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Polyoxometalates for continuous power generation by atmospheric humidity

Nano Research 2024年第3期17卷 1875-1885页

作者： Tuo Ji weilin chen Zhenhui Kang Liming Zhang Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices DepartmentSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyTaipaMacao 999078China Institute of Functional State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Atmospheric humidity is a sustainable low-value energy widely existing in natural environment,which is a promising candidate to solve the noncontinuous and low efficiency of low-value energy power generation.Here the mono-substituted Dawson-type polyoxometalates are constructed to be highly dispersed organic ammonium-polyoxoanion clusters and are assembled into thin films power generators with micropores,working in atmospheric humidity.The optimal polyoxometalates generator with the thickness of 7.2μm and the area of 0.36 cm^(2) produces a voltage of 0.68 V and a current density of 19.5μA·cm^(-2) under simulated natural environment,and works continuously and stably under almost all-natural environments(humidity 10%–90%).The highly dispersed polyoxometalate nanoclusters can form microporous in polyoxometalate films to effectively absorb atmospheric humidity and spontaneously form distribution gradient of water,which is the structural basis of power generation.The continuous power generation may be maintained by the effective adsorption and utilization of H_(2)O,the huge electrostatic field of organic ammonium-polyoxoanion clusters,and the reasonably designed polyoxometalates containing inorganic small ions with high mobility.It is the first humidity generator designed with polyoxometalates,which may provide a new research direction for polyoxometalates in sustainable utilization of low-value energy.

关键词： atmospheric humidity continuous power generations nanomaterials polyoxoanions polyoxometalates

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Flow Loss Mechanism in a Supercritical Carbon Dioxide Centrifugal Compressor at Low Flow Rate Conditions

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Journal of Thermal Science 2024年第1期33卷 114-125页

作者： YANG Zimu JIANG Hongsheng ZHUGE weilin CAI Ruikai YANG Mingyang chen Haoxiang QIAN Yuping ZHANG Yangjun State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

With the advantages of high efficiency and compact structure,supercritical carbon dioxide(sC02)Brayton cycles have bright prospects for development in energy conversion field.As one of the core components of the power cycle,the centrifugal compressor tends to operate near the critical point(304.13 K,7.3773 MPa).Normally,the compressor efficiency increases as the inlet temperature decreases.When the inlet temperature is close to the critical point,the density increases sharply as the temperature decreases,which results in quickly decreasing of volume flow rate and efficiency reducing.The flow loss mechanism of the sCO_(2) compressor operating at low flow rate is studied in this paper.Computational fluid dynamics(CFD) simulations for sCO_(2)compressor were carried out at various inlet temperatures and various mass flow rates.When the sCO_(2)compressor operates at low volume flow rate,the flow loss is generated mainly on the suction side near the trailing edge of the blade.The flow loss is related to the counterclockwise vortexes generated on the suction side of the main blade.The vortexes are caused by the flow separation in the downstream region of the impeller passage,which is different from air compressors operating at low flow rates.The reason for this flow separation is that the effect of Coriolis force is especially severe for the sCO_(2) fluid,compared to the viscous force and inertial force.At lower flow rates,with the stronger effect of Coriolis force,the direction of relative flow velocity deviates from the direction of radius,resulting in its lower radial component.The lower radial relative flow velocity leads to severe flow separation on the suction side near the trailing edge of the main blade.

关键词： supercritical CO_(2) centrifugal compressor flow loss mechanism Coriolis force

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Fabricating AC/DC nanogenerators based on single ZnO nanowires by using a nanomanipulator in a scanning electron microscope

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Nanotechnology and Precision Engineering 2024年第2期7卷 25-31页

作者： Mei Liu Mengfan He Aristide Djoulde Lingdi Kong weilin Su Xin Bai Jinbo chen Jinjun Rao Zhiming Wang Shanghai Key Laboratory of Intelligent Manufacturing and Robotics School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200444China Guangdong Provincial Key Laboratory of Fuel Cell Technology School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China

Single zinc oxide nanowires(ZnO NWs)are promising for nanogenerators because of their excellent semiconducting and piezoelectric properties,but characterizing the latter efficiently is challenging.As reported here,an electrical breakdown strategy was used to construct single ZnO NWs with a specific length.With the high operability of a nanomanipulator in a scanning electron microscope,ZnO-NW-based twoprobe and three-probe structures were constructed for fabricating AC/DC nanogenerators,respectively.For a ZnO NW,an AC output of between−15.31 mV and 5.82 mV was achieved,while for a DC nanogenerator,an output of24.3 mV was realized.Also,the three-probe structure’s output method was changed to verify the distribution of piezoelectric charges when a single ZnO NW is bent by a probe,and DC outputs of different amplitudes were achieved.This study provides a low-cost,highly convenient,and operational method for studying the AC/DC output characteristics of single NWs,which is beneficial for the further development of nanogenerators.

关键词： Zinc oxide nanowire Piezoelectric properties Nanomanipulator SEM AC/DC nanogenerators

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Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance

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Science China(Life Sciences) 2024年第7期67卷 1413-1426页

作者： Xueyan chen weilin Wu Ji-Hak Jeong Matjaz Rokavec Rui Wei Shaolong Feng Werner Schroth Hiltrud Brauch Shangwei Zhong Jun-Li Luo Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Molecular Medicine The Scripps Research InstituteJupiter 33458USA Dr.Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart 70376Germany iFIT Cluster of Excellence University of TübingenTübingen 72074Germany The Cancer Research Institute and the Second Affiliated Hospital Henyang Medical SchoolUniversity of South ChinaHengyang 421001China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410008China

Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive(ER+)breast cancer.However,the efficacy of agents such as tamoxifen(Tam)is often compromised by the development of resistance.Here we report that cytokines-activated nuclear IKKαconfers Tam resistance to ER+breast cancer by inducing the expression of FAT10,and that the expression of FAT10 and nuclear IKKαin primary ER+human breast cancer was correlated with lymphotoxinβ(LTB)expression and significantly associated with relapse and metastasis in patients treated with adjuvant mono-Tam.IKKαactivation or enforced FAT10 expression promotes Tam-resistance while loss of IKKαor FAT10 augments Tam sensitivity.The induction of FAT10 by IKKαis mediated by the transcription factor Pax5,and coordinated via an IKKα-p53-miR-23a circuit in which activation of IKKαattenuates p53-directed repression of FAT10.Thus,our findings establish IKKα-to-FAT10 pathway as a new therapeutic target for the treatment of Tam-resistant ER+breast cancer.

关键词： nuclear IKKα breast cancer Tam-resistance FAT10 Pax5 lymphotoxin nuclear IKKα-FAT0 pathway

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Flocculated unclassified tailings settling efficiency improvement by particle collision optimization in the feedwell

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International Journal of Minerals,Metallurgy and Materials 2022年第12期29卷 2126-2135页

作者： Huazhe Jiao weilin chen Aixiang Wu Yang Yu Zhuen Ruan Rick Honaker Xinming chen Jianxin Yu School of Civil Engineering Henan Polytechnic UniversityJiaozuo 454003China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China School of Surveying and Land Information Engineering Henan Polytechnic UniversityJiaozuo 454000China China Geological Environmental Monitoring Institute Beijing 100081China State Collaborative Innovation Center of Coal Work Safety and Clean-efficiency Utilization Jiaozuo 454150China Mining Engineering Faculty University of KentuckyLexington 40506America

Efficient thickening of tailings is a prerequisite for the metal mine tailings backfill and surface disposal operation.The effective collision of ultrafine tailings particles in suspension with flocculant molecules is essential for flocs aggregates formation and settling.Unreasonable feeding speed and flocculant adding method will lead to the failure of effective dispersion of flocculant and high particle content in thickener overflow.In this work,the effect of turbulence intensity and flocculant adding method on floc size,strength,and movement characteristics are analysed.Aiming to solve the turbidity increased,a pilot-scale continuous thickening test was carried out.Taking a single particle and multiple flocs of full tailings as the research object,the particle iterative settlement model of flocs was established.The influence of turbulence intensity on collision effect is studied by tracking and simulating particle trajectory.The results show that in the process of single particle settlement,chaos appears in the iterative process owing to particle adhesion which caused by micro action.When the turbulence intensity is 25.99%,the maximum particle size of tailings floc is 6.21 mm and the maximum sedimentation rate is 5.284 cm·s^(−1).The tailings floc presents a multi-scale structure of particle-force chain system when hindered settling,and the interweaving of strong and weak force chains constitutes the topological structure of particles.The results are applied to a thicker in plant,the flocculant addition mode and feed rate are optimized,and the flocs settling speed and overflow clarity are improved.

关键词： unclassified tailings flocculation settling rate thickener feedwell turbulence intensity flocs micro-structure

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Regulating interfacial morphology and charge-carrier utilization of Ti_(3)C_(2)modified all-sulfide CdS/ZnIn_(2)S_(4)S-scheme heterojunctions for effective photocatalytic H_(2) evolution

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Journal of Materials Science & Technology 2022年第17期112卷 85-95页

作者： Junxian Bai weilin chen Rongchen Shen Zhimin Jiang Peng Zhang Wei Liu Xin Li Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China College of Materials and Energy South China Agricultural UniversityGuangzhou 510642China State Centre for International Cooperation on Designer Low-Carbon and Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The separation efficiency of electrons and holes and the enhancement of the surface reductive reaction in the metal sulfide semiconductor photocatalysts are important factors in boosting photocatalytic H_(2)evolution from water.The control of both interface morphology and the charge-carrier utilization of metal sulfide-based photocatalysts can effectively improve the separation efficiency of electrons and holes and increase the surface reaction active sites,which are considered to be effective methods to improve the photocatalytic activity of semiconductors.Here,the Ti_(3)C_(2)(Mxene)modified all-sulfide 2D/2D Sscheme heterojunction Ti_(3)C_(2)/Zn In_(2)S_(4)(ZIS)/CdS composite material was firstly synthesized by a two-step solvothermal method.The formation of all-sulfide S-scheme heterojunction improves the efficiency of electron-hole separation.The intimate 2D/2D van der Waals structure provides a strong interaction force and a large contact area to enhance charge transfer.The addition of 2D Ti_(3)C_(2)forms the accumulation layer,reducing the recombination of electrons and holes.Under the synergistic promotion,the highest hydrogen production of the prepared Ti_(3)C_(2)/ZIS/CdS composite photocatalyst could reach 8.93 mmol/h/g.This work not only enriches the photocatalytic systems through integrating the ohmic junction and the 2D/2D all-sulfide S-scheme heterojunction,but also provides a satisfactory design strategy for engineering interfacial morphology and charge-carrier utilization.

关键词： S-scheme heterojunction Photocatalytic hydrogen evolution Ti_(3)C_(2)Mxene-based ohmic junction ZnIn_(2)S_(4)nanosheets 2D/2D van der Waals interfaces

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UCHL5 inhibits U251 glioma cell proliferation and tumor growth via stabilizing and deubiquitinating PTEN

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BIOCELL 2023年第12期47卷 2617-2625页

作者： YUE XIAO WENJING MA XINYI chen WEIWEI HU QIANQIAN DI XIBAO ZHAO GUODONG HUANG weilin chen Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of NeurosurgeryShenzhen Second People’s HospitalThe first Affiliated Hospital of Shenzhen UniversityShenzhen University Medical SchoolShenzhen UniversityShenzhen518055China Institute of Biological Therapy Department of ImmunologyShenzhen UniversityShenzhen518055China Department of Neurosurgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou310058China

Glioma is the most common primary brain tumor.Exploration of new tumorigenesis mechanism of glioma is critical to determine more effective treatment targets as well as to develop effective prognosis methods that can enhance the treatment efficacy.We previously demonstrated that the deubiquitinase biquitin carboxyl-terminal hydrolase L5(UCHL5)was downregulated in human glioma.However,the effect and mechanism of UCHL5 on the proliferation of glioma cells remains unknown.Methods:Transfection of siRNA was used to knockdown the expression of UCHL5 in U251 cells.The 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide(MTT)assay,Edu assay,and colony formation assay were employed to identify the effect of UCHL5 on the proliferation of U251 glioma cells.Western blotting and quantitative real-time PCR were carried out to detect the interaction of UCHL5 and PTEN.The effect of UCHL5 on the growth of glioma in vivo was evaluated in nude mice.Then Immunohistochemistry(IHC)were performed to analysis the expression of UCHL5 and PTEN in human glioma tissues.Results:Here,we have reported that silencing of UCHL5 could promote the proliferation of U251 glioma cells through MTT assay,Edu assay,and colony formation assay.Mechanically,we revealed that UCHL5 stabilizes the phosphatase and tensin homolog(PTEN)expression by deubiquitination,thereby inhibiting cell proliferation in U251 cells.Tumor xenograft experiments further demonstrated that silencing the UCHL5 expression could accelerate U251 cell growth in vivo.Finally,in human glioma tissue microarray,the positive correlation between UCHL5 and PTEN expression was confirmed through IHC assay.Conclusion:UCHL5 restrains the proliferation of U251 glioma cells by stabilizing and deubiquitinating PTEN.Our findings provide ideas for developing enhanced targeted PTEN therapy for patients with glioma.

关键词： Ubiquitination Glioblastoma Tumorigenesis UCH37

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用于高风险环境安全监测和可调热管理的具有分层核壳结构的耐化学品纱线

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Engineering 2024年第1期32卷 217-225页

作者： Duo Xu Yingcun Liu Can Ge Chong Gao Ze chen Ziyi Su Haoran Gong weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Chemical resistant textiles are vital for safeguarding humans against chemical hazards in various settings.such as industrialproduction,chemicalaccidents,laboratory activities,and road transportation.However,the ideal integration of chemical resistance,thermal and moisture management,and wearer condition monitoring in conventional chemically protective textiles remains challenging.Herein,the design,manufacturing,and use of stretchable hierarchical core-shell yarns(HCSYs)for integrated chemical resistance,moisture regulation,and smart sensing textiles are demonstrated.These yarns con-tain helically elastic spandex,wrapped silver-plated nylon,and surface-structuredpolytetrafluo-roethylene(PTFE)yarns and are designed and manufactured based on a scalable fabrication process.In addition to their ideal chemical resistance performance,HCSYs can function as multifunctional stretch-able electronics for real-time human motion monitoring and as the basic element of intelligent textiles.Furthermore,a desirable dynamic thermoregulation function is achieved by exploiting the fabric structure with stretching modulation.Our HCSYs may provide prospective opportunities for the future development of smart protective textiles with high durability,flexibility,and scalability.

关键词： Hierarchical core-shell structure Chemical resistant yam Wearable strain sensor Thermoregulation

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MEF2C promotes M1 macrophage polarization and Th1 responses

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Cellular & Molecular Immunology 2022年第4期19卷 540-553页

作者： Xibao Zhao Qianqian Di Han Liu Jiazheng Quan Jing Ling Zizhao Zhao Yue Xiao Han Wu Zherui Wu Wengang Song Huazhang An weilin chen Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of ImmunologyShenzhen University School of MedicineShenzhen518060China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Institute of Immunology Zhejiang University School of MedicineHangzhou310058China Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJingshi Road 16766JinanShandong250014China

The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in inflammation and host defense;however,the underlying molecular mechanism remains unclear.Here,we show that myocyte enhancer factor 2 C(MEF2C)is essential for regulating M1 macrophage polarization in response to infection and inflammation.Global gene expression analysis demonstrated that MEF2C deficiency in macrophages downregulated the expression of M1 phenotypic markers and upregulated the expression of M2 phenotypic markers.MEF2C significantly promoted the expression of interleukin-12 p35 subunit(Il12a)and interleukin-12 p40 subunit(Il12b).Myeloid-specific Mef2c-knockout mice showed reduced IL-12 production and impaired Th1 responses,which led to susceptibility to Listeria monocytogenes infection and protected against DSS-induced IBD in vivo.Mechanistically,we showed that MEF2C directly activated the transcription of Il12a and Il12b.These findings reveal a new function of MEF2C in macrophage polarization and Th1 responses and identify MEF2C as a potential target for therapeutic intervention in inflammatory and autoimmune diseases.

关键词： Myocyte enhancer factor 2C Macrophage polarization Interleukin-12 T helper type 1 response Inflammation

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Atomically Dispersed Ruthenium Catalysts with Open Hollow Structure for Lithium-Oxygen Batteries

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Nano-Micro Letters 2024年第2期16卷 154-164页

作者： Xin chen Yu Zhang Chang chen Huinan Li Yuran Lin Ke Yu Caiyun Nan chen chen Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Solid State ChemistryUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875People’s Republic of China

Lithium–oxygen battery with ultrahigh theoretical energy density is considered a highly competitive next-generation energy storage device,but its practical application is severely hindered by issues such as difficult decomposition of discharge products at present.Here,we have developed N-doped carbon anchored atomically dispersed Ru sites cathode catalyst with open hollow structure(h-RuNC)for Lithium–oxygen battery.On one hand,the abundance of atomically dispersed Ru sites can effectively catalyze the formation and decomposition of discharge products,thereby greatly enhancing the redox kinetics.On the other hand,the open hollow structure not only enhances the mass activity of atomically dispersed Ru sites but also improves the diffusion efficiency of catalytic molecules.Therefore,the excellent activity from atomically dispersed Ru sites and the enhanced diffusion from open hollow structure respectively improve the redox kinetics and cycling stability,ultimately achieving a high-performance lithium–oxygen battery.

关键词： Atomically dispersed Open hollow structure Discharge product Lithium Oxygen battery

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