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Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis

Research 2024年第3期2023卷 513-527页

作者： Lang Linghu Wei Zong Yixuan liao Qianyu Chen Fancheng Meng Guowei Wang Zhihua liao Xiaozhong Lan Min Chen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Scholof Pharmacy Zunyi Medical UniversityZunyi 563000China School of Life Sciences Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City and Southwest University TAAHC SWU Medicinal Plant Joint R&D CentreSouthwest UniversityChongqing 400715China TAAHC-SWU Medicinal Plant R&D Center Tibet Agricultural and Animal Husbandry UniversityNyingchiTibet 860000China.

Non-alcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), is a leading cause of cirrhosis and liver cancer worldwide;nevertheless, there are no Food and Drug Administration-approved drugs for treating NASH until now. Peroxisome proliferator-activated receptor alpha (PPARα) is an interesting therapeutic target for treating metabolic disorders in the clinic, including NASH. Herpetrione, a natural lignan compound isolated from Tibetan medicine Herpetospermum caudigerum, exerts various hepatoprotective effects, but its efficacy and molecular mechanism in treating NASH have not yet been elucidated. Here, we discovered that herpetrione lessened lipid accumulation and inflammation in hepatocytes stimulated with oleic acid and lipopolysaccharide, and effectively alleviated NASH caused by a high-fat diet or methionine-choline-deficient diet by regulating glucolipid metabolism, insulin resistance, and inflammation. Mechanistically, RNA-sequencing analyses further showed that herpetrione activated PPAR signaling, which was validated by protein expression. Furthermore, the analysis of molecular interactions illustrated that herpetrione bound directly to the PPARα protein, with binding sites extending to the Arm III domain. PPARα deficiency also abrogated the protective effects of herpetrione against NASH, suggesting that herpetrione protects against hepatic steatosis and inflammation by activation of PPARα signaling, thereby alleviating NASH. Our findings shed light on the efficacy of a natural product for treating NASH, as well as the broader prospects for NASH treatment by targeting PPARα.

关键词： PPARα protective metabolism

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Study of factors influencing the occurrence rate of 60 Hz power line radiation in the topside ionosphere:A systematic survey using the CSES satellite

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Science China(Technological Sciences) 2024年第6期67卷 1879-1892页

作者： MA ZhenHui ZHAO ShuFan liao Li SHEN XuHui LU HengXin School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing100190China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing100085China Institute of Geophysics China Earthquake AdministrationBeijing100081China

We analyze the topside ionosphere power line radiation(PLR)at 60 Hz over the US using electric field data collected by CSES satellite between January 2019 and December *** study aimed to further investigate the month-to-month variation characteristic of PLR occurrence rate observed by satellite and its several influencing factors,including solar radiation,lightning activity,and try to clarify the influence of electricity *** results show that the solar radiation(solar zenith angle and F10.7)plays a major role in the variation of the PLR occurrence rate,and that there is no direct connection with the number of *** the relationship between PLR occurrence rate and electricity consumption,the low occurrence rate associated with decreased weekend electricity consumption was not observed in the ***,there is a significant difference in PLR occurrence rate between the East and West Coasts of the US at the same latitude during the same time period,suggesting that the significant difference in PLR occurrence rate is caused by the significant difference in electricity consumption between the two *** excluding the effect of solar radiation on PLR occurrence rate,we concluded that only a significant difference in regional electricity consumption could lead to a corresponding change in PLR occurrence rate detected by the Low-Earth-Orbit ***,we also found there is seasonal variation in the diurnal differences of the PLR occurrence rate caused by seasonal variation of the lower ionosphere.

关键词： CSES satellite power line radiation occurrence rate solar radiation lightning activity electricity consumption

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磷钨酸镧催化合成环己酮缩1,2-丙二醇

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稀有金属 2008年第2期32卷 220-223页

作者：许招会廖维林涂媛鸿王甡江西师范大学化学化工学院江西南昌330027 江西省精细化工重点实验室江西南昌330027

用硝酸镧对磷钨酸进行改性制备了具有Keggin结构的磷钨酸镧(LaPW12O40)催化剂,用FT-IR分析方法进行了结构表征。以环己酮和1,2-丙二醇为原料催化合成了环己酮缩1,2-丙二醇,考察了酮醇摩尔配比、催化剂用量、反应时间及催化剂的重复使用... 详细信息

用硝酸镧对磷钨酸进行改性制备了具有Keggin结构的磷钨酸镧(LaPW12O40)催化剂,用FT-IR分析方法进行了结构表征。以环己酮和1,2-丙二醇为原料催化合成了环己酮缩1,2-丙二醇,考察了酮醇摩尔配比、催化剂用量、反应时间及催化剂的重复使用性等因素对产品收率的影响。实验表明:合成环己酮缩1,2-丙二醇的较优反应条件为:环己酮0.1mol,n(环己酮)/n(1,2-丙二醇)=1.0/1.5(mol/mol),催化剂用量为反应物料总量的0.5%,带水剂甲苯12ml,回流反应时间1.5h。上述条件下,产品收率最高可达94.4%。

关键词：磷钨酸镧环己酮缩1,2-丙二醇 Keggin结构

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碘催化合成2,2-二甲基-1,3-二噁烷-4,6-二酮

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精细石油化工 2010年第3期27卷 45-47页

作者：严楠许招会刘百强廖维林江西省精细化工重点实验室江西南昌330027

实验以丙二酸和丙酮为原料,乙酸酐为缩合剂,在碘催化作用下,合成2,2-二甲基-1,3-二噁烷-4,6-二酮,并通过红外光谱、核磁共振氢谱对其结构进行了表征。其最佳的反应条件为:取0.1 mol丙二酸,n(丙二酸)∶n(丙酮)=1.0∶1.1,催化剂用量为0.2 ... 详细信息

实验以丙二酸和丙酮为原料,乙酸酐为缩合剂,在碘催化作用下,合成2,2-二甲基-1,3-二噁烷-4,6-二酮,并通过红外光谱、核磁共振氢谱对其结构进行了表征。其最佳的反应条件为:取0.1 mol丙二酸,n(丙二酸)∶n(丙酮)=1.0∶1.1,催化剂用量为0.2 g/0.1 mol丙二酸,反应温度30℃,反应时间为3.0 h,产物收率达77.1%。

关键词： 2,2-二甲基-1,3-二噁烷-4,6-二酮碘丙二酸丙酮

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Progress and prospects of EOR technology in deep,massive sandstone reservoirs with a strong bottom-water drive

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Energy Geoscience 2024年第1期5卷 249-255页

作者： Haiying liao Ting Xu Hongmin Yu SINOPEC Exploration&Production Research Institute Beijing100083China

The Triassic massive sandstone reservoir in the Tahe oilfield has a strong bottom-water drive and is characterized by great burial depth,high temperature and salinity,a thin pay zone,and strong *** present,the water-cut is high in each block within the reservoir;some wells are at an ultrahigh water-cut stage.A lack of effective measures to control water-cut rise and stabilize oil production have necessitated the application of enhanced oil recovery(EOR)*** paper investigates the development and technological advances for oil reservoirs with strong edge/bottom-water drive globally,and compares their application to reservoirs with characteristics similar to the Tahe *** the technological advances,gas injection from the top and along the direction of structural dip has been used to optimize the flow field in a typical bottom-water drive ***-water coning is restrained by gas injection-assisted water *** addition,increasing the lateral driving pressure differential improves the plane sweep efficiency which enhances oil recovery in *** injection technology in combination with technological measures like channeling prevention and blocking,and water plugging and profile control,can achieve better results in reservoir *** flooding tests in the Tahe oilfield are of great significance to identifying which EOR technology is the most effective and has the potential of large-scale application for improving development of deep reservoirs with a strong bottomwater drive.

关键词： Edge water Bottom water Water coning Massive reservoir Water injection Gas injection

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Agricultural Investment Project Decisions Based on an Interactive Preference Disaggregation Model Considering Inconsistency

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3125-3146页

作者： Xingli Wu Huchang liao Shuxian Sun Zhengjun Wan Business School Sichuan UniversityChengdu610064China National Institute of Measurement and Testing Technology Chengdu610021China

Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and *** literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of *** this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision *** enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference *** linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise *** address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of ***,we conduct a case study and comparative *** reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information.

关键词： Multiple criteria analysis preference disaggregation inconsistency probability linguistic preference relation investment project selection

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Development of Mixed Insulation Oil as Alternative Liquid Dielectric:A Review

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1242-1258页

作者： Jian Hao Jingwen Zhang Wenyu Ye Ruijing liao Lijun Yang State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqing 400044China IEEE CSEE

Use of traditional mineral oil(MO)as a liquid insulation in transformers has spanned more than 130 ***,MO has poor heat resistance,a low ignition point,and is a non-renewable resource,which does not meet development requirements for high-performance and environmentally friendly insulation ***,researchers have explored alternatives such as natural ester(NE)and synthetic ester(SE)oils,as well as mixed insulation *** insulating oil is a blend of diverse insulating oil types,with optimal performance achieved by adjusting proportions of base *** article summarizes the innovative achievements and development of mixed insulation oil in terms of development of mixed ratio,basic physical chemical properties,electrical properties,thermal stability,and application including operation and maintenance *** these efforts,this article aims to provide recommendations for future development of mixed insulating oils to advance liquid dielectric research based on enhancement mechanisms.

关键词： Environmentally friendly insulation oil ester oils high-performance mineral oil mixed insulation oils

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Optical scattering imaging with sub-nanometer precision based on position-ultra-sensitive giant Lamb shift

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 96-105页

作者： Zeyang liao Yu-Wei Lu Wei Li Xue-Hua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The Lamb shift of a quantum emitter in close proximity to a plasmonic nanostructure can be three or more orders of magnitude larger than that in the free space and is ultra-sensitive to the emitter position and *** demonstrate that this large Lamb shift can be sensitively observed from the scattering or absorption spectrum dip shift of the coupled system when the plasmonic nanoparticle or tip scans the *** these observations,we propose a scanning optical scattering imaging method based on the plasmonic-enhanced Lamb shift with achieves sub-nanometer *** method is based on the scattering or absorption spectrum of the plasmon-emitter coupling system,which is free of the fluorescence quenching problem and easier to implement in a plasmon-emitter coupling *** addition,our scheme works even if the quantum emitter is slightly below the dielectric surface,which can bring about broader applications,such as detecting atoms and molecules or quantum dots above or under a surface.

关键词： Lamb shift plasmon optical scattering imaging

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Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and the microenvironment in ApcMin/+ mice

Mushroom polysaccharides and jiaogulan saponins exert cancer...

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2019年海峡两岸暨港澳青年科学家毒理学学术交流会

作者： Imran Khan 黄国鑫 Xiao-ang Li weilin liao Wai Kit Leong Wenrui Xia Xiqing Bian Jianlin Wu W.L.Wendy Hsiao State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology 澳门科技大学-中药质量研究国家重点实验室

The incidence of colorectal cancer(CRC) is alarming among younger *** no effective chemopreventive drug available in the market,researchers have been searching for alternative strategies against CRC that are in ***,we tested the cancer-preventive properties of Ganoderma lucidum(Lingzhi) polysaccharides(GLP),along with the saponins extracted from Gynostemma pentaphyllum(GpS),an herbal tea with prebiotic-like ***,we report that saponins from Gynostemma pentaphyllum(GpS) and polysaccharides from Ganoderma lucidum(GLP together with GpS) profoundly improved the inflamed gut barrier of Apc mice by reducing polyps,shifting colonic M1 to M2 macrophages,positively reverting E-cadherin/N-cadherin ratio,and downregulating oncogenic signaling *** treatments also markedly promoted short-chain fatty acids(SCFAs)-producing bacteria and abridged sulfate-reducing bacteria in a time-dependent manner.G-protein coupled-receptors were significantly stimulated in the treated mice,accompanied by the modulated expressions of histone deacetylases,anti-cancer gut hormone PYY,and PPAPγ.These findings suggest that some of the herbal medicinal foods could modulate the relationship between the host and the GM to exert their beneficial properties to the *** study also implicates that these dietary mushroom polysaccharides and the Gp saponins have the potential to be developed as new preventive medicines against CRC.

关键词： Gut microbiota Saponins Polysaccharides SCFAs GPCRs ApcMin/+ mice

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Upgrading waste NO_(x) into amino acids via electrocatalysis on Co nanoparticles encapsulated in hollow carbon nanofibers

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Science China Chemistry 2024年第6期67卷 1946-1952页

作者： Jiahui Xian Kaixing Cai Peisen liao Shihan Wang Guangqin Li Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education LIFMIGCMESchool of ChemistrySun Yat-Sen UniversityGuangzhou510275China

Electrocatalytic conversion of waste nitrogen oxide(NO_(x))into value-added nitrogenous chemicals,especially amino acid,is an emerging strategy to alleviate NO_(x)***,this process suffers from the coexistence of multiple competitive reactions leading to complex product distribution and low efficiency,and thus the rational design and modulation of efficient catalysts remains a formidable ***,well-designed Co nanoparticles encapsulated in hollow carbon nanofiber(CoHCNF)were constructed to promote the amino acid electrosynthesis via dealing waste NO_(x)coupling with biomass-derived keto *** to the rapid reactant diffusion,electron transport and efficient contact with abundant accessible Co catalytic sites stemmed from the unique hollow nanotubular structure,Co-HCNF manifested impressive glycine synthesis performance in one-pot adopting NO as the nitrogen source with Faradaic efficiency(FE)of 41.7%and a corresponding yield rate of 222.3μmol h^(-1)as well as 120 h robust ***,it also demonstrates an excellent performance with the FE of 42.8%for NO_(3)~-solution as the nitrogen ***,this strategy displays a broad universality for the synthesis of other amino *** work not only highlights the importance of hollow-structuring electrocatalyst towards upgrading wasted NO_(x)species into amino acids,but also promotes the further development of electrosynthetic systems for high-valued N-containing organic chemicals.

关键词： electrocatalysis NO_(x)reduction amino acid porous materials hollow structure

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