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Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

Cellular & Molecular Immunology 2023年第10期20卷 1216-1231页

作者： weinian liao Chaonan Liu Ke Yang Jun Chen Yiding Wu Shuzhen Zhang Kuan Yu Lisha Wang Li Ran Mo Chen Fang Chen Yang Xu Song Wang Fengchao Wang Qian Zhang Jinghong Zhao Lilin Ye Changhong Du Junping Wang State Key Laboratory of Trauma Burnsand Combined InjuryInstitute of Combined InjuryChongqing Engineering Research Center for NanomedicineCollege of Preventive MedicineArmy Medical University(Third Military Medical University)400038ChongqingChina Department of Nephrology The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of ChongqingKidney Center of PLAXinqiao HospitalArmy Medical University(Third Military Medical University)400037ChongqingChina Institute of Immunology Army Medical University(Third Military Medical University)400038ChongqingChina National Key Laboratory of Medical Immunology Institute of ImmunologyNaval Medical University200433ShanghaiChina

Although DNA mutation drives stem cell aging,how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly ***,using a mouse model of irradiation-induced premature aging and middle-aged mice,we show that DNA mutation accumulation in hematopoietic stem cells(HSCs)during aging upregulates their surface expression of major histocompatibility complex class II(MHCII).MHCII upregulation increases the chance for recognition by bone marrow(BM)-resident regulatory T cells(Tregs),resulting in their clonal expansion and accumulation in the HSC *** the basis of the establishment of connexin 43(Cx43)-mediated gap junctions,BM Tregs transfer cyclic adenosine monophosphate(cAMP)to aged HSCs to diminish apoptotic priming and promote their survival via activation of protein kinase A(PKA)***,targeting the HSC–Treg interaction or depleting Tregs effectively prevents the premature/physiological aging of *** findings show that aged HSCs use an active self-protective mechanism by entrapping local Tregs to construct a prosurvival niche and obtain a clonal advantage.

关键词： Hematopoietic stem cell regulatory T cell Aging

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Fatigue Strength Analysis of Dissimilar Aluminum Alloy TIG Welds

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 265-274页

作者： liao Xiangyun WANG Ruijie LIU Guoshou ZHAO Pinglin Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China Faculty of Civil Engineering and Mechanics Kunming University of Science and TechnologyKunming 650500China

The constant amplitude loading fatigue tests were carried out on the 6061/7075 aluminum alloy TIG fillet welded lap specimens in this study,and the weld seam cross-section hardness was *** experimental results show that most specimens mainly failed at the 7075 side weld toes even though the base material tensile strength of 7075 is higher than that of *** maximum stress-strain concentration in the two finite element models is located at the 7075 side weld toe,which is basically consistent with the actual fracture *** weld zone on the 7075 side experiences severe material softening,with a large ***,the Vickers hardness value on the 6061 side negligibly changes and fluctuates around 70 *** obvious defects are found on the fatigue fracture,but a large number of secondary cracks *** germinate from the weld toe and propagate in the direction of the plate *** reinforcement has a serious impact on fatigue *** life will decrease exponentially as the weld reinforcement increases under low *** is found that the notch stress method can give a better fatigue life prediction for TIG weldments,and the errors of the predicted results are within the range of two factors,while the prediction accuracy decreases under low *** equivalent structural stress method can also be used for fatigue life prediction of TIG weldments,but the errors of prediction results are within the range of three factors,and the accuracy decreases under high stress.

关键词： TIG welding notch stress method equivalent structural stress method fatigue life finite element analysis

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Enhancing Deepfake Detection:Proactive Forensics Techniques Using Digital Watermarking

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Computers, Materials & Continua 2025年第1期82卷 73-102页

作者： Zhimao Lai Saad Arif Cong Feng Guangjun liao Chuntao Wang School of Automation Guangdong University and TechnologyGuangzhou510006China School of Immigration Administration(Guangzhou) China People’s Police UniversityGuangzhou510663China Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Cyber Police Division Guangzhou Public Security BureauGuangzhou510030China School of Forensic Science and Technology Guangdong Police CollegeGuangzhou510320China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou510642China

With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly *** paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking *** detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic *** contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake *** offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal ***,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking *** systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.

关键词： Deepfake proactive forensics digital watermarking traceability detection techniques

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Smoothness of invariant manifolds and foliations for in nite dimensional random dynamical systems--Dedicated to Professor Shantao liao

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Science China Mathematics 2020年第9期63卷 1877-1912页

作者： Jun Shen Kening Lu weinian Zhang Department of Mathematics Sichuan UniversityChengdu 610064China Department of Mathematics Brigham Young UniversityProvoUT 84602USA

In this paper,we investigate the smoothness of invariant manifolds and foliations for random dynamical systems with nonuniform pseudo-hyperbolicity in Hilbert *** discuss on the effect of temperedness and the spectral gaps in the nonuniform pseudo-hyperbolicity so as to prove the existence of invariant manifolds and invariant foliations,which preserve the CN,τ;(ω)Holder smoothness of the random system in the space variable and the measurability of the random system in the sample ***,we also prove that the stable foliation is CN-1;(ω)in the base point.

关键词： random dynamical system invariant manifold invariant foliation pseudo-hyperbolicity measurability

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High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Polymer membrane electrodes

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建立斑马鱼激光祛斑模型探索色素再生的机制

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激光生物学报 2018年第5期27卷 411-422页

作者：廖伟年张津坤黄祥玉邓其跃陆军军医大学基础医学院神经生物学教研室神经生物学重庆市市级重点实验室重庆400038

病理性色素沉着通常在创伤、手术、日照等条件下发生,临床首选方法为激光治疗,虽疗效显著但存在色斑复发,具体机制尚不清楚。本研究首次选用成年斑马鱼建立激光祛斑动物模型,结果发现:激光祛斑后斑马鱼皮肤重新出现色斑,其灰度值、面积... 详细信息

病理性色素沉着通常在创伤、手术、日照等条件下发生,临床首选方法为激光治疗,虽疗效显著但存在色斑复发,具体机制尚不清楚。本研究首次选用成年斑马鱼建立激光祛斑动物模型,结果发现:激光祛斑后斑马鱼皮肤重新出现色斑,其灰度值、面积及分布与照射激光的能量密度和脉冲时间等参数显著相关;色斑面积缩减在照射后第1、2天最显著,复发在第5天最高;高能量组在祛斑效应上总体不如低能量组,且后者色斑复发也不显著;色斑复发部位巨噬细胞迁移抑制因子(macrophage migration inhibitory factor,MIF)表达上调且与色斑复发程度成正相关。MIF对血管新生具有较强的促进作用,故色斑复发可能与MIF上调引起的血管新生有关。以上研究结果提示,祛斑效果皮秒激光(picosecond laser,下文简称Ps激光)显著优于纳秒激光(nanosecond laser,下文简称Ns激光),低能量激光结合MIF表达调控可能有助于抑制祛斑后的血管新生,从而降低色斑复发,对激光祛斑的临床应用有直接的理论指导价值。

关键词：斑马鱼色斑激光色素消融术色斑复发

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Local Search-Based Anytime Algorithms for Continuous Distributed Constraint Optimization Problems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 288-290页

作者： Xin liao Khoi Hoang Xin Luo the College of Computer and Information Science Southwest University the Department of Computer Science and Engineering Washington University in St.Louis IEEE

Dear Editor,The distributed constraint optimization problems(DCOPs) [1]-[3]provide an efficient model for solving the cooperative problems of multi-agent systems, which has been successfully applied to model the real-world problems like the distributed scheduling [4], sensor network management [5], [6], multi-robot coordination [7], and smart grid [8]. However, DCOPs were not well suited to solve the problems with continuous variables and constraint cost in functional form, such as the target tracking sensor orientation [9], the air and ground cooperative surveillance [10], and the sensor network coverage [11].

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Growth behavior and electronic regulation of Pt on various Mo-based supports for hydrogen evolution electrocatalysis

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Science China Chemistry 2025年

作者： Lulu Chen Yichao Huang Jiajun Wang Meihong liao Zhiyuan Liu Meiqi Liu Hanqing Cai Lin Wang Lidong Gao Dawei Hu Lianming Zhao Ning Pu Zhuangjun Fan State Key Laboratory of Chemical Safety School of Materials Science and Engineering China University of Petroleum (East China) School of Mechanical and Electronic Engineering Qingdao Binhai University Qingdao Chuangqi New Energy Catalysis Technology Co.Ltd. Sinopec Research Institute of Petroleum Processing Co.Ltd. Institute of Energy Hefei Comprehensive National Science Center

Insight into the growth behavior and electronic regulation of platinum （Pt） on various transition metal supports is paramount in developing high-performing electrocatalysts for hydrogen evolution reactions （HER）.Herein,we studied the influence of molybdenum-based supports （MoX,X=C,N,P,and S） on the growth behavior and electronic regulation of *** found that the formation energy variations between Pt single atom and clusters on MoX supports play a pivotal role in the growth behavior of ***,the electronic regulation of Pt induced by metal-support interaction may reflect the valence changes of Pt in Pt-MoX/*** Pt-MoC/C catalyst with a moderate valence state of Pt exhibits the best HER activity with an overpotential of 12.0 mV at 10 mA cm-2and a mass activity of 27.1 A mgPt-1,12.3 times as high as that of commercial 20 wt% Pt/*** work provides constructive guidance for the design of high-performance HER catalysts.

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低氧习服在小鼠造血干细胞急性放射损伤修复中的作用观察

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中华损伤与修复杂志（电子版） 2023年第4期18卷 293-298页

作者：全勇冉新泽胡梦佳陈芳陈乃成廖伟年陈默申明强陈石磊王崧王军平陆军军医大学(第三军医大学)军事预防医学系全军复合伤研究所创伤、烧伤与复合伤国家重点实验室重庆市纳米医学工程研究中心重庆400038

目的研究低氧习服在小鼠造血干细胞急性放射损伤后修复中的作用。方法采用随机数字表法将6~7周龄雄性C57BL/6J小鼠分为常氧辐照组和低氧习服辐照组。建立低氧习服急性放射损伤动物模型,低氧习服后再进行60 Co全身一次性照射6.0Gy。连续... 详细信息

目的研究低氧习服在小鼠造血干细胞急性放射损伤后修复中的作用。方法采用随机数字表法将6~7周龄雄性C57BL/6J小鼠分为常氧辐照组和低氧习服辐照组。建立低氧习服急性放射损伤动物模型,低氧习服后再进行60 Co全身一次性照射6.0Gy。连续监测辐照前后小鼠尾静脉血血常规;流式细胞术检测低氧习服前后小鼠骨髓造血干细胞;取低氧习服小鼠长骨进行病理分析和VE-Cadherin免疫荧光染色;ELISA检测低氧习服小鼠低氧诱导因子-1α(HIF-1α)和血管生成素-1(ANGPT1)。结果低氧习服加速辐照后小鼠外周血恢复,低氧习服辐照组外周血红细胞和血小板最低值高于常氧辐照组[(7.0±0.6)×10^(12)/L vs(5.1±0.4)×10^(12)/L,t=2.483,P<0.05;(203±30)×10^(9)/L vs(141±25)×10^(9)/L,t=2.541,P<0.05];低氧习服组骨髓LSK细胞和长期造血干细胞(LT-HSC)的比例及数量均高于常氧对照组[(3.91±0.21)‰vs(3.37±0.11)‰,t=2.536,P=0.032;(7.18±0.84)×10^(4)/L vs(6.01±0.82)×10^(4)/L,t=2.641,P=0.029;(12.05±0.53)%vs(9.37±0.45)%,t=3.512,P=0.023;(0.74±0.12)×10^(3)/L vs(0.58±0.11)×10^(3)/L,t=2.667,P=0.027]。低氧习服促进骨髓窦的增殖扩张和VE-Cadherin在窦内皮细胞的表达,减轻造血细胞凋亡和血管龛损伤;低氧习服组小鼠骨髓LSK细胞中HIF-1α和骨髓腔冲洗上清液中ANGPT1含量明显增加[(2.97±0.28)pg/cell vs(1.95±0.22)pg/cell,t=4.896,P=0.013;(12.30±3.70)pg/ml vs(6.25±2.70)pg/ml,t=6.742,P=0.001]。结论低氧习服减轻造血干细胞和血管龛的放射损伤,加快造血恢复,其原因可能与低氧习服调节LT-HSC比例,促进HIF-1α、ANGPT1在造血干细胞中的表达有关。

关键词：低氧习服放射损伤造血干细胞低氧诱导因子-1α 血管生成素-1

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