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UHRF1/DNMT1—MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2086-2106页

作者： Shuye Lin Hanli Xu Lin Qin Mengdi Pang Ziyu Wang Meng Gu Lishu Zhang Cong Zhao Xuefeng Hao Zhiyun Zhang weimin ding Jianke Ren Jiaqiang Huang Cancer Research Center Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China College of Life Sciences&Bioengineering Beijing Jiaotong UniversityBeijing 100044China Department of Endoscopic Diagnosis and Treatment Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

As confusion mounts over RNA isoforms involved in phenotypic plasticity,aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity(ITH).Protease serine 3(PRSS3),possessing four splice variants(PRSS3-SVs;PRSS3-V1—V4),is an indispensable trypsin that shows paradoxical effects on cancer ***,we found that PRSS3 transcripts and their isoforms were divergently expressed in lung cancer,exhibiting opposing functions and clinical outcomes,namely,oncogenic PRSS3-V1 and PRSS3-V2 versus tumorsuppressive PRSS3-V3,by targeting different downstream *** identified an intragenic CpG island(iCpGI)in *** of iCpGI was mediated by UHRF1/DNMT1 complex interference with the binding of myeloid zinc finger 1(MZF1)to regulate PRSS3 *** garlic-derived compound diallyl trisulfide cooperated with 5-aza-2'-deoxycytidine to exert antitumor effects in lung adenocarcinoma cells through site-specific iCpGI demethylation specifically allowing MZF1 to upregulate PRSS3-V3 *** silencing of PRSS3-V3 via i CpGI methylation(iCpGIm)in BALF and tumor tissues was associated with early clinical progression in patients with lung cancer but not in those with squamous cell carcinoma or inflammatory ***,UHRF1/DNMT1—MZF1 axismodulated site-specific iCpGIm regulates divergent expression of PRSS3-SVs,conferring nongenetic functional ITH,with implications for early detection of lung cancer and targeted therapies.

关键词： Lung cancer Intratumor heterogeneity Splice variants Intragenic CpG methylation Protease serine 3 Myeloid zinc finger 1 UHRF1/DNMT1 5-Aza-CdR

New analysis model for rotor-bearing systems based on plate theory

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Frontiers of Mechanical Engineering 2019年第4期14卷 461-473页

作者： Zhinan ZHANG Mingdong ZHOU weimin ding Huifang MA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Mechanical System and Vibration Shanghai Key Laboratory of Digital Manufacture for Thin-walled StructuresShanghai Jiao Tong UniversityShanghai 200240China Ningbo Donly Co. Ltd.Ningbo 315000China AECC Commercial Aircraft Engine Co. Ltd.Shanghai 200240China

The purpose of this work is to develop a new analysis model for angular-contact,ball-bearing systems on the basis of plate theory instead of commonly known approaches that utilize spring *** and radial stiffness on an annular plate are developed based on plate,Timoshenko beam,and plasticity *** model is developed using theoretical and inductive methods and validated through a numerical simulation with the finite element *** new analysis model is suitable for static and modal analyses of rotor-bearing *** examples are presented to reveal the effectiveness and applicability of the proposed approach.

关键词： rotor-bearing system rolling element bearing plate theory finite element analysis

Design and experimental validation of sliding knife notch-type disc opener for a no-till combine harvester cum seed drill

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International Journal of Agricultural and Biological Engineering 2018年第4期11卷 96-103页

作者： Kuan Qin weimin ding Fiaz Ahmad Zhichao Fang College of Engineering Nanjing Agricultural UniversityJiangsu ProvinceNanjing 210031China Department of Agricultural Engineering Bahauddin Zakariya UniversityMultanPakistan

One major constraint in developing a combine harvester cum seed drill(CHCSD)is the limited space available for the attachment of no-till furrow *** the straw stubble cutting and furrow opening performance of small-sized disc furrow openers is critically important for the development and the optimization of the no-till seeding assemblies.A set of down-scaled sliding knife notch-type disc opener(SKO),modified notch-type disc opener(MNO)and smooth-type disc opener(SDO),with upper size limit of 160 mm,were designed and fabricated for field *** results show that for small-sized disc furrow openers of the same type,a larger disc diameter yields a greater furrow depth and *** small-sized disc furrow openers with an identical diameter,SKOs yield a greater furrow depth and width than MNOs,with SDOs yielding the lowest *** measured furrow depth and width for an SKO with diameter of 160 mm are 3.52 cm and 3.56 cm,respectively,meeting the no-tillage furrowing requirements for a *** highest stubble cover rate of 62.5%is obtained for the SKO with diameter of 160 ***,this opener has greater ability to remove stubble from the furrow and seeding band than the other ***,experimental results of the stubble cutting rates confirm that,for irregularly placed straw and residue,the stubble cutting rate of the SKO with diameter of 160 mm is the highest at 61.7%.

关键词： no-tillage small-sized disc furrow opener furrow type stubble removal

Droplet size and spray pattern characteristics of PWM-based continuously variable spray

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International Journal of Agricultural and Biological Engineering 2009年第1期2卷 8-18页

作者： Deng Wei He Xiongkui ding weimin College of Science China Agricultural UniversityBeijing 100193China College of Engineering Nanjing Agricultural UniversityNanjing 210031China

A Pulse-Width-Modulation-based(PWM-based)continuously variable sprayer was developed using a proportional regulating solenoid *** flow-rate was obtained by varying the duty cycle of the actuating signal with 24 kHz ***-rate regulating ranges of the PWM-based continuously variable spray(*** turndown ratio responding to 100%-40%duty cycle)are 7.14:1,3.57:1,and 3.70:1 for flat-fan,hollow-cone and solid-cone nozzles,*** purpose of the study was to evaluate the PWM-based continuously variable *** method was to quantify the effects of flow-rate control on spray characteristics in terms of droplet size spectra,spray distribution patterns,and spray angle for flat-fan,hollow-cone,solid-cone *** all nozzles tested,spray distribution concentrated on the center of the spray field with the decrease of *** the spray shape is still *** sensitivities of the spray angles to flow-rate were 0.83,0.67,and 0.58(o)/%respectively for flat-fan,hollow-cone and solid-cone *** with the sensitivities of spray angle for PWM-based intermittent variable spray,they are somewhat *** flow-rate was reduced from the maximum(100%flow-rate)to the minimum controllable rate,the observed median diameter of spray droplets decreased by 5.4%,9.8%,and 9.9%for flat-fan,hollow-cone and solid-cone nozzles,*** indicates that spray droplet size was affected slightly by flow-rate control.

关键词： Pulse Width Modulation(PWM) continuously variable spray droplet size spray distribution pattern spray angle

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合理利用临床资源,不断提高肺结核诊断水平

中华结核和呼吸杂志 2022年第11期45卷 1073-1079页

作者：丁卫民唐神结首都医科大学附属北京胸科医院结核内科知名专家门诊及内镜诊疗科北京101149 首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所北京101149

肺结核为临床常见病及多发病,但其临床表现不具特异性,只有坚持以相关指南共识为指导,充分合理利用有效临床资源,高度关注结核病发病及临床特点,合理使用辅助检查手段,全面正确掌握肺结核诊断标准,才能避免临床肺结核尤其是不典型肺结... 详细信息

肺结核为临床常见病及多发病,但其临床表现不具特异性,只有坚持以相关指南共识为指导,充分合理利用有效临床资源,高度关注结核病发病及临床特点,合理使用辅助检查手段,全面正确掌握肺结核诊断标准,才能避免临床肺结核尤其是不典型肺结核被长期误诊及漏诊,不断提高肺结核的诊断水平,早日实现终止结核病的目标,造福人类健康。

关键词：肺结核诊断辅助检查手段不典型肺结核临床资源结核病诊断水平临床常见病发病及临床特点

Design and test of a novel crawler-type multi-channel air-assisted orchard sprayer

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International Journal of Agricultural and Biological Engineering 2020年第6期13卷 60-67页

作者： Wei Qiu Xiaolong Li Chongchong Li weimin ding Xiaolan Lv Yande Liu College of Engineering Nanjing Agricultural UniversityNanjing 210031China Jiangsu Academy of Agricultural Sciences Nanjing 210000China Co-Innovation Center of the Intelligent Management and Equipment for Orchard on the Hilly Land in South China Nanchang 330013China

In order to solve the problem of poor traveling stability and excessive pesticide application during plant protection operations in hilly orchards,a novel crawler-type multi-channel air-assisted sprayer that is particularly appropriate for hilly orchards was designed in this *** anti-rolling requirements and the orchard environment in hilly areas,this study selected limits for uphill and downhill rolling angles as well as the transverse rolling angle as the evaluation indexes for determining both the layout and parameter settings of the *** to freely submerged jets and the requirements in plant protection operation,a multi-channel air-assisted system was *** test results showed that the anti-rolling performance and the designed air-assisted system were *** 2 m from the longitudinal center plane of the sprayer,the airflow exhibited wavy distribution patterns under different parameter combinations since the four streams of the airflow were not thoroughly intersected and *** 3 m from the longitudinal center plane of the sprayer,the jet was ejected at great velocity but underwent rapid attenuation;the airflow velocity in most areas barely satisfied the requirements for plant protection *** addition,different air outlet layout schemes led to significant differences in the spatial distribution of the airflow *** with a traditional air-assisted sprayer,using the developed multi-channel air-assisted sprayer enhanced the droplet coverage uniformity by 19.4%,and the mean droplet deposition in the front,middle,and rear of the canopy was enhanced by 32.9%,50.3%,and 78.1%,respectively,while reducing ground deposition and air drift by 26.8%.

关键词： fan dual-flow-channel plant protection air-assisted test

Tilting stability analysis and experiment of the 3-DOF lifting platform for hilly orchards

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International Journal of Agricultural and Biological Engineering 2018年第6期11卷 73-80页

作者： Zhenhua Duan Wei Qiu weimin ding Yande Liu Yuping Ouyang Liang Huang College of Engineering Nanjing Agricultural UniversityNanjing 210031China Co-Innovation Center of the Intelligent Management and Equipment for Orchard on the Hilly Land in South China Nanchang330013China

An orchard-lifting platform is a type of mechanical equipment to assist growers in fruit picking,fruit tree pruning,flower thinning,and other *** its operational processes,the tilting stability directly affects the operational safety and adaptability under complex terrain conditions,while critical tilting angle is an important criterion to evaluate the tilting *** on the structure and the operating characteristics of the three degree of freedom(3-DOF)lifting platform for hilly orchards,the tilting stability was analyzed in different parked states,and the theoretical expressions of critical tilting angle were obtained;in the theoretical expressions,the influencing factors on tilting stability were determined as the parked positionβ1,the manned worktable rotary positionβ2,the lifting height h,and the load *** on the multi-body dynamics principle,the tilting stability simulation was carried *** relative error of tilting angles was approximately 4.6%between simulation and tilting verification experiment,which indicated that the results of tilting stability simulation were ***,the multi-body dynamics simulation was used for further clarifying the influencing factors on tilting stability.A virtual orthogonal test was designed,and the results showed that critical tilting angle ranged from 20°to 44°when the factors were at different values,which indicated that the 3-DOF lifting platform for hilly orchards had a high tilting stability performance and could adapt to the operating conditions of hills with slope angles from 5°to 20°.The results of the range analysis and ANOVA showed that the influence intensity of factors on tilting stability wasβ1>h>m>β2;at the same time,β1,h,and m exerted significant effect on tilting *** tilting stability first decreased and then either increased or decreased with the increasing lifting height;it gradually decreased with the increasing *** also showed that the position of the manned

关键词： orchard-lifting platform hills areas tiling stability influencing factors analysis and experiment

Tunnel-convective air-assisted spraying technology for improving droplet deposition on hedgerow vines

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International Journal of Agricultural and Biological Engineering 2021年第9期14卷 9-18页

作者： Zhenjie Wen Wei Qiu Zhentao Zhang weimin ding Xiaolan Lyu Fiaz Ahmad Hui Wang College of Engineering Nanjing Agricultural UniversityNanjing 210031China Jiangsu Academy of Agricultural Sciences Nanjing 210014China Department of Agricultural Engineering Bahauddin Zakariya UniversirtyMultan 60800Pakistan

Given the impermeability,larger dosage,and higher drift of pesticides used in modern hedgerow vine canopies,a novel tunnel-convective air-assisted spraying technology was *** spraying equipment with high penetration and low drift was *** air-assisted system of this equipment was centrosymmetric,and the fan type was *** fan outlet width was 138 mm and the air duct’s main body followed a logarithmic spiral profile,based on parallel flow *** external diameter of the impeller was 157 mm,which was fixed into a barrel structure by 23 strong forward-curved blades,each being 1 mm *** central angle of the blades was 108°,and the ratio of the internal and external diameters was *** impeller and air duct served as guides to circulate and reciprocate airflow around the crown,forming a tunnel-convective air-assisted to the *** MATLAB interpolation,the airflow trajectory of the air convection circulation in the door-shaped cover was *** velocity field distribution test showed that,in the case of a canopy,there were tunnel-convective circulating airflows with high velocity on both sides and uniform velocity in the middle of the *** to the tunnel-convective air-assisted spraying technology,the vertical distribution uniformity of spray deposition has been significantly improved,spray penetration has been enhanced,penetrability has been effectively improved,and droplets on the ground and in the air have been significantly *** results of this study can assist in providing further optimization and improvement of plant protection *** new tunnel-convective air-assisted spraying technology may be a more favorable choice for future spray applications and the environment.

关键词： plant protection air-assisted hedgerow vines cross-flow fan droplet deposition

Effects of fan speed on spray deposition and drift for targeting air-assisted sprayer in pear orchard

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International Journal of Agricultural and Biological Engineering 2016年第4期9卷 53-62页

作者： Qiu Wei Zhao Sanqin ding weimin Sun Chengda Lu Jiang Li Yinian Gu Jiabing College of Engineering/Key Laboratory of Intelligent Equipment for Agriculture of Jiangsu Province Nanjing Agricultural UniversityNanjing 210031China

In order to reduce the application dosage of pesticides,a targeting air-assisted(TAA)sprayer was developed and tested in this *** trees were assayed by an infrared detection system to determine if the canopy needs to be *** TAA sprayer was compared with conventional air-assisted(CAA)sprayers,and the impacts of various fan speeds(0,800 r/min,1300 r/min,and 1800 r/min)on spray deposition,coverage,and drift amount were *** 2R was used as tracer to measure spray deposition under each *** coverage and canopy deposition were best when the CAA application fan speed was increased to 1300 r/min,but at higher fan speeds,spray deposition and coverage in canopy did not increase because extra air flow blew droplets from the ground into the *** TAA spraying,droplet sizes increased at opening and closing *** spray effects were achieved when the auxiliary airflow velocity was increased at a fan speed of 1800 r/*** research provides a useful reference for the design of TAA and parameters optimization method with respect to the relationship between droplets deposition into tree canopy,ground and drift in the air.

关键词： sprayers infrared detectors spray deposition drift fruit trees plant protection