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Progress in Natural Science:Materials International 2023年第4期33卷 467-477页

作者： Yang Zheng He Tong Jiawen liu Jia Lu weirong li Fangfei liu Ziyue Zhang Yan li School of Aeronautics and Astronautics Tiangong University School of Mechanical Engineering Tiangong University Dongguan Eontec Co.Ltd. School of Materials Science and Engineering Beihang University

The extruded Mg–4Zn–1Mn alloy was prepared and its in vitro corrosion behavior in different physiological solutions of simulated body fluid(SBF), artificial saliva(AS) and artificial urine(AU) was investigated for biomedical applications. The microstructural characterization by optical microscope(OM), X-ray diffractometer(XRD), scanning electron microscopy(SEM) and energy dispersive X-ray spectrometer(EDS) showed that the alloy with an average grain size of approximate 20 μm was mainly composed of α-Mg matrix phase along with some MgZn2and α-Mn precipitates. The results of electrochemical corrosion and immersion corrosion tests revealed a distinct corrosion behavior for the alloy in different solutions with increasing immersion time. The corrosion morphologies were featured with flocculent precipitates in the SBF, flower-like clusters in the AS and columnar crystals in the AU. The alloy exhibited highest corrosion resistance and lowest corrosion rate in the AS compared with the SBF and the AU, which was attributed to the formation of a stable corrosion products layer.

关键词： Biodegradable metals Corrosion behavior Mg–4Zn–1Mn alloy Physiological solutions

A unified framework of temporal information expression in geosciences knowledge system

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Geoscience Frontiers 2023年第5期14卷 343-352页

作者： Shu Wang Yunqiang Zhu Yanmin Qi Zhiwei Hou Kai Sun weirong li Lei Hu Jie Yang Hairong Lv State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China University of Nottingham Ningbo China Faculty of Science and EngineeringNingbo 315154China Guangzhou Institute of Geography Guangdong Academy of SciencesGuangzhou 510070China University of Chinese Academy of Sciences Beijing 100101China Department of Automation Tsinghua UniversityBeijing 100084China

Time is an essential reference system for recording objects,events,and processes in the field of geosciences.There are currently various time references,such as solar calendar,geological time,and regional calendar,to represent the knowledge in different domains and regions,which subsequently entails a time conversion process required to interpret temporal information under different time references.However,the current time conversion method is limited by the application scope of existing time ontologies(e.g.,“Jurassic”is a period in geological ontology,but a point value in calendar ontology)and the reliance on experience in conversion processes.These issues restrict accurate and efficient calculation of temporal information across different time references.To address these issues,this paper proposes a Unified Time Framework(UTF)in the geosciences knowledge system.According to a systematic time element parsing from massive time references,the proposed UTF designs an independent time root node to get rid of irrelevant nodes when accessing different time types and to adapt to the time expression of different geoscience disciplines.Furthermore,this UTF carries out several designs:to ensure the accuracy of time expressions by designing quantitative relationship definitions;to enable time calculations across different time elements by designing unified time nodes and structures,and to link to the required external ontologies by designing adequate interfaces.By comparing the time conversion methods,the experiment proves the UTF greatly supports accurate and efficient calculation of temporal information across different time references in SPARQL queries.Moreover,it shows a higher and more stable performance of temporal information queries than the time conversion method.With the advent of the Big Data era in the geosciences,the UTF can be used more widely to discover new geosciences knowledge across different time references.

关键词： Unified Time Framework(UTF) Time ontology Geosciences knowledge system Time conversion Time scale Big data

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基于微囊化技术的益生菌功能性评价研究进展

中国食品学报 2024年第1期24卷 418-429页

作者：杨动听黄莎杨选王晔洋李伟荣丽水市农林科学研究院浙江丽水323000

为解决益生菌产品在胃肠液中裸菌存活率低,活菌数不够,性能不理想的问题,近年来微囊化技术被广泛研究并逐渐运用于商业益生菌产品。本文主要介绍目前基于微囊化益生菌产品近年来在体内外的功能性评价研究,包括体外试验探究微囊化益生菌... 详细信息

为解决益生菌产品在胃肠液中裸菌存活率低,活菌数不够,性能不理想的问题,近年来微囊化技术被广泛研究并逐渐运用于商业益生菌产品。本文主要介绍目前基于微囊化益生菌产品近年来在体内外的功能性评价研究,包括体外试验探究微囊化益生菌的存活、释放、黏附和抗菌等功能特性,以及体内试验探究益生菌存活、黏附、定植、抗腹泻、抗菌、抗炎、抗氧化、调控代谢综合征等功能特性,为后续进一步开发对人体有效的益生菌产品提供一定的指导。

关键词：益生菌微囊化体外体内功能性

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食品呈味肽的呈味机制及计算机辅助分析研究进展

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食品工业科技 2024年第13期45卷 378-388页

作者：杨动听王晔洋杨选黄莎李伟荣丽水市农林科学研究院浙江丽水323000

食品呈味肽主要通过与咸味受体ENaC、TRPV1和TMC4、鲜味受体T1R1/T1R3、甜味受体T1R2/T1R3、苦味受体T2R和浓厚感味受体CaSR互相作用引发PLCβ2/IP3或cAMP/PKA等多种途径达成味觉信号转导。分子对接、动力学模拟、虚拟筛选和深度学习等... 详细信息

食品呈味肽主要通过与咸味受体ENaC、TRPV1和TMC4、鲜味受体T1R1/T1R3、甜味受体T1R2/T1R3、苦味受体T2R和浓厚感味受体CaSR互相作用引发PLCβ2/IP3或cAMP/PKA等多种途径达成味觉信号转导。分子对接、动力学模拟、虚拟筛选和深度学习等计算机辅助分析技术可以高效、准确、广泛地鉴定和开发新型呈味肽,有效推动营养健康食品产业高质量发展。本文旨在介绍人体味觉感受机制、食品呈味肽呈味机制及计算机辅助分析技术在呈味肽领域的最新研究进展,为实现未来大算力时代食品呈味肽研发领域的降本增效和后续深入研究开发新型呈味肽产品提供思路方向。

关键词：呈味肽味觉受体呈味机制分子对接分子动力学模拟

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Biofunctional magnesium coating of implant materials by physical vapour deposition

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Biomaterials Translational 2021年第3期2卷 248-256页

作者： Qingchuan Wang Weidan Wang Yanfang li weirong li lili Tan Ke Yang Department of Advanced Materials Research Institute of Metal ResearchChinese Academy of SciencesShenyangLiaoning ProvinceChina Department of Orthopaedic Surgery Affiliated Zhongshan Hospital of Dalian UniversityDalianLiaoning ProvinceChina Dongguan Eontec Co.Ltd. DongguanGuangdong ProvinceChina

The lack of bioactivity of conventional medical materials leads to low osseointegration ability that may result in the occurrence of aseptic loosening in the clinic.To achieve high osseointegration,surface modifications with multiple biofunctions including degradability,osteogenesis,angiogenesis and antibacterial properties are required.However,the functions of conventional bioactive coatings are limited.Thus novel biofunctional magnesium(Mg)coatings are believed to be promising candidates for surface modification of implant materials for use in bone tissue repair.By physical vapour deposition,many previous researchers have deposited Mg coatings with high purity and granular microstructure on titanium alloys,polyetheretherketone,steels,Mg alloys and silicon.It was found that the Mg coatings with high-purity could considerably control the degradation rate in the initial stage of Mg alloy implantation,which is the most important problem for the application of Mg alloy implants.In addition,Mg coating on titanium(Ti)implant materials has been extensively studied both in vitro and in vivo,and the results indicated that their corrosion behaviour and biocompatibility are promising.Mg coatings continuously release Mg ions during the degradation process,and the alkaline environment caused by Mg degradation has obvious antibacterial effects.Meanwhile,the Mg coating has beneficial effects on osteogenesis and osseointegration,and increases the new bone-regenerating ability.Mg coatings also exhibit favourable osteogenic and angiogenic properties in vitro and increased long-term bone formation and early vascularization in vivo.Inhibitory effects of Mg coatings on osteoclasts have also been proven,which play a great role in osteoporotic patients.In addition,in order to obtain more biofunctions,other alloying elements such as copper have been added to the Mg coatings.Thus,Mg-coated Ti acquired biofunctions including degradability,osteogenesis,angiogenesis and antibacterial properties.These novel multi-functional Mg coatings are

关键词： biofunction coating degradability magnesium osteogenesis review

Improved Corrosion Behavior of Biodegradable Mg-4Zn-1Mn Alloy Modified by Sr/F co-doped CaP Micro-arc Oxidation Coatings

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Research and Application of Materials Science 2023年第2期5卷 1-8页

作者： weirong li Yanfang li Qian li Xuan XIONG Fangfei liU Ronghui li Heng li Dong PANG Jia LU Xuan ZHANG Dongguan Eontec Co. Ltd.DongguanGuangdong523000China School of Mechanical Engineering Tiangong UniversityTianjin 300387China

The Sr/F co-doped CaP(Sr/F-CaP)coatings were prepared by micro-arc oxidation(MAO)under different voltages to modify the microstructure and corrosion behavior of Mg-4Zn-1Mn alloy.The surface and interface characteristics investigated using scanning electron microscopy(SEM)and energy dispersive X-ray spectrometer(EDS)showed that the MAO coatings displayed uneven crater-like holes and tiny cracks under lower voltage,while they exhibited relatively homogeneous crater-like holes without cracks under higher voltage.The thickness of MAO coatings increased with increasing voltage.The corrosion behavior of Mg-4Zn-1Mn alloy was improved by the MAO coatings.The MAO coatings prepared under 450 V and 500 V voltages possessed the best corrosion resistance with regard to the electrochemical corrosion tests and immersion corrosion tests,respectively.The MAO coatings fabricated under 450-500 V could provide a better corrosion protection effect for the substrate.

关键词： Biodegradable Mg alloys Mg-4Zn-1Mn alloy Micro-arc oxidation Sr/F co-doped CaP coatings

Evaluation of the performance of Ca-deficient hydroxyapatite(CDHA)/MgF_(2)bilayer coating on biodegradable high-purity magnesium in a femoral condyle defect model in rabbits

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Regenerative Biomaterials 2022年第1期9卷 806-815页

作者： Shibo Huang Junlei li Kairong Qin Zhiqiang Wang Jiahui Yang Fang Cao weirong li Yupeng liu lipeng liu Dewei Zhao Faculty of Electronic Information and Electrical Engineering School of Biomedical EngineeringDalian University of TechnologyNo.2 Linggong RoadGanjingzi DistrictDalianLiaoning 116024China Orthopaedic Department Affiliated Zhongshan Hospital of Dalian University No.6 Jiefang StreetZhongshan DistrictDalianLiaoning 116001China Department of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyNo.2 Linggong RoadGanjingzi DistrictDalianLiaoning 116024China Dongguan Eontec Co. LtdSongshan Lake Science and Technology Industrial ParkDongguanGuangdong 523000China

The two most critical factors in promoting the clinical translation of magnesium(Mg)are reducing its degradation rate and improving its osteogenesis.In this study,a Ca-deficient hydroxyapatite(CDHA)/MgF_(2)bilayer coating was prepared on high-purity magnesium(HP Mg)rods by fluorination and hydrothermal treatment.Scanning electron microscope showed that the thickness of the bilayer coating was 3.78 lm and that the surface morphology was nanoscale.In an in vivo experiment on femoral condyle defects in rabbits,the serum magnesium ion levels of rabbits were always in the normal range after surgery,and the liver and kidney functions were not abnormal,which indicated that the CDHA/MgF_(2)bilayer coating has good biosafety.Micro-CT showed that the CDHA/MgF_(2)bilayer coating significantly reduced the degradation rate of the HP Mg rods and enhanced the promotion of bone formation.Hard tissue sections showed that the CDHA/MgF_(2)bilayer coating gave the bone tissue a tight contact interface with the HP Mg rod and improved the bone mass.Immunohistochemistry showed that the expression of vascular endothelial growth factor and BMP-2 was more obvious.These results confirm that the CDHA/MgF_(2)bilayer coating can improve the properties of HP Mg and provide a basis for the further transformation of HP Mg in the future.It also provides a new reference for the surface modification of magnesiummetal.

关键词： high-purity magnesium MgF_(2) Ca-deficient hydroxyapatite femoral condyle

Geospatial data ontology:the semantic foundation of geospatial data integration and sharing

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Big Earth Data 2019年第3期3卷 269-296页

作者： Kai Sun Yunqiang Zhu Peng Pan Zhiwei Hou Dongxu Wang weirong li Jia Song State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application NanjingPeople’s Republic of China Center for Collaborative Innovation in Baiyangdian River Basin Ecological Protection and Beijing-Tianjin-Hebei Sustainable Development BaodingPeople’s Republic of China Appraisal Center for Environment and Engineering Ministry of Ecology and EnvironmentBeijingPeople’s Republic of China f State Environmental Protection Key Laboratory of Numerical Modeling for Environment Impact Assessment BeijingPeople’s Republic of China Beijing GEOWAY Software Co. LtdBeijingPeople’s Republic of China

Effective integration and wide sharing of geospatial data is an important and basic premise to facilitate the research and applications of geographic information science.However,the semantic heterogeneity of geospatial data is a major problem that significantly hinders geospatial data integration and sharing.Ontologies are regarded as a promising way to solve semantic problems by providing a formalized representation of geographic entities and relationships between them in a manner understandable to machines.Thus,many efforts have been made to explore ontology-based geospatial data integration and sharing.However,there is a lack of a specialized ontology that would provide a unified description for geospatial data.In this paper,with a focus on the characteristics of geospatial data,we propose a unified framework for geospatial data ontology,denoted GeoDataOnt,to establish a semantic foundation for geospatial data integration and sharing.First,we provide a characteristics hierarchy of geospatial data.Next,we analyze the semantic problems for each characteristic of geospatial data.Subsequently,we propose the general framework of GeoDataOnt,targeting these problems according to the characteristics of geospatial data.GeoDataOnt is then divided into multiple modules,and we show a detailed design and implementation for each module.Key limitations and challenges of GeoDataOnt are identified,and broad applications of GeoDataOnt are discussed.

关键词： Geospatial data ontology geospatial semantics semantic heterogeneity data integration data sharing

Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer

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Chinese Journal of Cancer Research 2014年第1期26卷 95-103页

作者： Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang weirong li Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical University

Objective：MicroRNAs （miRNAs） have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer （CRC） has not been reported.Methods：We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC （OM-CRC）.Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC （L-CRC）,72 synchronous liver-metastatic CRC （SLM-CRC） and 36 other OM-CRC by quantitative real-time PCR.Results：Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic （ROC） curve showed serum miR-126 had a cut-off [log10 relative quantity （log10RQ）=--0.2005] with 77.78％ sensitivity and 68.97％ specificity with an area under curve （AUC） of 0.7564,miR-141 had a cut-off （1og10RQ=-0.2285） with 86.11％ sensitivity and 76.11％ specificity with an AUC of 0.8279,and miR-21 had a cut-off （log10RQ=-0.1310） with 73.61％ sensitivity and 66.38％ specificity with an AUC of 0.7479.Conclusions：We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC.

关键词： MicroRNA （miRNAs） colorectal cancer （CRC） liver metastasis diagnosis

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Degradation and biological properties of Ca-P contained micro-arc oxidation self-sealing coating on pure magnesium for bone fixation

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Regenerative Biomaterials 2015年第2期2卷 107-118页

作者： Weidan Wang Peng Wan Chen liu lili Tan weirong li Lugee li Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China EONTEC Co. LtdDongguanGuangdong523662China

Poor corrosion resistance is one of the main disadvantages for biodegradable magnesium-based metals,especially applied for bone fixation,where there is a high demand of bio-mechanical strength and stability.Surface coating has been proved as an effective method to control the in vivo degradation.In this study a Ca-P self-sealing micro-arc oxidation(MAO)coating was studied to verify its efficacy and biological properties by in vitro and in vivo tests.It was found that the MAO coating could effectively retard the degradation according to immersion and electrochemical tests as well as 3D reconstruction by X-ray tomography after implantation.The MAO coating exhibited no toxicity and could stimulate the new bone formation.Therefore,the Ca-P self-sealing MAO coating could be a potential candidate for application of biodegradable Mg-based implant in bone fixations.

关键词： pure magnesium degradation self-sealing micro-arc oxidation coating in vivo implantation