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Modulation of starch digestibility using non-thermal processing techniques:A review

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Grain & Oil Science and Technology 2024年第3期7卷 209-218页

作者： Liyuan Rong weiqi Fei Zhijun Wang Xianxiang Chen Huiliang Wen Jianhua Xie Mingyue Shen State Key Laboratory of Food Science and Resources Nanchang UniversityNanchang 330047China School of Biosystems and Food Engineering University College DublinDublinIreland

Obesity and type 2 diabetes are widespread throughout the world, especially in developed countries. Starch is an important part of human staple food, the modulating of starch digestibility is conducive to reducing postprandial blood glucose levels and alleviating the chronic disease caused by high caloric intake. The digestion properties of starch are correlated with its structural features, including crystallization, amylose/amylopectin ratio, non-starch components, etc. Among the modified methods applied to regulate starch digestibility, non-thermal processing techniques(NTPT) receive extensive attention due to the characteristics of safety, environmental friendliness and high efficiency. The influence and mechanism of NTPT on the digestion properties of starch are discussed in this review, including ultrasounds, high pressure, γ-irradiation, etc. NTPT induces the alternation of morphological and structural characteristics of native starch, changing their sensitivity to enzymes. The effects of NTPT on the digestibility of starch are highly related to the processing parameters and structure characteristics of native starch. The review shows that NTPT is an effective way to modulate the digestion properties of starch and prevent people from suffering from chronic diseases such as obesity and type 2 diabetes.

关键词： Digestibility Non-thermal processing Chronic disease Starch

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液压互联ISD悬架系统模式切换研究

机械工程学报 2017年第6期53卷 110-115页

作者：汪若尘叶青孙泽宇周卫琪陈龙江苏大学汽车与交通工程学院镇江212013

为实现液压互联ISD悬架全局工况最优,提出一种基于模糊控制的液压互联ISD悬架系统模式切换控制策略。研究液压互联ISD悬架系统工作原理,仿真对比液压互联ISD悬架两种工作模式力学特性,确定模式切换参数,并设计悬架工作模式识别以及模式... 详细信息

为实现液压互联ISD悬架全局工况最优,提出一种基于模糊控制的液压互联ISD悬架系统模式切换控制策略。研究液压互联ISD悬架系统工作原理,仿真对比液压互联ISD悬架两种工作模式力学特性,确定模式切换参数,并设计悬架工作模式识别以及模式切换控制策略,针对液压互联ISD悬架工作模式构建液压互联ISD悬架模糊控制器,并进行整车仿真分析,仿真结果与预期基本一致。在此基础上设计液压互联ISD悬架样机,进行台架试验,验证了所提出的液压互联ISD悬架系统模型的正确性以及模糊切换控制方法的有效性。

关键词：液压互联 ISD悬架系统模糊切换控制模式识别实车试验

A Study on Artistic Treatment in Vocal Works

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Journal of Social Science Development Research

Journal of Social Science Development Research 2024年第1期2卷 25-35页

作者： weiqi Pu Geely University of China ChengduChina.

The singing of a vocal work is far more than a simple series of notes,but a delicate artistic process that requires the performer to skillfully use sound,emotion,and *** process is not just about performing music,but also about transmitting emotions,a spiritual dialogue resonating with the *** the wonderful stage of artistic treatment,the performer becomes the second creator of the song,infusing the work with new life through their unique personality and insightful *** the clever concatenation of notes,the performer can unfold the layers of emotion contained within the song,making it richer and deeper.

关键词： Vocal music works Artistic treatment Singing skill

MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer

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Research 2024年第2期2023卷 239-257页

作者： Cui Wang Kuan Yang Xiaoqian Liu Si Wang Moshi Song Juan Carlos Izpisua Belimonte Jing Qu Guang-Hui Liu weiqi Zhang CAS Key Laboratory of Genomic and Precision Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Bejing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ ***,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also regulates human stem cell *** answer this question,we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell *** found that human mesenchymal stem cells(hMSCs)were sensitive to MAVS deficiency,as manifested by accelerated senescence *** uncovered that the role of MAVS in maintaining mitochondrial structural integrity and functional homeostasis depends on its interaction with the guanosine triphosphatase optic atrophy type 1(OPA1).Depletion of MAVS or OPA1 led to the dysfunction of mitochondria and cellular senescence,whereas replenishment of MAVS or OPA1 in MAVS-knockout hMSCs alleviated mitochondrial defects and premature senescence *** together,our data underscore an uncanonical role of MAVS in safeguarding mitochondrial homeostasis and antagonizing human stem cell senescence.

关键词： CRISPR/Cas9 homeostasis Mitochondrial

Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms

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Food Science and Human Wellness 2024年

作者： Jinhai Luo weiqi Yan Zhi Chen Baojun Xu Guangdong Provincial Key Laboratory IRADS and Department of Life Sciences， BNU-HKBU United International College Centre for Cancer and Inflammation Research， School of Chinese Medicine， Hong Kong Baptist University Faculty of Biochemistry and Molecular Medicine， University of Oulu

Obesity has become a significant global public health issue. Previous studies have found that the Chenpi has the anti-obesity activity. However， the anti-obesity phytochemicals and their mechanisms are still unclear. This study investigated the anti-obesity phytochemicals and molecular mechanisms involved in treating obesity by Chenpi through network pharmacology and molecular docking. Seventeen bioactive phytochemicals from Chenpi and its 475 related anti-obesity targets have been identified. The KEGG pathway analysis showed that the PI3K/Akt signaling pathway， MAPK signaling pathway， AMPK signaling pathway， and NF-kappa B signaling pathway are the main signaling pathways involved in the anti-obesity effect of Chenpi. According to molecular docking analysis， the phytochemicals of Chenpi can bind to central anti-obesity targets. Based on the ADMET analysis and network pharmacology results， tangeretin exhibited the lowest predicted toxicity and the highest potential for anti-obesity effects. In the in vitro lipid accumulation model， tangeretin effectively suppressed the FFA-induced lipid in HepG2 cells by upregulating the PI3K/Akt/GSK3β signaling pathway based on the result of q-PCR and Western Blotting. The outcomes of this research give insights for future research on the anti-obesity phytochemicals and molecular mechanisms derived from Chenpi， also providing the theoretical basis for developing anti-obesity functional foods based on Chenpi.

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Parallel Physics-Informed Neural Networks Method with Regularization Strategies for the Forward-Inverse Problems of the Variable Coefficient Modified KdV Equation

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Journal of Systems Science & Complexity 2024年第2期37卷 511-544页

作者： zhou Huijuan School of Science Shanghai Maritime UniversityShanghai 201306China

This paper mainly introduces the parallel physics-informed neural networks(PPINNs)method with regularization strategies to solve the data-driven forward-inverse problems of the variable coefficient modified Korteweg-de Vries(VC-MKdV)*** the forward problem of the VC-MKdV equation,the authors use the traditional PINN method to obtain satisfactory data-driven soliton solutions and provide a detailed analysis of the impact of network width and depth on solving accuracy and ***,the author finds that the traditional PINN method outperforms the one with locally adaptive activation functions in solving the data-driven forward problems of the VC-MKdV *** for the data-driven inverse problem of the VC-MKdV equation,the author introduces a parallel neural networks to separately train the solution function and coefficient function,successfully addressing the function discovery problem of the VC-MKdV *** further enhance the network’s generalization ability and noise robustness,the author incorporates two regularization strategies into the *** amount of numerical experimental data in this paper demonstrates that the PPINNs method can effectively address the function discovery problem of the VC-MKdV equation,and the inclusion of appropriate regularization strategies in the PPINNs can improves its performance.

关键词： Data-driven forward-inverse problems parallel physics-informed neural networks regularization strategies variable coefficient modified KdV equation

区域景观格局视角的绿地生态网络优化研究——以徐州为例

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中国农业资源与区划 2020年第1期41卷 259-268页

作者：汤姚楠王佳周伟奇中国科学院生态环境研究中心/城市与区域生态国家重点实验室中国城市建设研究院有限公司

[目的]基于景观格局演变的区域绿地生态网络与生态功能优化研究是景观生态学研究的热点领域之一。[方法]文章以徐州示范为例,在城市研究区景观格局演变及其异质性研究分析基础上,探索城市规划区城乡绿地景观格局的优化路径;运用经济学... 详细信息

[目的]基于景观格局演变的区域绿地生态网络与生态功能优化研究是景观生态学研究的热点领域之一。[方法]文章以徐州示范为例,在城市研究区景观格局演变及其异质性研究分析基础上,探索城市规划区城乡绿地景观格局的优化路径;运用经济学与生态学原理,按"山水林田湖草"一体化理念,以区域生态系统服务优化及人与自然和谐发展为前提,从市域与城市规划区视角,合理配置城乡绿地生态网络景观组分,进而优化区域绿地生态网络。[结果]研究得出2005—2015年研究范围城市化造成大量耕地消失,城市建设用地快速增加,随着生态园林建设的快速推进,林地面积占比大幅度增加;地表覆被变化直接表现为景观格局的快速破碎化和景观多样性的下降,景观类型的丰富度和复杂度急需提高,景观多样性指数、景观均匀度指数也均呈现较为明显的下降趋势。同时,重点提出了强化景观格局与过程的完整性与连通性,挖掘潜在生态功能等的区域绿地生态网络一系列优化方案。[结论]文章为研究区及延伸的城乡区域绿地生态网络构建和生态系统服务优化提供了科学的依据、方法与途径。

关键词：生态网络优化生态功能完整性与连通性景观格局城乡区域视角

Influence of stearic acid surface modification on flowability and agglomeration of battery grade Li_(2)CO_(3)powder

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Particuology 2024年第9期92卷 263-277页

作者： Ming zhou Lithium Industry Center Zhejiang New Era Zhongneng Technology Co.Ltd.Shaoxing312000China

This work investigates the flow and agglomeration behaviors of battery grade Li_(2)CO_(3)powder and the influence of stearic acid surface *** degree of agglomeration is directly related to the uniformity of Li_(2)CO_(3)and its powder *** to the Chinese National Nonferrous Metal Industry Standard,battery grade Li_(2)CO_(3)powder has D50 equal to 3–8μm which belongs to a micron-sized superfine ***,with the extension of storage time,the serious agglomeration phenomenon occurs due to the large specific surface area and rough and irregular powder *** Hausner ratio(HR)of the unmodified sample increases from 1.14 to 1.41,and the corresponding flowability is classified as good to ***,among samples with doping stearic acid,the optimum amount of it is 0.10 wt%which exhibits an extremely stable HR value from 1.14 to ***,after 156 days,the repose angle(AR)obtained for samples without surface modification and using 0.10 wt%stearic acid are calculated to be 49°and 28°,*** on the values of HR and AR,the flowability of the unmodified sample is poor while the sample modified with 0.10 wt%of stearic acid still maintain excellent powder flow ***,The LiMn_(2)O_(4)cathode material synthesized from modified Li_(2)CO_(3)powder with a stearic acid content of 0.10 wt%exhibits good crystallinity and comparable electrochemical performance to that prepared by commercial Li_(2)CO_(3).These results indicate that stearic acid has the potential to be an ideal modifier for battery grade Li_(2)CO_(3)powder that needs to be kept for a long time.

关键词： Battery grade Li_(2)CO_(3)powder Flowability Surface modification Stearic acid

Carbene-Catalyzed Asymmetric Ring-Opening Reaction of Biaryl Lactams to Access Axially Chiral Biaryls

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Chinese Journal of Chemistry 2024年第15期42卷 1734-1740页

作者： Guanjie Wang Guowei Yuan Chenlong Wei Ye Zhang Haibin Zhu weiqi Yang Dongping Shi Xiaoxiang Zhang Zhenqian Fu Institute of Advanced Materials Nanjing Tech UniversityNanjingJiangsu 211816China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjingJiangsu 210037China

Axially chiral biaryls represent the most important class of atropisomers,and they widely exist in natural products and biologically active *** also constitute a unique scaffold for chiral ligands and catalysts in organic *** development of synthetic methods to obtain such chiral compounds has received widespread attention,among which catalytically atroposelective ring-opening of configurationally labile compounds represents one of the most attractive *** substrates with strained cyclic structures,such as the renowned Bringmann's lactones,can undergo asymmetric transformation into stable *** advancement primarily relies on metal catalyst combined with well-designed chiral ligands,the approaches utilizing organocatalysis as a critical resolution strategy are notably *** this study,we disclosed a N-heterocyclic carbene(NHC)-catalyzed asymmetric ring-opening reaction of biaryl lactams via direct atroposelective nucleophilic *** optimized bulky carbene catalyst ensures that the reaction can proceed under mild conditions,affording the desired product with good to excellent yields and atroposelectivity.

关键词： N-Heterocyclic carbene Axially chiral biaryls Organocatalysis Ring-opening reactions Dibenzo cyclic lactams Axially chiral amino acids Amide C-N bond activation Atropisomerism Asymmetric catalysis Lactams