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Stability of the Phase Separation State for Compressible Navier-Stokes/Allen-Cahn System

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 45-74页

作者： Ya-zhou Chen Hakho Hong Xiao-ding Shi Department of Mathematics College of Mathematics and PhysicsBeijing University of Chemical TechnologyBeijing100029China Institute of Mathematics State Academy of SciencesPyongyangKorea

This paper is concerned with the large time behavior of the Cauchy problem for Navier-Stokes/AllenCahn system describing the interface motion of immiscible two-phase flow in 3-D. The existence and uniqueness of global solutions and the stability of the phase separation state are proved under the small initial perturbations. Moreover, the optimal time decay rates are obtained for higher-order spatial derivatives of density,velocity and phase. Our results imply that if the immiscible two-phase flow is initially located near the phase separation state, then under small perturbation conditions, the solution exists globally and decays algebraically to the complete separation state of the two-phase flow, that is, there will be no interface fracture, vacuum, shock wave, mass concentration at any time, and the interface thickness tends to zero as the time t → +∞.

关键词： Navier-Stokes/Allen-Cahn system existence uniqueness large time behavior decay rate

Long way up:rethink diseases in light of phase separation and phase transition

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Protein & Cell 2024年第7期15卷 475-492页

作者： Mingrui ding Weifan Xu gaofeng Pei Pilong Li State Key Laboratory of Membrane Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China NuPhase Therapeutics Beijing 100083China

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

关键词： multivalency compartments aberant phase separation therapeutics gain or loss of phase separation diseases

Sedimentary and Heavy Mineral Records for the Oligocene-Miocene Exhumation of the Easternmost Tianshan

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Journal of Earth Science 2024年第2期35卷 449-461页

作者： Yan ding Tianyi Shen guocan Wang Junliang Ji School of Earth Sciences Center for Global TectonicsChina University of GeosciencesWuhan430074China State Key Laboratory of geological Processes and Mineral Resources China University of GeosciencesWuhan430078China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan430074China

The topography of the Harlik Mountain has a strong impact on the formation of current arid climate in the Turpan-Hami ***,it is still controversial if Harlik Mountain experienced significant exhumation during the Middle to Late Cenozoic according to the previous thermochronology *** features of the Oligocene to Miocene sediments in the foreland basin could provide productive information for resolving the *** peak ages of detrital apatite fission track analysis of the Oligocene–Miocene sandstone in the Turpan-Hami Basin are well comparable with the cooling age records of the Harlik Mountain rocks,indicating that the Oligocene–Miocene Taoshuyuanzi Formation in the basin was mostly derived from the Harlik *** stratigraphic sequence exhibits coarsening upward,reflecting that the source area was in a tectonically active period during the deposition *** mineral assemblages also suggest that the unstable minerals in the sediment increased significantly at the end of the ***,the proportion of apatite increased up-section,while the garnet content decreased significantly,indicating that the Carboniferous metamorphic rocks have been gradually eroded out and more intrusive rocks have been exposed to the *** observations suggest that the Harlik Mountain experienced exhumation during the Oligocene to Miocene,and the denudation depth afterward was probably less than 2.5 km according to the previously apatite(U-Th)/He *** Oligocene–Miocene exhumation probably acted as one of the triggers for the heavy drought of the Turpan-Hami Basin during the Middle–Late Neogene.

关键词： Turpan-Hami Basin Harlik Mountain Taoshuyuanzi Formation Oligocene–Miocene uplift sedimentology structural geology

Recent progress of vaccines administration via microneedles for cancer immunotherapy

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Chinese Chemical Letters 2024年第3期35卷 96-103页

作者： Yuanzheng Chen Jiaojiao Zhu Jinsong ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

Therapeutic cancer vaccines have undergone a resurgence in the past *** of the high level of immune cell accumulation and abundant capillary lymphatic system in the dermis,percutaneous vaccination is considered to be an ideal treatment *** convenient administration,the recent development of microneedles(MNs)provides a safe,painless,and low-cost transdermal delivery strategy,which could bypass the first-pass metabolism of vaccines for enhanced stability and ***,the therapeutic effect of MNs-based cancer vaccines is not optimal,which is limited by the complex set of host,tumor,and environmental factors,as well as the limited vaccine loading ***,further improvements are still required to push their clinical *** this critical review,we deliberate on how to improve the therapeutic effect of MNs-based vaccines for cancer immunotherapy,summarize the recent advances in MNs-based cancer vaccination,and provide an overview of various design strategies and mechanisms for active or passive targeting delivery,aiming to develop safer,more effective,and more stable MNs-based cancer ***,we briefly describe the potential of vaccine platforms in combination with other therapies,suggest the need to design vaccines according to specific circumstances,and discuss the biosafety of repeated administration for enhancing clinical efficacy.

关键词： Transdermal delivery Microneedles Cancer vaccine Immunotherapy Nanoparticle Lymph node

Aagab is required for zebrafish larval development by regulating neural activity

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Journal of genetics and genomics 2024年第6期51卷 630-641页

作者： Shihui ding Tursunjan Aziz Anming Meng Shunji Jia State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China guangzhou Laboratory GuangzhouGuangdong 510320China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Clathrin-mediated endocytosis has been implicated in various physiological processes,including nutrient uptake,signal transduction,synaptic vesicle recycling,maintenance of cell polarity,and antigen *** prior knowledge of its importance as a key regulator in promoting clathrin-mediated endocytosis,the physiological function of α-and γ-adaptin binding protein(aagab)remains *** this study,we investigate the biological function of aagab during zebrafish *** establish a loss-of-function mutant of aagab in zebrafish,revealing impaired swimming and early larval *** the high expression level of aagab in the brain,we probe into its physiological role in the nervous *** mutants display subdued calcium responses and local field potential in the optic tectal neurons,aligning with reduced neurotransmitter release(e.g.,norepinephrine)in the tectal neuropil of aagab *** aagab mRNA or nervous stimulant treatment in mutants restores neurotransmitter release,calcium responses,swimming ability,and ***,our observations show delayed release of FM 1-43 in AAgAB knockdown differentiated neuroblastoma cells,pointing towards a probable link to defective clathrin-mediated synaptic vesicle *** conclusion,our study underscores the significance of Aagab in neurobiology and suggests its potential impacts on neurological disorders.

关键词： Aagab Endocytosis Neural activity Synaptic transmitter release Zebrafish

Dynamic Modeling and Experimental Verification of an RPR Type Compliant Paralle Mechanism with Low Orders

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 83-94页

作者： Shuang Zhang Jingfang Liu Huafeng ding Yanbin Zhang School of Mechatronics Engineering Henan University of Science and TechnologyLuoyangHenanChina Faculty of Materials and Manufacturing College of Mechanical Engineering and Applied Electronics TechnologyBeijing University of TechnologyBeijingChina Key laboratory of advanced manufacturing technology Beijing University of TechnologyBeijingChina School of Mechanical Engineering and Electronic Information China University of Geosciences(Wuhan)WuhanChina Center of Machinery Equipment Advanced Manufacturing of Henan Province LuoyangChina

Efficiency of calculating a dynamic response is an important point of the compliant mechanism for posture *** modeling with low orders of a 2R1T compliant parallel mechanism is studied in the *** mechanism with two out-of-plane rotational and one lifting degrees of freedom(DoFs)plays an important role in posture *** on elastic beam theory,the stiffness matrix and mass matrix of the beam element are established where the moment of inertia is *** improve solving efficiency,a dynamic model with low orders of the mechanism is established based on a modified modal synthesis ***,each branch of the RPR type mechanism is divided into a ***,a set of hypothetical modes of each substructure is obtained based on the C-B ***,dynamic equation of the whole mechanism is established by the substructure assembly.A dynamic experiment is conducted to verify the dynamic characteristics of the compliant mechanism.

关键词： Compliant parallel mechanism Dynamic model Modal synthesis method Dynamic experiment

Seed-assisted growth for high-performance perovskite solar cells:A review

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Journal of Energy Chemistry 2024年第9期96卷 588-610页

作者： Zhimin Fang Ting Nie Jianning ding Shengzhong(Frank)Liu Institute of Technology for Carbon Neutralization Yangzhou UniversityYangzhou 225127JiangsuChina Dalian National Laboratory for Clean Energy iChEMDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119ShaanxiChina

The rapid increase in the power conversion efficiency(PCE)of perovskite solar cells(PSCs)is closely related to the development of deposition techinique for perovskite *** high-quality perovskite film enables efficient charge transportation and less trap states,which are eventually translated into enhanced device ***-assisted growth(SAg)is a potential technique for depositing highly-crystallized perovskite films with preferential crystal orientation among the numerous approaches related to crystallization *** this review,we summarize the recent advances in the SAg technique for both one-step and two-step processed perovskite ***,seeding at the buried interface and on the top surface are also *** present different seeds and their corresponding seeding mechanism in detail,such as inorganic nanomaterials,organic ammoniums,alkali metal halides,and perovskite ***,challenges and perspectives are proposed to investigate the potential expansion of seeding engineering in high-performance PSCs,particularly large-area devices.

关键词： Perovskite solar cell Seed Crystallization Efficiency

Deformation and Locomotion of Untethered Small-Scale Magnetic Soft Robotic Turtle with Programmable Magnetization

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Journal of Bionic Engineering 2024年第2期21卷 754-763页

作者： Lin Xu Liu Yang Tao Li Xingbang Zhang Jianning ding School of Mechanical Engineering Jiangsu UniversityZhenjiang212013China The Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130012China Shanghai Tianchun Technology Co. LtdShanghai201802China School of Mechanical Engineering Yangzhou UniversityYangzhou225009China

Inspired by the way sea turtles rely on the Earth’s magnetic field for navigation and locomotion,a novel magnetic soft robotic turtle with programmable magnetization has been developed and investigated to achieve biomimetic locomotion patterns such as straight-line swimming and turning *** soft robotic turtle(12.50 mm in length and 0.24 g in weight)is integrated with an Ecoflex-based torso and four magnetically programmed acrylic elastomer VHB-based limbs containing samarium-iron–nitrogen particles,and was able to carry a load more than twice its own *** to the limb locomotion characteristics of sea turtles,the magnetic torque causes the four limbs to mimic sinusoidal bending deformation under the influence of an external magnetic field,so that the turtle swims continuously ***,when the bending deformation magnitudes of its left and right limbs differ,the soft robotic turtle switches from straight-line to turning swimming at 6.334 rad/***,the tracking swimming activities of the soft robotic turtle along specific planned paths,such as square-shaped,S-shaped,and double U-shaped maze,is anticipated to be utilized for special detection and targeted drug delivery,among other applications owing to its superior remote directional control ability.

关键词： Magnetic soft robotic turtle Programmable magnetization Untethered soft robotics Bending deformation

Explosion resistance performance of reinforced concrete box girder coated with polyurea:Model test and numerical simulation

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Defence Technology（防务技术） 2024年第3期33卷 1-18页

作者： guangpan Zhou Rong Wang Mingyang Wang Jianguo ding Yuye Zhang School of Science Nanjing University of Science and TechnologyNanjing 210094JiangsuChina School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina State Key Laboratory of Explosion and Impact and Disaster Prevention and Mitigation Army Engineering University of PLANanjing 210007JiangsuChina

To study the anti-explosion protection effect of polyurea coating on reinforced concrete box girder,two segmental girder specimens were made at a scale of 1:3,numbered as g(without polyurea coating)and PCg(with polyurea coating).The failure characteristics and dynamic responses of the specimens were compared through conducting explosion *** reliability of the numerical simulation using LS-DYNA software was verified by the test *** effects of different scaled distances,reinforcement ratios,concrete strengths,coating thicknesses and ranges of polyurea were *** results show that the polyurea coating can effectively enhance the anti-explosion performance of the *** top plate of middle chamber in specimen g forms an elliptical penetrating hole,while that in specimen PCg only shows a very slight local *** peak vertical displacement and residual displacement of PCg decrease by 74.8% and 73.7%,respectively,compared with those of specimen *** the TNT explosion with small equivalent,the polyurea coating has a more significant protective effect on reducing the size of *** the increase of TNT equivalent,the protective effect of polyurea on reducing girder displacement becomes more *** optimal reinforcement ratio,concrete strength,thickness and range of polyurea coating were also drawn.

关键词： Explosive load Explosion resistance performance Model test Polyurea Concrete box girder Numerical simulation