检索结果-南通市图书馆

p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a

引用

Journal of Molecular Cell Biology 2018年第4期10卷 331-340页

作者： Text Lei Duan Ricardo E. Perez Ling Chen lothar A. Blatter Carl G. Maki Department of Cell & Molecular Medicine Rush University Medical Center Chicago IL 60612 USA Department of Laboratory Medicine Shiyan Taihe Hospital College of Biomedical Engineering Hubei University of Medicine Shiyan 442000 China Department of Physiology & Biophysics Rush University Medical Center Chicago IL 60612 USA

Nutlin-3a is a MDM2 antagonist and preclinical drug that activates p53. Cells with MDM2 gene amplification are especially prone to Nutlin-3a-induced apoptosis, though the basis for this is unclear. Glucose metabolism can inhibit apoptosis in response to Nutlin-3a through mechanisms that are incompletely understood. Glucose metabolism through the pentose phosphate pathway （PPP） produces NADPH that can protect cells from potentially lethal reactive oxygen species （ROS）. We compared apoptosis and glucose metabolism in cancer cells with and without MDM2 gene amplification treated with Nutlin-3a. Apoptosis in MDM2-amplified cells was associated with a reduction in glycolysis and the PPP, reduced NADPH, increased ROS, and depletion of the transcription factor SP1, which normally promotes PPP gene expression. In contrast, glycolysis and the PPP were maintained or increased in MDM2 non-amplified cells treated with Nutlin-3a. This was dependent on p53-mediated AKT activation and was associated with maintenance of SP1 and continued expression of PPP genes. Knockdown or inhibition of AKT, SP1, or the PPP sensitized MDM2-non-amplified cells to apoptosis. The data indicate that p53 promotes AKT and SP1-dependent activation of the PPP that protects cells from Nutlin-3a-induced apoptosis. These findings provide insight into how glucose metabolism reduces Nutlin-3a-induced apoptosis, and also provide a mechanism for the heightened sensitivity of MDM2-amplified cells to apoptosis in response to Nutlin-3a.

关键词： Nutlin p53 MDM2 SP1 glycolysis pentose phosphate pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precalculus mathematics for calculus JamesStewart, lothar Redlin, Saleem Watson. 4th ed.

引用

2002年

作者： JamesStewart lothar Redlin Saleem Watson.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

The Bronzes from Xiasi and Their Owners

考古学研究

引用

考古学研究 2003年 755-786页

作者： lothar von Falkenhausen UCLA

The aristocratic lineage cemetery at Xiasi,Xichuan county,in southwest Henan near the border with Hubei,is one of the most important archaeological discoveries from the Springs and Autumns period to *** in 1977 and excavated in 1978-1979,it can be subdivided into three clusters,comprising a total of nine major tombs,five horseand-chariot pits,and fifteen small tombs.A monograph report(hereafter referred to as

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

DIFFERENTIATION OF THE TRUE AND INTERVENTION INDUCED PSEUDO-MILKING EFFECT BY INTRAVASCULAR ULTRASOUND

引用

Chinese Medical Journal 1995年第3期 70-71页

作者： Peter Kearney lothar Koch Gunter Gorge Ramund Erbel Department of Cardiolgy University Essen GermanyDepartment of Cardiolgy University Essen GermanyDepartment of Cardiolgy University Essen GermanyDepartment of Cardiolgy University Essen Germany

We have shown the value of intravascular ultrasound (IVUS) in the evaluation of myocardial bridging (MB). The purpose of the study was to elucidate the mechanism of inter-

关键词： IVUS DIFFERENTIATION OF THE TRUE AND INTERVENTION INDUCED PSEUDO-MILKING EFFECT BY INTRAVASCULAR ULTRASOUND

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Esther Jacobson-Tepfer,The Hunter,the Stag,and the Mother of Animals:Image,Monument,and Landscape in Ancient North ***:Oxford University Press,2015

引用

浙江大学艺术与考古研究 2018年第1期 243-259页

作者： lothar von Falkenhausen UCLA

One cannot help feeling envious of Esther Jacobson-Tepfer. Many times since the late1980s she has explored some of the most magnificently beautiful—and, for ordinary travelers, largely inaccessible—landscapes on ear... 详细信息

关键词： Esther Jacobson-Tepfer,The Hunter,the Stag,and the Mother of Animals:Image,Monument,and Landscape in Ancient North Asia.Oxford:Oxford University Press,2015

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Li Feng,Bureaucracy and the State in Early China:Governing the Western Zhou

引用

浙江大学艺术与考古研究 2014年第1期 252-277页

作者： lothar von Falkenhausen UCLA

The field of Early China studies is sometimes faulted for being *** here for once is a book that addresses an issue of obvious relevance to our world:the roots of Chinese *** Feng plumbs the bronze inscriptions of the Western Zhou period for information on govemment officeholders and their activities,and he presents a complex and largely plausible reconstruction of the operation of the royal administration.

关键词： Chinese bureaucracy Li Feng Western Zhou

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于压缩体素模型的鼓形刀空间扫描体构造方法及其应用

引用

计算机辅助设计与图形学学报 2006年第8期18卷 1192-1196页

作者：侯增选 Frank-lothar Krause 常钢高新瑞西北工业大学现代设计与集成制造技术教育部重点实验室 Institute of Machine Tool and Factory Management Technical University of BerlinBerlin D-10587

首先给出了鼓形刀空间扫描体构造公式并构造出其表面模型,利用Ray Casting方法将该表面模型进行离散,转化为压缩体素模型,该模型采用沿X,Y,Z3个坐标轴方向相互垂直的Dexel模型表示,各个Dexel模型之间按体素模型大小均匀分布.刀具空间扫... 详细信息

首先给出了鼓形刀空间扫描体构造公式并构造出其表面模型,利用Ray Casting方法将该表面模型进行离散,转化为压缩体素模型,该模型采用沿X,Y,Z3个坐标轴方向相互垂直的Dexel模型表示,各个Dexel模型之间按体素模型大小均匀分布.刀具空间扫描体模型和仿真工件模型之间的布尔运算转化为Dexel模型之间的一维布尔运算,简化了布尔操作并提高了操作速度.通过Marching Cubes方法提取数控加工仿真工件表面三角网格模型并进行图形显示,提高了仿真工件显示质量,NC编程人员可实时地从任意方向观察、验证仿真结果.该方法已成功地应用于基于压缩体素模型的五坐标数控加工仿真系统中,克服了现有五坐标数控加工仿真方法和商品化软件系统的不足.

关键词：五坐标数控加工仿真鼓形刀具刀具扫描体压缩体素模型虚拟数控加工

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants

引用

Molecular Plant 2012年第5期5卷 1113-1124页

作者： Yariv Brotman Udi Landau Smadar Pnini Jan Lisec Salma Balazadeh Bernd Mueller-Roeber Aviah Zilberstein lothar Willmitzer Ilan Chet Ada Viterbo Genes and Small Molecules AG Willmitzer Max-Planck-lnstitut of Molecular Plant Physiology Am Muhlenberg 1 D-14476 Potsdam-Golm Germany Department of Plant Pathology and Microbiology The Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem Rehovot 76100 Israel Department of Plant Science Tel Aviv University Tel Aviv 69978 Israel University of Potsdam Institute of Biochemistry and Biology KarI-Liebknecht-Strae 24-25 Haus 20 14476 Potsdam-Golrn Germany

Application of crab shell chitin or pentamer chitin oligosaccharide to Arabidopsis seedlings increased toler- ance to salinity in wild-type but not in knockout mutants of the LysM Receptor-Like Kinasel （CERK1/LysM RLK1） gene, known to play a critical role in signaling defense responses induced by exogenous chitin. Arabidopsis plants overexpress- ing the endochitinase chit36 and hexoaminidase excyl genes from the fungus Trichoderma asperelleoides T203 showed increased tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection. Resistant lines, overexpressing fungal chitinases at different levels, were outcrossed to lysm rlkl mutants. Independent homozygous hybrids lost resistance to biotic and abiotic stresses, despite enhanced chitinase activity. Expression analysis of 270 stress-related genes, including those induced by reactive oxygen species （ROS） and chitin, revealed constant up-regulation （at least twofold） of 10 genes in the chitinase-overexpressing line and an additional 76 salt-induced genes whose expression was not elevated in the lysm rlkl knockout mutant or the hybrids harboring the mutation. These findings elucidate that chitin-induced signaling mediated by LysM RLK1 receptor is not limited to biotic stress response but also encompasses abiotic-stress signaling and can be conveyed by ectopic expression of chitinases in plants.

关键词： abiotic stress chitin-induced signaling chitinases LysM receptor kinase Trichoderma.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Involvement of the Hexose Transporter Gene LeHT1 and of Sugars in Resistance of Tomato to Tomato Yellow Leaf Curl Virus

引用

Molecular Plant 2013年第5期6卷 1707-1710页

作者： Dagan Sade Yariv Brotman Assa f Eybishtz Alvaro Cuadros-lnostroza Alisdair R. Fernie lothar Willmitzer Henry Czosnek Institute of Plant Sciences and Genetics in Agriculture The Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem Rehovot 76100 Israel Max-Planck Institute of Molecular Plant Physiology Am Muhlenberg 1 14476 Potsdam-Golm Germany

Dear Editor, Tomato yellow leaf curl virus （TYLCV） is a whitefly-trans- mitted geminivirus infecting tomato crops （Czosnek, 2007）. TYLCV-resistant （R） and susceptible （S） lines with the same genetic background have been bred using Solanum habro- chaites as the resistance source. The gene（s） conferring resist- ance are unknown. Previously, we demonstrated that the hexose transporter gene LeHT1 is up-regulated upon infec- tion in R plants and its silencing in R plants （RH） leads to the collapse of resistance （Eybishtz et al., 2010）. To uncover the role of LeHT1 in resistance, we （1） analyzed the transcriptome reprogramming in leaves of S, R, and RH plants using a home- designed microarray, before and 7 d after TYLCV inoculation （0, 7 dpi）, and （2） measured the concentration of sugars and their derivatives in S, R, and RH leaves at 1 and 7 dpi because LeHT1 is transporting both glucose and fructose （McCurdy et al., 2010）.

关键词： curl virus whitefly-transmitted geminivirus TYLCV inoculation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Special issue on enhanced photodynamic therapy:Part Ⅱ

引用

Journal of Innovative Optical Health Sciences 2022年第6期15卷 1-3页

作者： Buhong Li lothar Lilge School of Science Hainan University Haikou 570228P.R.China Department of Medical Biophysics University of Toronto and Ontario Cancer Institute Toronto M5G 2M9 Canada

We welcome the readers to Part Ⅱ of the special issue on Enhanced Photodynamic Therapy(PDT),an issue dedicated to highlighting the latest developments in both fundamental mechanisms and clinical applications for enhanced *** part of this special issue was published in July 2022 as Issue 4 of Volume 15,andve research articles were included.1 It is really exciting that we have an enthusiastic response from our colleagues that continuously contributed eight articles to produce Part *** believe these two special issues will provide a better understanding of enhanced PDT.

关键词： clinical Therapy really

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：