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Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells

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Bone Research 2023年第4期11卷 784-802页

作者： Yu Wang Shanshan Jin Dan Luo Danqing He Min Yu Lisha zhu Zixin Li Liyuan Chen Chengye Ding Xiaolan Wu Tianhao Wu weiran Huang Xuelin Zhao Meng Xu Zhengwei Xie Yan Liu Laboratory of Biomimetic Nanomaterials Department of OrthodonticsPeking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&Translational Research Center for Orocraniofacial Stem Cells and Systemic HealthBeijing 100081China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China Peking University International Cancer Institute Health Science CenterPeking UniversityBeijing 100083China Department of Orthopedics the Fourth Medical Center of PLA General HospitalBeijing 100048China

Adult tendon stem/progenitor cells(TSPCs)are essential for tendon maintenance,regeneration,and repair,yet they become susceptible to senescence with age,impairing the self-healing capacity of *** this study,we employ a recently developed deep-learning-based efficacy prediction system to screen potential stemness-promoting and senescence-inhibiting drugs from natural products using the transcriptional signatures of *** top-ranked candidate,prim-O-glucosylcimifugin(POG),a saposhnikovia root extract,could ameliorate TPSC senescent phenotypes caused by long-term passage and natural aging in rats and humans,as well as restore the self-renewal and proliferative capacities and tenogenic potential of aged *** vivo,the systematic administration of POG or the local delivery of POG nanoparticles functionally rescued endogenous tendon regeneration and repair in aged rats to levels similar to those of normal ***,POG protects TSPCs against functional impairment during both passage-induced and natural aging by simultaneously suppressing nuclear factor-κB and decreasing mTOR signaling with the induction of ***,the strategy of pharmacological intervention with the deep learning-predicted compound POG could rejuvenate aged TSPCs and improve the regenerative capacity of aged tendons.

关键词： tendon endogenous progenitor

Retained Placenta Creta After Selective Fetal Reduction in Twin Pregnancy:A Case Report

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Maternal-Fetal Medicine 2021年第4期3卷 281-284页

作者： weiran Zheng Xinrui Yang Yuchun zhu Jie Yan Huixia Yang Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 10034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus Beijing 10034China

Placenta accreta spectrum(PAS)disorders are severe obstetric complications and can cause life-threatening hemorrhage,hysterectomy,or even *** disorders in one of dichorionic diamniotic twins are rare to be seen in clinical practice and lack of standard management *** reported a case of retained placenta creta after selective fetal reduction in one of dichorionic diamniotic twins.A 32-year-old woman with a history of cesarean section was diagnosed with placenta increta in one of dichorionic diamniotic twins at 16 weeks of *** discussion,the couple required to be hospitalized for selective fetal *** received selective termination by ultrasound-guided single fetal intracardiac injection of potassium *** follow-up prenatal ultrasound examinations detected the placenta of the reduced fetus did not stop invade the myometrium of the uterus but developed from placenta increta to placenta *** patient was diagnosed with placental percreta by prenatal ultrasound signs and surgical *** patient underwent scheduled cesarean delivery at 34^(+5)gestational *** outcome of maternal and fetal was satisfactory for our elaborate operation and optimal *** disorders are severe obstetric complications with an increasing *** with twin pregnancy makes PAS disorders more *** should learn that selective fetal reduction probably cannot solve it *** and standard management is essential to promote maternal and fetal outcomes.

关键词： Placenta accreta Placenta previa Selective fetal reduction Twin pregnancy

深穗中跨珠江口通道选用盾构法隧道方案的风险及对策

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现代隧道技术 2014年第4期51卷 178-184页

作者：黄威然竺维彬刘人怀暨南大学理工学院广州510632 广州轨道交通建设监理有限公司广州510010 广州市地下铁道总公司广州510335

长大深水底隧道面临着复杂地质、环境保护、港口产业、航道交通、空域交通、异常气象等风险,盾构法隧道作为一种环境友好型工法,具有自身独特的优势去克服以上风险。文章针对深圳、广州至中山跨珠江口通道工程的特点,基于广州地铁在类... 详细信息

长大深水底隧道面临着复杂地质、环境保护、港口产业、航道交通、空域交通、异常气象等风险,盾构法隧道作为一种环境友好型工法,具有自身独特的优势去克服以上风险。文章针对深圳、广州至中山跨珠江口通道工程的特点,基于广州地铁在类同复合地层盾构工程的大规模实践成果,同时结合国内外大直径、高水压、长距离推进等盾构施工关键技术的突破和经验,对施工方案进行了综合研究,认为盾构法三隧洞方案"功能齐备、质量保障、经济合理、风险可控等优势明显,为本工程最优方案,并进一步分析了本盾构隧道工程的风险及对策。

关键词：珠江口通道复合地层盾构法隧道风险及对策

一种可迭代基于多向自相关的航拍电力线图像增强方法

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机器人 2015年第6期37卷 738-747页

作者：曹蔚然朱琳琳韩建达中国科学院沈阳自动化研究所辽宁沈阳110016 中国科学院大学北京100049 沈阳师范大学软件学院辽宁沈阳110034

针对无人机航拍电力线图像环境背景复杂、电力线目标细弱导致目标识别率低的问题,提出了一种可迭代运行的多向自相关(iterable multidirectional autocorrelation,IMA)增强方法.该方法根据航拍图像中电力线目标的局部纵向及横向灰度分... 详细信息

针对无人机航拍电力线图像环境背景复杂、电力线目标细弱导致目标识别率低的问题,提出了一种可迭代运行的多向自相关(iterable multidirectional autocorrelation,IMA)增强方法.该方法根据航拍图像中电力线目标的局部纵向及横向灰度分布特征设计有效的滤波模板,用方向滤波的结果进行自相关增强.同时,这种自我增强可以多次迭代运行以达到满意的图像增强效果.通过一系列实验将Canny、Hessian与IMA方法的增强结果进行对比,实验结果显示,所提出的IMA方法比Canny和Hessian方法更适于无人机航拍电力线图像的增强操作.IMA方法不但运算速度快,而且能在大幅减弱航拍图像中复杂环境背景的同时增强电力线目标,从而有效提高图像的电力线目标检测识别率.

关键词：航拍电力线图像可迭代多向自相关图像增强灰度分布滤波

Path Planning of Shallow Submersible Unmanned Ship Based on MSFA Method

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Path Planning of Shallow Submersible Unmanned Ship Based on ...

第32届中国过程控制会议(CPCC2021)

作者： Lei Zhao Pengfei Zhi Wanlu zhu Haiyang Qiu Hui Wang weiran Wang School of Electronic and Information Engineering Jiangsu University of Science and Technology

In order to enable the shallow submersible unmanned ship to quickly and accurately collect water area information when working in unknown waters,carry out real-time path planning,shorten the planned path,and solve the limitations of traditional unmanned ship path *** paper proposes a shallow submersible unmanned ship path planning method based on multi-sensor information fusion and firefly optimization algorithm(MSFA).First of all,real-time information of the water area is acquired through the sensors mounted on the shallow-submersible unmanned ship,information fusion is carried out,and real-time modeling of the water area ***,the Firefly algorithm is optimized to increase the computing speed to meet the needs of real-time path ***,the real-time model of the water environment based on multi-sensor information fusion is combined with the Firefly optimization algorithm to form a shallow submersible unmanned ship path planning based on MSFA ***,the method proposed by me was verified by simulation analysis.

关键词： shallow submersible unmanned ship data fusion firefly optimization algorithm route plan

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施工阶段盾构隧道漂移控制的研究

现代隧道技术 2005年第1期42卷 71-76页

作者：黄威然竺维彬广州市地下铁道设计研究院广州510010 广州市地下铁道总公司广州510030

盾构隧道位移控制是满足建筑限界的关键。文章从盾构工法特性、地质条件、盾构姿态、衬背注浆和设计五个方面进行研究,对施工阶段的盾构隧道漂移控制提出了建议。

关键词：盾构隧道位移控制

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泥水盾构过江工程江底塌方风险的应对及处理

现代隧道技术 2006年第2期43卷 49-53页

作者：黄威然竺维彬广州地铁设计院广州510405 广州地铁建设总部广州510385

泥水盾构过江工程的重大挑战之一是江底塌方的处理,正确地分析坍方的原因和采取有效的措施是应对风险的关键。文章结合工程实例对江底坍方的应对及处理进行了分析研究。

关键词：江底隧道泥水盾构塌方处理

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两种磁流变阻尼器的结构设计与性能分析

机床与液压 2016年第3期44卷 89-93页

作者：祝世兴王巍然中国民航大学航空工程学院天津300300

针对传统磁流变(MR)阻尼器阻尼通道利用率低的问题,提出了两种磁路结构的优化设计方案。运用ANSYS软件对这两种MR阻尼器的磁路结构进行二维电磁场有限元仿真,分析结果表明两种MR阻尼器磁路结构设计切实可行。采用Bingham模型对两种阻尼... 详细信息

针对传统磁流变(MR)阻尼器阻尼通道利用率低的问题,提出了两种磁路结构的优化设计方案。运用ANSYS软件对这两种MR阻尼器的磁路结构进行二维电磁场有限元仿真,分析结果表明两种MR阻尼器磁路结构设计切实可行。采用Bingham模型对两种阻尼器输出力进行预估并得到不同工作状态下的力-速度曲线,结果表明:由于增加了阻尼通道的有效长度,两种改进的阻尼器比活塞尺寸相同的传统阻尼器的最大出力提高1倍以上。

关键词：磁流变阻尼器磁路结构 Bingham模型阻尼通道

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非对称差速三螺杆挤出机混合机理分析

塑料 2023年第2期52卷 175-180页

作者：马超朱向哲马尉然辽宁石油化工大学机械工程学院辽宁抚顺113001

设计了非对称差速三螺杆挤出机端面造型,并且,对比其与常规三螺杆、非对称双螺杆挤出机内流体混合行为。对流场中速度矢量场和压力场进行分析,同时,比较分布混合性能中停留时间、分离尺度和混合效率,分散混合性能中最大剪切应力、对数... 详细信息

设计了非对称差速三螺杆挤出机端面造型,并且,对比其与常规三螺杆、非对称双螺杆挤出机内流体混合行为。对流场中速度矢量场和压力场进行分析,同时,比较分布混合性能中停留时间、分离尺度和混合效率,分散混合性能中最大剪切应力、对数拉伸率和混合指数。结果表明,与常规三螺杆相比,非对称差速三螺杆能有效地避免常规三螺杆中心区回流较大的问题,正向输送能力更强,并且,啮合区两侧压差更大,有利于物料压延。流域内粒子停留时间分布区间集中,分离尺度显著降低,有利于物料分布混合。同时,能提供较强的拉伸作用,使流域内粒子受到更好的拉伸和折叠,从而使其具有较好的混沌混合能力,有利于物料分散混合。

关键词：非对称差速三螺杆端面型线流场分析分布混合分散混合