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Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice

Acta Pharmaceutica Sinica B 2019年第4期9卷 758-768页

作者： jiamei Le Xiaoying Zhang Weiping Jia Yong Zhang Juntao Luo Yongning Sun jianping Ye Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Traditional Chinese Medicine Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Central Laboratory Shanghai Jiaotong University Affiliated Sixth People's Hospital EastShanghai 201306China Diabetes Institute Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Antioxidant and Gene Regulation Laboratory Pennington Biomedical Research CenterLSUBaton RougeLA 70808 USA Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China

Sennoside A(SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet(HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR(homeostatic model assessment for insulin resistance) and glucose tolerance test(GTT). SA restored plasma level of glucagon-like peptide 1(GLP1) by 90% and mRNA expression of Glp1 by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids(SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota–GLP1 axis to improve glucose metabolism in the obese mice.

关键词： Sennoside A Insulin sensitivity Mitochondria Gut microbiota Short chain fatty acids GLP1

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Effectiveness of quality of care for patients with type 2 diabetes in China:findings from the Shanghai Integration Model(SIM)

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Frontiers of Medicine 2022年第1期16卷 126-138页

作者： Chun Cai Yuexing Liu Yanyun Li Yan Shi Haidong Zou Yuqian Bao Yun Shen Xin Cui Chen Fu Weiping Jia the SIM Study Group Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People’s HospitalNational Office for Primary Diabetes CareShanghai Technical Center for Diabetes Prevention and Clinical CareShanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and MetabolismShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai 200233China Shanghai Municipal Center for Disease Control&Prevention Shanghai 200336China Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai General HospitalShanghai Engineering Center for Visual Science and PhotomedicineShanghai 200040China Shanghai Municipal Health Commission Information Center Shanghai 200040China 不详

This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai,China.A total of 173235 patients with type 2 diabetes in 2017 were included in the analysis.Profiles of risk factors and intermediate outcomes were determined.The patients had a mean age of 66.43±8.12(standard deviation(SD))years and a mean diabetes duration of 7.95±5.53(SD)years.The percentage of patients who achieved the target level for HbA_(1c)(<7.0%)was 48.6%.Patients who achieved the target levels for blood pressure(BP)<130/80 mmHg and low-density lipoprotein-cholesterol(LDL-c)<2.6 mmol/L reached 17.5%and 34.0%,respectively.A total of 3.8%achieved all three target levels,and the value increased to 6.8%with an adaptation of the BP target level(<140/90 mmHg)for those over 65 years.Multivariable analysis identified the factors associated with a great likelihood of achieving all three target levels:male,young age,short diabetes duration,low body mass index,macrovascular complications,no microvascular complications,prescribed with lipid-lowering medication,and no prescription of antihypertensive medication.In conclusion,nearly 50%and one-third of the patients with diabetes met the target levels for HbA_(1c)and LDL-c,respectively,with a low percentage achieving the BP target level.The percentage of patients who achieved all three target levels needs significant improvement.

关键词： type 2 diabetes quality of care macrovascular complication microvascular complication treatment pattern epidemiology

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血糖监测技术的进步与展望

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上海交通大学学报（医学版） 2022年第9期42卷 1171-1175页

作者：贾伟平上海交通大学医学院附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病重点实验室上海市糖尿病研究所上海200233

血糖监测是糖尿病综合管理的重要组成部分。近1个多世纪以来,糖尿病监测技术由最初的尿糖检测,到后来的血糖检测,再到目前的持续葡萄糖监测(continuous glucose monitoring,CGM),不断向便捷、准确、微创,甚至无创的方向发展。近年来不... 详细信息

血糖监测是糖尿病综合管理的重要组成部分。近1个多世纪以来,糖尿病监测技术由最初的尿糖检测,到后来的血糖检测,再到目前的持续葡萄糖监测(continuous glucose monitoring,CGM),不断向便捷、准确、微创,甚至无创的方向发展。近年来不断发展的CGM技术,可连续、动态地监测全天人体组织间液葡萄糖浓度的变化,发现不易被传统血糖监测方法探测到的隐匿性高血糖和低血糖。利用CGM技术提供的海量血糖信息,有望使糖尿病管理方案的制定更具针对性,真正做到精准控糖。而与之相应的,以葡萄糖目标范围内时间(time in range,TIR)为代表的血糖控制新指标备受关注,能更全面地提供包括高血糖、低血糖以及血糖波动等信息,与传统血糖指标糖化血红蛋白等互为补充。未来,应进一步研发舒适、稳定、准确性高的成熟、微创甚至无创血糖监测技术,以大幅提高患者血糖监测的体验感和积极性;同时,积极推动闭环胰岛素输注系统研发,真正实现个体化、自动化血糖控制,以进一步提高糖尿病患者的血糖控制水平。

关键词：糖尿病持续葡萄糖监测葡萄糖目标范围内时间

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Research on adaptive dual task offloading decision algorithm for parking space recommendation service

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The Journal of China Universities of Posts and Telecommunications 2019年第6期26卷 30-42页

作者： Peng weiping Su Zhe Song Cheng jia Zongpu School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo 454000China

In order to improve the efficiency of tasks processing and reduce the energy consumption of new energy vehicle(NEV), an adaptive dual task offloading decision-making scheme for Internet of vehicles is proposed based on information-assisted service of road side units(RSUs) and task offloading theory. Taking the roadside parking space recommendation service as the specific application Scenario, the task offloading model is built and a hierarchical self-organizing network model is constructed, which utilizes the computing power sharing among nodes, RSUs and mobile edge computing(MEC) servers. The task scheduling is performed through the adaptive task offloading decision algorithm, which helps to realize the available parking space recommendation service which is energy-saving and environmental-friendly. Compared with these traditional task offloading decisions, the proposed scheme takes less time and less energy in the whole process of tasks. Simulation results testified the effectiveness of the proposed scheme.

关键词： parking space recommendation service Internet of vehicles RSU adaptive dual task offloading

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Knowledge, attitudes, and beliefs of healthcare workers regarding stem cell research

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Science China(Life Sciences) 2016年第3期59卷 325-327页

作者： Deng Luo Wenzhuo Ran Gongfang Zhao Chaxiang Guan Chen Wang Weiping Jia Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Key Laboratory of Diabetes Mellitus Diabetes Institute Department of Physiology Xiangya School of Medicine Central South University Department of Gastroenterology The Second Affiliated Hospital of Kunming Medical University

Dear Editors,China has made rapid advances in the field of stem cell research,especially in terms of the scale of financing received,numbers of published papers,and investors and new investment products(Yuan et al.,20... 详细信息

关键词：公共知识干细胞信念投资者工作者中国评估论文

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Flexible heteroatom-doped porous carbon nanofiber cages for electrode scaffolds

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Carbon Energy 2020年第3期2卷 472-481页

作者： weiping Cai Yuanyuan Zhang Yongtang jia jianhua Yan School of Textile Materials and Engineering Wuyi UniversityJiangmenChina State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of TextilesDonghua UniversityShanghaiChina

Porous carbon nanofibers(PCNFs)with rich functionalities and high surface areas are important electrode scaffolds to load active materials,but increasing their pore volumes and strength simultaneously is a challenge.Here,we report a scalable method to fabricate B-F-N triply doped PCNF cages with high porosity of greater than 92.8%and small bending stiffness of 10 mN by electrospinning the mixed sol of poly(tetrafluoroethylene),poly(vinyl alcohol),boric acid,and carbon nanotubes(CNTs)followed by pyrolysis.The macromicro dual-phase separation creates well-controlled macropores(>60 nm)and meso-micropores with large pore volumes(0.55 cm3/g)on carbon nanofibers,while the interior CNTs can cushion the applied stress and render the PCNF films with superior flexibility.Fabricated symmetrical supercapacitors with the PCNF cages exhibit high gravimetric capacitance of 164 F/g at 20 mV/s and 92.5%capacity retention after 20000 cycles at 2 A/g.The reported approach allows the green synthesis of a new PCNF scaffold material with properties appealing for applications.

关键词： electrode scaffold electrospinning energy storage devices high porosity and strength porous carbon nanofiber

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

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Frontiers of Medicine 2021年第3期15卷 460-471,F0004页

作者： Lingli Cai Jun Yin Xiaojing Ma Yifei Mo Cheng Li Wei Lu Yuqian Bao jian Zhou Weiping Jia Department of Endocrinology and Metabolism Shanghai Clinical Center for DiabetesShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Lifestyle interventions,including dietary adjustments and exercise,are important for obesity management.This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet(LCD)or exercise is more effective in metabolism improvement.Forty-five eligible subjects were randomly divided into an LCD group(n=22)and an exercise group(EX,n=23).The subjects either adopted LCD(carbohydrate intake<50 g/day)or performed moderate-to-vigorous exercise(≥30 min/day)for 3 weeks.After the interventions,LCD led to a larger weight loss than EX(−3.56±0.37 kg vs.−1.24±0.39 kg,P<0.001),as well as a larger reduction in fat mass(−2.10±0.18 kg vs.−1.25±0.24 kg,P=0.007)and waist circumference(−5.25±0.52 cm vs.−3.45±0.38 cm,P=0.008).Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance.Triglycerides decreased in both two groups,whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group.Various glycemic parameters,including serum glycated albumin,mean sensor glucose,coefficient of variability(CV),and largest amplitude of glycemic excursions,substantially declined in the LCD group.Only CV slightly decreased after exercise.This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance.Compared with exercise,LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

关键词： low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose

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NF-κB regulates brown adipocyte function through suppression of ANT2

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1186-1197页

作者： Shiqiao Peng Xiaoying Zhang Lili Yu Yanhong Xu Yang Zhou Shengnan Qian Xinyu Cao Xiaotong Ye jiajun Yang Weiping Jia jianping Ye Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Immunology School of Basic Medical SciencesXinxiang Medical UniversityXinxiang 453003China Neurology Department Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China National Demonstration Center for Experimental Fisheries Science Education College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai 201306China Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Center for Advanced Medicine College of MedicineZhengzhou UniversityZhengzhou 450007China

The transcription factor nuclear factor of kappa-light-chain-enhancer of activated B cells(NF-κB)is expressed in brown adipocytes,but its role remains largely unknown in the cells.This issue was addressed in current study by examining NF-κB in brown adipocytes in vitro and in vivo.NF-κB activity was increased by differentiation of brown adipocytes through elevation of p65(RelA)expression.The transcriptional activity of NF-κB was induced by the cold stimulation with an elevation in S276 phosphorylation of p65 protein.Inactivation of NF-κB in brown adipocytes made the knockout mice[uncoupling protein 1(Ucp1)-CreER-p65^(f/f),U-p65-KO]intolerant to the cold environment.The brown adipocytes exhibited an increase in apoptosis,a decrease in cristae density and uncoupling activity in the interscapular brown adipose tissue(iBAT)of p65-KO mice.The alterations became severer after cold exposure of the KO mice.The brown adipocytes of mice with NF-κB activation(p65 overexpression,p65-OE)exhibited a set of opposite alterations with a reduction in apoptosis,an increase in cristae density and uncoupling activity.In mechanism,NF-κB inhibited expression of the adenine nucleotide translocase 2(ANT2)in the control of apoptosis.Data suggest that NF-κB activity is increased in brown adipocytes by differentiation and cold stimulation to protect the cells from apoptosis through down-regulation of ANT2 expression.

关键词： RelA Mitochondria Brown adipocyte Energy metabolism ANT2

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规范诊断主动筛查科学评估—《国家基层糖尿病防治管理指南(2018)》糖尿病诊断章节的解读

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中华内科杂志 2019年第3期58卷 221-223页

作者：贾伟平上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病重点实验室上海市糖尿病研究所200233

糖尿病的诊断、分型、筛查及评估是糖尿病防治管理的主要内容之一,在糖尿病的规范诊断、早期发现和综合管理中具有重要作用。本文就《国家基层糖尿病防治管理指南(2018)》糖尿病诊断章节内容进行解读,以期为基层医务人员规范诊断、主动... 详细信息

糖尿病的诊断、分型、筛查及评估是糖尿病防治管理的主要内容之一,在糖尿病的规范诊断、早期发现和综合管理中具有重要作用。本文就《国家基层糖尿病防治管理指南(2018)》糖尿病诊断章节内容进行解读,以期为基层医务人员规范诊断、主动筛查及科学评估提供必备的基础知识及建议。

关键词：糖尿病诊断

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糖尿病与肠道菌群研究进展

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Science Bulletin 2022年第17期67卷 1720-1723页

作者：贾伟平 Gianni Panagiotou Shanghai Key Laboratory of Diabetes Mellitus Department of Endocrinology and MetabolismShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Systems Biology and Bioinformatics Unit Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll InstituteJena 07745Germany State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina

Diabetes mellitus is a global public health problem that causes great economic and social burdens.Its pathogenesis is complex and unclear.Recently,with considerable attention paid to the interaction between gut microbiota and host,gut microbiota has been found to play an important role in several chronic diseases,including diabetes.

关键词： diseases pathogenesis Diabetes

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