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Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

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Zoological Research 2023年第6期44卷 1003-1014页

作者： Zhongyun Zhang Ning Zhang Xuancheng Lu Min Zhou Xiaoxiang Yan weiqiong gu Jingru Yang Qin Zhang Cheng Zhang Yuhuan Gong Mingjun Jia Xiaoyu Zhang Peng Ning Mei Liu Xiaoyan Li Xiaomeng Shi Wenjun Liu George FGao guang Ning Jiqiu Wang Yuhai Bi Department of Endocrinology and Metabolism Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineShanghai 200025China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Laboratory Animal Center Chinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Department of Respiratory and Critical Care Medicine Institute of Respiratory DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Cardiology Institute of Cardiovascular DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325000China University of Chinese Academy of Sciences Beijing 100049China

Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and ***,the precise mechanisms responsible for the combined impact of coronavirus disease 2019(COVID-19)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain *** investigate the disease pathogenesis,K18-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were *** two mouse models were intranasally infected with a 5×10^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days *** h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1 mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1×10^(4) TCID_(50)of SARS-Co *** drug administration continued until the euthanasia of the *** of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were *** demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)***,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1α(HIF-1α),and increased ***,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory *** conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-19patients with diabetes.

关键词： SARS-CoV-2 Diabetes Mouse model Heparin Antiviral therapy

The Inherent Law of the Unpredictability of Financial Asset Price Fluctuations: Multistability and Chaos

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Journal of Systems Science & Complexity 2024年第2期37卷 776-804页

作者： gu Enguo Huanghe University of Science and Technology Zhengzhou 450006China

This paper aims at understanding the price dynamics generated by the interaction of traders relying on heterogeneous expectations in an asset pricing *** the present work the authors analyze a financial market populated by five types of boundedly rational speculators-two types of fundamentalists,two types of chartists and trend followers which submit buying/selling orders according to different trading *** authors formulate a stock market model represented as a 2 dimensional piecewise linear discontinuous *** proposed contribution to the existing financial literature is two ***,the authors perform study of the model involving a 2 dimensional piecewise linear discontinuous map through a combination of qualitative and quantitative *** authors focus on the existence conditions of chaos and the multi-stability regions in parameter *** border collision bifurcation curves and basins of multi-attractors are also *** authors find that chaos or quasi-period exists only in the case of fixed point being a saddle(regular or flip)and that the coexistence of multiple attractors may exist when the fixed point is an attractor,but it is common for spiral and flip fixed points.

关键词： BCB curve chaos financial market heterogeneous agents multiple attractors piecewise linear discontinuous map

Mir-144/451 promotes cell proliferation via targeting PTEN/AKT pathway in insulinomas

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Mir-144/451 promotes cell proliferation via targeting PTEN/A...

Serum MicroRNA 122 Levels Correlate Positively with Insulin Resistance and Alanine Aminotransferase Concentrations in Chinese Han Young Adults

中华医学会第十三次全国内分泌学学术会议

作者： Xiuli Jiang Aijing Shan Yutong Su Yulong Cheng weiqiong gu Weiqing Wang guang Ning Yanan Cao Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Key Laboratory for Endocrine TumorsRui-Jin HospitalShanghai Jiao-Tong University School of Medicine

Background MicroRNAs(miRNAs),which are differentially expressed in normal tissues and cancers,contribute to cancer development and *** lack of understanding of the roles of miRNAs in insulinoma tumorigenesis prompted us to explore the miRNAs differentially expressed in *** A full-scale analysis of the miRNome in human pancreatic islets and insulinomas is conducted in this *** miRNA expression levels were determined in four human islet

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Serum MicroRNA 122 Levels Correlate Positively with Insulin ...

中华医学会第十二次全国内分泌学学术会议

作者： Rui Wang Yanan Cao Juan Shi weiqiong gu Yifei Zhang Weiqing Wang guang Ning Jie Hong Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic DiseasesRuijin HospitalSchool of medicineShanghai Jiao-Tong University

Background and Aims MicroRNA 122(miR-122),an abundant liver-specific microRNA,regulates cholesterol metabolism, promotes hepatitis C virus replication and was reduced in hepatocellular ***,its role in insulin resistance remains *** aimed to investigate the association of serum miR-122 levels with insulin resistance and biomarkers of

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石化企业高盐污水生物处理技术探讨

石油化工安全环保技术 2008年第4期24卷 53-57页

作者：顾薇琼中国石油化工股份有限公司镇海炼化分公司浙江宁波315207

介绍了石化企业高盐污水的来源与水质特性,分析了传统活性污泥法处理高盐污水存在的问题及原因,对石化企业高盐污水的生物处理技术进行了探讨,并针对污水特性提出了可行的处理方法。

关键词：石化高盐污水生物处理

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回用污水杀藻与效果探讨

石油化工环境保护 2005年第3期28卷 26-28,32页

作者：顾薇琼镇海炼油化工股份有限公司浙江宁波315207

简单介绍炼化企业回用污水水质概况、藻类和悬浮物对污水回用工作的制约,着重介绍杀藻工作的净水效果、对污水回用工作的作用,并就存在的问题作进一步探讨。

关键词：污水回用悬浮物杀藻污水水质炼化企业净水效果

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免疫检查点抑制剂致甲状腺损伤的诊治进展

诊断学理论与实践 2021年第4期20卷 338-342页

作者：顾卫琼上海交通大学医学院附属瑞金医院内分泌科上海200025

免疫检查点抑制剂(immune checkpoint inhibitor,ICI)是一类用于癌症免疫治疗的新型药物,近年来其在晚期癌症患者中的应用越来越广泛,其适应证已从黑色素瘤扩展到其他晚期癌症[1]。目前临床应用的ICI主要包括细胞毒性T淋巴细胞相关蛋白4... 详细信息

免疫检查点抑制剂(immune checkpoint inhibitor,ICI)是一类用于癌症免疫治疗的新型药物,近年来其在晚期癌症患者中的应用越来越广泛,其适应证已从黑色素瘤扩展到其他晚期癌症[1]。目前临床应用的ICI主要包括细胞毒性T淋巴细胞相关蛋白4(cytotoxic T lymphocyte-associated antigen-4,CTLA-4)抑制剂、程序性死亡蛋白1(programmed death-1,PD-1)抑制剂和PD-1配体(programmed death-ligand 1,PD-L1)抑制剂三类。

关键词：免疫检查点抑制剂免疫不良反应甲状腺

An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

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Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng gu Haiyuan Li Baoming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN

Ultra-simplified diffraction-based computational spectrometer

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Light(Science & Applications) 2024年第6期13卷 1022-1031页

作者： Chuangchuang Chen Honggang gu Shiyuan Liu State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanHubei430074China Optics Valley Laboratory WuhanHubei430074China

Miniaturizing spectrometers for compact and cost-effective mobile platforms is a major challenge in current spectroscopy research,where conventional spectrometers are impractical due to their bulky *** miniaturized designs primarily rely on precalibrated response functions of nanophotonic structures to encode spectral information captured in a snapshot by detector *** spectrum reconstruction is achieved through computational techniques,but this requires precise component design,high-precision fabrication,and *** propose an ultra-simplified computational spectrometer that employs a one-to-broadband diffraction decomposition strategy facilitated by a numerical regularized transform that depends only on the spectrum of the diffracted *** key feature of our design is the use of a simple,arbitrarily shaped pinhole as the partial disperser,eliminating the need for complex encoding designs and full spectrum *** spectrometer achieves a reconstructed spectral peak location accuracy of better than 1 nm over a 200 nm bandwidth and excellent resolution for peaks separated by 3 nm in a bimodal spectrum,all within a compact footprint of under half an ***,our approach also reveals a breakthrough in broadband coherent diffractive imaging without requiring any prior knowledge of the broadband illumination spectrum,assumptions of non-dispersive specimens,or correction for detector quantum efficiency.

关键词： simplified spectrum illumination