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安罗替尼联合复方斑蝥胶囊治疗不耐受化疗的驱动基因阴性晚期NSCLC合并COPD的效果

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中国医学创新 2024年第2期21卷 45-48页

作者：李洁吴文峰陈卫琴曾中华刘云抚州市第一人民医院呼吸与危重症医学科江西抚州344000

目的:探讨安罗替尼联合复方斑蝥胶囊治疗不耐受化疗的驱动基因阴性晚期非小细胞肺癌(NSCLC)合并慢性阻塞性肺疾病(COPD)的效果。方法:选取2021年10月—2022年12月抚州市第一人民医院收治的48例不耐受化疗的驱动基因阴性晚期NSCLC合并COP... 详细信息

目的:探讨安罗替尼联合复方斑蝥胶囊治疗不耐受化疗的驱动基因阴性晚期非小细胞肺癌(NSCLC)合并慢性阻塞性肺疾病(COPD)的效果。方法:选取2021年10月—2022年12月抚州市第一人民医院收治的48例不耐受化疗的驱动基因阴性晚期NSCLC合并COPD患者,按随机数字表法分为试验组和对照组,每组24例。对照组采用复方斑蝥胶囊治疗,试验组在对照组的基础上采用安罗替尼治疗,两组均治疗2个疗程。比较两组近期疗效、细胞生长相关因子[血管内皮细胞生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)]、肿瘤标志物[鳞状细胞癌抗原(SCCA)、癌胚抗原(CEA)、细胞角蛋白19片段(Cyfra21-1)]、生活质量及不良反应发生情况。结果:试验组疾病控制率高于对照组,治疗后VEGF、MMP-9、SCCA、CEA、Cyfra21-1水平均低于对照组,生活质量优于对照组,差异均有统计学意义(P0.05)。结论:安罗替尼联合复方斑蝥胶囊治疗不耐受化疗驱动基因阴性晚期NSCLC合并COPD患者的安全性较高,且能降低肿瘤标志物水平,改善生活质量,增强治疗效果。

关键词：不耐受化疗驱动基因阴性非小细胞肺癌慢性阻塞性肺疾病安罗替尼复方斑蝥胶囊

基于儿童早期预警评分的分级干预模式促进重症肺炎患儿康复进程及对呼吸功能的影响

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广州医药 2024年第8期55卷 929-933页

作者：李翠娥孙岚郑秋芳陈伟琴王慧娉泉州市妇幼保健院(泉州市儿童医院)重症医学科福建泉州362000 泉州市妇幼保健院(泉州市儿童医院)呼吸科福建泉州362000

目的研究基于儿童早期预警评分(PEWS)的分级干预模式促进重症肺炎患儿康复进程及对呼吸功能的影响。方法回顾性分析2021年4月—2023年4月我院收治的100例重症肺炎患儿临床资料。将其按照干预方式的差异分为研究组(n=50)及对照组(n=50)... 详细信息

目的研究基于儿童早期预警评分(PEWS)的分级干预模式促进重症肺炎患儿康复进程及对呼吸功能的影响。方法回顾性分析2021年4月—2023年4月我院收治的100例重症肺炎患儿临床资料。将其按照干预方式的差异分为研究组(n=50)及对照组(n=50)。对照组选用常规干预,研究组则于对照组基础上增加基于PEWS的分级干预。对比两组康复进程(相关指标涵盖症状持续时长及住院天数)、呼吸功能(涵盖通气流速、每分钟最大通气量、肺活量、用力肺活量及深吸气量)、并发症发生情况(涵盖呼吸机相关性肺炎、肺大疱及胸膜炎)、患儿家属满意度。结果研究组各项症状持续时长及住院天数均短于对照组(均P0.05)。研究组患儿家属满意度高于对照组(96.00%vs 82.00%,P<0.05)。结论基于PEWS的分级干预模式促进重症肺炎患儿康复进程的效果较佳,且能改善呼吸功能,提高患儿家属满意度。

关键词：重症肺炎儿童早期预警评分分级干预模式康复进程呼吸功能

基于接纳承诺疗法的心理治疗模型对胰腺癌患者疼痛的影响

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健康研究 2024年第2期44卷 172-176页

作者：徐英萍董锐增陈伟琴盛华英郭安阳浙江省肿瘤医院肝胆胰胃外科浙江杭州310022 中国科学院杭州医学研究所浙江杭州310018

目的了解胰腺癌患者的疼痛、睡眠状况,探讨接纳承诺疗法对患者心理灵活性的影响,为改善患者生活质量提供思路。方法 62例胰腺癌患者随机分为对照组(30例)和观察组(32例),对照组接受常规肿瘤护理,观察组在对照组的基础上接受接纳承诺疗... 详细信息

目的了解胰腺癌患者的疼痛、睡眠状况,探讨接纳承诺疗法对患者心理灵活性的影响,为改善患者生活质量提供思路。方法 62例胰腺癌患者随机分为对照组(30例)和观察组(32例),对照组接受常规肿瘤护理,观察组在对照组的基础上接受接纳承诺疗法。分别采用疼痛数字评分表(NRS)、匹兹堡睡眠指数量表(PSQI)、接纳与行动问卷第二版(AAQ-Ⅱ)和认知融合问卷(CFQ)进行问卷调查,比较2组患者干预前后的疼痛、睡眠状况及心理灵活性。结果干预前,患者NRS、PSQI、AAQ-Ⅱ和CFQ评分分别为(2.3±0.7)分、(11.4±3.2)分、(20.2±7.8)分和(31.8±11.8)分,2组间差异无统计学意义(均P>0.05)。干预后,观察组各量表评分均低于干预前,且观察组低于对照组,差异有统计学意义(均P0.05)。胰腺癌患者的NRS评分与PSQI、AAQ-Ⅱ、CFQ评分显著正相关(r=0.790、0.925、0.898,P<0.05)。结论胰腺癌患者存在一定的疼痛和睡眠困扰,接纳承诺疗法可提高其心理灵活性,改善疼痛程度和睡眠质量。

关键词：胰腺癌接纳承诺疗法心理灵活性疼痛睡眠质量

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New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 670-687页

作者： Lei Liu Jia Wu Minxin Shi Fengying Wang Haimin Lu Jibing Liu weiqin chen Guanzhen Yu Dan Liu Jing Yang Qin Luo Yan Ni Xing Jin Xiaoxia Jin Wen-Lian chen Department of Thoracic Surgery The Affiliated Tumor Hospital of Nantong UniversityNantong 226361China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Epidemiology Tumor InstituteThe Affiliated Tumor Hospital of Nantong UniversityNantong 226361China Department of Clinical Laboratory Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China The Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310029China Department of Pathology The Affiliated Tumor Hospital of Nantong UniversityNantong 226361China

Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor *** several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic alterations and predictive biomarkers in sera have not been ***,we enrolled 34 treatment-naive patients with ESCC and collected their pre-and post-esophagectomy sera together with the sera from 34 healthy volunteers for a metabolomic *** comprehensive analysis identified ESCC tumor-associated metabolic alterations as represented by a panel of 12 serum ***,postoperative abrosia and parenteral nutrition substantially perturbed the serum ***,we performed an examination using sera from carcinogen-induced mice at the dysplasia and ESCC stages and identified three ESCC tumor-associated metabolites conserved between mice and ***,among these metabolites,the level of pipecolic acid was observed to be progressively increased in mouse sera from dysplasia to cancerization,and it could be used to accurately discriminate between mice at the dysplasia stage and healthy control ***,this metabolite is essential for ESCC cells to restrain oxidative stress-induced DNA damage and cell proliferation ***,this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse,presented evidence for refining parenteral nutrition composition,and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis.

关键词： Esophageal squamous cell carcinoma Serum metabolome Esophagectomy Predictive potential Pipecolic acid

Large-scale self-normalizing neural networks

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Journal of Automation and Intelligence 2024年第2期3卷 101-110页

作者： Zhaodong chen weiqin Zhao Lei Deng Yufei Ding Qinghao Wen Guoqi Li Yuan Xie University of California Santa BarbaraSanta Barbara93106CAUnited States University of Hong Kong Hong Kong999077China Tsinghua University Beijing100084China University of California San DiegoSan Diego92093CAUnited States University of Sydney Sydney2006Australia Institute of Automation Chinese Academy of ScienceBeijing100190China University of Chinese Academy of Science Beijing100190China The Hong Kong University of Science and Technology Hong Kong999077China

Self-normalizing neural networks(SNN)regulate the activation and gradient flows through activation functions with the self-normalization *** SNNs do not rely on norms computed from minibatches,they are more friendly to data parallelism,kernel fusion,and emerging architectures such as ReRAM-based ***,existing SNNs have mainly demonstrated their effectiveness on toy datasets and fall short in accuracy when dealing with large-scale tasks like *** lack the strong normalization,regularization,and expression power required for wider,deeper models and larger-scale *** enhance the normalization strength,this paper introduces a comprehensive and practical definition of the self-normalization property in terms of the stability and attractiveness of the statistical fixed *** is comprehensive as it jointly considers all the fixed points used by existing studies:the first and second moment of forward activation and the expected Frobenius norm of backward *** practicality comes from the analytical equations provided by our paper to assess the stability and attractiveness of each fixed point,which are derived from theoretical analysis of the forward and backward *** proposed definition is applied to a meta activation function inspired by prior research,leading to a stronger self-normalizing activation function named‘‘bi-scaled exponential linear unit with backward standardized’’(bSELU-BSTD).We provide both theoretical and empirical evidence to show that it is superior to existing *** enhance the regularization and expression power,we further propose scaled-Mixup and channel-wise scale&*** these three techniques,our approach achieves 75.23%top-1 accuracy on the ImageNet with Conv MobileNet V1,surpassing the performance of existing self-normalizing activation *** the best of our knowledge,this is the first SNN that achieves comparable accuracy to batch normalization on ImageNet.

关键词： Self-normalizing neural network Mean-field theory Block dynamical isometry Activation function

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四旋翼倾转飞行器操纵冗余设计

南京航空航天大学学报 2020年第2期52卷 255-263页

作者：杨洋陈维芹陈仁良南京航空航天大学直升机旋翼动力学国家级重点实验室南京210016

建立了四旋翼倾转飞行器旋翼、机翼、机身的非线性气动模型和飞行动力学模型,并在Matlab/Simulink环境下搭建了仿真模型,根据仿真模型计算各个操纵面的操纵效率,确定了不同状态下各个通道需要用到的操纵方式,结合飞行动力学模型和操纵方... 详细信息

建立了四旋翼倾转飞行器旋翼、机翼、机身的非线性气动模型和飞行动力学模型,并在Matlab/Simulink环境下搭建了仿真模型,根据仿真模型计算各个操纵面的操纵效率,确定了不同状态下各个通道需要用到的操纵方式,结合飞行动力学模型和操纵方式,在纵向通道上进行了全包线的配平计算,表明了操纵策略的可行性。

关键词：四旋翼倾转飞行动力学操纵策略配平计算

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极限上下限定律的对偶性和规划问题

上海交通大学学报 1989年第3期23卷 37-46页

作者：沈伟琴陈铁云上海交通大学工程力学系

提出用惩罚线性规划方法,求解受有集中载荷的梁、桁架和平面刚架的极限载荷.并采用逐步逼近与惩罚线性规划求解空间刚架及受有分布载荷的平面刚架的极限载荷.本文还提出了用二次齐次规划求解加筋圆柱薄壳加筋扁壳和加筋球壳受任意法向... 详细信息

提出用惩罚线性规划方法,求解受有集中载荷的梁、桁架和平面刚架的极限载荷.并采用逐步逼近与惩罚线性规划求解空间刚架及受有分布载荷的平面刚架的极限载荷.本文还提出了用二次齐次规划求解加筋圆柱薄壳加筋扁壳和加筋球壳受任意法向载荷时的极限问题.

关键词：极限塑性分析对偶性数值计算

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Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

Development and validation of a nomogram prediction model for the risk of parastomal hernia

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Intelligent Medicine 2024年第2期4卷 128-133页

作者： Huasheng Liu weiqin Wang chen Qin Hongxia Wang Wei Qi Yanhua Wei Longbo Zheng Jilin Hu Department of Gastroenterology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Qingdao Municipal Hospital Group QingdaoShandong 266300China Qingdao Center Medical Group QingdaoShandong 266042China

Background Parastomal hernia is one of the potential complications after *** is currently no early risk assessment tool for parastomal *** The current investigation was conducted using retrospective studies.A total of 302 cases were used develop and internally to validate a nomogram prediction model,and 67 cases were used for external *** risk factors for parastomal hernia after permanent sigmoid colostomy were assessed via univariate analysis and binary logistic regression *** nomogram prediction model was established based on independent risk *** Body mass index,serum albumin,age,sex,and stoma diameter were independent risk factors for parastomal *** areas under the receiver operating characteristic curves were 0.909 in the development group and 0.801 in the validation *** Hosmer-Lemeshow test(P>0.05)and calibration curves indicated good consistency between actual observations and predicted *** A nomogram prediction model was constructed and validated based on risk factors for parastomal *** nomogram could be generalized to patients undergoing surgery for stoma by specialized surgeons to provide relevant references for stoma patients.

关键词： Nomogram Parastomal hernia Risk factors