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Cost burden following esophagectomy:A single centre observational study

World Journal of Gastrointestinal surgery 2024年第7期16卷 2255-2269页

作者： Vered Buchholz dong Kyu Lee david.s.Liu Ahmad Aly stephen A Barnett Riley Hazard Peter Le Benjamin Kioussis Vijayaragavan Muralidharan Laurence weinberg department of surgery Austin HealthMelbourne 3084VictoriaAustralia department of Anesthesiology and Pain Medicine Dongguk University Ilsan HospitalSeoul 14566GoyangSouth Korea department of surgery Austin HealthThe University of MelbourneMelbourne 3084VictoriaAustralia department of Anesthesia Austin HealthMelbourne 3084VictoriaAustralia department of Anesthesia Austin HospitalHeidelberg 3084VictoriaAustralia department of Critical Care The University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUNd Cost analyses of patients undergoing esophagectomy is valuable for identifying modifiable expenditure drivers to target and curtail costs while improving the quality of *** aimed to define the cost-complication relationship after esophagectomy and delineate the incremental contributions to *** To assess the relationship between the hospital costs and potential cost drivers post esophagectomy and investigate the relationship between the cost-driving variables(predicting variables)and hospital costs(dependent variable).METHOds In this retrospective single center study,the severity of complications was graded using the Clavien-dindo(Cd)classification *** esophagectomy complications were categorized and defined according to consensus *** costing data included the in-hospital costs of the index admission and any unplanned admission within 30 postoperative *** used correlation analysis to assess the relationship between key clinical variables and hospital costs(in United.s.ates dollars)to identify cost drivers.A mediation model was used to investigate the relationship between these variables and hospital *** A total of 110 patients underwent primary esophageal *** median admission cost was $47822.7(interquartile range:35670.2-68214.0).The total effects on costs were $13593.9(95%CI:10187.1-17000.8,Pse in Cd.s.verity grade,$4781(95%CI:3772.7-5789.3,Pse in the number of complications,and $42552.2(95%CI:8309-76795.4,P=0.015)if a key esophagectomy complication *** esophagectomy complications drove the costs directly by $11415.7(95%CI:992.5-21838.9,P=0.032).CONCLUsION The severity and number of complications,and the development of key esophagectomy complications significantly contributed to total hospital *** institutional initiatives and.s.rategies are needed to enhance patient outcomes and minimize costs.

关键词： Anesthesia Esophagectomy Complications Cancer surgery

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Flexible ultra-thin super-resolution end.s.opy

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science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 171-172页

作者： George s.d.Gordon department of Electrical and Electronic Engineering University of NottinghamNottingham NG7 2RDUK

In recent years, multimode fiber(MMF) has become an important tool for high-resolution end.s.opic imaging in narrow channels(e.g., in the brain via needles or inside blood vessels) due to its high mode density and fine diameter, typically stacle to wid.s.read deployment in applications is that realistic perturbations, including bending, twisting and changes in temperature, cause unacceptable image degradation.

关键词： fiber resolution typically

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Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： d.LEE s.CHANG J.LEE department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea school of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random *** method consists of a generalized polynomial chaos expansion(GPCE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data *** the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random *** allows for avoiding repeated computations of invariant substructures while generating the input-output data *** substructuring with static condensation further improves the computational efficiency of the reanalysis without losing ***,the GPCE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional *** numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPCE using full finite element analyses(FEAs).We also demonstrate the efficiency and.s.alability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPCE) static reanalysis method static condensation substructuring

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Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma science and Technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIN M.R.NURGALIEV A.R.NEMETs I.A.ZEMTsOV s.d.s.NTsOV T.B.MYALTON d.s.sERGEEV N.A.sOLOVEV d.V.sARYCHEV d.V.RYJAKOV s.N.TUGARINOV N.N.NAUMENKO National Research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow state Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JsC“sOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field.s.de to the low-field.s.de by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. d.s.harges with high anomalous ion heat transport are obtained in all considered regimes. In these d.s.harges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are d.s.inguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

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叙述性回顾:直肠肿瘤患者一级亲属的直肠结肠癌筛查

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 1-1页

作者： Eisen G.M. weinberg d.s. 马卉 Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 United States Dr.

Many patients and providers are aware that colorectal cancer (CRC) “ runs in families." A patient with 1 first- degree relative with CRC has approximately twice the personal risk for CRC as a similar person without this family history. Colorectal cancer is the third most common type of cancer in the United.s.ates. When providers neglect to collect information on family history, they may fail to appropriately tailor recommendations for screening for CRC for many patients. This review considers the existing data and.s.mmarizes an evidence- based approach to the common clinical problem of how and when to implement screening for CRC in a patient with a family history of colonic neoplasia. The authors d.s.uss the varying risks for CRC given the patient’ s age, health habits, and personal and family histories. In the context of a clinical case that focuses on the effect of a single affected first- degree relative, the authors weigh the risks and benefits of various screening alternatives and briefly address chemoprevention, genetic testing, and future directions in screening for CRC.

关键词：直肠结肠癌直肠肿瘤一级亲属筛查方法结肠直肠癌叙述性患病风险肿瘤家族史聚集性循证医学方法

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The magnetosheath at high spectral resolution

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Earth and Planetary Physics 2024年第1期8卷 234-246页

作者： K.d.Küntz d.Koutroumpa W.R.dunn A.Foster F.s.Porter d.G.sibeck B.Walsh The Henry A.Rowland department of Physics and Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NAsA Goddard.s.ace Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOs-OVsQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance department of Physics and Astronomy University College LondonLondonUK The Centre for Planetary science at UCL/Birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for space Physics Boston University110 Cummington MallBostonMAUSA

While we eagerly anticipate sMILE’s(solar wind Magnetosphere Ionosphere Link Explorer)unprecedented X-ray observations of the Earth’s magnetosheath and the initiation of a new era of magnetospheric research,it seems appropriate to look ahead to the abilities of the next generation of astrophysics *** these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based mission,is currently planned to be able to observe the magnetosheath at high spectral resolution(~2 eV).With a field of view of~30′,LEM will allow higher spatial resolution and higher cadence measurement of the motion of a very small portion of the magnetopause over relatively short periods of time(multiple hours),complementing sMILE’s global ***’s strength is its spectral *** will be able to measure the abundance of a broad range of elements and ionization states,many of which are inaccessible to current in situ instruments,and will be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background using the difference in their relative velocities.

关键词： magnetosheath charge exchange solar wind abundances

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地球演化历史中氧逸度变化对壳幔循环启动、风化和超大陆循环的指示

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science Bulletin 2024年第1期69卷 97-102页

作者：王瑞邬绍宸 Roberto F.weinberg William J.Collins Peter A.Cawood state Key Laboratory of Geological Processes and Mineral Resources Institute of Earth SciencesChina University of GeosciencesBeijing 100083China Frontiers science Center for deep-time digital Earth China University of Geosciences(Beijing)Beijing 100083China school of Earth Atmosphere and EnvironmentMonash UniversityClayton VIC 3800Australia The Institute for Geoscience Research Curtin UniversityPerth WA 6102Australia

We apply a zircon redox index to a global compilation of detrital zircons to track the variation of oxidation state,expressed asΔFMQ,through Earth's *** from I-type rocks,which comprise mantle and crustal igneous protoliths,including tonalite–trondhjemite–granodiorites(TTGs),generally have a high oxidation state(ΔFMQ>0).In contrast,zircons from igneous rocks derived from supracrustal source rocks(s-type)are commonly reduced(ΔFMQdensity function derived from the Gaussian-Kernel-density-Estimation,we use the maximum likelihood estimation(MLE)to d.s.inguish stype from I-type zircons through Earth's history using zircon *** s-type magma production shows a ca.600 Ma cyclicity that is closely related to the supercontinent *** link a cyclic drop in redox values after 2.6 Ga to periodic s-type magma generation associated with burial and melting of metasedimentary rocks during supercontinent assembly and ***ΔFMQ of the detrital zircons rise at~3.5 Ga followed by a consistent averageΔFMQ>0 over the last 3 *** that the redox state of magmas is independent of crustal thickness and.s.lica variation,and elevated values are likely more closely related to tectonic setting,we suggest that the consistent averageΔFMQ>0 from ca.3.5 Ga onwards relates to recycling of oceanic lithosphere back into the mantle in what eventually became established as subduction *** more reduced magmas associated with sedimentary sources,became established at 2.6 Ga,presumably in response to continental rocks rising above sealevel,and follow peaks of productivity associated with the supercontinent cycle.

关键词： Oxidation state supercontinent Weathering subduction Zircon Granite

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The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Padilla Lourd.s.sánchez-salido Anne Baron-Van Evercooren Beatriz García-díaz Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONANd) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and chronic condition widely found in the general *** reason for this is the extensive variety of damage or d.s.ases that can spark this unpleasant constant feeling in *** the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical ***,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies satellite glial cells sensory neurons

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development and testing of a high-power s-band klystron at BINP sB RAs

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Nuclear science and Techniques 2024年第7期35卷 58-67页

作者： A.Levichev A.Barnyakov s.samoylov d.Nikiforov V.Ivanov M.Arsentyeva d.Chekmenev O.Pavlov I.Pivovarov Budker Institute of Nuclear Physics Lavrentyeva Av.11NovosibirskRussia630090 Novosibirsk state University Pirogova Str.2NovosibirskRussia630090

This paper details the development and testing of the first working prototype of the s-band high-power klystron,accomplished at the Budker Institute of Nuclear Physics,siberian Branch,Russian Academy of sciences(BINP sB RAs).Upon testing,the klystron demonstrated the following parameters:an operating frequency of 2856 MHz and a peak power output of 50 *** paper presents the klystron's d.s.gn,its constituent units,and pertinent processing procedures,along with d.s.ussions on the measurement of its parameters.

关键词： Klystron Linear accelerator Electron beam

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Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia d.V.Mashtalyar M.A.Piatkova A.I.Pleshkova I.M.Imshinetskiy M.s.Gerasimenko E.A.Belov V.V.Kumeiko d.N.Kozyrev K.A.Fomenko V.V.Mostovaya B.R.Torpanov A.R.Biktimirov I.s.Osmushko s.L.sinebryukhov s.V.Gnedenkov Institute of Chemistry FEB RAs 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmunsky National scientific Center of Marine Biology FEB RAs 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical dermatovenerological d.s.ensary 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic vancomycin,widely used in the treatment of infections caused by staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to sEM,Eds,XRd and XPs data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PEO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite Vancomycin

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