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Chinese Journal of Plastic and Reconstructive Surgery 2022年第4期4卷 171-177页

作者： Youbai Chen Tianqi Li Yujian Xu Jiahua Xing weiqian jiang Xiangye Yin Haizhong Zhang Meredith August Katherine P.Klein Tong Zhang Department of Plastic and Reconstructive Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Oral and Maxillofacial Surgery Massachusetts General HospitalBeijing 100853China Department of Stomatology The First Medical CenterChinese PLA General HospitalBostonMA 02114USA Harvard School of Dental Medicine BostonMA 02115USA

Background:Although oral health-related quality of life(OHRQoL)in orthodontic patients has been assessed in the past,to date,no study has compared the OHRQoL between two *** aimed to compare the OHRQoL between Chinese and American orthodontic ***:We conducted a two-center questionnaire-based cross-sectional study among patients who underwent orthodontic treatments at the Chinese PLA General Hospital(PLAGH)in Beijing,China and Massachusetts General Hospital(MGH)in Boston,Massachusetts,United *** variables included the participating center,patients’age,sex,Angle’s classification of malocclusion,evaluation stage,and appliances *** primary outcome was patients’OHRQoL assessed with the Oral Health Impact Profile-14(OHIP-14).Descriptive statistics,stratification,and univariate and multivariate analyses were ***:The average age was lower for PLAGH patients than for MGH patients(21.1±7.9 vs.33.1±14.6 years,P<0.001).The most common type of malocclusion was Angle’s Class III malocclusion at PLAGH(39%)and Class I malocclusion at MGH(59.5%).Clear aligners were used in 34.1%and 2.7%of the patients at MGH and PLAGH,***-14 scores were lower for PLAGH patients than for MGH patients(18.4±4.7 vs.22.3±7.4,P<0.001),particularly in functional limitation,psychological discomfort/disability,and *** regression analysis demonstrated that participating center,age,Class I malocclusion,and the use of clear aligners were significantly associated with overall OHIP-14 *** regression analysis demonstrated that patients at PLAGH were associated with lower OHIP-14 scores(coefficient:-3;95%CI:-5,-1.3;P=0.001),and age was positively associated with OHIP-14 scores(coefficient:0.1;95%CI:0.004,0.13;P=0.038).Conclusion:Chinese orthodontic patients had lower OHIP-14 scores,indicating a higher OHRQoL than American *** addition to the younger age,this difference may be attributed to the different ethical

关键词： Oral Health Impact Profile Orthodontic treatment Quality of life Chinese PLA General Hospital Massachusetts General Hospital

3D-printed models improve surgical planning for correction of severe postburn ankle contracture with an external fixator

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第10期22卷 866-875页

作者： Youbai CHEN Zehao NIU weiqian jiang Ran TAO Yonghong LEI Lingli GUO Kexue ZHANG Wensen XIA Baoqiang SONG Luyu HUANG Qixu ZHANG Yan HAN Department of Plastic and Reconstructive Surgery the First Medical CenterChinese PLA General HospitalBeijing 100853China Graduate School Medical School of Chinese PLABeijing 100853China Department of Pediatric Orthopedics the First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Plastic Surgery Xijing HospitalAir Force Medical UniversityXi’an 710038China Department of Orthopedics Xijing HospitalAir Force Medical UniversityXi’an 710038China Department of Plastic Surgery the University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA

Gradual distraction with an external fixator is a widely used treatment for severe postburn ankle contracture(SPAC).However,application of external fixators is complex,and conventional two-dimensional(2D)imaging-based surgical planning is not particularly helpful due to a lack of spatial *** purpose of this study was to evaluate the surgical planning process for this procedure with patient-specific three-dimension-printed models(3DPMs).In this study,patients coming from two centers were divided into two cohorts(3DPM group *** group)depending on whether a 3DPM was used for preoperative surgical *** duration,improvement in metatarsal-tibial angle(MTA),range of motion(ROM),the American Orthopedic Foot and Ankle Society(AOFAS)scores,complications,and patient-reported satisfaction were compared between two *** 3DPM group had significantly shorter operation duration than the control group((2.0±0.3)h vs.(3.2±0.3)h,P<0.01).MTA,ROM,and AOFAS scores between the two groups showed no significant differences pre-operation,after the removal of the external fixator,or at *** feet were achieved and gait was substantially improved in all patients at the final ***-tract infections occurred in two patients(one in each group)during distraction and were treated with wound care and oral *** in the 3DPM group reported higher satisfaction than those in the control group,owing to better patient-surgeon *** planning using patient-specific 3DPMs significantly reduced operation duration and increased patient satisfaction,while providing similar improvements in ankle movement and function compared to traditional surgical planning for the correction of SPAC with external fixators.

关键词： Ankle contracture Ilizarov Postburn contracture 3D printing Surgical planning

显微计算机断层扫描对体表恶性肿瘤成像的研究

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中华整形外科杂志 2020年第3期36卷 242-250页

作者：姜伟乾陈犹白陶然杨京润韩岩解放军总医院第一医学中心整形修复科北京100853 解放军总医院第一医学中心皮肤科北京100853

目的探讨术中应用显微计算机断层扫描(Micro-CT)对体表恶性肿瘤成像的参数设置和效果,总结体表软组织和肿瘤的Micro-CT影像特点。方法根据入选标准,收集2018年10月至2020年1月解放军总医院第一医学中心整形修复科收治的体表恶性肿瘤患... 详细信息

目的探讨术中应用显微计算机断层扫描(Micro-CT)对体表恶性肿瘤成像的参数设置和效果,总结体表软组织和肿瘤的Micro-CT影像特点。方法根据入选标准,收集2018年10月至2020年1月解放军总医院第一医学中心整形修复科收治的体表恶性肿瘤患者。通过手术切除肿瘤,将离体肿瘤标本分割成合适大小(长×宽×厚不超过5 cm×3 cm×3 cm),置于Micro-CT扫描床上,在不同参数下进行扫描。(1)采用不同时间扫描:保持扫描电压不变(肉瘤为50 kV、鳞状细胞癌及其他肿瘤为70 kV),对同一标本选择4 min和14 min分别进行扫描。(2)采用不同电压扫描:保持扫描时间不变(4 min),对同一标本选择30、50、70、90 kV 4种电压分别进行扫描。对比不同扫描时间及扫描电压下的成像效果,得出不同肿瘤的最佳扫描参数。(3)对影像学感兴趣区进行取材,制作病理学HE染色切片,并采用Precice全自动数字切片扫描系统扫描获得数字切片,与Micro-CT相应截面的影像图进行对比,记录不同组织的影像学特点。结果共纳入27例患者,其中男15例,女12例,年龄33~82岁,平均63.9岁,其中皮肤鳞状细胞癌16例、基底细胞癌2例、乳房外Paget病2例、黑色素瘤1例、隆突性皮肤纤维肉瘤3例、血管肉瘤1例、脂肪肉瘤2例,对比影像学和病理学标本共65组。(1)扫描时间:扫描4 min与14 min均能获得清晰的影像,并能满足观察肿瘤形态、判读肿瘤边界的要求。(2)扫描电压:对于鳞状细胞癌,电压为30、50 kV时成像不清晰,70、90 kV时成像效果较好,部分病例中的微小钙化点在90 kV时与肿瘤组织对比度不高;对于各种肉瘤,电压为30 kV时成像不清晰,50 kV时成像效果较好,70、90 kV时肿瘤与周围脂肪组织对比度不高。(3)Micro-CT影像图与病理切片对比结果显示,体表肿瘤及其周围正常软组织的影像学形态与病理学切片十分接近。正常皮肤与皮下组织分界清楚,毛囊清晰可辨。肿瘤组织的影像特点与肿瘤的种类、瘤细胞密集程度有关,主要表现为高密度影,体积较正常皮肤明显增厚,基底部相对平滑、无皮下脂肪伸入真皮内形成参差的低密度影,也无毛囊等正常的皮肤附属器影,偶尔可见散在的高密度钙化点。鳞状细胞癌、肉瘤与正常皮肤、皮下的边界可以分辨。对于局限于皮肤内的肿瘤,如基底细胞癌、乳房外Paget病等,成像效果不佳。结论Micro-CT扫描参数需要根据肿瘤性质进行选择,扫描时间对评估肿瘤影响不大,推荐术中扫描时长为4 min;鳞状细胞癌扫描电压推荐为70 kV,肉瘤为50 kV。Micro-CT对体表软组织标本皮肤结构成像清楚;对侵袭至皮下、与周围组织密度相差较大的肿瘤,形态可辨;对于生长范围不超过真皮的肿瘤,成像效果不佳。

关键词：显微计算机断层扫描肿瘤鳞状细胞癌隆突性皮肤纤维肉瘤病理学

西妥昔单抗对A-431细胞系增殖和凋亡的影响

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解放军医学院学报 2023年第9期44卷 1025-1029,1059页

作者：殷祥烨姜伟乾韩愚弟韩岩解放军医学院北京100853 解放军总医院第一医学中心整形修复科北京100853

背景皮肤鳞状细胞癌(cutaneous squamous cell carcinoma,cSCC)是临床上最常见的皮肤恶性肿瘤之一,cSCC死亡人数占所有皮肤癌死亡人数的20%。部分晚期cSCC患者无法通过手术得到有效治疗,而指南推荐这类患者采用分子靶向治疗、免疫治疗... 详细信息

背景皮肤鳞状细胞癌(cutaneous squamous cell carcinoma,cSCC)是临床上最常见的皮肤恶性肿瘤之一,cSCC死亡人数占所有皮肤癌死亡人数的20%。部分晚期cSCC患者无法通过手术得到有效治疗,而指南推荐这类患者采用分子靶向治疗、免疫治疗、化疗等全身系统性治疗的方式改善预后。目的研究西妥昔单抗对高表达表皮生长因子受体(epidermal growth factor receptor,EGFR)的皮肤鳞状细胞癌细胞系A-431增殖和凋亡的影响。方法于人类蛋白质图谱数据库中筛查并通过Western blot实验验证A-431细胞的EGFR表达情况。将A-431细胞随机分为对照组和西妥昔单抗治疗组(200μg/mL),通过细胞增殖抑制实验(MTT法)检测西妥昔单抗对体外培养的A-431细胞增殖和毒性的影响,应用流式细胞术检测西妥昔单抗对A-431细胞凋亡的影响。结果在人类蛋白质图谱数据库中对照了收录的41种正常组织及肿瘤细胞系,其中A-431细胞EGFR表达量最高。在Western blot实验中我们发现,与人永生化表皮细胞HaCat相比,A-431细胞中EGFR确为高表达状态。MTT实验表明,在200μg/mL浓度下,西妥昔单抗对A-431细胞表现出了较强的抑制增殖作用,可使约61.35%肿瘤细胞死亡(P<0.01)。流式细胞术显示,西妥昔单抗在150μg/mL浓度时,细胞凋亡率达到29.85%,而对照组的细胞凋亡率仅10.44%(P<0.01)。结论西妥昔单抗对于高表达EGFR的皮肤鳞状细胞癌细胞A-431具有良好的肿瘤细胞杀伤能力,并可以促进肿瘤细胞的凋亡,为临床中无法接受手术治疗的皮肤鳞状细胞癌患者提供了一种治疗策略。

关键词：皮肤鳞状细胞癌表皮生长因子受体西妥昔单抗细胞增殖凋亡

皮肤鳞状细胞癌小鼠模型建立与应用的研究进展

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解放军医学院学报 2023年第1期44卷 86-91页

作者：姜伟乾陶然许育健张聚磊韩岩解放军医学院北京100853 解放军总医院第一医学中心整形修复科北京100853

皮肤鳞状细胞癌(简称皮肤鳞癌)是常见的恶性肿瘤之一,建立相应的动物模型在发病机制研究、药物检测、临床前研究等方面具有重要作用。本文从皮肤鳞癌小鼠模型种类、建模方法、优缺点和应用领域等方面进行总结,以期为临床工作和科研探索... 详细信息

皮肤鳞状细胞癌(简称皮肤鳞癌)是常见的恶性肿瘤之一,建立相应的动物模型在发病机制研究、药物检测、临床前研究等方面具有重要作用。本文从皮肤鳞癌小鼠模型种类、建模方法、优缺点和应用领域等方面进行总结,以期为临床工作和科研探索提供参考。

关键词：皮肤鳞癌小鼠模型细胞系移植成瘤模型诱导成瘤模型基因工程成瘤模型人源性肿瘤移植成瘤模型

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确定皮肤恶性肿瘤边界方法的研究进展

解放军医学院学报 2019年第12期40卷 1192-1195页

作者：姜伟乾陶然韩岩解放军总医院第一医学中心整形修复科北京100853

皮肤恶性肿瘤的首选治疗方式是手术切除,精准确定边界对于彻底切除肿瘤、保护健康组织具有重要意义。本文综述了目前常用的判断皮肤恶性肿瘤边界的方法,包括外科医生视触判断、术前术中病理学检测、莫氏手术、影像学检查等,也对反射共... 详细信息

皮肤恶性肿瘤的首选治疗方式是手术切除,精准确定边界对于彻底切除肿瘤、保护健康组织具有重要意义。本文综述了目前常用的判断皮肤恶性肿瘤边界的方法,包括外科医生视触判断、术前术中病理学检测、莫氏手术、影像学检查等,也对反射共聚焦显微镜、光学相干层析成像、近红外荧光成像等处于试验探索中的新方法进行了归纳总结。

关键词：皮肤恶性肿瘤肿瘤边界手术范围

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors

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Science China Mathematics 2025年第1期68卷 1-18页

作者： Masataka Iwai Chen jiang Haidong Liu Department of Mathematics Graduate School of ScienceOsaka University Shanghai Center for Mathematical Sciences & School of Mathematical Sciences Fudan University Department of mathematics Sun Yat-sen University

In this paper,we study Miyaoka-type inequalities on Chern classes of terminal projective 3-folds with nef anti-canonical *** X be a terminal projective 3-fold such that-KXis *** show that if c1（X） · c2（X）≠0,then c1（X） · c2（X） ≥ 1/252;if further X is not rationally connected,then c1（X） · c2（X） ≥ 4/5 and this inequality is *** order to prove this,we give a partial classification of such varieties along with many *** also study the nonvanishing of c1（X）dim X-2· c2（X） for terminal weak Fano varieties and prove a Miyaoka-Kawamata-type inequality.

关键词： terminal threefolds Miyaoka-type inequality boundedness

Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

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Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan Chen Yuan jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system