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makeTwin:A reference architecture for digital twin software platform

Chinese Journal of Aeronautics 2024年第1期37卷 1-18页

作者： Fei TAO Xuemin SUN Jiangfeng CHENG Yonghuai ZHU weiran liu Yong WANG Hui XU Tianliang HU Xiaojun liu Tingyu liu Zheng SUN Jun XU Jinsong BAO Feng XIANG Xiaohui JIN Digital Twin International Research Center International Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Institute of Advanced Manufacturing and Intelligent Technology Beijing University of TechnologyBeijing 100124China RIAMB(Beijing)Technology Development Co Ltd(R.T.D.)Beijing 100120China School of Mechanical Engineering Shandong UniversityJinan 250061China School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China College of Mechanical Engineering Donghua UniversityShanghai 201620China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan 430081China Beijing Aero-top Hi-tech Co LtdBeijing 100176China

Digital twin is currently undergoing a significant transformation from the conceptual and theoretical research phase to the implementation and application phase.However,a universally adaptable research and development platform for digital twin is critically needed to meet the development requirements.Specifically,a publicly accessible simulation,testing,and validation platform which can support digital twin model building,data processing,algorithm design,configuration,etc.,is urgently required for researchers.Furthermore,for developers from the industry,a lowcode development platform that can offer a customizable suite of functions such as model creation,data management,protocol configuration,and visualization is urgently needed.Meanwhile,for enterprise users,there is a lack of an application management platform that can be configured and migrated for various application scenarios,functions,and modes.Therefore,based on the system research of digital twin theories and key technologies by the authors(such as the five-dimension digital twin model,digital twin modeling and digital twin data theory,digital twin standards,and so on),a digital twin software platform reference architecture,namely make Twin,is proposed and designed,as well as its ten core functions.The workflow of the make Twin and the interaction mechanisms among its core functions are described.Finally,a digital twin application system for a chemical fiber textile shop floor(CFTS)which was developed according to make Twin,is introduced,which validates the proposed reference architecture.

关键词： Digital twin Digital twin software platform Industrial software makeTwin Reference architecture

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Relationship between the unique microstructures and behaviors of high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1350-1363页

作者： Yaqi Wu Peter KLiaw Ruixuan Li weiran Zhang Guihong Geng Xuehui Yan Guiqun liu Yong Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Xi’an Rare Metal Materials Institute Co.Ltd. Xi’an 710016China School of Materials Science and Engineering North Minzu UniversityYinchuan 750030China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

High-entropy alloys(HEAs),which were introduced as a pioneering concept in 2004,have captured the keen interest of nu-merous researchers.Entropy,in this context,can be perceived as representing disorder and randomness.By contrast,elemental composi-tions within alloy systems occupy specific structural sites in space,a concept referred to as structure.In accordance with Shannon entropy,structure is analogous to information.Generally,the arrangement of atoms within a material,termed its structure,plays a pivotal role in dictating its properties.In addition to expanding the array of options for alloy composites,HEAs afford ample opportunities for diverse structural designs.The profound influence of distinct structural features on the exceptional behaviors of alloys is underscored by numer-ous examples.These features include remarkably high fracture strength with excellent ductility,antiballistic capability,exceptional radi-ation resistance,and corrosion resistance.In this paper,we delve into various unique material structures and properties while elucidating the intricate relationship between structure and performance.

关键词： high-entropy alloys unique microstructure special properties alloy design

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Evaluation of the safety and efficiency of cytotoxic T cell therapy sensitized by tumor antigens original from T-ALL-iPSC in vivo

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Cancer Innovation 2024年第1期3卷 50-60页

作者： weiran Li Meiling Zhou Lu Wang Liying Huang Xuemei Chen Xizhuo Sun Tao liu Department of Tumor Immunotherapy Shenzhen Luohu People's HospitalThe Third Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongChina Cell Quality Testing Laboratory of Shenzhen Luohu Hospital Group ShenzhenGuangdongChina

Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent years.Previously,we showed that iPSCs derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia(T-ALL)have a gene expression profile similar to that of T-ALL cell lines.Methods:Mice with T-ALL were treated with dendritic and T(DC-T)cells loaded with intact and complete antigens from T-ALL-derived iPSCs(T-ALL-iPSCs).We evaluated the safety and antitumor efficiency of autologous tumor-derived iPSC antigens by flow cytometry,cytokine release assay,acute toxicity experiments,long-term toxicity experiments,and other methods.Results:Our results indicate that complete tumor antigens from T-ALL-iPSCs could inhibit the growth of inoculated tumors in immunocompromised mice without causing acute and long-term toxicity.Conclusion:T-ALL-iPSC-based treatment is safe and can be used as a potential strategy for leukemia immunotherapy.

关键词： adoptive cell therapy drug safety evaluation IPSCs T-ALL

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A 5M Synchronization Mechanism for Digital Twin Shop-Floor

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 105-126页

作者： weiran liu Jiangfeng Cheng Zhiwen Wen Xiaofu Zou Zhaozong Wang Hongting liu Fei Tao School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Xi’an Precision Machinery Research Institute Xi’an 710077China Institute of Artificial Intelligence Beihang UniversityBeijing 100191China Digital Twin International Research Center International Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing 100191China

In recent years,as a promising way to realize digital transformation,digital twin shop-floor(DTS)plays an impor-tant role in smart manufacturing.The core feature of DTS is the synchronization.How to implement and maintain the synchronization is critical for DTS.However,there is still a lack of a common definition for synchronization in DTS.Besides,a systematic synchronization mechanism for DTS is strongly needed.This paper first summarizes the defi-nition and requirements of synchronization in DTS,to clarify the understanding of synchronization in DTS.Then,a 5M synchronization mechanism for DTS is proposed,where 5M refers to multi-system data,multi-fidelity model,multi-resource state,multi-level state,and multi-stage operation.As a bottom-up synchronization mechanism,5M synchronization mechanism for DTS has the potential to support DTS to achieve and maintain physical-virtual state synchronization,and to realize operation synchronization of DTS.The implementation methods of 5M synchronization mechanism for DTS are also introduced.Finally,the proposed synchronization mechanism is validated in a digital twin satellite assembly shop-floor,which proves the effectiveness and feasibility of the mechanism.

关键词： Digital twin Digital twin shop-floor Synchronization in digital twin shop-floor Synchronization mechanism Satellite assembly shop-floor

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Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy

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Chinese Chemical Letters 2024年第6期35卷 385-391页

作者： An Lu Yuhao Guo Yi Yan Lin Zhai Xiangyu Wang weiran Cao Zijie Li Zhixia Zhao Yujie Shi Yuanjun Zhu Xiaoyan liu Huining He Zhiyu Wang Jian-Cheng Wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Department of Immuno-oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Pharmacy Clinical Trial Research CenterChina-Japan Friendship HospitalBeijing 100029China Laboratory of innovative formulations and pharmaceutical excipients Ningbo Institute of Marine MedicinePeking UniversityNingbo 315832China

Immunosuppressive microenvironments present critical problems in clinical chemotherapy.To regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)with chemotherapeutics has been applied clinically.In this study,miriplatin(MiPt),the lipidic derivative of 5-fluorouracil(Fu-OA),as well as the programmed death ligand 1(PD-L1)target si RNA(siPD-L1)were integrated into Lip-Pt/Fu@siPD-L1 nanoparticles(NPs)for chemo-immunotherapy.In vitro results showed that Lip-Pt/Fu@siPD-L1 NPs could exhibit effective siRNA gene silencing and promote the phagocytosis of tumor cells by macrophages.Furthermore,in vivo results revealed that LipPt/Fu@siPD-L1 NPs showed significantly higher anti-tumor efficiency than that of the physical mixing of Mi Pt,5-fluorouracil,and Lip@siPD-L1 NPs(delivery of siPD-L1 by liposomes).The best anti-tumor efficiency of Lip-Pt/Fu@siPD-L1 NPs resulted from the synergistic immunotherapeutic effects of Mi Pt and siPD-L1 based on the inhibition of CD47 expression and the downregulation of PD-L1 in tumor cells,which elicited a robust anti-tumor immune response through the activation of macrophage phagocytosis and immune checkpoint inhibition.The Lip-Pt/Fu@siPD-L1 NPs provide a potential strategy for tumor chemo-immunotherapy.

关键词： Chemo-immunotherapy Immune checkpoint inhibition Gene silencing Miriplatin Macrophage phagocytosis Nanotechnology

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Revocable Hierarchical Identity-Based Broadcast Encryption

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Tsinghua Science and Technology 2018年第5期23卷 539-549页

作者： Dawei Li Jianwei liu Zongyang Zhang Qianhong Wu weiran liu School of Electronic and Information Engineering Beihang University Beijing 100191 China

Hierarchical Identity-Based Broadcast Encryption （HIBBE） organizes users into a tree-like structure, and it allows users to delegate their decryption ability to subordinates and enable encryption to any subset of users while only intended users can decrypt. However, current HIBBE schemes do not support efficient revocation of private keys. Here, a new primitive called Revocable Hierarchical Identity-Based Broadcast Encryption （RHIBBE） is formalized that allows revocation of the HIBBE. Ciphertext indistinguishability is defined against the selectively Bounded Revocable Identity-Vector-Set and Chosen-Plaintext Attack （IND-sBRIVS-CPA）. An IND-sBRIVS-CPA secure RHIBBE scheme is constructed with efficient revocation on prime-order bilinear groups. The unbounded version of the scheme is also shown to be secure but a little weaker than the former under the decisional n-Weak Bilinear Diffie-Hellman inversion assumption.

关键词： Revocable Hierarchical Identity-Based Broadcast Encryption （RHIBBE） revocation provable security

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脑脊液单细胞测序技术在神经退行性疾病中的应用进展

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中国医学前沿杂志（电子版） 2024年第6期16卷 52-57页

作者：赵卫然刘小璇何及北京大学第三医院神经内科北京100191

随着脑脊液单细胞测序技术的发展,其在神经退行性疾病研究中的应用日益广泛。本文通过归纳近年相关文献,概述了脑脊液单细胞测序技术在神经退行性疾病方面的应用,包括利用该技术发现神经退行性疾病的特异性细胞及差异表达基因、结合细... 详细信息

随着脑脊液单细胞测序技术的发展,其在神经退行性疾病研究中的应用日益广泛。本文通过归纳近年相关文献,概述了脑脊液单细胞测序技术在神经退行性疾病方面的应用,包括利用该技术发现神经退行性疾病的特异性细胞及差异表达基因、结合细胞学标志物提高疾病诊断的准确性、通过识别关键信号通路及抗原靶点设计靶向治疗等。总而言之,多组学检测有助于从多维度理解细胞状态,脑脊液单细胞测序技术在神经退行性疾病研究中具有广阔的应用前景。

关键词：脑脊液单细胞测序技术神经退行性疾病

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锌精矿氧压浸出技术研究进展

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有色金属（冶炼部分） 2024年第5期 19-26页

作者：刘鑫宇郭宝左蔚然福州大学紫金地质与矿业学院福州350108

传统湿法炼锌工艺存在烟气处理成本高、综合回收率低等问题,近年来,氧压浸出技术因其原料适应性强、锌回收率高、环境污染小等优点被应用于锌冶炼工业。介绍了锌精矿氧压浸出的生产工艺,论述了浸出过程反应的基本原理,以及离子催化、温... 详细信息

传统湿法炼锌工艺存在烟气处理成本高、综合回收率低等问题,近年来,氧压浸出技术因其原料适应性强、锌回收率高、环境污染小等优点被应用于锌冶炼工业。介绍了锌精矿氧压浸出的生产工艺,论述了浸出过程反应的基本原理,以及离子催化、温度、酸度、分散剂等条件对浸出过程离子行为的影响与机理。讨论了锌精矿中伴生元素铁、镓、锗、铟、银等的浸出行为及在不同浸出条件下浸出行为的变化。

关键词：湿法炼锌锌精矿氧压浸出硫酸浸出

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青藏高原形成演化动力机制及其远程效应

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地学前缘 2024年第1期31卷 154-169页

作者：刘德民王杰姜淮赵悦郭铁鹰杨巍然中国地质大学(武汉)地球科学学院湖北武汉430074 中国地震局地震研究所湖北武汉430071 湖北省地震局湖北武汉430071

作为第三极的青藏高原的形成是新生代以来的地球节律构造事件中最典型、最显著的新构造运动的结果,其构造地貌特征及其重要性,内部单元组成,构造演化历程及动力机制,以及对周边盆地乃至整个中国大陆的影响及远程效应至今一直是学术关注... 详细信息

作为第三极的青藏高原的形成是新生代以来的地球节律构造事件中最典型、最显著的新构造运动的结果,其构造地貌特征及其重要性,内部单元组成,构造演化历程及动力机制,以及对周边盆地乃至整个中国大陆的影响及远程效应至今一直是学术关注的焦点。本文重新圈定了青藏高原构造地貌范围,确立了其在全球构造中的地位。青藏高原的远程效应向南北两侧延伸,北到北冰洋,南到太平洋,总体上围绕东经105°经线穿越了整个亚洲大陆,本文采用东经105°所在经线大圆作为划分东西半球的分界线,该线以东为东半球,以西为西半球。青藏高原处于全球最大、最重要的南北向构造和东西向构造的交汇处,其内部的帕米尔高原更是区域构造的中流砥柱。青藏高原起源于帕米尔高原,它是一个印支期的热穹窿,晚期转化出一条直径200 km的异常重力柱,垂直下沉至600 km,构成一个垂向上的挤压-伸展构造,完成于白垩纪。以它为中心向东西扩展,东边三条、西边一条水平方向挤压-伸展构造。喜山期它还遭受到岩体的侵入,白垩系基本上未变形。古近纪,印度陆块与亚洲陆块碰撞,形成先压后升的雄伟的喜马拉雅造山带。以它为中心向北扩展,第四纪3个地幔枝上升,导致整个青藏高原上升。青藏高原形成与演化的深部动力机制模型:早期表现为地质体在垂向上的离心运动和在水平上的伸展运动;后期是以挤压为主的阶段,表现为地质体在垂向上的向心运动和水平上的挤压运动。从驱动力的角度,早期以热能为主驱动力,后期以重力势能为主驱动力。青藏高原的隆升及其形成演化是欧亚陆块新生代最令人瞩目的地质事件,其直接影响到岩石圈浅部及地壳表层与人类生存发展息息相关的地形地貌、能源、资源、生态、环境和灾害等,产生了具有举足轻重的近区及远程效应。3个远程效应分别是贝加尔湖裂谷、汾渭裂谷以及东非三叉裂谷的形成。本文最后对印支运动的命名和穿时问题、印支运动起止时间和类型、青藏高原是研究各类造山带的最佳基地、喜马拉雅造山带东西构造结的确定和帕米尔高原四维动力学模型的探索等5个问题进行了简单讨论。

关键词：青藏高原帕米尔高原地热能地幔枝动力机制构造演化远程效应

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火炮远方瞄准点法误差分析研究

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火力与指挥控制 2024年第1期49卷 118-123页

作者：韩超闫媛媛刘广生段纬然刘亮陆军工程大学石家庄校区石家庄050003

针对火炮方向瞄准时因周视瞄准镜与火炮回转中心不同心所造成的瞄准误差,使用几何建模方法对方向瞄准过程进行建模,并推导瞄准误差与标定点距离、装定角度和标定点位置之间的函数关系式。通过绘制和分析多组标定点距离、装定角度、标定... 详细信息

针对火炮方向瞄准时因周视瞄准镜与火炮回转中心不同心所造成的瞄准误差,使用几何建模方法对方向瞄准过程进行建模,并推导瞄准误差与标定点距离、装定角度和标定点位置之间的函数关系式。通过绘制和分析多组标定点距离、装定角度、标定点位置和瞄准误差数据图像,总结减小瞄准误差的若干方法。给出了装定角度、标定距离和对应瞄准误差极值之间的多项式拟合关系式,供相关人员使用。

关键词：方向瞄准远方瞄准点瞄准误差分析标定点设置

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