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Artificial Bear Bile:A Novel Approach to Balancing Medical Requirements and Animal Welfare

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Engineering 2024年第7期38卷 100-112页

作者： Yong Li Yuhong Huang Nan Feng Heping Zhang Jing Qu Shuanggang Ma Yunbao Liu Jiang Li Shaofeng Xu Ling Wang Mi Zhang Jie Cai weiping Wang Ru Feng Hang Yu Bo Yu Dailiang Liang Heping Qin Suxiang Luo Yanfen Li Meifeng Li Ruihua Wang Chen Ma Yan Wang Xiaobo Cen Xiaoxian Xu Boli Zhang Xiaoliang Wang Shishan Yu state Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China The Second Affiliated Hospital of Tianjin university of Traditional Chinese Medicine Tianjin 300250China Zhongshan Belling Biotechnology Co. Ltd.Zhongshan 528437China Zhongshan Anshi Biopharmaceutical Co. Ltd.Zhongshan 528437China WestChina-Frontier Pharma Tech Co. Ltd.Chengdu 610041China Tianjin university of Traditional Chinese Medicine Tianjin 301617China

Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine(TCM)for over 13 ***,the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear ***,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear *** study addresses the scientific challenges of creating bear bile alternatives through interdisciplinary collaborations across various fields,including resources,chemistry,biology,medicine,pharmacology,and TCM.A comprehensive efficacy assessment system that bridges the gap between TCM and modern medical terminology has been established,allowing for the systematic screening of therapeutic *** the utilization of chemical synthesis and enzyme engineering technologies,our research has achieved the environmentally friendly,large-scale production of bear bile therapeutic compounds,as well as the optimization and recomposition of ABB *** resulting ABB not only closely resembles natural bear bile in its composition but also offers advantages such as consistent product quality,availability of raw materials,and independence from threatened or wild *** preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effects from ABB and those from commercially available drained bear bile(DBB).Furthermore,preclinical toxicological assessment and phase I clinical trials show that the safety of ABB is on par with that of the currently used *** innovative strategy can serve as a new research paradigm for developing alternatives for other endangered TCMs,thereby strengthening the integrity and sustainability of TCM.

关键词： Artificial bear bile Chemical profile Formula optimization Pharmacodynamic consistency Preclinical toxicological assessment

Interfacial Tunnel-type GMR in Granular PerovskiteLa_(1-x)Sr_xMnO_3

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Journal of Materials Science & Technology 1999年第4期15卷 373-374页

作者： Ning ZHANG and Minyu ZENG(Department of Physics, Nanjing Normal university, Nanjing 210097, China)weiping DING, Wei ZHONG and Youwei DU(National Laboratory of Solid state Microstructures, Nanjing university, Nanjing 210093, China)To whom correspondence sh Nanjing Normal Univ Dept Phys Nanjing 210097 Peoples R China Nanjing Univ Natl Lab Solid State Microstruct Nanjing 210093 Peoples R China

The spin-dependent intedecial tunneling and the corresponding tunnef-type magnetoresistance (TMR) have been observed in granular perovskite La_(1-x)Sr_xMnO_3 with x from 0.05 to *** shows that the intedecial tunneling originates from the magnetic difference between thegrain core and the sudece, and the TMR stems from the field-induced change of magnetic orderin the interface.

关键词： Sr x)SrxMnO3 MnO GMR Interfacial Tunnel-type GMR in Granular PerovskiteLa type

Adsorption of Acetanilide Herbicides on Soil and Its Components: Ⅳ. Sorption of Acetanilide Herbicides on Soils and its Correlation with Soil Properties

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Pedosphere 2001年第3期11卷 217-226页

作者： LIU weiping WANG QIQUAN YANG WEICHUN and WANG XIAORONG state Key Laboratory of Pollution Control and Resource Reuse Research, Nanjing university, Nanjing 210093 (China) Institute of Environmental Science, Zhejiang university at Yuquan, Hangzhou 510027 南京大学污染控制与资源化研究国家重点实验室江苏南京 210093 浙江大学浙江杭州 510027

Sorption of acetanilide herbicides, metolachlor, acetochlor, pretilachlor and butachlor on eight soils with various physical and chemical properties was studied. The adsorption isotherms could fit Freundich equation well (r 2 ≥0.91) and the adsorption extents increased in the order: metolachlor < acetochlor < pratilachlor < butachlor. The product of Freundlich adsorption constants, Kf (1/n), showed to have a good correlation with organic matter content (OM) of soils for each of these herbicides, suggesting that OM is the primary factor dominating in the adsorption process of these asetanilide herbicides. Multivariant correlation regression between Kf (1/n) and two factors, water solubility (S.) of herbicides and OM, was also performed. Kf(1/n) correlated with 1/S. and OM/S. well, showing that high S. corresponds to a weak tendency to adsorb on soils. Infrared (IR) spectra and electron spin resonance (ESR) parameters confirmed that multifunctional H-bonds and charge-transfer bonds were the main adsorption mechanisms of these acetanilide herbicides. The abilities of herbicides to form these adsorption bonds with HA increased in the same order as the extent of adsorption.

关键词： acetanilide herbicide adsorption mechanism correlation soil

针对电力CPS数据驱动算法对抗攻击的防御方法

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中国电力 2024年第9期57卷 32-43页

作者：朱卫平汤奕魏兴慎刘增稷国网江苏省电力有限公司江苏南京210024 东南大学电气工程学院江苏南京211189 南瑞集团有限公司(国网电力科学研究院有限公司) 江苏南京211106

大规模电力电子设备的接入为系统引入了数量庞大的强非线性量测/控制节点,使得传统电力系统逐渐转变为电力信息物理系统(cyber-physical system,CPS),许多原本应用模型驱动方法解决的系统问题不得不因维度灾难等局限转而采取数据驱动算... 详细信息

大规模电力电子设备的接入为系统引入了数量庞大的强非线性量测/控制节点,使得传统电力系统逐渐转变为电力信息物理系统(cyber-physical system,CPS),许多原本应用模型驱动方法解决的系统问题不得不因维度灾难等局限转而采取数据驱动算法进行分析。然而,数据驱动算法自身的缺陷为系统的安全稳定运行引入了新的风险,攻击者可以对其加以利用,发起可能引发系统停电甚至失稳的对抗攻击。针对电力CPS中数据驱动算法可能遭受的对抗攻击,从异常数据剔除与恢复、算法漏洞挖掘与优化、算法自身可解释性提升3个方面,提出了对应的防御方法:异常数据过滤器、基于生成式对抗网络(generative adversarial network,GAN)的漏洞挖掘与优化方法、数据-知识融合模型及其训练方法,并经算例分析验证了所提方法的有效性。

关键词：对抗攻击数据驱动算法电力CPS 攻击防御

间歇式运行模式下黄土地基中能量桩热-力特性模型试验

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土木工程学报 2024年第9期57卷 123-134页

作者：曹卫平李清源赵敏吴奇兴李庆西安建筑科技大学土木工程学院陕西西安710055 西安建筑科技大学陕西省岩土与地下空间工程重点实验室陕西西安710055 西安工业大学陕西西安710021

能量桩是将传统桩基与地源热泵相结合的一种建筑节能新技术。为研究黄土地层中能量桩热交换效率及承载变形特性,了解黄土饱和状态对能量桩热交换效率、桩土温度、桩土沉降及桩身轴力、摩阻力的影响规律,开展间歇式运行模式下黄土处于天... 详细信息

能量桩是将传统桩基与地源热泵相结合的一种建筑节能新技术。为研究黄土地层中能量桩热交换效率及承载变形特性,了解黄土饱和状态对能量桩热交换效率、桩土温度、桩土沉降及桩身轴力、摩阻力的影响规律,开展间歇式运行模式下黄土处于天然湿密状态及饱和状态的能量桩模型试验。试验采用的黄土为人工配制黄土,模型桩为内置单U形换热管的现浇钢筋混凝土桩。试验结果表明:黄土中能量桩具有较高的热交换效率,黄土饱和时能量桩的热交换效率大于黄土处于天然湿密状态,随着无量纲直径D/L的增大,能量桩的热交换效率增加。不论黄土处于天然湿密状态还是饱和状态,桩顶沉降呈现出棘轮形式并随冷热循环次数增加逐渐增大。热循环、冷循环对能量桩的承载力影响不同,经过每一个完整的冷热循环后,桩的承载力均降低了。该文还建立了计算能量桩热交换效率的新公式,该公式考虑了桩身侧表面积及循环液与初始地温差的影响。

关键词：能量桩承载变形特性冷热循环黄土模型试验

ELECTRONIC AND MAGNETIC PROPERTIES OF La_(0.7-xPrxSr0.3MnO3

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南京大学学报(自然科学) 1997年第2期 144-145页

作者： Guo Zaibing Zhang Ning Ding weiping Zhang Jianrong Du Youwei ( National Laboratory of Solid state Microstructrues,Nanjing university,210093,Nanjing,PRC)

ＥＬＥＣＴＲＯＮＩＣＡＮＤＭＡＧＮＥＴＩＣＰＲＯＰＥＲＴＩＥＳＯＦＬａ０．７－ｘＰｒｘＳｒ０．３ＭｎＯ３＊ＧｕｏＺａｉｂｉｎｇＺｈａｎｇＮｉｎｇＤｉｎｇＷｅｉｐｉｎｇＺｈａｎｇＪｉａｎｒｏｎｇＤｕＹｏｕｗｅｉ（Ｎａ... 详细信息

ＥＬＥＣＴＲＯＮＩＣＡＮＤＭＡＧＮＥＴＩＣＰＲＯＰＥＲＴＩＥＳＯＦＬａ０．７－ｘＰｒｘＳｒ０．３ＭｎＯ３＊ＧｕｏＺａｉｂｉｎｇＺｈａｎｇＮｉｎｇＤｉｎｇＷｅｉｐｉｎｇＺｈａｎｇＪｉａｎｒｏｎｇＤｕＹｏｕｗｅｉ（ＮａｔｉｏｎａｌＬａｂｏｒａｔｏｒｙｏ...

关键词： Lanthanum manganese Giant magnetoresistance Metalinsulator transition

考虑机器学习建模中训练/测试集时空划分原则的滑坡易发性预测建模

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地球科学 2024年第5期49卷 1607-1618页

作者：黄发明欧阳慰平蒋水华范宣梅连志鹏周创兵南昌大学工程建设学院江西南昌330031 成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059 中国地质调查局武汉地质调查中心湖北武汉430205

滑坡易发性预测时大多按空间随机来划分模型训练/测试数据集,但随机划分方式难免将不确定性因素引入建模中.因为理论上滑坡易发性是基于过去的滑坡来预测将来发生滑坡的空间概率,具有显著的时间顺序特征而非单纯的空间随机,可见有必要... 详细信息

滑坡易发性预测时大多按空间随机来划分模型训练/测试数据集,但随机划分方式难免将不确定性因素引入建模中.因为理论上滑坡易发性是基于过去的滑坡来预测将来发生滑坡的空间概率,具有显著的时间顺序特征而非单纯的空间随机,可见有必要探索基于滑坡发生的时间顺序划分模型训练/测试集.以浙江文成县为例获取11类环境因子及128个时间准确的滑坡;之后将联接了环境因子的滑坡-非滑坡样本分别按照滑坡时间顺序和空间随机的原则,划分为两类不同训练/测试集;其划分比例分别设定为9∶1、8∶2、7∶3、6∶4和5∶5等以避免不同比例影响研究结果,由此得到10种组合工况下的训练/测试集;最后再训练测试支持向量机(SVM)、多层感知器(MLP)和随机森林(RF)等模型以预测滑坡易发性并分析其不确定性.结果表明:(1)训练/测试集按时间顺序划分的SVM、MLP和RF模型预测的滑坡易发性的不确定性略低于按空间随机性划分的模型,验证了按时间顺序划分的可行性;(2)训练/测试集按时间顺序划分实际上是其在空间随机划分下的一种更符合滑坡发生实际情况的“确定性”特征,当然对缺乏滑坡发生时间的数据集开展空间随机划分也是可行的.

关键词：滑坡滑坡易发性时间顺序训练/测试集比例机器学习工程地质

横向振动作用下螺栓连接节点松动规律数值模拟

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振动与冲击 2024年第8期43卷 61-69,88页

作者：赵卫平常昊坛籍春雷郭新锁何宇翔中国矿业大学(北京)力学与土木工程学院北京100083 中铁十六局集团路桥工程有限公司北京101500

输电铁塔螺栓连接节点因常常受到横向往复荷载作用发生松动,从而导致输电铁塔的损害。目前许多在紧固件振动试验机上进行的单个螺栓试验与有限元研究因螺栓约束条件问题并不适用于角钢-螺栓群节点的实际工作情况,针对这一问题在ABAQUS... 详细信息

输电铁塔螺栓连接节点因常常受到横向往复荷载作用发生松动,从而导致输电铁塔的损害。目前许多在紧固件振动试验机上进行的单个螺栓试验与有限元研究因螺栓约束条件问题并不适用于角钢-螺栓群节点的实际工作情况,针对这一问题在ABAQUS软件中建立考虑螺纹升角的精细化螺栓模型,根据紧固件试验结果验证有限元模型的适用性,再将螺栓模型推广到复杂的单肢、单包及双包的角钢-螺栓群节点模型,分析螺栓群节点在横向振动荷载下松动机理与预紧力变化过程。分析结果表明:在横向循环载荷作用下,预紧力出现交替的上升与下降;螺纹接触面先于螺头承压面进入滑移状态;螺栓预紧力随摩擦因数、预紧扭矩的增大而降低,随着振动幅值的增大而增大,振动频率对螺栓松动影响不显著;单包与双包节点螺栓松动程度从外侧到内侧逐渐递减,施加预压力在一定程度上可降低螺栓的松动趋势,双肢单包节点螺栓松动程度下降了16.00%~23.24%,双肢双包节点下降了2.63%~3.80%。因此在实际工程要做好对易松动部位螺栓的监测,保证节点的承载能力。

关键词：螺栓连接节点横向振动荷载螺栓松动预紧力下降有限元仿真

Immune regulation in the tumor microenvironment and its relevance in cancer therapy

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Cellular & Molecular Immunology 2022年第1期19卷 1-2页

作者： weiping Zou Department of Surgery Center of Excellence for Cancer Immunology and ImmunotherapyUniversity of Michigan Rogel Cancer CenterAnn ArborMIUSA Department of Pathology Graduate Program in Immunology and Graduate Program in Cancer BiologyUniversity of Michigan School of MedicineAnn ArborMIUSA

Cancer immunotherapy,including immune checkpoint blockade and CAR-T cell therapy,has introduced revolutionary approaches to treating patients with *** success and hope of cancer immunotherapy have continuously stimulated high interest in dissecting immunotherapy resistance mechanisms,researching previously unknown therapeutic targets,and informing novel clinical trials in cancer *** notion that the tumor microenvironment holds the key to understanding tumor immunity and developing novel immunotherapy has been well established in the field of tumor immunology and medical oncology[1].This special issue of Cellular&Molecular Immunology(CMI)compiles a series of review articles,presenting state-ofthe-art literature and concepts focused on several important aspects concerning the most recent advancement in immune sensitive and resistant mechanisms in the tumor microenvironment,and their relevance in cancer therapy.

关键词： cancer immunity Immune