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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-Yue Cai weiming shi Zhao-Hui Jin Zhi-Xiang Yu Jin-Xin Zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom economy.Computational studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol reaction.Of the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and cycloolivil.Given the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

LncRNA HOTTIP facilitated tumor growth via stimulating the hnRNPA2B1/DKK1/Wnt/β-catenin regulatory axis in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 53-56页

作者： Weiqiang Zeng Chuanjian shi Liqiang Deng weiming Fu Jinfang Zhang Cancer Center Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China

Hepatocellular carcinoma(HcC)has become the fifth leading cause of cancer mortality worldwide in the past decade.1 Dysregulated long noncoding RNAs(lncRNAs)are closely associated with its occurrence and progression.Recently identified IncRNA named"HOXA transcript at the distal tip"(HOTTIP)has been considered as an oncogene in multiple cancers.However,the mechanism underlying HOTTiP-mediated hepatocarcinogenesis remains mostly unknown.

关键词： DKK1 mortality stimulating

Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-Decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses

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Rice science 2024年第1期31卷 87-102页

作者： DI Dongwei MA Mingkun ZHANG Xiaoyang LU Yufang Herbert J.KRONZUCKER shi weiming State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Food Science and Engineering Foshan UniversityFoshan 528000China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia University of Chinese Academy of Sciences Beijing 100049China

Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and secretion.We applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-D),which was previously identified in rice root exudates.Our results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-D biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-D release from roots into the soil medium.Our finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-D and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-D secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils.

关键词： 1,9-decanediol biological nitrification inhibitor metabolomic analysis nitrogen-use efficiency transcriptomic analysis

Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots

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Chinese Herbal Medicines 2024年第3期16卷 392-400页

作者： Lin shi Tong Cui Xinyue Wang Rina Wu Junrui Wu Yanqun Wang weiming Wang College of Food Science Shenyang Agricultural University Institute of Chinese Materia Medica Heilongjiang Academy of Chinese Medicine Sciences

In Northeast China,Goubao pickle is a popular food fermented from the roots of Platycodon grandiflorum as the main material,offering a unique flavor and rich nutritional value.Platycosides in roots of P.grandiflorum may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation.However,biotransfermation of platycosides has not been reviewed during fermentation.In this study,we reviewed platycosides in chemical diversity,metabolic processes in vivo,biotransformation of platycosides in vitro,and pharmacological effects.Finally,we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.

关键词： biotransformation Goubao pickle microorganisms pharmacological activities platycosides Platycodon grandiflorum (Jacq.) A. DC

Biochar can Increase Chinese Cabbage(Brassica oleracea L.)Yield,Decrease Nitrogen and Phosphorus Leaching Losses in Intensive Vegetable Soil

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 197-206页

作者： Haijun Sun Paramsothy Jeyakumar Hongdong Xiao Xuewen Li Jiayou Liu Min Yu Prabal Bir Jung Rana weiming shi Co-Innovation Center for Sustainable Forestry in Southern China College of ForestryNanjing Forestry UniversityNanjing210037China Department of Horticulture College of Food Science and TechnologyFoshan UniversityFoshan528000China Environmental Sciences School of Agriculture and EnvironmentMassey UniversityPalmerston North4442New Zealand State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing210008China

There are few evidences on the effect of biochar on vegetable yield,nitrogen(N)and phosphorus(P)leaching losses under intensive vegetable production soil.The current field plot scale study evaluated responses of Chinese cabbage(Brassica oleracea L.)yield,N and P leaching losses using five N treatments of common N application rate according to local farmers’practice(N100%),reducing 20%or 40%N fertilizer(N80%and N60%),and reducing 40%N fertilizer but incorporating 10 or 20 t/ha biochar(N60%+BC10 and N60%+BC20).Results showed that N80%and N60%decreased both the cabbage economic and leaf yields by 6.8%-36.3%and 27.4%-37.7%,respectively.Incorporation of biochar with reduced N fertilizer rates improved the cabbage yield,in particular the N60%+BC20 matched the yield that observed in N100%treatment.Enhanced N and P uptake capacities of cabbage shoot probably contributed the higher vegetable production under both biochar amendment schemes.Biochar application mitigated the NH_(4)^(+)-N and total P leaching losses by 20%-30%and 29%-32%,respectively,compared with their counterpart treatment N60%.Nevertheless,biochar exerted no influence on the NO_(3)^(-)-N leaching.In addition,soil organic matter content was recorded with 7.4%-28.7%higher following 10-20 t/ha biochar application.In conclusion,biochar application can increase economic yield of cabbage via increasing N and P use efficiency,decrease N and P leaching losses,and improve soil quality in an intensive vegetable production system.

关键词： Biochar leachate non-point source pollution vegetable yield soil quality

Acupuncture for ischemic stroke:where are we now?

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Acupuncture and Herbal Medicine 2024年第1期4卷 36-55页

作者： weiming Zhu Qingqing Jia Alberto Cantidio Ferreira Hailun Jiang Jieying Zhang Boxuan Li Menglong Zhang Bifang Zhuo Yuanhao Lyu Junjie Chen Li Li Guang Tian shizhe Deng Zhihong Meng Xuemin shi Graduate School Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital Tianjin University of Traditional Chinese MedicineTianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine JinanChina Taos Institute of Traditional Chinese Medicine Recife/PEBrazil

Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and fatigue.However,the mechanisms underlying the effects of acupuncture in IS remain unclear.Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and immunity.Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.

关键词： Acupuncture Curative effect Electroacupuncture Ischemic stroke Mechanism Review

Nondestructive estimation of bok choy nitrogen status with an active canopy sensor in comparison to a chlorophyll meter

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Pedosphere 2020年第6期30卷 769-777页

作者： Rongting JI weiming shi Yuan WANG Hailin ZHANG Ju MIN State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Plant and Soil Sciences Oklahoma State UniversityStillwater OK 74078-6028USA

Precise estimation of vegetable nitrogen(N)status is critical in optimizing N fertilization management.However,nondestructive and accurate N diagnostic methods for vegetables are relatively scarce.In our two-year field experiment,we evaluated whether an active canopy sensor(GreenSeeker)could be used to nondestructively predict N status of bok choy(Brassica rapa subsp.chinensis)compared with a chlorophyll meter.Results showed that the normalized difference vegetation index(NDVI)and ratio vegetation index(RVI)generated by the active canopy sensor were well correlated with the aboveground biomass(AGB)(r=0.698–0.967),plant N uptake(PNU)(r=0.642–0.951),and root to shoot ratio(RTS)(r=-0.426 to-0.845).Compared with the chlorophyll meter,the active canopy sensor displayed much higher accuracy(5.0%–177.4%higher)in predicting AGB and PNU and equal or slightly worse(0.54–1.82 times that of the chlorophyll meter)for RTS.The sensor-based NDVI model performed equally well in estimating AGB(R2=0.63)and PNU(R2=0.61),but the meter-based model predicted RTS better(R2=0.50).Inclusion of the days after transplanting(DAT)significantly improved the accuracy of sensor-based AGB(19.0%–56.7%higher)and PNU(24.6%–84.6%higher)estimation models.These findings suggest that the active canopy sensor has a great potential for nondestructively estimating N status of bok choy accurately and thus for better N recommendations,especially with inclusion of DAT,and could be applied to more vegetables with some verification.

关键词： aboveground biomass GreenSeeker model prediction N diagnosis normalized difference vegetation index plant N uptake root to shoot ratio ratio vegetation index soil and plant analyer development(SPAD)

Phosphorus supply and management in vegetable production systems in China

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Frontiers of Agricultural Science and Engineering 2019年第4期6卷 348-356页

作者： Rui WANG weiming shi Yilin LI State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

Vegetable production systems involve high rates of chemical and organic fertilizer applications,leading to significant P accumulation in vegetable soils,as well as a decrease in P use efficiency(PUE),which is one of the key limiting factors in vegetable production.This review introduces the vegetable production systems in China and their fertilization status,and analyzes probable causes of overfertilization of vegetable fields.Poorly developed root systems and high P demand have led to the need to maintain much higher available P concentrations in the root zone for regular growth of vegetables,which might necessitate higher phosphate fertilizer input than the plants require.Research on strategies to improve vegetable PUE and the mechanisms of these strategies are summarized in this review.Increasing the P uptake by vegetables by supplying P during the critical growth stage and effectively utilizing the accumulated P by optimizing the C:P ratio in soils can substantially increase PUE.These advances will provide a basis for improving PUE and optimizing phosphate fertilizer applications in vegetable production through regulatory measures.In addition,some policies are recommended that could ensure the safety of vegetables and improve product quality.This review also aims to improve understanding of P cycling in vegetable fields and assist in the development of best practices to manage P reserves globally.

关键词： phosphate fertilizer phosphorus use efficiency vegetable production systems phosphorus management policy recommendation

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桥梁施工工艺优化及质量控制研究

现代工程科技 2024年第7期3卷 37-40页

作者：师为明中交二航局第四工程有限公司安徽芜湖241000

随着工程技术的快速发展,桥梁施工工艺优化及其质量控制成为工程领域的重要课题。探讨了如何通过优化施工工艺来提高桥梁工程的质量和效率。分析了当前桥梁施工领域的主要问题,包括材料选择、技术应用、现场管理及安全控制等方面。针对... 详细信息

随着工程技术的快速发展,桥梁施工工艺优化及其质量控制成为工程领域的重要课题。探讨了如何通过优化施工工艺来提高桥梁工程的质量和效率。分析了当前桥梁施工领域的主要问题,包括材料选择、技术应用、现场管理及安全控制等方面。针对这些问题,提出了4个改进措施。讨论了施工材料的选择与应用,强调了选用高性能材料的重要性,以及其环境影响;探讨了施工过程中技术创新的必要性,包括现代施工技术的应用和信息技术在施工管理中的作用;对施工现场管理的优化进行了详细分析,着重探讨流程优化、管理体系完善以及施工人员的培训和管理;强调了施工安全控制措施的重要性,包括风险评估、安全管理制度的建立和应急预案的制定。这些措施旨在全方位提升桥梁施工的效率和质量,确保工程的顺利完成。希望通过这项研究,能够为桥梁工程领域提供实用的指导和参考,推动施工工艺的不断优化和质量控制的提升。

关键词：桥梁施工工艺优化质量控制施工管理

Haplotype variations in QTL for salt tolerance in Chinese wheat accessions identified by marker-based and pedigree-based kinship analyses

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The Crop Journal 2020年第6期8卷 1011-1024页

作者： shizhou Yu Jianhui Wu Meng Wang weiming shi Guangmin Xia Jizeng Jia Zhensheng Kang Dejun Han State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYangling 712100ShaanxiChina Molecular Genetics Key Laboratory of China Tobacco Guizhou Academy of Tobacco ScienceGuiyang 550081GuizhouChina State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008JiangsuChina Key Laboratory of Plant Cell Engineering and Germplasm Innovation Ministry of EducationSchool of Life SciencesShandong UniversityJinan 250100ShandongChina Key Laboratory of Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture/The National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Most modern wheat cultivars were selected on the basis of yield-related indices measured under optimal fertilizer and irrigation inputs.With climate change,land degradation and salinity caused by sea water encroachment,wheat is increasingly subjected to environmental stress.Moreover,expanding urbanization increasingly encroaches upon prime agricultural land in countries like China,and alternative cropping areas must be found.Some of these areas have moderate constraining factors,such as salinity.Therefore,it is important to investigate whether current genetic materials and breeding procedures are maintaining adequate variability to address future problems caused by abiotic stress.In this study,a panel of 307 wheat accessions,including local landraces,exotic cultivars used in Chinese breeding programs and Chinese cultivars released during different periods since1940,were subjected to a genome-wide association study to dissect the genetic basis of salinity tolerance.Both marker-based and pedigree-based kinship analyses revealed that favorable haplotypes were introduced in some exotic cultivars as well as a limited number of Chinese landraces from the 1940 s.However,improvements in salinity tolerance during modern breeding are not as obvious as that of yield.To broaden genetic diversity for increasing salt tolerance,there is a need to refocus attention on local landraces that have high degrees of salinity tolerance and carry rare favorable alleles that have not been exploited in breeding.

关键词： Genome-wide association study Linkage disequilibrium Salt tolerance Haplotype tracing Triticum aestivum