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Supramolecular Vesicles Based on Water-Soluble 2,6-Helic[6]arene:High Affinity Binding,Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells

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Chinese Journal of Chemistry 2019年第6期37卷 575-580页

作者： Xuan Yang weipeng mao Yamin Liu Libai Li Da Ma Department of Chemistry Fudan University220 Handan RoadShanghai 200433China

Water-soluble 2,6-helic[6]arene was used to construct supramolecular vesicles via host-guest interaction. Water-soluble 2,6-helic[6]arene was discovered to be high affinity host for suitable biomarkers. Supramolecular vesicles were responsive to multiple stimuli types, including temperature, pH, Ca^2+, CO2 bubbling and biomarker displacement. Supramolecular vesicles were used to load and deliver anti-tumor drug doxorubicin to HeLa cells in vitro.

关键词： host-guest systems nanostructures molecular recognitions self-assembly supramolecular vesicles

Smart supramolecular vesicles based on glutathione-reactive pillar[6]arene and acid-labile prodrug:Dual drug loading and sequential release

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Chinese Chemical Letters 2022年第1期33卷 209-212页

作者： Yamin Liu Siyang Jiang weipeng mao Pintao Li Fang Zhou Da Ma College of Chemistry and Green Catalysis CenterZhengzhou UniversityZhengzhou 450001China Department of Chemistry Fudan UniversityShanghai 200433China

Glutathione thiol-reactive pillar[6]arene(TWP6)is designed and synthesized as the first example of reducing agent-reactive host ***6 shows high affinity binding towards suitable anti-tumor drugs and ***-based acid-labile prodrugs and TWP6 are used to construct supramolecular vesicles,which are also loaded with *** supramolecular vesicles loaded with two drugs demonstrate glutathione-and acid-responsive drug release as well as sequential release to both stimuli *** vesicles show combination therapeutic effect towards tumor cells in vitro.

关键词： Host-guest systems Pillararene Self-assembly Redox responsive Drug delivery

关于2k-h型行星传动中行星轮个数的配置和行星架刚度问题的探讨

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传动技术 2012年第2期26卷 18-21,33页

作者：冒维鹏上海盛运机械工程有限公司上海200030

本文介绍2k-h型行星传动中行星轮个数的配置、传动比和行星架刚度三者之间的关系。列举出在工程实践中的应用满足邻接条件下行星架的刚度验算实例。

关键词： 2k—h型行星机构邻接条件行星轮个数行星架刚度

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纳米TiO2光催化剂的改性及应用研究进展

微纳电子技术 2008年第3期45卷 145-152页

作者：曹沛森许璞王玉宝乔青安毛伟鹏唐荣高善民潍坊职业学院化学工程系山东潍坊261031 鲁东大学化学与材料科学学院山东烟台264025

对纳米TiO2的光催化反应机理及制备方法做了简要阐述,重点介绍了目前在纳米TiO2掺杂改性方面,尤其是非金属掺杂和共掺杂改性方面的研究进展。氮掺杂的TiO2是新发现的具有可见光催化活性的复合光催化剂,非金属掺杂可以使复合物的禁带宽... 详细信息

对纳米TiO2的光催化反应机理及制备方法做了简要阐述,重点介绍了目前在纳米TiO2掺杂改性方面,尤其是非金属掺杂和共掺杂改性方面的研究进展。氮掺杂的TiO2是新发现的具有可见光催化活性的复合光催化剂,非金属掺杂可以使复合物的禁带宽度小于纯TiO2的禁带宽度,从而使TiO2的吸收边向可见光方向移动。对TiO2的N、C、S、P、卤素掺杂以及共掺杂的国内外研究现状进行了评述,分析了提高TiO2可见光催化活性的原因。对纳米TiO2光催化应用领域进行简单介绍,最后提出了在TiO2光催化剂研究中期待解决的问题及今后的发展方向。

关键词：二氧化钛纳米光催化剂掺杂改性

A 217-year precipitation reconstruction in the Habahe area, Xinjiang, Northeast China

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Journal of Forestry Research 2024年第6期35卷 242-254页

作者： Heli Zhang Youping Chen Feng Chen Lu Li Huaming Shang Daming He Shengxia Jiang mao Hu Xiaoen Zhao weipeng Yue Shijie Wang Honghua Cao Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Institute of International Rivers and Eco-SecurityYunnan UniversityKunming 650500China Institute of Desert Meteorology China Meteorological Administration/Key Laboratory of Tree-Ring Physical and Chemical Research of China Meteorological Administration/Xinjiang Key Laboratory for Tree Ring EcologyÜrümqi 830002China Xinjiang Meteorological Observatory Ürümqi 830002China

Evaluating long-term changes in precipitation resources is important for accurate hydrological evaluation and forecasting,water security and rational allocation of water *** this purpose in the Xinjiang Habahe area,tree-ring specimens were collected from Picea obovata,Larix sibirica,and Betula platyphylla to establish a tree-ring width chronology,which was used to analyse a correlation with the average temperature and precipitation per month for *** on correlation coefficients for monthly temperature and precipitation with the chronology of tree-ring widths,radial tree growth was mainly restricted by precipitation,and tree-ring width chronology was significantly correlated with overall precipitation from the previous July to the next June(r=0.641,P<0.01).The above results were used to establish a transformation equation,and the overall precipitation from the previous July to the following June from 1800 to 2016 in Habahe was reconstructed after adjusted degrees of freedom,and obtain an explanatory rate of the variation up to 41.1%(40.0%).In addition to the reliability of the reconstructed values,the stability of the conversion function was determined via the“leave-one-out”method,which is commonly used in research on tree rings,and by cross-checking the conversion function with the reduced error value(RE),product mean test(t),with a sign test(ST).During the last 217 years,there were nine dry periods:1803-1829,1861-1865,1872-1885,1892-1905,1916-1923,1943-1954,1961-1966,1973-1981,and 2005-2011;and 12 wet periods:1830-1834,1836-1860,1866-1871,1886-1891,1906-1915,1925-1930,1934-1942,1955-1960,1967-1972,1982-1996,2000-2004,and *** of the reconstructions for neighboring regions and a spatial correlation analysis showed that the reconstructed sequence of the present precipitation data better represented the changes in precipitation in ***,a power spectrum analysis revealed that precipitation over the past 217 years in

关键词： Tree ring Chronology Climate response Reconstruction Comparison

HCS: Expanding H-Code RAID 6 without Recalculating Parity Blocks in Big Data Circumstance

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国际计算机前沿大会会议论文集 2015年第1期 20-22页

作者： Shiying Xia Yu mao Minsheng Tan weipeng Jing University of South China HengyangHunanChina Hengyang Normal University HunanChina College of Information and Computer Engineering Northeast Forestry UniversityHarbinChina

This paper introduces a new RAID 6 expanding method HCS, which is facing the circumstance of big data. HCS expands H-Code manner RAID 6. Two key techniques are used to avoid parity blocks’ *** first one is anti-diagonal data blocks’ selection, and the other one is horizontal data migration. These two techniques ensure the data blocks are retained in the same verification zone, that is horizontal verification zone and anti-diagonal verification zone. Experimental results showed that, compared with SDM, which is also a fast expansion method, HCS can reduce 3.6% expansion time and promote 4.62% performance under four traces.

关键词： Big data H-Code RAID expanding Horizontal coding Anti-diagonal parity Horizontal parity

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分段取阈值正交匹配追踪反卷积声源识别算法

振动与冲击 2023年第15期42卷 268-276页

作者：赵卫鹏毛锦刘凯杜进辅西安理工大学机械与精密仪器工程学院西安710048

正交匹配追踪反卷积声源识别算法(orthogonal matching pursuit deconvolution approach for the mapping of acoustic sources, OMP-DAMAS)具有极高的计算效率、空间分辨率和重构精度,被广泛应用声源识别领域。但在实际的工程运用中,... 详细信息

正交匹配追踪反卷积声源识别算法(orthogonal matching pursuit deconvolution approach for the mapping of acoustic sources, OMP-DAMAS)具有极高的计算效率、空间分辨率和重构精度,被广泛应用声源识别领域。但在实际的工程运用中,无法满足提前确定声源数目的条件,可能造成识别结果不准确。因此提出了一种分段取阈值的OMP-DAMAS算法,在声源稀疏度未知的情况下,通过对内积和最小二乘解取阈值将伪声源和旁瓣对应的列序号从原子支撑集中删除,直接精确的识别出真实声源的位置。仿真和试验结果表明了所提算法与传统的延时求和算法相比,可以明显的减小主瓣宽度,提高空间分辨率,同样能达到OMP-DAMAS算法的重构效果,对噪声具有较好的鲁棒性,且具有极高的识别稳定性。

关键词：正交匹配追踪反卷积声源识别算法阈值

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环流反应器的流动、混合与传递特性

化工学报 2014年第7期65卷 2465-2473页

作者：黄青山张伟鹏杨超毛在砂中国科学院青岛生物能源与过程研究所中国科学院生物燃料重点实验室山东青岛266101 中国科学院过程工程研究所中国科学院绿色过程与工程重点实验室北京100190 南京九章化工科技有限公司江苏南京211800

由于环流反应器内存在定向循环,与鼓泡塔反应器相比,其混合性能大幅提升,已广泛应用于许多工业过程,如发酵、反应器结晶等工业过程,近年来成为国内外学者研究的热点。针对环流反应器内操作条件下的流动形态、流体力学(包括相含率分布、... 详细信息

由于环流反应器内存在定向循环,与鼓泡塔反应器相比,其混合性能大幅提升,已广泛应用于许多工业过程,如发酵、反应器结晶等工业过程,近年来成为国内外学者研究的热点。针对环流反应器内操作条件下的流动形态、流体力学(包括相含率分布、循环液速、混合时间以及离集指数等)及传质/传热特性,总结了其最新研究进展,分析了相含率尤其是固含率变化对反应器中关键参数如循环液速和化学反应速率的影响,展望了从机理上研究相互耦合的多相流动、传质/传热和化学反应规律,为进一步推动其工业应用提供参考。

关键词：环流反应器多相流混合传质传热

TGF-β promotes colorectal cancer immune escape by upregulating B7-H3 and B7-H4 via miR-155/miR-143 axis

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TGF-β promotes colorectal cancer immune escape by upregulat...