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Multi-path navigation method using solar panel-reflected solar oscillations for Earth satellites

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Science China(Information Sciences) 2024年第7期67卷 327-328页

作者： Yuqing YANg Haonan YANg Xiaolin NINg weiren WU Jiancheng FANg School of Instrument Science & Opto-electronics Engineering Beihang University Lunar Exploration and Space Program Center China National Space Administration

Several autonomous navigation methods have been studied to reduce reliance on the ground stations. geomagnetic navigation, gravity gradient navigation, and celestial navigation using optical sensors are typical autonomous navigation methods. geomagnetic and gravity gradient navigation have low navigation accuracy (1301 m [1] and 235 m [2], respectively) due to the poor accuracy of the geomagnetic and gravity gradient maps.

关键词： Solar panels

Multiscale urban design based on the optimization of the wind and thermal environments:A case study of the core area of Suzhou Science and Technology City

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Frontiers of Architectural Research 2024年第4期13卷 822-841页

作者： Hua Liu Xin Zhou Xin ge Dongqing Han weiren Zhuang Ying Tang Xiaohan Shen Architects&Engineers CO. LTD of Southeast UniversityNanjing 210096China School of Architecture Southeast UniversityNanjing 210096China

New methods are need to coordinate the conflicting spatial demands through urban design research and strategies from the perspective of multi-scale urban climate *** integrate windethermal environment with urban design,we propose three scale levels,namely the district-superblock,superblock-block,and block-building levels,and divide the urban design elements into voids and ***,we establish a multiscale methodological framework in which the urban design contents are clarified by each scale,and the information transmitted between scales is obtained to ensure consistent value propositions and strategic *** microclimate shaping of the urban open space is transformed into guiding strategies and quantitative indicators of the spatial form of the solid *** is transmitted between the scales through the windethermal indicators of windward side and the morphological indicators of solid ***,the methodology was applied to the project in the core area of Suzhou Science and Technology City,and the findings preliminarily verify the effectiveness and feasibility of the *** research influences urban climate studies and urban design practice in three ways:1)improving understanding of the correlation between scales;2)facilitating interaction between the two domains;and 3)providing tools for urban design practices.

关键词： Multiscale transmission Windethermal environment optimization Urban design strategy Urban form

Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei Khine Khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo Myat Myat Moe San San Aye weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

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合成生物学在肿瘤疫苗设计中的应用进展

合成生物学 2024年第2期5卷 239-253页

作者：方超黄卫人中国科学院深圳先进技术研究院合成生物学研究所广东深圳518035 深圳大学第一附属医院深圳市第二人民医院泌尿外科深圳转化医学研究院广东深圳518035 广东省泌尿生殖肿瘤系统生物学与合成生物学重点实验室广东深圳518035

根据中心法则和细胞免疫学原则,利用合成生物学设计和生产新型肿瘤疫苗代表了癌症免疫治疗中的一个重要途径。本文概述了利用合成生物学针对两个主要方面(抗原选择和疫苗设计)的创新治疗性肿瘤疫苗的最新研究进展。针对肿瘤相关或特定抗... 详细信息

根据中心法则和细胞免疫学原则,利用合成生物学设计和生产新型肿瘤疫苗代表了癌症免疫治疗中的一个重要途径。本文概述了利用合成生物学针对两个主要方面(抗原选择和疫苗设计)的创新治疗性肿瘤疫苗的最新研究进展。针对肿瘤相关或特定抗原,开发更精确和有效的肿瘤疫苗引起了广泛关注。传统方法在抗原选择中主要针对肿瘤中的特定基因,而以高通量测序及质谱为基础筛选新抗原的方法明显改善了疫苗的靶向性及免疫原性。在疫苗类别方面,与传统多肽疫苗相比,通过对DNA、mRNA、病毒/细菌、细胞的工程化修饰而成的新型疫苗显著扩大了肿瘤疫苗的范围,从而大幅增强了不同肿瘤疫苗的免疫效果。合成生物学的快速发展将加速对肿瘤疫苗的实验研究进度,最终导致临床治疗效果的持续增强。

关键词：肿瘤疫苗新抗原树突状细胞细胞疫苗合成生物学

黑龙江省中药材产业高质量发展的现实困境与实现路径

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北方园艺 2024年第10期 126-131页

作者：徐珉钰孙伟仁大庆师范学院经济管理学院黑龙江大庆163712 哈尔滨商业大学计算机与信息工程学院黑龙江哈尔滨150028

中药材产业的高质量发展是中医药传承创新发展的基础,且对优化农业生产结构、拓宽农民增收渠道、推动乡村产业振兴、促进中医药事业发展等都具有重要意义。针对黑龙江省中药材产业发展面临的问题,提出需从强化种质创新及良种繁育、实现... 详细信息

中药材产业的高质量发展是中医药传承创新发展的基础,且对优化农业生产结构、拓宽农民增收渠道、推动乡村产业振兴、促进中医药事业发展等都具有重要意义。针对黑龙江省中药材产业发展面临的问题,提出需从强化种质创新及良种繁育、实现种源良种化,打造规范化生态种植示范区、实现种植生态化,加强初深加工能力建设、实现运营产业化,深化寒地龙药品牌培育、实现产品品牌化,加快现代流通体系建设、推动产业数字化,创新药旅融合发展模式、实现三产融合化等方面加快推进中药材产业高质量发展。

关键词：中药材产业黑龙江省高质量发展发展路径

Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DgKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma

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Cancer Communications 2024年第2期44卷 226-250页

作者： weiren Liu Huqiang Wang Qianfu Zhao Chenyang Tao Weifeng Qu Yushan Hou Run Huang Zimei Sun guiqi Zhu Xifei Jiang Yuan Fang Jun gao Xiaoling Wu Zhixiang Yang Rongyu Ping Jiafeng Chen Rui Yang Tianhao Chu Jian Zhou Jia Fan Zheng Tang Dong Yang Yinghong Shi Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of Ministry of EducationShanghaiP.R.China Research Unit of Liver cancer Recurrence and Metastasis Chinese Academy of Medical SciencesBeijingP.R.China State Key Laboratory of Medical Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijingP.R.China

Background:Intrahepatic cholangiocarcinoma(iCCA)is a highly heteroge-neous and lethal hepatobiliary tumor with few therapeutic *** metabolic reprogramming of tumor cells plays an essential role in the develop-ment of tumors,while the metabolic molecular classification of iCCA is largely ***,we performed an integrated multiomics analysis and metabolic classification to depict differences in metabolic characteristics of iCCA patients,hoping to provide a novel perspective to understand and treat ***:We performed integrated multiomics analysis in 116 iCCA samples,including whole-exome sequencing,bulk RNA-sequencing and proteome *** on the non-negative matrix factorization method and the protein abundance of metabolic genes in human genome-scale metabolic models,the metabolic subtype of iCCA was *** and prognostic gene analy-ses were used to compare overall survival(OS)differences between metabolic *** proliferation analysis,5-ethynyl-2’-deoxyuridine(EdU)assay,colony formation assay,RNA-sequencing and Western blotting were performed to investigate the molecular mechanisms of diacylglycerol kinaseα(DgKA)in iCCA ***:Three metabolic subtypes(S1-S3)with subtype-specific biomarkers of iCCA were *** metabolic subtypes presented with distinct prog-noses,metabolic features,immune microenvironments,and genetic *** S2 subtype with the worst survival showed the activation of some special metabolic processes,immune-suppressed microenvironment and Kirsten ratsar-coma viral oncogene homolog(KRAS)/AT-rich interactive domain 1A(ARID1A)*** the S2 subtype-specific upregulated proteins,DgKA was further identified as a potential drug target for iCCA,which promoted cell proliferation by enhancing phosphatidic acid(PA)metabolism and activating mitogen-activated protein kinase(MAPK)***:Viamultiomics analyses,we identified three metabolic subtypes of iCCA,revealing

关键词： diacylglycerol kinaseα intrahepatic cholangiocarcinoma MAPK signaling metabolic classifi-cation multiomics analysis phosphatidic acid metabolism

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数字经济时代中国农产品流通体系构建研究

北方园艺 2024年第13期 135-142页

作者：孙伟仁徐珉钰大庆师范学院经济管理学院黑龙江大庆163712 哈尔滨商业大学计算机与信息工程学院黑龙江哈尔滨150028

农产品现代流通体系的建设是一项重要的战略任务,具有重要的现实意义,数字经济时代,农产品流通发展的内外部环境发生了巨变,传统农产品流通体系亟待变革与重构。倡导将农产品流通从农产品产业链中间环节转向农产品价值链主导环节,以多... 详细信息

农产品现代流通体系的建设是一项重要的战略任务,具有重要的现实意义,数字经济时代,农产品流通发展的内外部环境发生了巨变,传统农产品流通体系亟待变革与重构。倡导将农产品流通从农产品产业链中间环节转向农产品价值链主导环节,以多重战略目标为指引,统筹运用宏观调控政策工具与市场经济运行机制,以先进的技术、理论、模式和管理方式为工具,以体制机制创新为手段,以农产品流通供应链整合和数字化转型为突破口,从农产品流通产业体系、流通支撑体系、流通政策体系三大模块入手,构建了数字经济时代中国农产品现代流通体系,并对农产品流通体系的框架结构、主要内容及运行机制等进行了系统设计与深入阐述。

关键词：农产品流通体系数字经济数字化

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肿瘤类器官及其在合成生物学中的研究进展

合成生物学 2024年第1期5卷 191-201页

作者：孟倩尹聪黄卫人深圳大学第一附属医院泌尿外科国家地方联合医学合成生物学临床应用关键技术工程实验室广东深圳518036 中国科学院深圳先进技术研究院合成生物学研究所广东深圳518000

类器官技术的发展为更接近机体细胞组成和病理生理特征的癌症模型开辟了新途径。患者来源的肿瘤类器官在多次传代后仍能维持原有肿瘤的组织病理学及遗传表型特征,不仅可作为测试新型抗癌药物的优良模型,也可通过其药物敏感性测试预测患... 详细信息

类器官技术的发展为更接近机体细胞组成和病理生理特征的癌症模型开辟了新途径。患者来源的肿瘤类器官在多次传代后仍能维持原有肿瘤的组织病理学及遗传表型特征,不仅可作为测试新型抗癌药物的优良模型,也可通过其药物敏感性测试预测患者的临床反应,为肿瘤患者的个体化精准治疗提供可靠的依据。合成生物学是以工程学思想为指导,提供独特工具来重建空间和动态信号,调控细胞间通信。合成生物学的快速发展,为肿瘤类器官在肿瘤的发生发展及肿瘤治疗等方面提供了一系列崭新的思路和方法,包括如何工程化重建类器官空间与动态信号、细胞稳态维持、细胞间通信调控等。本文概述了肿瘤类器官的构建过程及其在合成生物学中的应用,讨论了肿瘤类器官当前在构建效率、标准化、自动化、精确度等方面的局限性,最后展望了合成生物学在推动肿瘤类器官结构和功能复杂化方面的前景。

关键词：肿瘤类器官药物筛选精准医疗基因线路合成生物学

地铁列车地板铝型材结构参数的轻量化隔声特性影响研究

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城市轨道交通研究 2024年第5期27卷 96-101页

作者：李拥军林维仁中车南京浦镇车辆有限公司南京210031

[目的]轻量化和低噪声是当前轨道交通的发展趋势,实现地铁列车地板型材结构的轻量化低噪声设计对提高乘车舒适性具有重要意义。[方法]基于FE-SEA(有限元-统计能量分析)混合法建立地铁列车地板铝型材结构隔声特性预测模型,将仿真与测试... 详细信息

[目的]轻量化和低噪声是当前轨道交通的发展趋势,实现地铁列车地板型材结构的轻量化低噪声设计对提高乘车舒适性具有重要意义。[方法]基于FE-SEA(有限元-统计能量分析)混合法建立地铁列车地板铝型材结构隔声特性预测模型,将仿真与测试结果进行对比验证模型有效性,分析地板铝型材结构的筋板角度、筋板厚度、上下板厚度4个参数对其隔声特性的影响,并以质量定律的轻量化原则为判定标准对4个结构参数进行选择,确定优化结构,最终实现地板铝型材结构的轻量化声学优化。[结果及结论]结果表明,在所列举的铝型材结构参数优化结构中,选择筋板角度为47°、筋板厚度为2.0 mm、上板厚度为2.7 mm、下板厚度为2.7 mm时,单位面积结构质量减小1.18 kg/m^(2),整节车厢地板质量可减小约70.8 kg,而计权隔声量仅减小0.3 dB,其轻量化声学优化效果更好。可为地铁列车地板铝型材结构的轻量化降噪优化设计提供参考。

关键词：地铁列车地板型材结构 FE-SEA 轻量化质量定律隔声特性