆

p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model

Neural Regeneration Research 2024年第10期19卷 2299-2309页

作者： Lemeng Feng Chao Wang Cheng Zhang Wulong Zhang Weiming Zhu Ye He Zhaohua Xia weitao Song National Clinical Research Center for Geriatric Diseases Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Eye Center of Xiangya Hospital Central South UniversityChangshaHunan ProvinceChina Hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina

Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogenactivated protein kinase(MAPK) pathway inhibitor SB202190 has a potential ability to suppress ferroptosis, and its downstream targets, such as p53, have been shown to be associated with ferroptosis. However, whether ferroptosis also occurs in retinal ganglion cells in response to glutamate excitotoxicity and whether inhibition of ferroptosis reduces the loss of retinal ganglion cells induced by glutamate excitotoxicity remain unclear. This study investigated ferroptosis in a glutamate-induced glaucoma rat model and explored the effects and molecular mechanisms of SB202190 on retinal ganglion cells. A glutamate-induced excitotoxicity model in R28 cells and an N-methyl-D-aspartate-induced glaucoma model in rats were used. In vitro experiments showed that glutamate induced the accumulation of iron and lipid peroxide and morphological changes of mitochondria in R28 cells, and SB202190 inhibited these changes. Glutamate induced the levels of p-p38 MAPK/p38 MAPK and SAT1 and decreased the expression levels of ferritin light chain, SLC7A11, and GPX4. SB202190 inhibited the expression of iron death-related proteins induced by glutamate. In vivo experiments showed that SB202190 attenuated N-methyl-D-aspartate-induced damage to rat retinal ganglion cells and improved visual function. These results suggest that SB202190 can inhibit ferroptosis and protect retinal ganglion cells by regulating ferritin light chain, SAT1, and SLC7A11/Gpx4 pathways and may represent a potential retina protectant.

关键词： ferroptosis glaucoma glutamate excitotoxicity p38 MAPK retinal ganglion cell SB202190

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

水位下降诱发含水层-弱透水层1维黏弹性固结分析

引用

工程科学与技术 2021年第5期53卷 89-97页

作者：徐进杨伟涛陈征王少伟烟台大学土木工程学院山东烟台264005 武汉大学水工岩石力学教育部重点实验室湖北武汉430072

过量开采地下水引起的地面沉降是一种严重的环境地质灾害,其具有土层变形长期发展的特点,弱透水层黏性土与含水层砂土的流变性是导致这一现象的重要原因之一。为此,采用广义开尔文模型描述弱透水层和含水层的流变性,结合太沙基1维固结... 详细信息

过量开采地下水引起的地面沉降是一种严重的环境地质灾害,其具有土层变形长期发展的特点,弱透水层黏性土与含水层砂土的流变性是导致这一现象的重要原因之一。为此,采用广义开尔文模型描述弱透水层和含水层的流变性,结合太沙基1维固结理论和连续性条件,建立了水位变化诱发弱透水层–含水层双层系统流变固结的控制方程和定解条件。利用Laplace变换,给出基于传统矩阵传递法和边界转换法,分别推导了该双层系统在Laplace域内孔压和沉降的计算公式;采用Stehfest逆变换方法进行数值模拟并编写计算程序,得到真实物理空间解。通过与已有单层解析解、双层模型试验值和数值模拟结果的对比,验证了本文解法和程序的正确性。对比研究表明,相比于传统矩阵传递法,边界转换法可以将混合边界条件转换成单一边界条件,具有更高的计算精度和计算效率。最后,基于边界转换法,利用总沉降定义的固结度,研究了土体黏滞性系数、渗透系数以及水位下降速率等因素对土层长期变形的影响。结果表明:渗透系数和水位下降速率的影响主要体现在前中期,渗透性越小,水位下降速率越慢,固结发展得越慢;黏滞性系数的影响则主要体现在土层变形的后期,黏滞性越强,同等水位变化条件下变形完成所需时间越长。

关键词：地下水位变化地面沉降双层地基黏弹性模型半解析解

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于蛋白和多肽为模板的贵金属纳米簇合成研究

引用

化学学报 2014年第12期72卷 1209-1217页

作者：杨维涛郭伟圣张兵波常津天津大学材料学院纳米生物技术研究所天津市材料复合与功能化重点实验室天津300072 同济大学附属东方医院转化研究中心同济大学医学院生物医学工程与纳米科学研究院上海200092

贵金属(Au,Ag,Pt等)纳米簇通常指的是由几个到约一百个原子组成的分子聚集体,具有生物相容性好、超小尺寸(<2 nm)以及优异的物理化学性质,尤其是能发出较强荧光等特点引起了人们的广泛关注.目前多种贵金属纳米簇的合成方法已相继被报道... 详细信息

贵金属(Au,Ag,Pt等)纳米簇通常指的是由几个到约一百个原子组成的分子聚集体,具有生物相容性好、超小尺寸(<2 nm)以及优异的物理化学性质,尤其是能发出较强荧光等特点引起了人们的广泛关注.目前多种贵金属纳米簇的合成方法已相继被报道,且已应用于生物荧光成像、电化学发光、生物传感器以及细胞标记等多个领域.本文共分为五部分,首先重点介绍近几年兴起的以蛋白和多肽为模板来合成纳米簇的方法及优点,并随后总结列举了文献中所采用的蛋白以及自主设计的多肽组分序列的类别,随后探索了蛋白和多肽中的特定氨基酸与合成的贵金属纳米簇的荧光波长、量子产率、粒径之间的联系.本文最后总结阐述了蛋白和多肽为模板成功合成贵金属纳米簇的先决条件并对其生物医学应用前景进行了展望.

关键词：贵金属纳米簇蛋白多肽荧光

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study of the Relationship Between New Ionic Interaction Parameters and Salt Solubility in Electrolyte Solutions Based on Molecular Dynamics Simulation

引用

Journal of Ocean University of China 2024年第2期23卷 467-476页

作者： SUN Wenting HU yangdong ZHENG Jiahuan SUN Qichao Chen Xia DING Jiakun ZHANG weitao WU Lianying College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China Institute of Chemical Engineering Guangdong Academy of Science Guangzhou 510665China

Studying the relationship between ionic interactions and salt solubility in seawater has implications for seawater desalination and mineral *** this paper,a new method of expressing ion-to-ion interaction is proposed by using molecular dynamics simulation,and the relationship between ion-to-ion interaction and salt solubility in a simulated seawater water-salt system is *** analyzing the variation of distance and contact time between ions in an electrolyte solution,from both spatial and temporal perspectives,new parameters were proposed to describe the interaction between ions:interaction distance(ID),and interaction time ratio(ITR).The best correlation between characteristic time ratio and solubility was found for a molar ratio of salt-to-water of 10:100 with a correlation coefficient of *** the same salt,a positive correlation was found between CTR and the molar ratio of salt and *** type 1-1,type 2-1,type 1-2,and type 2-2 salts,the correlation coefficients between CTR and solubility were 0.93,0.96,0.92,and 0.98 for a salt-to-water molar ratio of 10:100,*** solubility of multiple salts was predicted by simulations and compared with experimental values,yielding an average relative deviation of 12.4%.The new ion-interaction parameters offer significant advantages in describing strongly correlated and strongly hydrated electrolyte solutions.

关键词： molecular dynamics simulation interaction distance interaction time rate electrolyte aqueous solutions solubility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kinetically and thermodynamically expediting elementary steps via high-valence Cr-incorporated of nickel selenide for water electrolysis

引用

Nano Research 2024年第3期17卷 1199-1208页

作者： Huafeng Fan Dongxu Jiao Jinchang Fan Dewen Wang Bilal Zaman Wei Zhang Lei Zhang weitao Zheng Xiaoqiang Cui State Key Laboratory of Automotive Simulation and Control School of Materials Science and EngineeringKey Laboratory of Automobile Materials of MOEJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy CenterJilin UniversityChangchun 130012China College of Chemistry Jilin UniversityChangchun 130012China

Designing high-performance electrocatalysts toward hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is essential to reduce the activation barrier and optimize free adsorption energy of reactive ***,we report that incorporating high-valence Cr into NiSe_(2)(Cr_(x)Ni_(1-x)Se_(2))kinetically and thermodynamically expedites elementary steps of both HER and *** as-prepared Cr_(0.05)Ni_(0.95)Se_(2) catalyst displays excellent HER and OER activities,with low overpotentials of 89 and 272 mV at the current density of 10 mA·cm^(-2)(j10),respectively,and remains stable during operation for 30 h.A low cell voltage of only 1.59 V is required to drive j10 in alkaline *** situ Raman spectroscopy reveals that Cr incorporation facilitates the formation of NiOOH active species during the OER ***,theoretical explorations demonstrate that high-valence Cr incorporation efficiently accelerates water dissociation kinetics and improves H*adsorption during HER process,lowering the activation barrier of OER and optimizing the adsorption energy of oxygen-based intermediate,thus kinetically and thermodynamically enhancing the intrinsic performance of NiSe_(2) for over water *** strategy provides a new horizon to design transition metal based electrocatalysts in the clean energy field.

关键词： nickel selenide electrocatalytic water splitting high-valence Cr density functional theory(DFT)calculation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biochar alleviates apple replant disease by reducing the growth of Fusarium oxysporum and regulating microbial communities

引用

Horticultural Plant Journal 2024年第3期10卷 657-671页

作者： Yinghao Liu Can Wang Ran Chen weitao Jiang Yun Li Chengmiao Yin Yanfang Wang Zhiquan Mao College of Chemistry and Material Science Shandong Agricultural UniversityTaianShandong 271018China State Key Laboratory of Crop Biology/College of Horticultural Science and Engineering Shandong Agricultural UniversityTaianShandong 271018China

Apple replant disease(ARD)negatively affects plant growth and reduces yields in replanted *** this study,biochar was applied to apple replant soil with Fusarium *** aim was to investigate whether biochar could promote plant growth and alleviate apple replant disease by reducing the growth of harmful soil microorganisms,changing soil microbial community structure and improving the soil *** experiment included five treatments:apple replant soil(CK),methyl bromide fumigation apple replant soil(FM),replant soil with biochar addition(2%),replant soil with *** spore solution(8×10^(7)spores·mL^(-1)),and replant soil with biochar and *** spore solution *** biomass,the activity of antioxidant enzymes in the leaves and roots,and soil environmental variables were *** community composition and community structure were analyzed using 16SrDNA and ITS2 gene *** significantly reduced the abundance of *** and increased soil microbial diversity and *** also increased the soil enzyme activities(urease,invertase,neutral phosphatase,and catalase),the biomass(plant height,fresh weight,dry weight)and the activity of antioxidant enzymes(superoxide dismutase,peroxidase,and catalase).The root indexes of apple seedlings was also increased in replant soil by *** sum,biochar promoted the growth of plants,improved the replant soil environment,and alleviated apple replant disease.

关键词： Biochar Fusarium oxysporum Apple replant disease Soil environment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

定标粒子液体理论应用于极性溶质体系及其盐效应系数的计算

引用

物理化学学报 1987年第3期3卷 258-264页

作者：谢文蕙杨伟涛北京大学化学系

1970年***和***将定标粒子理论应用于非极性溶质在电解质水溶液中的盐效应系数的计算,推导出便于应用的盐效应表达式。本文将定标粒子理论应用于极性溶质,推导出一个求极性溶质的盐效应常数表达式。作者用此表达式分别计算了乙酸、正丙... 详细信息

1970年***和***将定标粒子理论应用于非极性溶质在电解质水溶液中的盐效应系数的计算,推导出便于应用的盐效应表达式。本文将定标粒子理论应用于极性溶质,推导出一个求极性溶质的盐效应常数表达式。作者用此表达式分别计算了乙酸、正丙酸、正丁酸、正己酸及正庚酸各在KCl、KBr、NaCl和NaBr四种小离子盐水溶液中的理论盐析常数。修正后的盐析常数比用Masterton和Lee公式计算的盐析常数更接近实验值。

关键词：极性溶质电解质水溶液盐效应效应(化学) 定标决标粒子理论

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Progress in Linear Scaling Non-Orthogonal Localized Molecular Orbitals Method

引用

华南师范大学学报(自然科学版) 2014年第6期 142-142页

作者： Peng Liang Li Shaopeng Hu Linping yang weitao Gu Fenglong Key Laboratory of Theoretical Chemistry of Environment Ministry of Education

The non-orthogonal localized molecular orbital(NOLMO)is the most localized representation of electronic degrees of *** such,NOLMOs are thus potentially the most efficient for linear scaling calculations of electronic structures for large ***,direct ab initio calculations with NOLMO have not been fully implemented and widely used,partly because of the slow convergence issue in the optimization of *** devel-

关键词： Progress in Linear Scaling Non-Orthogonal Localized Molecular Orbitals Method

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

曲线分幅共墩悬浇T构梁纵、横桥向不平衡控制方法

引用

市政技术 2024年第1期42卷 60-67页

作者：杨卫涛刘兆奇丁建刚程高甘肃公航旅天庄高速公路管理有限公司甘肃天水741000 长安大学公路学院陕西西安710064 中铁七局集团有限公司河南郑州450016

依托某特大桥主桥预应力混凝土连续刚构桥工程,对悬浇T构梁进行了受力分析,并分析了齿块荷载对主梁线形的影响,发现在大悬臂状态下,较小重量的齿块会对主梁产生较大力矩,且在监控计算中需要考虑预应力锚固齿块对主梁的影响;运用有限元... 详细信息

依托某特大桥主桥预应力混凝土连续刚构桥工程,对悬浇T构梁进行了受力分析,并分析了齿块荷载对主梁线形的影响,发现在大悬臂状态下,较小重量的齿块会对主梁产生较大力矩,且在监控计算中需要考虑预应力锚固齿块对主梁的影响;运用有限元分析方法计算出了不平衡力矩,再根据等弯矩配重原理给出了悬浇T构梁纵、横桥向的配重方案,并对横桥向的配重方案加以计算分析,验证了配重方案的可行性和准确性。

关键词：大跨径连续梁悬浇T构梁配重不平衡齿块等弯矩有限元分析

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Medical Marvel

引用

China Weekly 2024年第2期 56-59页

作者： Lu weitao 不详

A 16th-century healer dedicated 30 years of his life to correcting,standardizing and expanding the practice of herbal medicine in China by writing a masterpiece that is celebrated to this day。

关键词： expanding writing correcting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：