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Graphdiyne oxide substrate-enhanced peroxidase-mimicking performance of Ru nanoparticles with physiological pH preference

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Nano Research 2024年第3期17卷 1123-1131页

作者： Cong Xu Wenjie Ma Haozhi Wang Leihou Shao weiqi li Ping Yu Lanqun Mao Beijing National Laboratory for Molecular Science Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China College of Chemistry Beijing Normal UniversityBeijing 100875China

Modulating electronic structure of metal nanoparticles via metal–support interaction has attracted intense interest in the field of catalytic ***,the roles of supporting substrates in regulating catalytic properties of nanozymes remain *** this study,we find that the use of graphdiyne oxide(GDYO)as the substrate for self-terminating growth of Ru nanoparticles(Ru@GDYO)endows the peroxidase-like activity of Ru nanoparticles with intrinsic physiological pH preference and natural horseradish peroxidase(HRP)comparable *** nanoparticles electrolessly deposited onto GDYO possess a partially oxidized electronic structure owing to limited charge transfer between Ru and GDYO,contributing to the intrinsic physiological pH preference of the peroxidase-mimicking *** importantly,the substrate GDYO plays an influential factor in enhancing catalytic activity,that is,the activity of Ru@GDYO is much higher than that of Ru nanoparticles deposited on other carbon substrates including graphene oxides and *** demonstrate the application of Ru@GDYO nanozyme in neutral solutions,we employ Ru@GDYO with nicotinamide adenine dinucleotide(NAD+)-dependent dehydrogenases in physiological conditions to realize a sustainable cascade reaction by means of forming continuous NAD^(+)/dihydronicotiamide adenine dinucleotide(NADH)*** finding represents a promising perspective on designing high-performance peroxidase-mimicking nanozymes with broader applicability,raising fundamental understanding of structure–activity relationship,and investigating new applications of nanozymes in biological systems.

关键词： nanozyme graphdiyne reactive oxygen species electroless deposition metal–support interaction

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Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： weiqi li Chunting Wu Xinyu Zhou Xinhui Huang Chunmei Zhang Yongjie Ma Jinqiu Hu Xiaoyan Bi Junyu Ma Mengyao li Dong Lu liang Hu Jiahua Fan Fuli Ya Department of Nutrition， School of Public Health， Dali University Department of Laboratory Teaching Center， School of Public Health， Dali University Department of Health Management， Gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine School of Integrative Medicine， Shanghai University of Traditional Chinese Medicine School of Public Health， Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases， Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOX2 signaling. Thus， through modulating the cAMP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

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基于碳敏感性通用矩阵模型的燃煤机组碳排放强度扰动分析

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中国科学：技术科学 2024年第5期54卷 803-819页

作者：冉鹏王静李政樊钦洋高大明李伟起华北电力大学能源动力与机械工程学院保定071003 华北电力大学河北省低碳高效发电技术重点实验室保定071003 清华大学能源与动力工程系北京100084 清华四川能源互联网研究院城市与区域低碳转型研究所成都610200 天府永兴实验室成都610213

为从运行角度分析及评价燃煤机组碳排放强度,在矩阵分析法基础上,提出了碳敏感性通用矩阵模型,确定了其矩阵填写规则.采用常规热平衡法和等效焓降法验证了碳敏感性通用矩阵模型的准确性;利用碳敏感性通用矩阵模型分析了锅炉侧,汽轮机侧... 详细信息

为从运行角度分析及评价燃煤机组碳排放强度,在矩阵分析法基础上,提出了碳敏感性通用矩阵模型,确定了其矩阵填写规则.采用常规热平衡法和等效焓降法验证了碳敏感性通用矩阵模型的准确性;利用碳敏感性通用矩阵模型分析了锅炉侧,汽轮机侧以及发电机侧可控运行参数在不同波动强度下的碳敏感性;定义了碳敏感性变化率,比较了可控运行参数与碳敏感性间的关系;定义了碳敏感性因子,比较了不同量纲可控参数在相同比例波动下的碳敏感性.结果表明:排烟温度、排烟氧量、排渣温度、飞灰含碳量、主蒸汽温度、再热蒸汽压力、再热蒸汽温度、厂用电率等可控运行参数与碳敏感性指标近似呈线性关系,主蒸汽压力、给水温度以及末级高加上端差与碳敏感性指标呈非线性关系;主蒸汽温度、再热蒸汽温度、给水温度、主蒸汽压力、厂用电率、排烟氧量以及排烟温度的碳敏感因子较大,其数值分别为:1.463, 0.5071, 0.3345, 0.2221, 0.08623, 0.08579, 0.07506.机组运行人员可以重点监控和调节碳敏感因子较大的可控运行参数,降低电厂的碳排放量,从而助力实现碳减排的目标.

关键词：碳敏感性通用矩阵模型碳排放强度可控运行参数碳敏感因子燃煤机组

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激光熔化沉积Al-Mg-Sc-Zr合金单熔道成形质量预测

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中国有色金属学报 2024年第4期34卷 1010-1021页

作者：肖罡李伟奇谢莉路超刘筱朱必武杨钦文湖南科技大学机电工程学院湘潭411201 江西铜业技术研究院有限公司南昌330096 湖南大学机械与运载工程学院长沙410082 广东海洋大学材料科学与工程学院阳江529559

本研究探讨了激光熔化沉积(LMD)工艺参数对Al-Mg-Sc-Zr合金单熔道成形质量的影响,并采用BP神经网络模型和改进的PSO-BP神经网络模型预测了不同工艺参数下的成形孔隙率。结果表明:Al-Mg-Sc-Zr合金的LMD单熔道成形孔隙率,随着激光线能量... 详细信息

本研究探讨了激光熔化沉积(LMD)工艺参数对Al-Mg-Sc-Zr合金单熔道成形质量的影响,并采用BP神经网络模型和改进的PSO-BP神经网络模型预测了不同工艺参数下的成形孔隙率。结果表明:Al-Mg-Sc-Zr合金的LMD单熔道成形孔隙率,随着激光线能量密度的增加呈现先上升后下降再上升的趋势,在175 J/mm^(2)时孔隙率达到最小值,仅为1.38%。在相同的送粉工艺参数下,LMD成形熔道宽度和熔道深度均与激光功率呈现出正相关性,而熔道高度和熔道深度均与扫描速率呈现出负相关性。相较于BP神经网络模型,改进的PSO-BP神经网络模型的平均绝对误差降低了29.69%,平均相对误差降低了19.42%,均方误差降低了19.02%,相关系数提升了63.44%。

关键词：激光熔化沉积 Al-Mg-Sc-Zr合金熔池质量孔隙率神经网络

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火电机组碳排放量及碳敏感性通用矩阵模型

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动力工程学报 2024年第6期44卷 947-955页

作者：冉鹏王静李政刘旭曾庆华李伟起华北电力大学能源动力与机械工程学院河北保定071003 华北电力大学河北省低碳高效发电技术重点实验室河北保定071003 清华大学能源与动力工程系北京100084 国网湖南省电力有限公司电力科学研究院长沙410023 天府永兴实验室成都610213

为实现火电机组碳排放量的简便准确计量及掌握运行因素对机组碳排放强度的影响,在排放因子法技术上,参考传统q-γ-τ矩阵结构形式,根据求解火电机组碳排放量的需要,并掌握运行参数对发电碳排放强度的影响,建立了火电机组碳排放量及碳敏... 详细信息

为实现火电机组碳排放量的简便准确计量及掌握运行因素对机组碳排放强度的影响,在排放因子法技术上,参考传统q-γ-τ矩阵结构形式,根据求解火电机组碳排放量的需要,并掌握运行参数对发电碳排放强度的影响,建立了火电机组碳排放量及碳敏感性通用矩阵模型,确定了矩阵填写规则。采用热平衡法结合物料衡算法验证了模型的准确性,并与排放因子法核算结果对比;核算了某火电机组24 h的碳排放量,分析了排烟氧量、主蒸汽温度和压力波动时的发电碳排放强度的扰动量ΔM CO_(2)。结果表明:相较于排放因子法,本文所提模型缩短了碳排放量核算的时间跨度,且能提高碳排放量核算的精度;该机组24 h的碳排放量为5780.644 t;当排烟氧量降低0.1%时,ΔM CO_(2)为1.7726 g/(kW·h);当主蒸汽温度升高0.5 K时,ΔM CO_(2)为3.0206 g/(kW·h);当主蒸汽压力增加0.2 MPa时,ΔM CO_(2)为0.3788 g/(kW·h)。

关键词：碳排放量碳敏感性通用矩阵发电碳排放强度碳排放计量方法火电机组

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基于权参数优化的并行深度学习光伏功率预测

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动力工程学报 2024年第1期44卷 91-98页

作者：董坤冉鹏刘旭樊钦洋李政曾庆华李伟起华北电力大学能源动力与机械工程学院河北保定071003 华北电力大学河北省低碳高效发电技术重点实验室河北保定071003 清华大学能源与动力工程系北京100084 国网湖南省电力有限公司电力科学研究院长沙410007 天府永兴实验室成都610213

针对不同应用场景下光伏数据波动模式差异较大时,现有的光伏发电功率预测模型存在精度及适应性不足的问题,提出了一种具有权参数自适应性的并行深度学习光伏发电功率预测框架。该框架包含2种可以并行预测的深度学习算法单元(Attention-S... 详细信息

针对不同应用场景下光伏数据波动模式差异较大时,现有的光伏发电功率预测模型存在精度及适应性不足的问题,提出了一种具有权参数自适应性的并行深度学习光伏发电功率预测框架。该框架包含2种可以并行预测的深度学习算法单元(Attention-Seq2Seq单元、Transformer单元)以及一个权参数自适应优化单元。基于所提出的并行深度学习框架,对光伏发电功率进行预测,并分别与Attention-Seq2Seq、Transformer模型的预测结果进行了对比验证。结果表明:基于权参数优化的并行深度学习光伏功率预测框架弥补了不同数据波动模式下单一算法预测精度和适应性不足的问题,也可以有效解决时间序列预测中的长距离依赖问题,较单一算法预测精度更高,其平均绝对误差和均方根误差在夏季典型日最大降幅分别是41.18%和45.59%,在冬季典型日最大降幅分别是81.13%和82.86%。

关键词：光伏发电功率预测权参数优化并行深度学习框架量子粒子群

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Phospholipase D antagonist 1-butanol inhibited the mobilization of triacylglycerol during seed germination in Arabidopsis

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Plant Diversity 2018年第6期40卷 292-298页

作者： Yanxia Jia weiqi li Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences

Storage oil breakdown plays an important role in the life cycle of many plants by providing the carbon skeletons that support seedling growth immediately following germination. 1-Butanol, a specific inhibitor of phospholipase D(PLD)-dependent production of the signalling molecule phosphatidic acid(PA), inhibited Arabidopsis seed germination. N-Acylethanolamines(NAEs), which have been shown to inhibits PLDa1 activity, have no effect on seed germination. However, mobilization profile of triacylglycerols(TAG) that induced by each compound has not been reported. To gain deeper insights into the mode of mobilization of TAG during NAE 12:0 or 1-butanol treatment, we conducted a detailed comparative analysis of the effect of NAE 12:0, DMSO, 1-butanol and tert-butanol on Arabidopsis seed germination and fatty acid composition, tert-butanol and DMSO served as the corresponding controls treatment respectively. Our data show that 1-butanol, but not the inactive tert-butanol isomer, inhibited Arabidopsis seed germination, which is accompanied by a with retardation of the mobilization of triacylglycerols(TAG). In contrast, NAE 12:0 did not affect mobilization of TAG, nor did it significantly delay seed germination as monitored by radicle and cotyledon emergence. 1-Butanol induced RNA degradation in seeds and seedlings. We speculate that the large-scale degradation of RNA under the induction of 1-butanol may lead to abnormal gene expression in genes necessary for seed germination, including the genes needed for the mobilization of oil bodies, and thus cause a delay of seed germination. To the best of our knowledge, we report for the first time that 1-butanol delays the mobilization of TAG.

关键词： Germination 1-butanol N-Acylethanolamines Triacylglycerols Fatty acid

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韧性发展视角下省域低碳经济绩效评估与区域网络治理影响

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经济地理 2024年第6期44卷 42-51页

作者：兰泽英陈晓晖刘洋吴辉何文标李玮麒广东工业大学管理学院广东广州510520 广州市城市规划勘测设计研究院有限公司广东广州510060 乌鲁木齐市土地储备中心(乌鲁木齐市土地整理中心) 新疆乌鲁木齐830002

文章引入韧性发展理念,从经济、社会与生态3个维度的脱钩性能开展2011—2020年中国省域低碳经济绩效评估,并结合绩效网络模型探讨区域能级匹配与治理影响差异,为韧性网络优化治理与绩效提升提供适宜性路径选择。研究发现:(1)在中国经济... 详细信息

文章引入韧性发展理念,从经济、社会与生态3个维度的脱钩性能开展2011—2020年中国省域低碳经济绩效评估,并结合绩效网络模型探讨区域能级匹配与治理影响差异,为韧性网络优化治理与绩效提升提供适宜性路径选择。研究发现:(1)在中国经济低碳转型过程中各维度上呈现不均衡发展状态,大部分省域过于追求经济维度的低碳韧性发展,而忽略了社会与生态发展层面。(2)大多数省域在低碳经济绩效网络中的空间关联紧密度仍远远不够,尤其是社会与生态维度,并且区域网络具有较明显的地理邻近性特征。(3)到研究期末,结合省域分类发展规划,发现64%以上省域所处辐射能级能够表现出与之较高的匹配度。其中,提升型省域普遍具有集群优势,东部沿海区域的省域需加强社会维度的协同发展;壮大型中的华中地区省域有望成为区域内的新增长极;培育型中的西南地区省域可考虑作为区域优先发展省域。

关键词：低碳经济韧性发展绩效评估区域网络格局辐射能级空间治理影响

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Flavonoid scutellarin positively regulates root length through NUTCRACKER

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Plant Diversity 2021年第3期43卷 248-254页

作者： Xing Huang weiqi li Xudong Zhang Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming650201China University of the Chinese Academy of Sciences Beijing100049China

Exploring approaches to regulate meristem is of special importance and broad *** this study,we found that the flavonoid scutellarin,which has a 6-hydroxyl and a 7-glucoside,increased root length through the transcription factor NUTCRACKER(NUC).This root lengthening disappeared in NUCknockout and reappeared in NUC-rescue *** induced NUC expression and promoted the division of cortex/endodermal *** contrast,naringenin,which has same chemical backbone but without 6-hydroxyl and with 7-hydroxyl group,showed the opposite or no *** results demonstrate that scutellarin promotes root length through NUC-mediated regulatory pathways and reveal that flavonoids with and without the 6-hydroxyl and 7-glucoside have positive and negative effects on meristem size,respectively。

关键词： Root length Meristem size Flavonoid Scutellarin Naringenin NUTCRACKER

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Characterisation of manganese toxicity tolerance in Arabis paniculata

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Plant Diversity 2021年第2期43卷 163-172页

作者： Ting Tang Faqing Tao weiqi li School of life Sciences Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated UtilizationKey Laboratory of Ecological Remediation and Safe Utilization of Heavy Metal-Polluted SoilsHunan University of Science and TechnologyXiangtan411201China Plant Germplasm and Genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunming650201China

Manganese(Mn)contamination limits the production and quality of crops,and affects human health by disrupting the food *** paniculata is a pioneer species of Brassicaceae found in mining areas,and has the ability to accumulate heavy ***,little is known about the genetic mechanisms of Mn tolerance in *** this study,we found that Mn tolerance and ability to accumulate Mn were higher in *** than in Arabidopsis *** mechanisms underlying the response and recovery of *** to Mn toxicity were further investigated using transcriptome analysis.A total of 69,862,281 base pair clean reads were assembled into 61,627 high-quality unigenes,of which 41,591(67.5%)and 39,297(63.8%)were aligned in the Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO),*** response to Mn toxicity,genes were expressed in twelve distinct patterns,which can be divided into four general categories:initial,stable,dose-dependent,and *** that were differentially expressed during Mn response and recovery belong to several dominant KEGG *** early response to Mn toxicity in *** includes the upregulation of genes involved in glutathione ***-binding cassette(ABC)transporter proteins were up-regulated during the entire response phase,and genes involved in glycerophospholipid metabolism were upregulated during the late phase of the Mn *** in the phenylpropanoid pathway were differentially expressed in the repair process after Mn *** findings reveal ideal material and genetic resources for phytoremediation in Mn-contaminated areas and highlight new knowledge and theoretical perspectives on the mechanisms of Mn tolerance.

关键词： Arabis paniculata Manganese toxicity Transcriptome Gene expression

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