检索结果-南通市图书馆

Identification of malignant plasma cells in the primary mediastinal large B-cell lymphoma

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2024年

作者： Changchun Wang Lianhui Duan Guanyin Huang Chang Yu Xuping Yang Dangchi Li Yueyu Huang Wenhui Shen Xuefei Liu Qiaoli Lü Haiyan Yang weimin mao An Zhao Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine Chinese Academy of Sciences Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology School of Medicine Southern University of Science and Technology Department of Pathology Zhejiang Cancer Hospital Hangzhou Institute of Medicine Chinese Academy of Sciences Department of Ecology and Evolutionary Biology University of California Los Angeles Jiangxi Key Laboratory of Tumour Metastasis of Jiangxi Health Commission Jiangxi Cancer Hospital The Second Affiliated Hospital of Nanchang Medical College Jiangxi Cancer Institute Department of Hematology Zhejiang Cancer Hospital Hangzhou Institute of Medicine Chinese Academy of Sciences Zhejiang Cancer Institute Zhejiang Cancer Hospital Hangzhou Institute of Medicine Chinese Academy of Sciences

Dear Editor,Primary mediastinal large B-cell lymphoma (PMBCL) is a rare subtype of aggressive B cell lymphoma, accounting for 2%to 4%of total non-Hodgkin’s lymphoma(NHL) cases (Savage, 2022). Genomic rearrangements (e.g., isochromosome9p) and copy-number alterations at9p24.1 loci, which contain the genes encoding programmed death-ligand 1/2(PDL1/2) and JAK2, lead to the overexpression of these genes in PMBCL,distinguishing PMBCL from diffuse large B-cell lymphoma (DLBCL)(Green et al.,2010). Recent thymic single-cell gene profiling has advanced our understanding of the presence and functions of B cells in the thymus (Afzali et al., 2024). However,the etiology of thymic B cell-derived PMBCL and its cellular microenvironment remain unknown. In this study, from a single-cell perspective, we compared the single-cell profiles of PMBCL with those of DLBCL and normal lymph nodes (NLNs),and discovered a unique phenotype of PMBCL-associated malignant plasma cells.

关键词：

Influence of structure transition on plastic behaviors of iron based ordered alloys

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2012年第10期55卷 2920-2925页

作者： mao weimin YANG Ping State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Department of Materials University of Science and Technology BeijingBeijing 100083China

The influence of ordered structure on the dislocation configuration,structure of anti-phase domain boundary,partial dislocation slips,*** analyzed in the background of promoting the plasticity of iron based ordered solid solutions with second-order phase *** principles of deformation softening and annealing hardening in ordered solid solutions are discussed because of deformation induced structure *** is concluded that the independent slip ability of the partial dislocations and the corresponding low temperature plasticity of ordered solid solutions could be promoted obviously by proper alloying effects,which reduces the anti-phase domain boundary energy,or by maintaining the disordering state into the low temperature *** similar principles could be also used to modify the low temperature plasticity of other metal based ordered solid solutions.

关键词： ordered alloys solid solutions structure transition plasticity dislocation structure

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

面向台风灾害的大规模人群集中疏散方案研究

安全与环境学报 2024年第1期24卷 257-263页

作者：王维莉毛蔚敏王逸文上海海事大学物流研究中心上海201306

台风灾害的生成具有可预报性,提前对涉险区域人群进行转移安置是保障人民生命财产安全的必要手段。基于公共交通车辆对人群进行集中疏散,以车辆资源的有限性和避难点容量限制等为约束条件,以最小化区域的疏散完成时间为优化目标,构建多... 详细信息

台风灾害的生成具有可预报性,提前对涉险区域人群进行转移安置是保障人民生命财产安全的必要手段。基于公共交通车辆对人群进行集中疏散,以车辆资源的有限性和避难点容量限制等为约束条件,以最小化区域的疏散完成时间为优化目标,构建多避难点、多需求点、多点往返的车辆路径规划模型。结合模型特点引入虚拟需求点,设计一种二维实数编码的遗传算法进行求解,并通过算例验证模型有效性。最后,针对区域无安全住所人群开展案例分析,并与传统单点往返车辆路径规划模型生成的方案进行对比。结果显示:相比传统模型,多点往返模型生成的疏散方案能有效缩短疏散时间,且在交通资源紧缺地区更具优势。

关键词：公共安全台风灾害人群疏散车辆路径多点往返

On intergranular mechanical interactions and the theory of deformation crystallography of metals

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2021年第2期15卷 192-201页

作者： weimin mao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyArding Street 7Baotou 014010China Department of Materials University of Science and Technology BeijingXue-Yuan Road 30Beijing 100083China

The equilibrium of intergranular stress and strain can be realized simultaneously,whereas five independent slip systems of the Taylor principle and the criterion of minimal internal work are *** fact,the Taylor principle applied in current theories is incorrect both in practice and theory,in which the activation mechanism of plastic deformation systems must violate the Schmid’s law and deviate from the elastic-plastic characteristics of deformed *** intergranular reaction stress(RS)during deformation can be calculated according to Hooke’s law and elastic limit without additional subjective presupposition,therefore the RS theory is established *** the combination of the RS(the intergranular elastic effect)and the external loading the slips penetrating grains are activated and produce deformation texture,but certain non-penetrating slips near grain boundaries will become active(the intergranular plastic effect)and produce some random texture when a RS reaches the yield strength of *** RS theory is simple,intuitive and reasonable,based on which the texture simulation can well reproduce the texture formation of various metals under different external loadings and under different crystallographic mechanisms.

关键词： deformation crystallography plastic strain stress equilibrium Taylor principle reaction stress texture simulation

ANISOTROPY OF WORK HARDENING IN 5456 ALUMINUM ALLOY

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 1998年第1期8卷 40-44页

作者： mao, weimin Univ of Science and Technology Beijing Beijing China

ＡＮＩＳＯＴＲＯＰＹＯＦＷＯＲＫＨＡＲＤＥＮＩＮＧＩＮ５４５６ＡＬＵＭＩＮＵＭＡＬＬＯＹ①ＭａｏＷｅｉｍｉｎＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，Ｕｎｉｖｅｒｓｉｔｙｏｆ... 详细信息

ＡＮＩＳＯＴＲＯＰＹＯＦＷＯＲＫＨＡＲＤＥＮＩＮＧＩＮ５４５６ＡＬＵＭＩＮＵＭＡＬＬＯＹ①ＭａｏＷｅｉｍｉｎＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，ＵｎｉｖｅｒｓｉｔｙｏｆＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌ...

关键词： aluminum alloy rolling deformation texture work hardening anisotropy

半固态改性6061铝合金流变压铸试样组织及力学性能

在线全文

学校读者我要写书评

暂无评论

特种铸造及有色合金 2024年第4期44卷 516-520页

作者：张荣晟毛卫民李乃拥北京科技大学材料科学与工程学院北京100083

采用石墨质蛇形通道浇注复合流变压铸工艺进行半固态改性6061铝合金流变压铸成形。对比分析了传统液态压铸和流变压铸的改性6061铝合金试样的显微组织;研究了Si含量对半固态改性6061铝合金流变压铸试样组织及力学性能的影响。结果表明,... 详细信息

采用石墨质蛇形通道浇注复合流变压铸工艺进行半固态改性6061铝合金流变压铸成形。对比分析了传统液态压铸和流变压铸的改性6061铝合金试样的显微组织;研究了Si含量对半固态改性6061铝合金流变压铸试样组织及力学性能的影响。结果表明,相比于传统液态压铸,半固态改性6061铝合金流变压铸试样组织中的初生α-Al晶粒明显细化和球化,由粗大的枝晶演变为细小的球状晶或近球状晶。增加Si含量可以有效细化试样组织中的初生α-Al晶粒,并提升流变压铸试样的力学性能,当Si含量由0.6%增加至2.6%时,初生α-Al的平均晶粒直径由58μm左右逐渐减小至31μm左右,抗拉强度由(107±4)MPa逐渐增加至(209±14)MPa,伸长率由2.2%±0.3%逐渐增加至5.5%±0.5%。

关键词： 6061铝合金半固态流变压铸显微组织力学性能

维普期刊数据库博看期刊

On the Taylor principles for plastic deformation of polycrystalline metals

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2016年第4期10卷 335-345页

作者： weimin mao School of Materials and Metallurgy Inner Mongolia University of Science and Technology Arding Street 7 Baotou 014010 China Department of Materials University of Science and Technology Beijing Xue-Yuan Road 30 Beijing 100083 China

Grain orientation evolutions and texture formation based on the Taylor principles offer important references to reveal crystallographic mechanisms of deforma- tion behaviors. Strain equilibrium between grains is achieved in Taylor theory, however, stress equilibrium has not yet been reached perfectly even in many modifications of the theory though the textures predicted become very close to those of experimental observations. A reaction stress model is proposed, in which mechanical interactions between grains are considered in details and grain deformation is conducted by penetrating and non-penetrating slips. The new model offers both of the stress and strain equilibria and predicts the same textures indicated by Taylor theory. The rolling texture simulated comes very close to the experimental observations if the relaxation effect of the non-penetrating slips on the up-limits of reaction stresses is included. The reaction stress principles open theoretically a new field of vision to consider deformation behaviors of poiycrystaliine materials, whereas the Taylor principles become unnecessary both theoretically and practically. Detailed engineering conditions have to be included in simulations if the deformation textures of industrial products should be predicted.

关键词： Taylor principles micormechanical equilibrium plastic deformation dislocation slip texture simulation

The currently predominant Taylor principles should be disregarded in the study of plastic deformation of metals

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2018年第3期12卷 322-326页

作者： weimin mao School of Materials and Metallurgy Inner Mongolia University of Science and Technology Arding Street 7 Baotou 014010 China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Xue-Yuan Road 30 Beijing 100083 China

The original Taylor principles offer identical intergranular strain equilibrium without stress equilibrium in metals during deformation. In reality, however, the stress and strain equilibria are maintained individually for different grains. As key points, the principles have become a prerequisite predominantly in the current theories, which unreasonably indicate that strains instead of stresses induce grain deformation despite reaching the stress equilibrium by complicated combinations of the activation of slip systems or other crystallographic mechanism via different approaches. Real intergranular equilibria can be traced if mechanical interactions together with the external loading are considered step by step. In this work, several penetrating and non-penetrating slips were used to obtain the necessary elastic and plastic strain tensors of different grains in a natural manner. Without the Taylor principles, the stress and strain equilibria can be reached naturally, simply, easily, reasonably, and individually without complicated calculations. Results of the experimental observation conformed with the predicted deformation texture when certain important engineering stress conditions are included in the simulation. Therefore, the Taylor principles for plastic deformation of polycrystalline metals should now be disregarded.

关键词： deformation Taylor principles stress equilibrium strain equilibrium texture

Preparation of Semisolid A356 Alloy Feedstock Cast via a Pipe Consisting of Partial Inclined and Partial Vertical Sections

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2009年第2期25卷 273-276页

作者： Xiaorong Yang weimin mao School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China School of Materials Science and Engineering Taiyuan University of Science and Technology Taiyuan 030024 China

In the present work, the microstructures of A356 feedstock cast via a pipe consisting of partial inclined and partial vertical sections were investigated. The experimental results indicate that semisolid feedstock with ideal microstructures can be obtained at higher temperatures 645℃ and above by the proposed process, and the solid shell inside the pipe can be avoided at the optimum pouring temperature. Thus the process is attractive for industrial applications. The slanted angle of inclined section has an influence on the optimum pouring temperature. That is, the bigger the slanted angle, the higher the optimum pouring temperature, but accordingly, the greater the possibility of solid shell occurring inside the pipe. Therefore, small slanted angle should be considered first on the premise of ensuring a certain nucleation. The formation of semisolid feedstock is owed to the coactions of wall nucleation and stirring resulting from fluid flow. The inclined section greatly affects nucleation, and the vertical section has an important effect on both nucleation and generating stirring.

关键词： Semisolid Microstructure Inclined pipe Vertical pipe Primary α-Al