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Unveiling the performance of a novel alkalizing bacterium Enterobacter ***-2 in immobilization of available Cd

Journal of Environmental Sciences 2024年第3期137卷 245-257页

作者： Yixin Luo Min Liao Xiongxiong Lu Na Xu Xiaomei Xie weiming gao College of Environmental and Resource Science Zhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Hangzhou 310058China National Demonstration Center for Experimental Environmental and Resources Education Zhejiang UniversityHangzhou 310058China

A novel alkalizing strain Enterobacter ***-2 that could resist 400 mg/L Cd was isolated from Cd-contaminated soil,which immobilized 96.05%Cd^(2+)from *** distribution analysis demonstrated that more than half of the Cd^(2+)was converted into extracellular precipitated Cd through mobilization of the alkali-producing mechanism by the strain LYX-2,achieving the high immobilization efficiency of Cd^(2+).Biosorption experiments revealed that strain LYX-2 had superior biosorption capacity of 48.28 mg/g for *** experiments with Brassica rapa *** performed with and without strain *** to control,15.92%bioavailable Cd was converted to non-bioavailable Cd and Cd content in aboveground vegetables was decreased by 37.10%with addition of strain *** Cd was mainly immobilized through extracellular precipitation,cell-surface biosorption and intracellular accumulation of strain LYX-2,which was investigated through Cd distribution,Scanning Electron Microscope and Energy-Dispersive X-ray Spectroscopy(SEM-EDS),Fourier Transform Infrared Spectroscopy(FT-IR),X-ray Photoelectron Spectroscopy(XPS)and Transmission Electron Microscopy(TEM)*** addition,the application of strain LYX-2 significantly promoted the growth of vegetables about *** results indicated that highly Cd-resistant alkalizing strain LYX-2,as a novel microbial passivator,had excellent ability and reuse value to achieve the remediation of Cd-contaminated soil coupled with safe production of vegetables simultaneously.

关键词： Cadmium Enterobacter sp.LYX-2 Cd Immobilization Microbial passivator

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黄河中上游区土地使用结构与布局复合优化

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农业工程学报 2024年第9期40卷 252-262,F0003页

作者：童海燕董晓刘加平高伟铭长安大学建筑学院西安710061 西安长安大学工程设计研究院有限公司西安710064 西安建筑科技大学建筑学院西安710000

黄河中上游地区生态环境脆弱,空间发展问题突出,探索该区域土地使用结构和布局优化配置是实现黄河流域生态保护和高质量发展的有效途径。该研究以黄河中上游地区为研究对象,基于该区域土地使用、社会经济等数据,运用多目标规划(multi-ob... 详细信息

黄河中上游地区生态环境脆弱,空间发展问题突出,探索该区域土地使用结构和布局优化配置是实现黄河流域生态保护和高质量发展的有效途径。该研究以黄河中上游地区为研究对象,基于该区域土地使用、社会经济等数据,运用多目标规划(multi-objective programming,MOP)和PLUS模型模拟了惯性发展、生态保护、经济优先和生态-经济均衡4种情景下研究区未来土地格局和变化趋势,并在平衡生态与经济的目标下提出最优土地使用结构和布局方案。结果表明:1)4种情景下,土地使用比例结构存在较大差异;2)均衡情景下的区域土地使用结构和空间布局方案为最优,其综合效益值最高且达到19481.00亿元,与生态保护情景相比其经济效益(12223.88亿元)增长了4.07%,与经济优先情景相比其生态价值(7257.12亿元)增长了2.32%;经济优先情景下综合效益值为20273.96亿元,是4种情景下最高的。研究可为黄河中上游区域未来土地使用规划编制和土地可持续利用规划提供依据。

关键词：土地使用优化空间布局 MOP模型 PLUS模型黄河中上游地区

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低地基土承载力盐碱地大件吊装技术

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江苏建材 2024年第3期 91-92页

作者：张新国耿书林高卫明东营威联化学有限公司山东东营257200 山东产研中科高端化工产业技术研究院有限公司山东东营257200 大庆高新区庆新工程勘察有限责任公司黑龙江大庆163000

文章主要介绍在地基承载力较低的条件下,某炼厂在盐碱地进行大型设备吊装作业。从吊装设备选型与计算等方面分析了大型设备吊装可能出现的问题,并提出了相应地基处理方案,可供类似工程参考。

关键词：盐碱地低地基土承载力吊装

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A型肉毒毒素、乙醇肌内局部注射联合局部封闭治疗痉挛性斜颈14例

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安徽医药 2024年第5期28卷 992-998页

作者：陈明长高伟明胡文彬安徽中医药大学研究生院安徽合肥230001 安徽中医药大学神经病学研究所附属医院神经内科安徽合肥230001

目的分析颈项部肌内局部注射A型肉毒毒素(BTX-A)、肌内乙醇阻滞(MAB)和局部封闭联合方案治疗痉挛性斜颈的临床特点、疗效、预后以及长期随访。方法回顾性分析2004年5月至2021年10月在安徽中医药大学神经病学研究所附属医院就诊,明确诊... 详细信息

目的分析颈项部肌内局部注射A型肉毒毒素(BTX-A)、肌内乙醇阻滞(MAB)和局部封闭联合方案治疗痉挛性斜颈的临床特点、疗效、预后以及长期随访。方法回顾性分析2004年5月至2021年10月在安徽中医药大学神经病学研究所附属医院就诊,明确诊断为痉挛性斜颈并采用BTX-A、MAB以及封闭疗法联合治疗的病人的临床资料,在治疗前后行Tsui量表、全面肌张力障碍量表(FMRS)评估疗效,出院后进行长期随访调查和36项简明健康问卷调查(SF-36)。按随访结果将病人分为症状复发组和症状未复发组,比较各临床因素同临床结果之间的关系。结果14例病人中,男性4例,女性10例,年龄范围为18~47岁。Tsui量表治疗前为(11.86±4.37)分,治疗后为(1.07±0.92)分,治疗后评分显著降低(P14个月;4例随访丢失。病人出院半年后进行SF-36健康状况问卷调查,显示随访到的10例病人9项得分均>80.3分,提示生命质量较高,预后较好。按随访结果分组,两组年龄、性别、病程、身体质量指数(BMI)、临床分型、BTX-A剂量、BTX-A注射次数、封闭次数比较,差异无统计学意义(P>0.05);两组治疗前Tsui评分、MAB注射次数比较,差异有统计学意义(P<0.05)。结论BTX-A、MAB联合局部封闭疗法治疗痉挛性斜颈病人疗效显著,维持时间较长,未见明显并发症,值得临床上进一步扩大样本量进行对比分析等系列研究与推广应用。

关键词：斜颈 A型肉毒毒素肌内乙醇阻滞局部封闭疗效

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Multiple Uplift and Exhumation of the Southeastern Tibetan Plateau:Evidence from Low-Temperature Thermochronology

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 569-584页

作者： WU Limin PENG Touping FAN weiming ZHAO Guochun gao Jianfeng DONG Xiaohan PENG Shili MIN Kang Tin Aung MYINT State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Chinese Academy of Sciences Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Department of Earth Sciences The University of Hong KongHong Kong 999077China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519085China Department of Geology University of MandalayMandalay 05011Myanmar

Since the Cenozoic,the Tibetan Plateau has experienced large-scale uplift and outgrowth due to the India-Asia ***,the mechanism and timing of these tectonic processes still remain ***,using apatite fission track dating and inverse thermal modeling,we explore the mechanism of different phases of rapid cooling for different batholiths and intrusions in the southeastern Tibetan *** contrast to previous views,we find that the coeval granitic batholith exposed in the same tectonic zone experienced differential fast uplift in different sites,indicating that the present Tibetan Plateau was the result of differential uplift rather than the entire lithosphere uplift related to lithospheric collapse during Cenozoic *** addition,we also suggest that the 5-2 Ma mantle-related magmatism should be regarded as the critical trigger for the widely coeval cooling event in the southeastern Tibetan Plateau,because it led to the increase in atmospheric CO_(2)level and a hotter upper crust than before,which are efficient for suddenly fast rock weathering and ***,we propose that the current landform of the southeastern Tibetan Plateau was the combined influences of tectonic and climate.

关键词： apatite fission track rapid cooling differential uplift magmatism southeastern Tibetan Plateau

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Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease

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Nano Research 2024年第3期17卷 1748-1759页

作者： Zhenxing Zhu Dongtao Zhou Yi Yin Zhun Li Zhen Guo Yongchun Pan Yanfeng gao Jingjing Yang weiming Zhu Yujun Song Yi Li Department of General Surgery Affiliated Jinling HospitalMedical SchoolNanjing UniversityNanjing 210093China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of General Surgery Affiliated Drum Tower HospitalMedical SchoolNanjing UniversityNanjing 210008China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the *** pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in ***,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the *** can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting *** also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with *** work is believed to expand the biomedical application of nanomaterials for innate immunity modulation.

关键词： inflammatory bowel disease nanoinhibitors pyroptosis synergistic therapy antioxidant

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Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis

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Chinese Journal of Natural Medicines 2024年第6期22卷 554-567页

作者： LI weiming gao Ming XUE Weili LI Xiaoli CHANG Yu ZHANG Kaixin WEN Chenyu ZHANG Mingzhi Department of Oncology Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China

Diffuse large B-cell lymphoma(DLBCL)is characterized by significant treatment *** acid(PA)has shown promising antitumor *** study aims to elucidate the molecular mechanisms by which PA influences DLBCL *** quantified the expression levels of microRNAs(miRNAs),Forkhead box protein O1(FOXO1),and DNA methyltransferase 3A(DNMT3A)in both untreated and PA-treated DLBCL tumors and cell *** were made of cell viability,apoptosis,and autophagy-related protein expression following PA *** analyses among miR-429,DNMT3A,and FOXO1 were conducted using luciferase reporter assays and methylation-specific(MSP)Polymerase chain reaction(PCR).After transfecting the miR-429 inhibitor,negative control(NC)inhibitor,shRNA against DNMT3A(sh-DNMT3A),shRNA negative control(sh-NC),over-expression vector for DNMT3A(oe-DNMT3A),or overexpression negative control(oe-NC),we evaluated the effects of miR-429 and DNMT3A on cell viability,mortality,and autophagy-related protein expression in PA-treated DLBCL cell *** efficacy of PA was also tested in vivo using DLBCL tumor-bearing mouse ***-429 and FOXO1 expression levels were downregulated,whereas DNMT3A was upregulated in DLBCL compared to the control *** treatment was associated with enhanced autophagy,mediated by the upregulation of miR-429 and downregulation of *** luciferase reporter assay and MSP confirmed that miR-429 directly inhibits DNMT3A,thereby reducing FOXO1 *** experiments demonstrated that PA promotes autophagy and inhibits DLBCL progression by upregulating miR-429 and modulating the DNMT3A/FOXO1 *** vivo PA signific-antly reduced the growth of xenografted tumors through its regulatory impact on the miR-429/DNMT3A/FOXO1 *** acid may modulate autophagy and inhibit DLBCL progression by targeting the miR-429/DNMT3A/FOXO1 signaling pathway,suggesting a novel therapeutic target for DLBCL management.

关键词： Palmitic acid Diffuse large B-cell lymphoma MiR-429 DNMT3A FOXO1 Autophagy

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n -BUTANE ISOMERIZATION OVER PERSULFATE MODIFIED Al2O3 ZrO2 CATALYSTS

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Chinese Journal of Catalysis 1999年第5期20卷 487-488页

作者： Xia Yongde, Hua weiming, gao Zi (Department of Chemistry, Fudan University, Shanghai 200433) 复旦大学化学系上海 200433

The conversion of n-butane to isobutane over strong acid catalysts is an important process in the petrochemical refining industry, because isobutane is a valuable precursor to methyl-tert-butyl ether and other fuel additives. Many reports dealing with sulfate promoted zirconia as catalysts for n-butane isomerization have appeared[1, 2].

关键词： ywords n butane isomerization persulfated zirconia alumina acid strength distribution

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Microbiota in colorectal cancer related to liver metastasis

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Chinese Journal of Cancer Research 2024年第1期36卷 17-24页

作者： Peijun Wei weiming Han Zitong Zhang Xue Tian Chen Yang Qiaoxuan Wang Weihao Xie Ying Liu Yuanhong gao Hui Chang Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Guangdong Provincial Clinical Research Center for Cancer Guangzhou 510060China Sun Yat-sen University Cancer Center Guangzhou 510060China Department of Pediatric Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

The prevalence of colorectal cancer(CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum(F. nucleatum), Escherichia coli, and Bacteroides fragilis, and the development of gut tumors. Some strains can induce gut inflammation and produce toxins that directly harm gut epithelial cells, ultimately accelerating the onset and progression of CRC. However,little clinical evidence exists on the specific interplay between the gut microflora and colorectal cancer liver metastasis(CRLM). Some research showed the existence of viable F. nucleatum in distant metastasis of ***, gut microbiota products, such as lipopolysaccharides, sodium butyrate, and protein cathepsin K, were also found to affect the development of CRC. This article summarizes the mechanism and research status of the interplay between gut microflora and CRLM, discusses the importance of gut microflora in the treatment of CRLM, and proposes a new approach to understanding the mechanism of CRLM and potential treatments for the microbiome. It is anticipated that the gut microbiota will be a formidable therapeutic and prophylactic tool for treating and preventing CRLM.

关键词： Gut microbiota liver metastasis colorectal cancer

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Catalytic Decomposition of CFC-12 over Heteropolyacids

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Chinese Journal of Catalysis 2000年第1期21卷 3-4页

作者： MA Zhen, HUA weiming, TANG Yi, gao Zi(Department of Chemistry, Fudan University, Shanghai 200433, China) 复旦大学上海 2 0 0 43 3

Chlorine atoms from chlorofluorocarbons (CFCs) deplete stratospheric ozone and CFCs are green-house gases too. Owing to these environmental problems, many kinds of CFCs have been banned since the Montreal Protocol and two kinds of cleaning techniques have been developed. One is the synthesis of CFCs alternatives[1,2] and the other is the decomposition of banned CFCs in existing equipments[3,4].

关键词： environmental catalysis chlorofluorocarbon decomposition heteropolyacid

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