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Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 23-37页

作者： Yinan DU Zhiwei LI Yukui zhao Jing HAN weiping HU Zhiqiang LIU MOE Key Laboratory of Modern Teaching Technology Shaanxi Normal UniversityXi’an710062China

5-Hydroxytryptamine(5-HT)type 3 receptor(5-HT_(3)R)is the only type of ligand-gated ion channel in the 5-HT receptor *** the high permeability of Na+,K+,and Ca2+and activation of subsequent voltage-gated calcium channels(VGCCs),5-HT_(3)R induces a rapid increase of neuronal excitability or the release of neurotransmitters from axon terminals in the central nervous system(CNS).5-HT_(3)Rs are widely expressed in the medial prefrontal cortex(mPFC),amygdala(AMYG),hippocampus(HIP),periaqueductal gray(PAG),and other brain regions closely associated with anxiety *** have a bidirectional regulatory effect on anxiety reactions by acting on different types of cells in different brain regions.5-HT_(3)Rs mediate the activation of the cholecystokinin(CCK)system in the AMYG,and theγ-aminobutyric acid(GABA)“disinhibition”mechanism in the prelimbic area of the mPFC promotes anxiety by the activation of GABAergic intermediate inhibitory neurons(IINs).In contrast,a 5-HT_(3)R-induced GABA“disinhibition”mechanism in the infralimbic area of the mPFC and the ventral HIP produces anxiolytic effects.5-HT_(2)R-mediated regulation of anxiety reactions are also activated by 5-HT_(3)R-activated 5-HT release in the HIP and *** provides a theoretical basis for the treatment of anxiety disorders or the production of anxiolytic drugs by targeting 5-HT_(3)***,given the circuit specific modulation of 5-HT_(3)Rs on emotion,systemic use of 5-HT_(3)R agonism or antagonism alone seems unlikely to remedy anxiety,which deeply hinders the current clinical application of 5-HT_(3)R ***,the exploitation of circuit targeting methods or a combined drug strategy might be a useful developmental approach in the future.

关键词： 5-Hydroxytryptamine type 3 receptor(5-HT_(3)R) Anxiety Medial prefrontal cortex Amygdala Hippocampus Periaqueductal gray

Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

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Chinese Chemical Letters 2024年第2期35卷 380-385页

作者： Du Qiao Hongxia Li weiping Zhu Lili Zhu Danyang zhao Honglin Li Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116023China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Lingang Lab Shanghai 200031China

Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles ***,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and ***,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is *** effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement accurate prediction of particle *** is found that the separation efficiency of magnetic particles increased from 50.2%to 91.7%and decreased from 88.6%to 85.7%in the range of depth factors from 15µm to 27µm and width factors from 30µm to 60µm,*** particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional ***,the developed LOC prototype was generalized for extension to arbitrary *** work provides a new insight and robust method for the microfluidic separation of magnetic particles.

关键词： Microfluidic Particle separation Synergistic effect Hydrodynamics Magnetic field Numerical calculation

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen Liu Hui Jin Yan Chen Derong Wang Haohui Yan Mingzhao Wu Fang zhao weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

Decadal length-of-day and geomagnetic changes imply more complex Earth’s core motions

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Science Bulletin 2024年第13期69卷 2038-2041页

作者： Hao Ding Jiancheng Li weiping Jiang Wenbin Shen School of Geodesy and Geomatics Hubei Luojia LaboratoryWuhan UniversityWuhan 430079China GNSS Research Center Wuhan UniversityWuhan 430079China

Since the 1950s,the length-of-day variations(DLOD)of the Earth’s rotation have received extensive attention and research in various fields,including geodynamics,geomagnetism,geodesy,seismology,geology,marine science,environmental science,and even biology and *** the abundance of related studies and notable advancements,the underlying mechanism behind the decadal changes in DLOD remains a persistent unresolved *** essential aspect of investigating this issue lies in its potential to unveil the Earth’s core motions[1,2].Despite the presence of various hypothesized and constructed models about the Earth’s core motions,these models typically exhibit simplicity.

关键词： Earth geology geomagnetic

Clinical Trial of Cancer Therapy with Heavy Ions at Heavy Ion Research Facility in Lanzhou （HIRFL）

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Clinical Trial of Cancer Therapy with Heavy Ions at Heavy Io...

A Comprehensive Study on the Consequences of Gap-Graded Sands Considering the Loss of Fine Particles

第14届国际自由基学术大会

作者： Hong Zhang 1 2 Sha Li3 Xiaohu Wang 4 Qiang Li1 2 Shihua Wei3 Liying Gao4 weiping zhao1 2 Zhengguo Hu1 Ruishi Mao1 Hushan Xu1 Juntao Ran 4 Yangjun Yue3 Guoqing Xiao1 1 Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China 2 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province Lanzhou 730000 China 3 The General Hospital of Lanzhou Command Lanzhou 730050 China 4 Tumor Hospital of Gansu Province Lanzhou 730050 China

＜正＞From November 2006 to March 2008, 66 patients with superficially-placed tumors were treated with carbon ions at Heavy Ion Research Facility in Lanzhou （HIRFL） within six beam time blocks of 4-11 days, collaborating with the General Hospital of Lanzhou Command and the Tumor Hospital of Gansu Province. Patients and Methods

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Journal of Earth Science 2024年第2期35卷 597-612页

作者： weiping Liu Yu Gan Yunwei Cui Faming Huang Lina Hu School of Civil Engineering and Architecture Nanchang UniversityNanchang330031China

Water and sand leakage disasters are likely to occur during construction in water-rich sand layer areas,resulting in ground *** stress-strain action characteristics of discontinuous graded sand under different internal erosion degrees,and the evolution mechanism of water and sand leakage disasters caused by the internal erosion need to be further ***,this paper takes the discontinuous graded sand in a water rich sand layer area in Nanchang City of China as the research *** the influence of different fine particle losses(0,10%,20%and 30%)under the internal erosion of sand,the salt solution method is used to realize the specified loss of fine particles in the internal *** stress-strain behavior after the loss of fine particles due to internal erosion is studied by triaxial shear ***,the physical model test and PFC-CFD method are both used to study the evolution rules of water and sand leakage disaster considered the influence of internal erosion *** show that:(1)under the same confining pressure,the peak failure strength of sand samples decreases along with the increase of fine particle loss.(2)In the water and sand leakage test of saturated sand,a natural filter channel is formed above the observed soil *** greater the loss of fine particles,the steeper and wider the collapse settlement area.(3)The relationship between the cumulative amount of water and sand leakage and time is *** total mass loss of sand increases along with the increase of internal erosion degree.(4)After the soil arch is formed around the damaged opening,the sand continues to converge above the soil arch under the action of water flow,resulting in the dense convergence of contact force chains.

关键词： sandy soil internal erosion stress and strain water and sand leakage PFC3D engineering geology

D-band 4600 m wireless transmission with rates exceeding 100 Gbit/s based on photonics aided technologies

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Science China(Technological Sciences) 2024年第9期67卷 2968-2970页

作者： zhao XianMing YU JianJun YANG XiongWei WEI Yi LI weiping TAN JingWen WANG MingXu ZHANG QiuTong ZHANG Bing BIAN ChengZhen TIAN Peng HAN Yang ZHANG QingYi YU JianGuo zhao Feng Harbin Institute of Technology Harbin 150001China Key Laboratory for Information Science of Electromagnetic Waves Fudan UniversityShanghai 200433China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China School of Automation Xi’an University of Posts and TelecommunicationsXi’an 710121China

With the rise of emerging applications such as artificial intelligence(AI),virtual reality(VR), and short videos, the number of Internet terminals has increased dramatically [1]. According to the Cisco Annual Traffic Survey Report, annual traffic is growing at a compound annual growth rate of 20%[2]. To meet exploding growth in traffic demands, researchers have turned their attention to license-free high-band millimeter wave(MMW), such as W-band(75–110 GHz), D-band(110–170 GHz), and terahertz band(THz) [3,4].

关键词： millimeter exceeding artificial

Experimental and theoretical investigation of sulfur-doped g-C_(3)N_(4)nanosheets/FeCo_(2)O_(4)nanorods S-scheme heterojunction for photocatalytic H_(2)evolution

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Nano Research 2024年第9期17卷 8007-8016页

作者： Haitao Wang Lianglang Yu Jiahe Peng Jing Zou weiping Gong Jizhou Jiang School of Chemistry and Environmental Engineering School of Environmental Ecology and Biological EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationNovel Catalytic Materials of Hubei Engineering Research CenterWuhan Institute of TechnologyWuhan 430205China Guangdong Provincial Key Laboratory for Electronic Functional Materials and Devices Huizhou UniversityHuizhou 516007China

g-C_(3)N_(4)emerges as a promising metal-free semiconductor photocatalyst due to its cost-effectiveness,facile synthesis,suitable visible light response,and robust thermal ***,its practical application in photocatalytic hydrogen evolution reaction(HER)is impeded by rapid carrier recombination and limited light absorption *** this study,we successfully develop a novel g-C_(3)N_(4)-based step-scheme(S-scheme)heterojunction comprising two-dimensional(2D)sulfur-doped g-C_(3)N_(4)nanosheets(SCN)and one-dimensional(1D)FeCo_(2)O_(4)nanorods(FeCo_(2)O_(4)),demonstrating enhanced photocatalytic HER *** engineered SCN/FeCo_(2)O_(4)S-scheme heterojunction features a well-defined 2D/1D heterogeneous interface facilitating directed interfacial electron transfer from FeCo_(2)O_(4)to SCN,driven by the lower Fermi level of SCN compared to FeCo_(2)O_(4).This establishment of electron-interacting 2D/1D S-scheme heterojunction not only facilitates the separation and migration of photogenerated carriers,but also enhances visible-light absorption and mitigates electron-hole pair *** structure analysis and density functional theory calculations corroborate that the carrier migration in the SCN/FeCo_(2)O_(4)photocatalyst adheres to a typical S-scheme heterojunction mechanism,effectively retaining highly reactive photogenerated ***,the optimized SCN/FeCo_(2)O_(4)heterojunction exhibits a substantially high hydrogen production rate of 6303.5μmol·g^(-1)·h^(-1)under visible light excitation,which is 2.4 times higher than that of the ***,the conjecture of the S-scheme mechanism is confirmed by in situ XPS *** 2D/1D S-scheme heterojunction established in this study provides valuable insights into the development of high-efficiency carbon-based catalysts for diverse energy conversion and storage applications.

关键词： g-C_(3)N_(4) FeCo_(2)O_(4) S-scheme heterojunction photocatalytic hydrogen evolution reaction(HER)

Beamforming Design for IRS-and-UAV-Aided Two-Way Amplify-and-Forward Relay Networks in Maritime IoT

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China Communications 2024年第8期21卷 45-61页

作者： Wang Xuehui Shu Feng Wu Yuanyuan Shi weiping Yan Shihao zhao Yifan Cheng Qiankun Sun Zhongwen Wang Jiangzhou School of Information and Communication Engineering Hainan UniversityHaikou 570228China Collaborative Innovation Center of Information Technology Hainan UniversityHaikou 570228China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Network and Communication Nanjing Vocational College of Information TechnologyNanjing 210023China School of Science and Security Research Institute Edith Cowan UniversityPerthWA 6027Australia School of Engineering University of KentCanterbury CT27NTU.K

In this paper,an intelligent reflecting surface(IRS)-and-unmanned aerial vehicle(UAV)-assisted two-way amplify-and-forward(AF)relay network in maritime Internet of Things(IoT)is proposed,where ship1(S1)and ship2(S2)can be viewed as data collecting *** enhance the message exchange rate between S1 and S2,a problem of maximizing minimum rate is cast,where the variables,namely AF relay beamforming matrix and IRS phase shifts of two time slots,need to be *** achieve a maximum rate,a low-complexity alternately iterative(AI)scheme based on zero forcing and successive convex approximation(LC-ZF-SCA)algorithm is *** obtain a significant rate enhancement,a high-performance AI method based on one step,semidefinite programming and penalty SCA(ONSSDP-PSCA)is *** results show that by the proposed LC-ZF-SCA and ONS-SDP-PSCA methods,the rate of the IRS-and-UAV-assisted AF relay network surpass those of with random phase and only AF relay ***,ONS-SDP-PSCA perform better than LC-ZF-SCA in aspect of rate.

关键词： beamforming maritime Internet of Things phase shift rate performance two-way amplify-and-forward relay unmanned aerial vehicle