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蛋白质组学生物标志物预测补救性宫颈环扎术的临床成功率

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 6-7页

作者： weiner c.p. Lee K.-Y. Buhimschic.S. 张剑萍 Dept. physiol. Obstet. Gynecol. R. University of Maryland School of Medicine 655 W Baltimore St Baltimore MD 21201- 1559 United States Dr

Objective: The origin of incompetent cervix is multifactorial, and the success of rescue cerclage is unpredictable. We tested amniotic fluid from women who were preparing to undergo rescue cerclage for proteomic biomarkers and correlated their presence with clinical outcome. Study design: Amniocentesis was performed to facilitate rescue cerclage in 37 consecutive women with painless dilation (>2 cm) and no detectable uterine activity for 4 hours (range, 1- 24 hours) before cerclage. Thirty- nine consecutive women with a sonographically normal pregnancy and cervix who underwent amniocentesis for chromosomal testing during the same study interval at the same clinical site provided the control samples. A proteomic fingerprint was generated with the discarded sample and the Mass- Restricted score (MR score) for inflammation calculated. peaks corresponding to free hemoglobin chains were sought as evidence of decidual hemorrhage or intra- amniotic bleeding. Results: Amniocentesis was performed at 23.5 weeks in cerclage (mean dilation, 4 cm) versus 19.5 weeks in control subjects. cerclage subjects were delivered at 28.8 weeks; control subjects were delivered at 39.2 weeks. Thirty- two of 37 of cerclage subjects (86% ) were delivered prematurely. Ten of 37 of cerclage subjects (27% ), but no control subject, had a MR score that was indicative of inflammation (p peaks were present in 12 of 37 of cerclage subject (32% ), but no control subjects. Among cerclage subjects, those with a MR score of 3 to 4 were delivered earlier than those with a MR score of 0 to 2 (p core of 3 to 4 had a shorter latency period (days from amniocentesis to delivery; 3 days) and a shorter percentage of prolongation (1.8% ) than women with a MR score of 0 to 2 (35 days; p p cy period (6 days) and a shorter percentage of prolongation (3.8% ) than women without hemoglobin (38 days; p <. 05; 21.

关键词：宫颈环扎术补救性蛋白质组学生物标志物临床成功率宫颈机能不全羊膜腔穿刺游离血红蛋白宫口扩张正常妊娠

亲缘选择在植物从营养分配向繁殖分配转变中的潜在作用

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作者： E.S.c.weiner

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Journal of plant Ecology 2023年第6期16卷 135-145页

作者： Renfei chen cenxi Shi Liang Zhang chengyi Tu Jacob weiner School of Life Science Shanxi Normal UniversityTaiyuan 030000China State Key Laboratory of Grassland Agro-Ecosystem School of Life SciencesLanzhou UniversityLanzhou 730000China School of Economics and Management Zhejiang Sci-Tech UniversityHangzhou 310000China Department of Environmental Science Policyand ManagementUniversity of CaliforniaBerkeleyCA 94720USA Department of plant and Environmental Sciences University of CopenhagenDK-1871 FrederiksbergDenmark

根据经典的最优繁殖分配理论,植物生长过程中从营养生长向繁殖分配的转变是突然发生的。一些植物确实如此,这也是农作物产量最大化的一种有效策略。然而,自然界很多植物从营养生长向繁殖分配的转变是渐进发生的。一些修正的生物量分配... 详细信息

根据经典的最优繁殖分配理论,植物生长过程中从营养生长向繁殖分配的转变是突然发生的。一些植物确实如此,这也是农作物产量最大化的一种有效策略。然而,自然界很多植物从营养生长向繁殖分配的转变是渐进发生的。一些修正的生物量分配理论也预测了这种渐变趋势。本研究假设亲缘选择能够改变最优分配理论的预测。通过数学模型,我们研究了正负亲缘选择对植物向繁殖器官分配能量起始时间的影响。基于代价与收益的合理假设,当繁殖器官与营养器官起始生物量比值较高时,处于亲缘选择作用下的植物更可能以一种突变的方式实现从营养生长向繁殖生长的转变。经验数据的观测支持我们的理论预测。这一研究在连接植物生活史与能量分配以及提高农业产量方面具有重要意义。

关键词：广义适合度资源分配繁殖器官营养生长繁殖分配进程

pro-Inflammatory Substances and cognition in the Dallas Heart Study

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Open Journal of psychiatry 2016年第1期6卷 95-101页

作者： Keith A. Bernardo Heidi c. Rossetti Myron F. weiner colin Munro cullum James De Lemos Laura H. Lacritz Department of psychiatry University of Texas Southwestern Medical Center Dallas TX USA Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX USA Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA

cognitive decline in late adulthood might be partially mediated by subclinical generalized vascular disease. If so, atherogenic factors such as pro-inflammatory cytokines might be mid-life targets for prevention or treatment. Dallas Heart Study subjects (n = 997;mean age = 42.94 ± 10.2 yrs) underwent blood assays of pro-inflammatory biomarkers associated with atherosclerosis and 8 years later completed a cognitive outcome measure, the Montreal cognitive Assessment (MocA). Markers included c-reactive protein (c.p., Interleukin-18 (IL-18), Lipoprotein-associated phospholipase (Lp-pLA2), and Monocyte chemoattractant protein (Mcp-1), with Apolipoprotein E4 (ApoE4) as a potential modifier. We found weak evidence for Lp-pLA2 and c.p.as predictors of cognitive scores. No relationship was found between elevated Mcp-1, IL-18 and cognition. presence of the ApoE4 allele did not impact the relationship between biomarkers and cognitive function. Levels of atherogenesis-related pro-inflammatory blood biomarkers did not predict cognitive function in middle-aged adults after an interval of 8 years.

关键词： Montreal cognitive Assessment cognition Inflammation Dallas Heart Study

Technology development for ultraintense all-OpcpA systems

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High power Laser Science and Engineering 2019年第1期7卷 27-37页

作者： J.Bromage S.-W.Bahk I.A.Begishev c.Dorrer M.J.Guardalben B.N.Hoffman J.B.Oliver R.G.Roides E.M.Schiesser M.J.Shoup III M.Spilatro B.Webb D.weiner J.D.Zuegel Laboratory for Laser Energetics University of Rochester

Optical parametric chirped-pulse amplification(OpcpA) [Dubietis et al., Opt. commun. 88, 437(1992)] implemented by multikilojoule Nd:glass pump lasers is a promising approach to produce ultraintense pulses(>1023 W/cm2).Technologies are being developed to upgrade the OMEGA Ep Laser System with the goal to pump an optical parametric amplifier line(Ep OpAL) with two of the OMEGA Ep beamlines. The resulting ultraintense pulses(1.5 kJ, 20 fs,1024 W/cm2) would be used jointly with picosecond and nanosecond pulses produced by the other two beamlines. A midscale OpAL pumped by the Multi-Terawatt(MTW) laser is being constructed to produce 7.5-J, 15-fs pulses and demonstrate scalable technologies suitable for the upgrade. MTW OpAL will share a target area with the MTW laser(50 J, 1 to 100 ps), enabling several joint-shot configurations. We report on the status of the MTW OpAL system, and the technology development required for this class of all-OpcpA laser system for ultraintense pulses.

关键词： nonlinear optics optical parametric chirped-pulse amplification ultrafast lasers ultraintense lasers

Amelioration of Diabetes Mellitus Type II after Sleeve Gastrectomy—Data on Nationwide Survey on Quality Assurance in Bariatric Surgery in Germany

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Surgical Science 2013年第12期4卷 8-12页

作者： I. El-Sayes R. weiner M. Talai Rad S. Wolff c. Knoll T. Manger c. Stroh Department of General Abdominal and Paediatric Surgery SRH Hospital Gera Germany Department of General Abdominal and Vascular Surgery University Hospital Magdeburg Magdeburg Germany Helios Hospital Bad Saarow Germany Sachsenhausen Hospital Frankfurt Germany Stat consult Magdeburg Germany

Introduction: Sleeve Gastrectomy (SG) is becoming more popular due to its weight reducing effect and promising anti-diabetic efficacy. However, long term results are still lacking. Methods: The study focuses on anti-diabetic efficacy of SG through retrospective analysis of data for patients who underwent SG in Germany from 2005 to 2011. Anti-diabetic efficacy was assessed at 1, 2 and up to 4 years after surgery. Results: 5400 morbidly obese patients underwent SG. Of these 5400 patients 13.2% (n = 712) were insulin treated (IT) and 21.6% (n = 1165) were non-insulin treated (NIT). Total follow-up was accomplished in 41.24% of patients. percentage of remission and improvement (RI) at 1 year was 83.8% (80.2% for insulin treated (IT) vs. 85.1% for non-insulin treated (NIT)). RI% at 2 years dropped to 77.6% (76.9% for IT vs. 77.9% for NIT patients). With late follow up (up to 4 years), RI% was 65.9% (58.8% for IT vs. 66.7% for NIT patients). Difference between IT and NIT patients was insignificant. conclusion: SG shows promising ant-diabetic efficacy at 1 year, 2 years and up to 4 years after surgery. This efficacy gradually drops with prolonged time interval after surgery and seems to be insignificantly higher among NIT vs. IT patients.

关键词： Sleeve Gastrectomy Diabetes Mellitus Type II Diabetes Remission Metabolic Surgery

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Java企业级应用开发指南原书第2版二

MTW-OpAL:a technology development platform for ultra-intense optical parametric chirped-pulse amplification systems

丛书名： Sun公司核心技术丛书

2004年

作者：（美）Stephen Asbury （美）Scott R.weiner 王强等译

本书针对Java介绍当前企业级开发者所采用的主要技术，涉及用于连接数据库的JDBc，访问服务的Java命名和目录接口等。

ISBN: (纸本)711113298X

本书针对Java介绍当前企业级开发者所采用的主要技术，涉及用于连接数据库的JDBc，访问服务的Java命名和目录接口等。

关键词： JAVA语言程序设计

来源：畅想之星图书光盘版（南... 评论

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High power Laser Science and Engineering 2021年第4期9卷 200-211页

作者： J.Bromage S.-W.Bahk M.Bedzyk I.A.Begishev S.Bucht c.Dorrer c.Feng c.Jeon c.Mileham R.G.Roides K.Shaughnessy M.J.ShoupⅢ M.Spilatro B.Webb D.weiner J.D.Zuegel Laboratory for Laser Energetics University of RochesterNY 14623USA

Optical parametric chirped-pulse amplification implemented using multikilojoule Nd:glass pump lasers is a promising approach for producing ultra-intense pulses(>10^(23)W/cm^(2)).We report on the MTW-OpAL Laser System,an optical parametric amplifier line(OpAL)pumped by the Nd:doped portion of the multi-terawatt(MTW)*** midscale prototype was designed to produce 0.5-pW pulses with technologies scalable to tens of *** choices made for MTW-OpAL were guided by the longer-term goal of two full-scale OpALs pumped by the OMEGA Ep to produce 2×25-pW beams that would be co-located with kilojoule-nanosecond ultraviolet *** MTWOpAL campaigns that have been completed since“first light”in March 2020 show that the laser design is fundamentally sound,and optimization continues as we prepare for“first-focus”campaigns later this year.

关键词： nonlinear optics optical parametric chirped-pulse amplification ultra-intense lasers ultrafast lasers

Regulation of inflammation in the central nervous system:platelets as sensors of neuronal damage

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Regulation of inflammation in the central nervous system:Pla...