检索结果-南通市图书馆

负载干细胞的光交联蛋白基水凝胶在组织工程中应用的研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华损伤与修复杂志（电子版） 2024年第5期19卷 445-450页

作者：关丁丁李伟孔维诗包郁露孙瑜海军军医大学第一附属医院烧伤外科全军烧伤研究所上海200433

组织工程是一个多学科交叉领域,旨在除传统的创后或术后组织再生手段(自体移植、异体移植)外,利用现代技术设计和开发特定的生物材料,为组织损伤修复提供新的治疗思路。在众多组织工程相关生物材料中,水凝胶由于其独特的生物相容性、力... 详细信息

组织工程是一个多学科交叉领域,旨在除传统的创后或术后组织再生手段(自体移植、异体移植)外,利用现代技术设计和开发特定的生物材料,为组织损伤修复提供新的治疗思路。在众多组织工程相关生物材料中,水凝胶由于其独特的生物相容性、力学可调性、可降解性及高度亲水性等性质,被广泛应用于生物医学工程领域。除生物材料外,细胞也是组织工程的重要元素之一。干细胞具有多向分化潜能和低免疫原性,在组织工程中被广泛研究和应用。以明胶、胶原蛋白等材料制备的光交联蛋白基水凝胶具有良好的生物相容性和力学性能,可为干细胞提供类似细胞外基质的微环境,有利于促进其粘附、增殖及分化。负载干细胞的光交联蛋白基水凝胶充分发挥两者优势,协同促进组织损伤修复与再生。本文对光交联蛋白基水凝胶的制备及其负载干细胞在组织工程中的研究进行阐述与总结。

关键词：损伤与修复组织工程光交联水凝胶蛋白基水凝胶干细胞

负载脂肪干细胞的皮肤组织工程支架在创面修复中的研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华烧伤与创面修复杂志 2023年第11期39卷 1090-1095页

作者：李伟孔维诗包郁露孙瑜海军军医大学第一附属医院烧伤外科全军烧伤研究所中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元上海200433

组织工程皮肤被广泛应用于重度烧伤创面、糖尿病创面等难愈性创面的治疗。种子细胞和支架材料是构建组织工程皮肤的关键元素。脂肪干细胞凭借其低免疫原性和多向分化潜能的优势逐渐成为组织工程皮肤中种子细胞的重要选择。支架材料是皮... 详细信息

组织工程皮肤被广泛应用于重度烧伤创面、糖尿病创面等难愈性创面的治疗。种子细胞和支架材料是构建组织工程皮肤的关键元素。脂肪干细胞凭借其低免疫原性和多向分化潜能的优势逐渐成为组织工程皮肤中种子细胞的重要选择。支架材料是皮肤组织工程的重要组成部分, 单一材料的改性和复合材料的制备正成为构建皮肤组织工程支架的主要研究方向。该文介绍了近年来各类负载脂肪干细胞的皮肤组织工程支架在创面修复中的应用情况, 总结了应用各类支架材料构建皮肤组织工程支架时的优势与不足, 期待为开发负载脂肪干细胞的组织工程皮肤提供新的思路。

关键词：组织工程皮肤脂肪干细胞支架材料创面修复

Conformation and Counterion Distribution of Polyelectrolyte in Solution as Viewed from Dielectric Approach

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1278-1301,I0005页

作者： kong-Shuang Zhao College of Chemistry Beijing Normal UniversityBeijing 100875China

Polyelectrolyte solutions are more variable than uncharged macromolecule due to electrical interaction between charged molecules and surrounding ***,the subject of polyelectrolyte solutions has attracted a wide range of interests in both basic and applied research,and has also been extensively ***,the understanding of the molecular dynamics and conformation of polyelectrolytes in solution remains to be deepened,and universal consensus on some key issues have not been *** methods have contributed to solving the above problems in different ways,including dielectric relaxation spectroscopy(DRS).In this perspective,we briefly reviewed the history of dielectric spectroscopic research on polyelectrolyte solution,with emphasis on summarizing our *** particular,we expound the characteristics of DRS and its ability to obtain the internal information of the system of ***,we evaluate the advantages and limitations of the dielectric method and discussed future prospects of this field.

关键词： Polyelectrolyte Dielectric relaxation spectroscopy Chain conformation Thermosensitive microgel PNIPAM microgel Spherical polyelectrolyte brushes

Flat jet electrochemical milling of TC4 alloy with tailoring backward parallel flow

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第4期37卷 574-592页

作者： Huanghai kong Ningsong QU College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In flat jet electrochemical milling, the electrolyte forms a backward parallel flow after impacting the workpiece, resulting in a weak current density distribution on the workpiece. Poor surface quality usually occurs on the machined titanium alloy surface because it inevitably suffers from the weak current density. In this study, a method of flat jet electrochemical milling with tailoring the backward parallel flow was proposed to eliminate the negative effects caused by the weak current density. Multiphysics simulations are carried out to comprehend the mechanism of flat jetEC milling with tailoring backward parallel flow and better construct the novel tool *** on flat jet electrochemical milling of TC4 alloy with and without tailoring backward parallel flow are conducted. The results reveal that, compared with flat jet electrochemical milling without tailoring backward parallel flow, the recommended tool reduces the surface roughness by86% to 93%, and improves the material removal rate by 93% to 163% with different feed ***, the recommended tool is more conducive to maintaining the inherent hardness of the material. Finally, a surface with low Sa of 0.37 μm is obtained.

关键词： Flat jet electrochemical milling TC4 alloy Surface roughness Micro-hardness Material removal rate

Soil inorganic amendments produce safe rice by reducing the transfer of Cd and increasing key amino acids in brown rice

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 121-132页

作者： Fanyi kong Shenggao Lu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Key Laboratory of Environmental Remediation and Ecosystem HealthMinistry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human *** our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated *** the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased *** vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction *** showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal *** on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy *** amino acids(AAs)in brown rice were determined by high-performance liquid *** contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of *** structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown *** formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.

关键词： Cadmium digestibility Soil inorganic amendments Safe rice Amino acid Priming effect Health risk

Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-Xin Zhou Xian kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

Non-dimensional analysis on blast wave propagation in foam concrete:Minimum thickness to avoid stress enhancement

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第6期36卷 30-46页

作者： Ya Yang Xiangzhen kong Qin Fang State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing 210007JiangsuChina

Foam concrete is a prospective material in defense engineering to protect structures due to its high energy absorption capability resulted from the long plateau ***,stress enhancement rather than stress mitigation may happen when foam concrete is used as sacrificial claddings placed in the path of an incoming blast *** investigate this interesting phenomenon,a one-dimensional difference model for blast wave propagation in foam concrete is firstly proposed and numerically solved by improving the second-order Godunov *** difference model and numerical algorithm are validated against experimental results including both the stress mitigation and the stress *** difference model is then used to numerically analyze the blast wave propagation and deformation of material in which the effects of blast loads,stress-strain relation and length of foam concrete are *** particular,the concept of minimum thickness of foam concrete to avoid stress enhancement is ***,non-dimensional analysis on the minimum thickness is conducted and an empirical formula is proposed by curve-fitting the numerical data,which can provide a reference for the application of foam concrete in defense engineering.

关键词： Foam concrete Blast wave propagation Non-dimensional analysis Stress enhancement

Enhanced Natural Convection for Accelerating Melting of Phase Change Material in Cellular Structure through Inserting Fin

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第2期33卷 548-563页

作者： kong Dekui ZHANG Yongcun LIU Shutian State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian116024China

The design of thermal conductivity enhancers(TCE) is quite critical to overcoming the disadvantage of the poor thermal conductivity of phase change materials(PCM).The main contribution of this study is firstly to discuss how to actively enhance natural convection of the melted PCM in cellular structure by the fin formed in the structure under the condition of the same metal mass,apart from simultaneously improving heat conduction,which can boost the heat transfer ***,a tailored hybrid fin-lattice structure(HFS) as TCE is designed and fabricated by additive manufacturing(AM).A two-equation numerical method is applied to study the heat transfer of the PCM,and its feasibility is validated with the experimental *** numerical results indicate that enhanced natural convection and improved heat conduction can be obtained simultaneously when a well-designed fin is embedded into a lattice *** enhanced natural convection results in the improved melting rate and the decreased wall temperature;e.g.,the complete melting time and the wall temperature are reduced by 11.6% and 19.7%,respectively,because of the fin for metal ***,the parameters of HFS including the porosity,pore density,and fin dimension have a great impact on the heat *** enhancement effect of the fin for HFS on the melting rate of the PCM increases as the thermal conductivity of the base material *** example,when the fin is introduced into the lattice structure,the complete melting time is reduced by 24.1% for metal *** summary,this study enables us to obtain a good understanding of the mechanism of the heat transfer and provides necessary experimental data for the structural design of HFS fabricated by AM.

关键词： natural convection heat transfer enhancement phase change material additive manufacturing hybrid fin-lattice structure

在线全文

学校读者我要写书评

暂无评论

胶原蛋白水凝胶敷料的研究进展

中华整形外科杂志 2023年第12期39卷 1371-1376页

作者：程宇欣左扬清孔维诗孙瑜海军军医大学基础医学院上海200433 海军军医大学第一附属医院烧伤外科、中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元上海200433

胶原蛋白水凝胶是一种新型创面敷料,胶原蛋白和水凝胶的优势相结合,可有效发挥二者各自在创面修复再生中的优势。近年来,利用物理和化学的手段对胶原蛋白水凝胶的机械特性和生物功能等进行完善,使其更适用于创面环境,已成为科研与临床... 详细信息

胶原蛋白水凝胶是一种新型创面敷料,胶原蛋白和水凝胶的优势相结合,可有效发挥二者各自在创面修复再生中的优势。近年来,利用物理和化学的手段对胶原蛋白水凝胶的机械特性和生物功能等进行完善,使其更适用于创面环境,已成为科研与临床的研究热点。该文系统回顾了胶原蛋白水凝胶在创面修复中的理论基础、应用现状和研究进展,分析了其当前的优势、局限及未来的研究方向,以期为胶原蛋白水凝胶的研制及其在创面修复领域的临床应用提供参考和新的思路。

关键词：胶原水凝胶类生物敷料创面修复