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蛋白组学在干眼研究中的应用进展

国际眼科杂志 2024年第4期24卷 585-588页

作者：杨颖张嘉之姬慧杰高卫萍南京中医药大学附属医院眼科江苏省南京市210029

干眼的病理机制复杂,涉及免疫、炎症等多种通路,需要整体研究方案从全局进行把控。各类组学技术可以从整体和全局的高度阐明生物体复杂的生理病理状态,提供更加全面的生物信息。质谱技术可以灵敏检测出泪液样本中的蛋白含量变化,为干眼... 详细信息

干眼的病理机制复杂,涉及免疫、炎症等多种通路,需要整体研究方案从全局进行把控。各类组学技术可以从整体和全局的高度阐明生物体复杂的生理病理状态,提供更加全面的生物信息。质谱技术可以灵敏检测出泪液样本中的蛋白含量变化,为干眼的蛋白组学研究提供了便捷条件。目前蛋白组学在干眼类型鉴别、严重程度分级、疗效评价等方面都显示出应用价值,并且与代谢组学、微生物组学联用可以更加全面地阐释干眼发病机制。未来蛋白组学有望为干眼的精准诊疗提供更加有力的支持,并在靶向治疗中发挥优势。

关键词：系统生物学蛋白组学干眼生物标记物

Research perspectives for catalytic valorization of biomass

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Journal of Energy Chemistry 2023年第3期78卷 102-104,I0004页

作者： weiping Deng Ye Wang state Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005FujianChina

Efficient utilization of biomass for the supply of energy and synthetic materials would mitigate the heavy reliance on fossil resources and the growing CO_(2) emission, thus contributing to establishing sustainable and carbon–neutral societies. Much effort has been devoted to catalytic transformations of lignocellulosic biomass, the most abundant and nonedible form of biomass.

关键词： Biomass Lignocellulose fractionation CAO/CAC bond cleavage Thermo-/photo-/electro-catalysis Renewable chemicals and materials

A tightly coupled rotational SINS/CNS integrated navigation method for aircraft

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Journal of Systems Engineering and Electronics 2019年第4期30卷 770-782页

作者： NING Xiaolin YUAN weiping LIU Yanhong School of Instrument and Optoelectronic Engineering Beihang University

Strapdown inertial navigation system(SINS)/celestial navigation system(CNS)integrated navigation is widely used to achieve long-time and high-precision autonomous navigation for *** general,SINS/CNS integrated navigation can be divided into two integrated modes:loosely coupled integrated navigation and tightly coupled integrated *** the loosely coupled SINS/CNS integrated system is only available in the condition of at least three stars,the latter one is becoming a research *** major challenge of SINS/CNS integrated navigation is obtaining a high-precision horizon *** solve this problem,an innovative tightly coupled rotational SINS/CNS integrated navigation method is *** this method,the rotational SINS error equation in the navigation frame is used as the state model,and the starlight vector and star altitude are used as ***-physical simulations are conducted to test the performance of this integrated *** show that this tightly coupled rotational SINS/CNS method has the best navigation accuracy compared with SINS,rotational SINS,and traditional tightly coupled SINS/CNS integrated navigation method.

关键词： celestial navigation system(CNS) rotation modulation technology rotational strapdown inertial navigation system(SINS) rotational SINS/CNS integrated navigation

An Enhanced Attribute Co-evolutionary Game Reduction Algorithm by Integrating Self-adaptive Multi-level Nash Equilibrium

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Chinese Journal of Electronics 2016年第1期25卷 13-19页

作者： DING weiping GUAN Zhijin SHI Quan School of Computer Science and Technology Nantong University state Key Laboratory for Novel Software Technology Nanjing University

In order to further analyze the dynamical behavior of co-evolutionary populations in minimum attribute reduction, an Enhanced attribute co-evolutionary game reduction(EACGR) algorithm by integrating selfadaptive multi-level Nash equilibrium is proposed in this paper. First, a self-adaptive multi-level Nash game model with cross co-evolution is designed to provide the better solution for the dynamical symmetric co-evolution of multi-populations. Second, the profit matrix of elitist energy is constructed to explore the payoff mechanism of coevolutionary selection. And then a novel Nash equilibrium strategy is adopted to perform attribute co-evolutionary game reduction so that the admissible balance of attribute reduction can be well achieved. Experimental results indicate that EACGR has the higher performance of minimum attribute reduction, and the application into 3D brain MRI segmentation with promising results indicates its stronger robustness and practicability.

关键词： Cross co-evolutionary game Profit matrix of elitist energy Multi-level Nash equilibrium Minimum attribute reduction

基于微根管图像的作物根系分割和表型信息提取

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农业工程学报 2024年第18期40卷 110-119页

作者：郑一力张振翔邢达刘卫平北京林业大学工学院北京100083 林业装备与自动化国家林业和草原局重点实验室北京100083 林木资源高效生产全国重点实验室北京100083

微根管法采集的作物根系图像具有复杂的土壤背景和较小的根系占比,当深度学习的感受野较小或多尺度特征融合不充分时,会导致根系边缘处的像素被错分为土壤。同时,微根管法的图像采集周期长且在初期很难采集到大量有效样本,限制了根系提... 详细信息

微根管法采集的作物根系图像具有复杂的土壤背景和较小的根系占比,当深度学习的感受野较小或多尺度特征融合不充分时,会导致根系边缘处的像素被错分为土壤。同时,微根管法的图像采集周期长且在初期很难采集到大量有效样本,限制了根系提取模型的快速部署。为提升根系表型测算精度和优化提取模型部署策略,该研究设计了一种原位自动根系成像系统以实时获取作物的微根管图像,构建全尺度跳跃特征融合机制,使用感受野丰富的U^(2)-Net模型对微根管图像中的根系像素进行有效分类。结合数据增强以及迁移学习微调训练,实现对目标种类根系提取模型的快速部署。试验结果表明,使用加入全尺度跳跃特征融合机制的改进U^(2)-Net模型对蒜苗根系分割的F1得分和交并比IoU分别为86.54%和76.28%,相比改进前、U-Net、SegNet和DeeplabV3+_Resnet50模型,F1得分分别提高0.66、5.51、8.67和2.84个百分点;交并比分别提高1.02、8.18、12.52和4.31个百分点。迁移学习微调训练相比混合训练,模型的F1得分和交并比分别提高了2.89和4.45个百分点。改进U^(2)-Net模型分割图像的根系长度、面积和平均直径与手动标注结果的决定系数R^(2)分别为0.965、0.966、0.830。研究结果可为提升基于微根管图像的根系表型测算精度和根系提取模型的快速部署提供参考。

关键词：图像分割迁移学习微根管 U2-Net 蒜苗根系表型

基于非完美CSI的星空协作网络安全波束成形算法

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指挥与控制学报 2024年第2期10卷 177-183页

作者：王子宁谈苗苗林志程铭朱卫平南京邮电大学通信与信息工程学院南京210003 国防科技大学电子对抗学院合肥230037 康考迪亚大学电子与计算机学院蒙特利尔QC H3G 1M8

针对无人机作为中继的星空协作网络,提出了一种基于非完美信道状态信息的安全波束成形算法。建立以安全速率最大化和发射功率最小化为目标函数的多目标优化问题。考虑到窃听者和非网内用户的完美信道状态信息难以获得,提出一种结合加权... 详细信息

针对无人机作为中继的星空协作网络,提出了一种基于非完美信道状态信息的安全波束成形算法。建立以安全速率最大化和发射功率最小化为目标函数的多目标优化问题。考虑到窃听者和非网内用户的完美信道状态信息难以获得,提出一种结合加权和方法、角度离散化和连续凸逼近的求解方法,将非凸多目标问题转换成凸形式,并进一步利用半正定规划求解。仿真验证所提算法能够在安全性能和能耗之间获得一个较好的折中。

关键词：星空协作网络多目标优化鲁棒波束成形物理层安全

Light-responsive nanomedicine for cancer immunotherapy

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药学学报:英文版 2023年第6期13卷 2346-2368页

作者： Weirong Kang Yuwei Liu weiping Wang state Key Laboratory of Pharmaceutical Biotechnology the University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Laboratory of Molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research Centrethe University of Hong KongHong KongChina

Immunotherapy emerged as a paradigm shift in cancer treatments, which can effectively inhibit cancer progression by activating the immune system. Remarkable clinical outcomes have been achieved through recent advances in cancer immunotherapy, including checkpoint blockades, adoptive cellular therapy, cancer vaccine, and tumor microenvironment modulation. However, extending the application of immunotherapy in cancer patients has been limited by the low response rate and side effects such as autoimmune toxicities. With great progress being made in nanotechnology, nanomedicine has been exploited to overcome biological barriers for drug delivery. Given the spatiotemporal control,light-responsive nanomedicine is of great interest in designing precise modality for cancer immunotherapy. Herein, we summarized current research utilizing light-responsive nanoplatforms to enhance checkpoint blockade immunotherapy, facilitate targeted delivery of cancer vaccines, activate immune cell functions, and modulate tumor microenvironment. The clinical translation potential of those designs is highlighted and challenges for the next breakthrough in cancer immunotherapy are discussed.

关键词： Light-responsive nanoparticles Photodynamic therapy Photothermal therapy Nanomedicine Cancer therapy Immunotherapy Photopharmacology Light-triggered drug release

Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of β cells

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Journal of Environmental Sciences 2022年第5期34卷 162-172页

作者： weiping Qin Xiaomin Ren Lixia Zhao Lianghong Guo state Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China Institute of Environmental and Health Sciences China Jiliang UniversityHangzhou 310018China

Per-and polyfluoroalkyl substances(PFAS)are found to have multiple adverse outcomes on human ***,epidemiological and toxicological studies showed that exposure to PFAS had adverse impacts on pancreas and showed association with insulin *** explore how PFAS may contribute to diabetes,we studied impacts of perfluorooctane sul-fonate(PFOS)on cell viability and insulin release capacity of pancreatic β cells by using in vivo and in vitro *** found that 28-day administration with PFOS(10 mg/(kg body weight·day))caused reductions of pancreas weight and islet size in male *** admin-istration also led to lower serum insulin level both in fasting state and after glucose infusion among male *** cell-based in vitro bioassay,we used mouse β-TC-6 cancer cells and found 48-hr exposure to PFOS decreased the cell viability at 50 μmol/*** measuring insulin content in supernatant,48-hr pretreatment of PFOS(100 μmol/L)decreased the insulin re-lease capacity of β-TC-6 cells after glucose *** these concentrations were higher than the environmental concentration of PFOS,it might be reasonable for high con-centration of PFOS to exert observable toxic effects in mice considering mice had a faster removal efficiency of PFOS than *** exposure(50 μmol/L)to β-TC-6 cells induced intracellular accumulation of reactive oxidative specie(ROS).Excessive ROS induced the re-active toxicity of cells,which eventually invoke apoptosis and *** in this study provide evidence for the possible causal link of exposure to PFOS and diabetes risk.

关键词： Perfluorooctane sulfonate Insulin secretion Pancreaticβcells Apoptosis Reactive oxidative species

晶界工程调控Inconel 718合金晶界处δ相的析出

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精密成形工程 2024年第10期16卷 131-138页

作者：王素珍陈伟平张孟超李慧上海大学材料科学与工程学院上海200444

目的针对镍基Inconel 718合金在高温服役时强化相转化为晶界δ脆性相从而降低服役性能的问题,通过热机械处理工艺调整晶界脆性相的析出和分布,以提升合金在高温环境下的耐用性和服役性能。方法通过晶界工程(GBE)技术提高样品中低Σ重位... 详细信息

目的针对镍基Inconel 718合金在高温服役时强化相转化为晶界δ脆性相从而降低服役性能的问题,通过热机械处理工艺调整晶界脆性相的析出和分布,以提升合金在高温环境下的耐用性和服役性能。方法通过晶界工程(GBE)技术提高样品中低Σ重位点阵(CSL)晶界的比例,调整晶界处δ相的分布规律。利用扫描电子显微镜(SEM)和电子背散射衍射(EBSD)技术分析样品的显微组织演化规律。结果GBE处理使样品中低ΣCSL晶界比例较固溶态的54.34%提高至81.43%,显著优化了晶界特征分布。通过SEM分析了δ相在不同类型晶界处的分布特征:较小的δ相沿平行于Σ3c晶界两侧分布、沿垂直于Σ3i晶界两侧分布,沿Σ9晶界一侧呈针状分布;较大的δ相沿Σ27晶界一侧呈短棒状或层片状分布,在随机晶界处杂乱分布。GBE处理后合金的塑性显著提升,其延伸率从固溶态的21.1%提升至GBE态的26.6%。结论通过晶界工程技术提升了镍基合金中低ΣCSL晶界的比例,调整了晶界处δ相的析出规律,优化了Inconel 718合金的微观结构,从而有望提高其在高温环境下的服役性能。

关键词： Inconel 718合金镍基合金晶界工程晶界类型 δ相

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