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高等体育院校助力新时代体育文化建设的思考

成都体育学院学报 2018年第5期44卷 1-6页

作者：舒为平李杨刘合智成都体育学院四川成都610041

重视"文化建设"是新时代体育领域服从文化强国建设的必然举措,"体育文化建设"是新时代我国体育强国建设题中应有之义,当下我国体育文化建设的重要性与紧迫性日益凸显。服务、服从于体育文化建设是高等体育院校的使命和优势所在,着眼于... 详细信息

重视"文化建设"是新时代体育领域服从文化强国建设的必然举措,"体育文化建设"是新时代我国体育强国建设题中应有之义,当下我国体育文化建设的重要性与紧迫性日益凸显。服务、服从于体育文化建设是高等体育院校的使命和优势所在,着眼于新时代我国体育文化建设,高等体育院校应在"人才培养""科学研究""传承传播"等方面有所创新与发展。

关键词：高等体育院校新时代体育文化建设

Prediction of fracture initiation in cohesive soils based on data mining modelling and large-scale laboratory verification

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Underground Space 2024年第6期19卷 279-300页

作者： weiping Luo Dajun Yuan Yannick Choy Hing Ng Dalong Jin Ping Lu Teng Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of the Ministry of Education for Urban Underground Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Civil and Environmental Engineering National University of SingaporeSingapore 119077Singapore

Many empirical and analytical methods have been proposed to predict fracturing pressure in cohesive *** of them take into account three to four specific influencing factors and rely on the assumption of a failure *** this study,a novel data-mining approach based on the XGBoost algorithm is investigated for predicting fracture initiation in cohesive *** has the advantage of handling multiple influencing factors simultaneously,without pre-determining a failure mode.A dataset of 416 samples consisting of 14 distinct features was herein collected from past studies,and used for developing a regressor and a classifier model for fracturing pressure prediction and failure mode classification *** results show that the intrinsic characteristics of the soil govern the failure mode while the fracturing pressure is more sensitive to the stress *** XGBoost-based model was also tested against conventional approaches,as well as a similar machine learning algorithm namely random forest ***,several large-scale triaxial fracturing tests and an in-situ case study were carried out to further verify the generalization ability and applicability of the proposed data mining approach,and the results indicate a superior performance of the XGBoost model.

关键词： Fracturing pressure Failure mode Cohesive soil Data-mining Large-scale tests

Mechanism of nanoparticle aggregation in gas-liquid microfluidic mixing

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Chinese Chemical Letters 2024年第4期35卷 376-381页

作者： Hongxia Li Xiyang Wang Du Qiao Jiahao Li weiping Zhu Honglin Li Key Laboratory for Precision&Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116023China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China

Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been shown to be affected by the shear effect, the shear effect triggering conditions in gasliquid two-phase flow is unclear and the aggregation behavior of nanoparticles under the shear effect is difficult to predict, resulting in uncontrollable physical and chemical properties of nanoparticle aggregates. In this study, a numerical simulation of nanoparticle aggregation in gas-liquid two-phase flow under the shear effect is performed using the CFD-DEM method. Then, the effects of total flow rate,gas-liquid two-phase flow ratio, and particle volume fraction on particle aggregation were analyzed to achieve control of particle aggregation shape and size. Meanwhile, the triggering mechanism of the shear effect and the mechanism of the shear effect on the aggregation of nanoparticles were clarified. The results show that increasing the total flow rate or decreasing the gas-liquid two-phase flow rate ratio can induce the shear effect, which reduces the particle aggregation size and makes the morphology tend to be spherical. Moreover, increasing the particle volume fraction, and total flow rate or decreasing the gas-liquid two-phase flow rate ratio also increases the number of particle collisions and induce interparticle adhesion. Hence, particle adhesion and the shear effect compete with each other and together affect particle aggregation.

关键词： Microfluidic Gas-liquid segmented micromixer Nanoparticle aggregation Shear effect Numerical calculation

Ce6 nanoassemblies:Molecular mechanism and strategies for combinational anticancer therapy Special Collection:Aggregation-Induced Processes and Functions

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Aggregate

Aggregate 2024年第1期5卷 130-147页

作者： Yuwei Liu shuting Xu Qingyang Lyu Yi Huang weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Laboratory of Molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina

Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient *** therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety ***,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor *** overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic *** review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional *** self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.

关键词： cancer treatment carrier-free chlorin e6(Ce6) light nanomedicine photodynamic therapy(PDT) selfassembly

《体育之研究》融入体育课程思政的具身认知、价值意蕴及实践向度

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西安体育学院学报 2022年第5期39卷 618-624页

作者：张晓林关清文舒为平成都体育学院研究生院成都610041 四川师范大学体育学院成都610101 四川师范大学西部校园足球发展研究中心成都610101

运用具身认知理论对《体育之研究》一文所蕴含的具身认知内容和特征进行分析,并阐释其课程思政价值。《体育之研究》中主要体现出具身认知的意向性、具身性、情境性等特征,具有培养学生规则观、科学观、健康观、审美观、奋斗观和创新观... 详细信息

运用具身认知理论对《体育之研究》一文所蕴含的具身认知内容和特征进行分析,并阐释其课程思政价值。《体育之研究》中主要体现出具身认知的意向性、具身性、情境性等特征,具有培养学生规则观、科学观、健康观、审美观、奋斗观和创新观的体育课程思政价值意蕴,在学校体育教学实践中应从立“德”树人、启“智”慧人、健“体”强人、审“美”化人和助“劳”勤人的五位一体全面发展理念落实体育的具身育人价值。

关键词：《体育之研究》体育课程思政具身认知价值意蕴实践向度

联合国教科文组织优质体育教育政策的演进历程、特征及启示

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成都体育学院学报 2023年第4期49卷 97-105页

作者：张晓林关清文舒为平成都体育学院四川成都610041 四川师范大学体育学院四川成都610101

人权和健康问题在全球愈演愈烈,优质体育教育(quality physical education,QPE)政策肩负着推动包容性高质量体育教育发展的使命。自1978年起,QPE政策发展历经“起步萌芽期(1978—2000年)”“内容探索期(2000—2015年)”和“蓬勃发展期(2... 详细信息

人权和健康问题在全球愈演愈烈,优质体育教育(quality physical education,QPE)政策肩负着推动包容性高质量体育教育发展的使命。自1978年起,QPE政策发展历经“起步萌芽期(1978—2000年)”“内容探索期(2000—2015年)”和“蓬勃发展期(2015—至今)”,凸显出政策制定的科学性、落地的精准性、发展的渐进性和政策之间的耦合性等周期特征,体现出“主线”“双轮”“三维”和“四体”等内容特征。QPE政策的启示:从政策层面上,要坚持政策科学制定与精准落实、推进政策渐进发展与耦合互联;在内容层面上,实现优质体育教育从“全球共识”到“全面落地”;推动体育教育目的从“基本健康”到“终身发展”;激发体育教育参与从“单一主体”到“多方协作”。

关键词：联合国教科文组织优质体育教育学校体育政策 QPE 政策研究

Mechanical properties of steel mesh in anchor-mesh support for rocky tunnels

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Journal of Mountain Science 2024年第10期21卷 3487-3502页

作者： SUN Keguo JIA Jinglong XU weiping ZHANG Yu WANG Jinjin WANG Yichao LIU Yongkui Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSchool of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Intelligent Geotechnics and Tunnelling Chengdu 610031China Chengdu Rail Transit Group Co. Ltd.Chengdu 610036China China Railway 14th Bureau Group 2nd Engineering Corporation Limited China Railway Construction Corporation LimitedTaian 271000China

Underground geotechnical engineering encounters persistent challenges in ensuring the stability and safety of surrounding rock structures, particularly within rocky tunnels. Rock reinforcement techniques, including the use of steel mesh, are critical to achieving this goal. However, there exists a knowledge gap regarding the comprehensive understanding of the mechanical behavior and failure mechanisms exhibited by steel mesh under diverse loading conditions. This study thoroughly explored the steel mesh's performance throughout the entire loading-failure process, innovating with detailed analysis and modeling techniques. By integrating advanced numerical modeling with laboratory experiments, the study examines the influence of varying reinforcement levels and geometric parameters on the steel mesh strength and deformation characteristics. Sensitivity analysis, employing gray correlation theory, identifies the key factors affecting the mesh performance, while a BP (Backpropagation) neural network model predicts maximum vertical deformation with high accuracy. The findings underscore the critical role of steel diameter and mesh spacing in optimizing peak load capacity, displacement, and energy absorption, offering practical guidelines for design improvements. The use of a Bayesian Regularization (BR) algorithm further enhances the predictive accuracy compared to traditional methods. This research provides new insights into optimizing steel mesh design for underground applications, offering an innovative approach to enhancing structural safety in geotechnical projects.

关键词： Tunnel Steel mesh BP neural network Anchor-mesh support Rock reinforcement technique

Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

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Journal of Environmental Sciences 2024年第3期137卷 53-64页

作者： Chao Shen Xiaoyan Ding Jinpeng Ruan Fengkai Ruan weiping Hu Jiyi Huang Chengyong He Yi Yu Zhenghong Zuo Department of Nephrology State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesFujian Clinical Research Center for Chronic Glomerular DiseaseThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

As an ultrasmall derivative of black phosphorus(BP)sheets,BP quantum dots(BP-QDs)have been effectively used in many ***,information on the cardiotoxicity induced by BP-QDs remains *** aimed to evaluate BP-QD-induced cardiac toxicity in *** examination of heart tissue sections was *** sequencing,real-time quantitative PCR(RT–qPCR),western blotting,and enzyme-linked immunosorbent assay(ELISA)assays were used to detect the m RNA and/or protein expression of proinfammatory cytokines,nuclear factor kappa B(NF-κB),phosphatidylinositol3 kinase-protein kinase B(PI3K-AKT),peroxisome proliferator-activated receptor gamma(PPARγ),and glucose/lipid metabolism pathway-related *** found that heart weight and heart/body weight index(HBI)were significantly reduced in mice after intragastric administration of 0.1 or 1 mg/kg BP-QDs for 28 *** addition,obvious infammatory cell infiltration and increased cardiomyocyte diameter were observed in the BP-QD-treated *** expression of proinfammatory cytokines and genes related to the NF-κB signaling pathway further confirmed that BP-QD exposure induced infammatory *** addition,BP-QD treatment also affected the PI3K-AKT,PPARγ,thermogenesis,oxidative phosphorylation,and cardiac muscle contraction signaling *** expression of genes related to glucose/lipid metabolism signaling pathways was dramatically affected by BP-QD exposure,and the effect was primarily mediated by the PPAR signaling *** study provides new insights into the toxicity of BP-QDs to human health.

关键词： BP-QDs Cardiac toxicity Infammatory responses NF-κB signaling pathway PPARγsignaling pathway Glucose/lipid metabolism

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen Liu Hui Jin Yan Chen Derong Wang Haohui Yan Mingzhao Wu Fang Zhao weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm