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Accurate expression of neck motion signal by piezoelectric sensor data analysis

Chinese Chemical Letters 2024年第9期35卷 250-256页

作者： Neng Shi Haonan Jia Jixiang Zhang Pengyu Lu Chenglong Cai Yixin Zhang Liqiang Zhang Nongyue He weiran zhu Yan Cai Zhangqi Feng Ting Wang State Key Laboratory of Digital Medical Engineering National Demonstration Center for Experimental Biomedical Engineering EducationSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China SceneRay Co. Ltd.Suzhou 215123China School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

The development of high-precision sensors using flexible piezoelectric materials has the advantages of high sensitivity,high stability,good durability,and *** main problem with sensing equipment is low sensitivity,which is due to the mismatch between materials and analysis methods,resulting in the inability to effectively eliminate *** address this issue,we developed the denoising analysis method to motion signals captured by a flexible piezoelectric sensor fabricated from poly(l-lactic acid)(PLLA)and polydimethylsiloxane(PDMS)*** results demonstrate that this improved denoising method effectively removes noise components from neck muscle motion signals,thus obtaining high-quality,low-noise motion signal *** decomposition and reconstruction is a signal processing technique that involves decomposing a signal into different scales and frequency components using wavelets and then selectively reconstructing the signal to emphasize specific features or eliminate *** study employed the sym8 wavelet basis for wavelet decomposition and *** the denoised signals,a high degree of stability and periodic peaks are distinctly manifested,while amplitude and frequency differences among different types of movements also become noticeably *** a result of this study,we are enabled to accurately analyze subtle variations in neck muscle motion signals,such as nodding,shaking the head,neck lateral flexion,and neck *** temporal and frequency domain analysis of denoised motion signals,differentiation among various motion states can be ***,this improved analytical approach holds broad application prospects across various types of piezoelectric sensors,such as healthcare monitoring,sports biomechanics.

关键词： Piezoelectric transducer Wavelet decomposition Muscle motion signal Signal analysis Noise component Healthcare monitoring

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Accurate expression of neck motion signal by piezoelectric sensor data analysis

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Chinese Chemical Letters 2024年第09期 276-282页

作者： Neng Shi Haonan Jia Jixiang Zhang Pengyu Lu Chenglong Cai Yixin Zhang Liqiang Zhang Nongyue He weiran zhu Yan Cai Zhangqi Feng Ting Wang State Key Laboratory of Digital Medical Engineering National Demonstration Center for Experimental Biomedical Engineering EducationSchool of Biological Science and Medical EngineeringSoutheast University Scene Ray Co. Ltd. School of Chemistry and Chemical Engineering Nanjing University of Science and Technology

The development of high-precision sensors using flexible piezoelectric materials has the advantages of high sensitivity, high stability, good durability, and lightweight. The main problem with sensing equipment is low sensitivity, which is due to the mismatch between materials and analysis methods, resulting in the inability to effectively eliminate noise. To address this issue, we developed the denoising analysis method to motion signals captured by a flexible piezoelectric sensor fabricated from poly(l-lactic acid)(PLLA) and polydimethylsiloxane(PDMS) materials. Experimental results demonstrate that this improved denoising method effectively removes noise components from neck muscle motion signals, thus obtaining high-quality, low-noise motion signal waveforms. Wavelet decomposition and reconstruction is a signal processing technique that involves decomposing a signal into different scales and frequency components using wavelets and then selectively reconstructing the signal to emphasize specific features or eliminate noise. The study employed the sym8 wavelet basis for wavelet decomposition and reconstruction. In the denoised signals, a high degree of stability and periodic peaks are distinctly manifested, while amplitude and frequency differences among different types of movements also become noticeably visible. As a result of this study, we are enabled to accurately analyze subtle variations in neck muscle motion signals, such as nodding, shaking the head, neck lateral flexion, and neck circles. Through temporal and frequency domain analysis of denoised motion signals, differentiation among various motion states can be achieved. Overall, this improved analytical approach holds broad application prospects across various types of piezoelectric sensors, such as healthcare monitoring, sports biomechanics.

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Supramolecular cyclization induced emission enhancement in a pillar[5]arene probe for discrimination of spermine

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Chinese Chemical Letters 2024年第4期35卷 275-279页

作者： Yibin Zhou Hao Tang Hanlun Wu Xiaomei Jiang Lingyun Wang Derong Cao State Key Laboratory of Luminescent Materials and Devices School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China

Early diagnosis and treatment of cancer requires the development of tools that are both sensitive and selective in detecting *** this study,we presented a"supramolecular cyclization-induced emission enhancement"strategy for the sensitive and selective detection of spermine.A new pillar[5]arene probe(P1)demonstrated excellent solution/solid dual-state emission properties,and the addition of certain spermine(Spm)resulted in fluorescence enhancement due to the synergy of multiple weak interactions that restricted the free motion of P1 in the P1⊃Spm *** mechanism was further confirmed by time-resolved spectroscopy,DFT calculations,and IGM *** its low limit of detection and high selectivity,P1 is a promising tool for measuring spermine in artificial urine samples.

关键词： Spermine Pillararene Probe Supramolecular chemistry Supramolecular cyclization induced emission enhancement

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我国微生物农药的概述与进展

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工业微生物 2024年第3期54卷 153-155页

作者：朱伟冉刘媛赵晨王健河北北方学院河北张家口075000 国家粮食和物资储备局科学研究院北京昌平102209

微生物农药作为当前具有广阔应用前景的农药,在防控农作物病虫害、有效保障粮食安全方面发挥着重要的作用。文章通过对微生物农药的种类进行详细阐述,并对当前我国微生物农药的研究进展进行总结与展望,希望能够进一步促进微生物农药的... 详细信息

微生物农药作为当前具有广阔应用前景的农药,在防控农作物病虫害、有效保障粮食安全方面发挥着重要的作用。文章通过对微生物农药的种类进行详细阐述,并对当前我国微生物农药的研究进展进行总结与展望,希望能够进一步促进微生物农药的研发、应用和推广。

关键词：生物农药微生物农药绿色防控研究进展

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响应面法优化微酸性电生功能水萌发苦荞芽工艺及其富硒规律研究

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食品工业科技 2024年第17期45卷 155-162页

作者：赵一迪刘媛张凯尹晨朱伟冉王健李云龙周海涛牟建楼河北北方学院河北省农产品食品质量安全分析检测重点实验室河北张家口075000 山西农业大学山西功能食品研究院山西太原030031 河北农业大学食品科技学院河北保定071000 张家口市农业科学院河北张家口075000

为探究不同pH、有效氯浓度(Available Chlorine Contents,ACC)的微酸性电生功能水(Slightly Acidic Electrolyzed Water,SAEW)萌发条件对发芽苦荞的影响规律,以发芽率为考察指标,通过单因素和响应面试验优化微酸性电生功能水萌发苦荞芽... 详细信息

为探究不同pH、有效氯浓度(Available Chlorine Contents,ACC)的微酸性电生功能水(Slightly Acidic Electrolyzed Water,SAEW)萌发条件对发芽苦荞的影响规律,以发芽率为考察指标,通过单因素和响应面试验优化微酸性电生功能水萌发苦荞芽工艺;为获得总硒含量高且品质优良的富硒苦荞芽,以总硒含量和发芽率为考察指标,在微酸性电生功能水萌发基础上,研究了不同亚硒酸钠浓度对苦荞发芽的影响。结果表明,最佳工艺参数为:浸泡时间为2.3 h,pH为6.5,萌发温度为21℃,萌发时间为108 h,在该条件下发芽率为84.96%,与响应面预测值(85.36%)接近,相比蒸馏水组提高了14.3%,比自来水组提高了11.71%。优选的Na2SeO3溶液浓度为60 mg/L,苦荞芽的总硒含量为15.5 mg/L且发芽率为85.63%,高于响应面优化预测值且高于苦荞发芽实际值。本研究为微酸性电生功能水和富硒处理萌发苦荞芽产品的开发提供了理论基础和科学依据。

关键词：微酸性电生功能水苦荞发芽响应面法工艺优化富硒

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超密集小峰窝网中基于干扰协调的小区分簇和功率分配算法

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电子与信息学报 2016年第5期38卷 1173-1178页

作者：朱晓荣朱蔚然南京邮电大学通信与信息工程学院南京210003 东南大学移动通信国家重点实验室南京210003

干扰的有效管理是超密集小蜂窝网中的一个研究难点。该文提出将超密集小蜂窝网中的小区干扰协调和分簇相结合的算法,通过分配最优的功率降低干扰,最大化系统吞吐量。根据干扰的程度,将干扰强的小蜂窝划为一个簇,同一个簇内的小蜂窝共享... 详细信息

干扰的有效管理是超密集小蜂窝网中的一个研究难点。该文提出将超密集小蜂窝网中的小区干扰协调和分簇相结合的算法,通过分配最优的功率降低干扰,最大化系统吞吐量。根据干扰的程度,将干扰强的小蜂窝划为一个簇,同一个簇内的小蜂窝共享频谱资源,协作为用户服务,簇与簇之间实现频谱复用。仿真结果表明,该算法在网络密集部署时,有效地减小干扰,提高系统吞吐量。

关键词：超密集网络分簇功率分配干扰管理

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Mitochondrial components transferred by MSC-derived exosomes promoted bone regeneration under high salt microenvironment via DRP1/Wnt signaling

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Nano Research 2024年第9期17卷 8301-8315页

作者： Yiming Wang Shuai Lin Liujing Chen Mingzhao Li Zilu zhu Zimeng zhuang Meilian Cai Han Zhang Chenyang Xing weiran Li Ruili Yang Department of Orthodontics School and Hospital of StomatologyPeking UniversityBeijing 100081China National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China Beijing Key Laboratory of Digital Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China

Bone homeostasis relies on the dynamic balance of osteoblast mediated bone construction and osteoclast-based bone resorption processes,which has been reported to be controlled by various mineral ***,there is no direct evidence of the effect and the underlying mechanism of high salt stimulation on bone *** this study,we demonstrated that high salt stimulation promoted excessive mitochondrial fission mediated by dynamin-related protein 1 in mesenchymal stem cells,which resulted in impaired mitochondrial morphology and ***,this impairment hindered the bone formation of mesenchymal stem cells,resulting in osteopenia in ***,the impaired property of mesenchymal stem cells which was caused by high salt was controlled by dynamin-related protein 1 mediated mitochondrial fission,which inhibited the classical Wnt signaling ***,the osteogenic property of mesenchymal stem cells decreased by high salt could be restored by exosomes to transfer the mitochondrial DNA into the impaired mesenchymal stem *** study provides not only new strategies for promoting bone regeneration but also new insights into the effect and mechanism of exosome-mediated delivery.

关键词： high salt dynamin-related protein 1 mitochondrial injury exosomes bone regeneration

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makeTwin:A reference architecture for digital twin software platform

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Chinese Journal of Aeronautics 2024年第1期37卷 1-18页

作者： Fei TAO Xuemin SUN Jiangfeng CHENG Yonghuai zhu weiran LIU Yong WANG Hui XU Tianliang HU Xiaojun LIU Tingyu LIU Zheng SUN Jun XU Jinsong BAO Feng XIANG Xiaohui JIN Digital Twin International Research Center International Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Institute of Advanced Manufacturing and Intelligent Technology Beijing University of TechnologyBeijing 100124China RIAMB(Beijing)Technology Development Co Ltd(R.T.D.)Beijing 100120China School of Mechanical Engineering Shandong UniversityJinan 250061China School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China College of Mechanical Engineering Donghua UniversityShanghai 201620China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan 430081China Beijing Aero-top Hi-tech Co LtdBeijing 100176China

Digital twin is currently undergoing a significant transformation from the conceptual and theoretical research phase to the implementation and application ***,a universally adaptable research and development platform for digital twin is critically needed to meet the development ***,a publicly accessible simulation,testing,and validation platform which can support digital twin model building,data processing,algorithm design,configuration,etc.,is urgently required for ***,for developers from the industry,a lowcode development platform that can offer a customizable suite of functions such as model creation,data management,protocol configuration,and visualization is urgently ***,for enterprise users,there is a lack of an application management platform that can be configured and migrated for various application scenarios,functions,and ***,based on the system research of digital twin theories and key technologies by the authors(such as the five-dimension digital twin model,digital twin modeling and digital twin data theory,digital twin standards,and so on),a digital twin software platform reference architecture,namely make Twin,is proposed and designed,as well as its ten core *** workflow of the make Twin and the interaction mechanisms among its core functions are ***,a digital twin application system for a chemical fiber textile shop floor(CFTS)which was developed according to make Twin,is introduced,which validates the proposed reference architecture.

关键词： Digital twin Digital twin software platform Industrial software makeTwin Reference architecture

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Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy

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Chinese Chemical Letters 2024年第6期35卷 385-391页

作者： An Lu Yuhao Guo Yi Yan Lin Zhai Xiangyu Wang weiran Cao Zijie Li Zhixia Zhao Yujie Shi Yuanjun zhu Xiaoyan Liu Huining He Zhiyu Wang Jian-Cheng Wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Department of Immuno-oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Pharmacy Clinical Trial Research CenterChina-Japan Friendship HospitalBeijing 100029China Laboratory of innovative formulations and pharmaceutical excipients Ningbo Institute of Marine MedicinePeking UniversityNingbo 315832China

Immunosuppressive microenvironments present critical problems in clinical *** regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)with chemotherapeutics has been applied *** this study,miriplatin(MiPt),the lipidic derivative of 5-fluorouracil(Fu-OA),as well as the programmed death ligand 1(PD-L1)target si RNA(siPD-L1)were integrated into Lip-Pt/Fu@siPD-L1 nanoparticles(NPs)for *** vitro results showed that Lip-Pt/Fu@siPD-L1 NPs could exhibit effective siRNA gene silencing and promote the phagocytosis of tumor cells by ***,in vivo results revealed that LipPt/Fu@siPD-L1 NPs showed significantly higher anti-tumor efficiency than that of the physical mixing of Mi Pt,5-fluorouracil,and Lip@siPD-L1 NPs(delivery of siPD-L1 by liposomes).The best anti-tumor efficiency of Lip-Pt/Fu@siPD-L1 NPs resulted from the synergistic immunotherapeutic effects of Mi Pt and siPD-L1 based on the inhibition of CD47 expression and the downregulation of PD-L1 in tumor cells,which elicited a robust anti-tumor immune response through the activation of macrophage phagocytosis and immune checkpoint *** Lip-Pt/Fu@siPD-L1 NPs provide a potential strategy for tumor chemo-immunotherapy.

关键词： Chemo-immunotherapy Immune checkpoint inhibition Gene silencing Miriplatin Macrophage phagocytosis Nanotechnology

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数字建筑学的转向——数字孪生与人机协作

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当代建筑 2020年第2期 27-32页

作者：袁烽朱蔚然同济大学建筑与城市规划学院

文章通过梳理数字建筑学的脉络,详细阐述了在其发展历程中,如何从对于形式生成的关注转向在性能化设计引导下的数字化建造。在此基础上,文章提出数字建筑学的发展经历了三次转向,并指出当下的第三次转向必将走向数字孪生与人机协作的新... 详细信息

文章通过梳理数字建筑学的脉络,详细阐述了在其发展历程中,如何从对于形式生成的关注转向在性能化设计引导下的数字化建造。在此基础上,文章提出数字建筑学的发展经历了三次转向,并指出当下的第三次转向必将走向数字孪生与人机协作的新数字建筑学。最后,文章通过讲述几个数字孪生与人机协作思维下的建造实践,力图体现正在发生的数字建筑学转向。

关键词：数字建筑学转向数字孪生人机协作

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