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Science China(Life Sciences) 2017年第5期60卷 528-535页

作者： weiqi rong Lei Yang Liyuan Yin Yanning Gao Ting Xiao Shujun Cheng State Key Laboratory of Molecular Oncology Beijing Key Laboratory for Carcinogenesis and Cancer Prevention National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China Department of Abdominal Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China

Hepatocellular carcinoma(HCC) is a common malignant solid tumor characterized by rich vascularization. Pregnancy-specific glycoprotein 9(PSG9) is a member of the carcinoembryonic antigen(CEA)/PSG family and is produced at high levels during pregnancy. We previously identified PSG9 as an HCC-related protein. However, the expression of PSG9 and its regulation during HCC carcinogenesis remain poorly explored. In the present study, we first found that the levels of PSG9 protein were significantly increased in the plasma of HCC patients. PSG9 overexpression also increased the proliferation ability of an HCC cell line. High expression of PSG9 was associated with angiogenesis by accelerating VEGFA expression. In addition, Cox's proportional hazards model analysis revealed that the plasma level of PSG9 was an independent prognostic factor for overall survival. We propose that PSG9 is a novel indicator of prognosis in patients with HCC and could serve as a novel therapeutic target for HCC. Furthermore,our results indicate that PSG9 protein may facilitate the development of HCC by fostering angiogenesis via promoting VEGFA production in cancer cells.

关键词： hepatocellular carcinoma (HCC) PSG9 VEGFA angiogenesis

Surgical outcomes of hand-assisted laparoscopic liver resection vs. open liver resection: A retrospective propensity scorematched cohort study

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Chinese Journal of Cancer Research 2019年第5期31卷 818-824页

作者： Shengtao Lin Fan Wu Liming Wang Yunhe Liu Yiling Zheng Tana Siqin weiqi rong Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective: Hand-assisted laparoscopic liver resection has the advantages of open and laparoscopic *** is still lack of comparison of surgical outcomes between hand-assistied laparoscopic liver resection(HALLR)and open liver resection(OLR). This study compared the surgical outcomes of the two approaches between wellmatched patient ***: Patients who received liver resection during January 2014 and October 2017 in Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College were included in this retrospective study. Propensity score matching(PSM) was performed to reduce selection bias between the two groups. Operation and short-term surgical outcomes were compared between the well matched ***: During this period, 232 patients with a median age of 55.1 years old received OLR, while 49 patients with a median age of 54.7 years old received HALLR. Compared with HALLR group, OLR group has a higher proportion in male patients(190/232, 81.9% vs. 34/49, 69.4%, P=0.048) and lower albumin(43.2±4.5 vs. 44.8±3.7,P=0.020). After PSM, 49 patients from each group were included in the following analysis. Two groups were well balanced in their baseline characteristics, liver functions, preoperative treatments, abdominal surgery history, and surgical difficulty. None perioperative mortality was observed in both groups. Operation time and postoperative complications were similar in two groups(P=0.935, P=0.056). The HALLR group showed less bleeding amount(177.8±217.1 mL vs. 283.1±225.0 mL, P=0.003) and shorter postoperative stay period(6.9±2.2 d vs. 9.0±3.5 d,P=0.001).Conclusions: We demonstrated that hand-assisted laparoscopic surgery is feasible and safe for liver resection,including some difficult cases. HALLR can provide better bleeding control and faster recovery after surgery.

关键词： Surgical outcomes hand-assisted laparoscopic surgery liver resection

Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular carcinoma

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Frontiers of Medicine 2019年第2期13卷 250-258页

作者： weiqi rong Yang Zhang Lei Yang Lin Feng Baojun Wei Fan Wu Liming Wang Yanning Gao Shujun Cheng Jianxiong Wu Ting Xiao Department of Abdominal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Clinical Laboratory National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Biomarkers for hepatocellular carcinoma (HCC) following curative resection are not currently sufficient for prognostic indication of overall survival (OS) and disease-free survival (DFS). The aim of this study was to investigate the prognostic performance of osteopontin (OPN), matrix metalloproteinase 7 (MMP7), and pregnancy specific glycoprotein 9 (PSG9) in patients with HCC. A total of 179 prospective patients with HCC provided plasma before hepatectomy. Plasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay. Correlations between plasma levels, clinical parameters, and outcomes (OS and DFS) were overall analyzed. High OPN (≥149.97 ng/mL), MMP7 (≥2.28 ng/mL), and PSG9 (≥45.59 ng/mL) were prognostic indicators of reduced OS (P<0.001, P<0.001, and P=0.007, respectively). Plasma PSG9 protein level was an independent factor in predicting OS (P=0.008) and DFS (P=0.038). Plasma OPN+MMP7+PSG9 elevation in combination was a prognostic factor for OS (P<0.001). OPN was demonstrated to be a risk factor-associated OS in stage I patients with HCC and patients with low α-fetoprotein levels (<20 ng/mL). These findings suggested that OPN, MMP7, PSG9 and their combined panels may be useful for aiding in tumor recurrence and mortality risk prediction of patients with HCC, particularly in the early stage of HCC carcinogenesis.

关键词： biomarkers OPN MMP7 PSG9 HCC prognosis

Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence

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Chinese Journal of Cancer Research 2020年第5期32卷 645-653页

作者： weiqi rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90095USA Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing 102206China Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of Peritoneal Cancer Surgery Beijing Shijitan HospitalCapital Medical University BeijingBeijing 100038China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant ***:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control ***'outcome,adverse events,long-term recurrence and survival rates were ***:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin ***-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC.

关键词： Three-dimensional conformal radiotherapy recurrence long-term survival narrow-margin hepatectomy real-world evidence

Serum metabolic effects of corn oligopeptides with 7-day supplementation on early post-surgery primary liver cancer patients: a double-blind randomized controlled trial

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 834-847页

作者： weiqi rong Hui Xia Kai Zhang Yihan Zhang Changcheng Tao Fan Wu Liming Wang Hong Zhang Guiju Sun Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)BeijingChina Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjingChina Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjinChina

Background:Liver cancer as the main leading cancer has caused heavy burdens *** prognosis of liver cancer is closely related with postoperative nutrition *** oligopeptides(COPs)are protein hydrolysates produced by enzymatic treatments,which have shown potential bioactivities,such as inhibiting angiotensin I-converting enzyme,resisting lipid peroxidation and ***,the correlation between COPs and liver cancer patients is still unknown and the potential mechanism of COPs on liver cancer is unclear as *** aim of this study was to assess effects of 7-day intervention of COPs after surgery on liver function and serum metabolic profiles of liver cancer ***:Patients were assigned into COPs intervention group(n=50)and control group(n=91)for 7 *** were scheduled at 1st day and 7th day after liver resection surgery respectively,mainly including anthropometric,biochemical indexes and liquid chromatography-mass spectrometry(LC/MS)***:Seven-day supplementation of COPs on early post-surgery liver cancer patients down-regulated levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin and up-regulated prothrombin time activity and prealbumin ***/MS analysis revealed metabolic signatures including regulation of 16 metabolites,which was closely related with two metabolic pathways(nicotinate and nicotinamide metabolism,fatty acid metabolism).Conclusions:COPs supplementation has displayed the potentials on alleviating the injury of liver function and it may be due to regulation of fatty acid metabolism,nicotinate and nicotinamide metabolism,lipid peroxidation and anti-inflammatory *** researches are warranted in future to confirm the exact mechanisms.

关键词： Liver cancer corn oligopeptides supplementation metabolomics randomized controlled trial

The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 515-529,I0004页

作者： Liming Wang Yunhe Liu weiqi rong Fan Wu Weibo Yu Kan Liu Shengtao Lin Yiling Zheng Kai Zhang Tana Siqin Changcheng Tao Mei Liu Bo Chen Qinfu Feng Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Head and Neck Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCAUSA Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Surgical Oncology Fujian Provincial Hospital/Shengli Clinical Medical College of Fujian Medical UniversityFuzhouChina Laboratory of Cell and Molecular Biology&State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Postoperative radiotherapy (RT) is known to play an important role in the treatment of hepatocellular carcinomas (HCCs), but the specific role of intraoperative electron radiotherapy (IOERT) in HCCs remains unclear. The aim of this study was to investigate the safety and efficacy of IOERT in centrally located HCCs treated with narrow-margin (<1 cm) hepatectomy. Methods: This was a single-center, phase 2, prospective non-randomized controlled study, including 268 patients with centrally located HCCs who underwent narrow-margin hepatectomy. The patients were subsequently allocated to the IOERT group (n=59) or to the control group (n=65). The primary outcome of the study was to compare recurrence-free survival (RFS) between the IOERT group and the control group, and the secondary outcome was to compare overall survival (OS) rate between the two groups. Results: Of 268 patients enrolled, a total of 124 were included in the study: 59 in IOERT group, 65 in control group. The 1-, 2-, 3-year RFS rates were 79.3%, 62.1% and 45.8% for patients in the IOERT group, and 47.6%, 28.6%, and 22.9% for patients in the control group, respectively (P=0.025). The 1-, 2-, and 3-year OS rates were 100.0%, 94.9%, and 83.7% for patients in the IOERT group, and 92.3%, 87.5%, and 79.4% for patients in the control group, respectively (P=0.314). Subgroup analysis of MVI (+) patients revealed that RFS and OS are significantly prolonged in the IOERT subgroup as compared to the control, whereas there was no significant difference of RFS and OS between the two groups in MVI (−) patients. Conclusions: IOERT for centrally located HCCs with concurrent narrow-margin hepatectomy was feasible and safe. Statistically better RFS rate was observed in the IOERT group compared to the control group. Subgroup analysis revealed that IOERT was more beneficial for postoperative survival of HCC patients with MVI. Trial Registration: ChiCTR-TRC-12002802;***/ictrp.

关键词： Hepatocellular carcinoma(HCC) intraoperative electron radiotherapy(IOERT) microvascular invasion(MVI) relapse survival overall survival(OS)

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肝癌肝切除术后肝再生的研究进展

中华肝胆外科杂志 2023年第1期29卷 66-71页

作者：武安可荣维淇吴健雄中国医学科学院北京协和医学院肿瘤医院肝胆外科北京100021

肝脏是具有极强再生潜能的器官,当受到创伤、感染、手术等影响后,会启动一系列调控进行有序再生,以迅速恢复肝功能和肝体积,维持正常生理机能。本文概述了肝癌肝切除术后肝再生的发生过程,并总结了肝再生的评估方法和影响肝再生的因素,... 详细信息

肝脏是具有极强再生潜能的器官,当受到创伤、感染、手术等影响后,会启动一系列调控进行有序再生,以迅速恢复肝功能和肝体积,维持正常生理机能。本文概述了肝癌肝切除术后肝再生的发生过程,并总结了肝再生的评估方法和影响肝再生的因素,为临床开展精准肝外科治疗提供参考和借鉴。

关键词：肝肿瘤肝切除术肝再生

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肝淋巴上皮瘤样癌的研究进展

中华肿瘤杂志 2020年第12期42卷 996-1000页

作者：陶常诚张凯荣维淇吴健雄国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肝胆外科100021

肝淋巴上皮瘤样癌(LELC)是一种罕见的肝癌亚型,具有独特的流行病学、病理学特征,特点是大量的淋巴细胞浸润,可分为淋巴上皮瘤样肝细胞癌(LEL-HCC)和淋巴上皮瘤样肝内胆管细胞癌(LEL-CC),其诊断主要依靠病理学方法,治疗以手术为主。肝LEL... 详细信息

肝淋巴上皮瘤样癌(LELC)是一种罕见的肝癌亚型,具有独特的流行病学、病理学特征,特点是大量的淋巴细胞浸润,可分为淋巴上皮瘤样肝细胞癌(LEL-HCC)和淋巴上皮瘤样肝内胆管细胞癌(LEL-CC),其诊断主要依靠病理学方法,治疗以手术为主。肝LELC预后良好,可能与大量淋巴细胞浸润有关。关于LELC的资料非常有限,仅有少量的病例报道和小型回顾性研究,还需要进一步深入研究。截至目前,已有67例LEL-HCC和34例LEL-CC在文献中报道。文章总结了肝LELC的流行病学、临床治疗、病理学特点以及研究前景。

关键词：肝肿瘤淋巴上皮瘤样癌研究进展

Short-term effects of modified ultrasonography in laparoscopic anatomical hepatectomy for hepatocellular carcinoma

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iLIVER 2024年第3期3卷 7-15页

作者： Xun Wang Xuan Meng Liming Wang Peng Wang Zhihao Wang weiqi rong Zhiyu Lu Hongguang Wang Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background and aims:Laparoscopic hepatectomy is challenging,and ultrasound guidance is an effective aid but lacks *** study aimed to evaluate a modified approach for laparoscopic ultrasonography to enhance surgical ***:Between January 2020 and August 2023,122 patients who underwent real-time ultrasound-guided laparoscopic anatomical hepatectomy for hepatocellular carcinoma were enrolled and divided into modified and traditional ultrasonography *** modified ultrasound application comprised intraoperative protocol-based laparoscopic ultrasonography comprising application scenarios;standardized positions for the surgeon,trocar,and probe;and the resulting standardized sections for various laparoscopic liver *** characteristics and perioperative outcomes were compared between the two *** analysis was performed and comprised techniques for modified duct structure identification and portal vein branch puncture;both techniques were used in fluorescence probe-mounted laparoscopic liver resection using negative and positive staining procedures,***:The traditional and modified groups comprised 64 and 58 patients,*** patients’background characteristics were not significantly different between the *** duration(283.4 min vs.225.1 min;p<0.001),Pringle maneuver duration(47.4 min vs.39.5 min;p?0.014),bleeding volume(258.6 mL vs.174.8 mL;p?0.005),overall complication rate(31.3%vs.15.5%;p?0.041),and postoperative stay were significantly greater in the traditional *** ultrasonography groups,*** modified method positively affected the number of punctures,success rate of staining,intraoperative bleeding volume,and operation ***:Modified ultrasonography improves the safety and effectiveness of laparoscopic *** is pivotal,especially in fluorescence probe-assisted laparoscopic liver resection.

关键词： Laparoscopic ultrasound Anatomical hepatectomy Hepatocellular carcinoma Modified ultrasound guidance

肝细胞癌根治术后早期复发及其时间点的研究进展

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肿瘤防治研究 2022年第4期49卷 359-363页

作者：陶常诚张凯荣维淇吴健雄国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肝胆外科北京100021 天津医科大学肿瘤医院介入治疗科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心天津300060

肝细胞癌是我国常见的恶性肿瘤之一,外科手术是目前治疗肝细胞癌最主要的方法,但手术后的高复发率是影响其预后的重要原因,也是目前亟待解决的关键临床问题。按照复发时间,可分为早期复发及远期复发。早期复发患者的预后较远期复发差,... 详细信息

肝细胞癌是我国常见的恶性肿瘤之一,外科手术是目前治疗肝细胞癌最主要的方法,但手术后的高复发率是影响其预后的重要原因,也是目前亟待解决的关键临床问题。按照复发时间,可分为早期复发及远期复发。早期复发患者的预后较远期复发差,因此两种复发的鉴别对于外科决策来说至关重要,本文就肝细胞癌根治术后早期复发时间点的研究进展进行综述。

关键词：肝细胞癌早期复发远期复发复发时间