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Cognitive disorder and changes in cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury

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Neural Regeneration Research 2008年第3期3卷 305-308页

作者： weiliang zhao dezhi kang yuanxiang lin Department of Neurosurgery First Hospital Affiliated to Fujian Medical University Fuzhou 350005 Fujian Province China

BACKGROUND： Learning and memory damage is one of the most permanent and the severest symptoms of traumatic brain injury; it can seriously influence the normal life and work of patients. Some research has demonstrated that cognitive disorder is closely related to nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor. OBJECTIVE： To summarize the cognitive disorder and changes in nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury. RETRIEVAL STRATEGY： A computer-based online search was conducted in PUBMED for English language publications containing the key words ＂brain injured, cognitive handicap, acetylcholine, N-methyl-D aspartate receptors, neural cell adhesion molecule, brain-derived neurotrophic factor＂ from January 2000 to December 2007. There were 44 papers in total. Inclusion criteria： ① articles about changes in nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury; ② articles in the same researching circle published in authoritative journals or recently published. Exclusion criteria： duplicated articles. LITERATURE EVALUATION： References were mainly derived from research on changes in these four factors following brain injury. The 20 included papers were clinical or basic experimental studies. DATA SYNTHESIS： After craniocerebral injury, changes in these four factors in brain were similar to those during recovery from cognitive disorder, to a certain degree. Some data have indicated that activation of nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor could greatly improve cognitive disorder following brain injury. However, there are still a lot of questions remaining; for example, how do these fac

关键词： brain injured cognitive handicap acetylcholine N-methyl-D aspartate receptors neural cell adhesion molecule brain-derived neurotrophic factor

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Neural stem cell activation and glial proliferation in the hippocampal CA3 region of posttraumatic epileptic rats

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Neural Regeneration Research 2011年第16期6卷 1232-1237页

作者： yuanxiang lin Kun lin dezhi kang Feng Wang Department of Neurosurgery First Affiliated Hospital of Fujian Medical University Fuzhou 350005 Fujian Province China

The present study observed the dynamic expression of CD133, nuclear factor-κB and glial fibrUlary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether gliosis occurs after posttraumatic epilepsy. CD133 and nuclear factor-κB expression was increased at 1 day after posttraumatic epilepsy, peaked at 7 days, and gradually decreased up to 14 days, as seen by double-irnmunohistochemical staining. Glial fibrillary acidic protein/nuclear factor-EB double-labeled cells increased with time and peaked at 14 days after posttraumatic epilepsy. Results show that activation of hippocampal neural stem cells and glial proliferation after posttraumatic epilepsy-induced oxidative stress increases hippocampal glial cell density.

关键词： posttraumatic epilepsy neural stem cell glial cell CD133 nuclear factor-κB glialfibrillary acidic protein neural regeneration

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Synaptic plasticity effects on FeCl_2-induced post-traumatic epilepsy onset in the rat

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Neural Regeneration Research 2010年第18期5卷 1373-1377页

作者： yuanxiang lin Feng Wang Ruxiang Xu Xiaodan Jiang dezhi kang Yiquan Ke Mouxuan Du Lishuang Xu Department of Neurosurgery First Affiliated Hospital Fujian Medical University Fuzhou 350005 Fujian Province China Department of Neurosurgery Zhujiang Hospital Southern Medical University Guangzhou 510282 Guangdong Province China

Studies have confirmed that iron induces epilepsy onset, and iron ion-induced epilepsy in anima models closely resembles the clinical situation. Models of post-traumatic epilepsy （PTE） were established by intracortical injection of FeCl2 using stereotactic techniques. Electron microscopy revealed neuronal degeneration, with shrinkage of the neuronal soma, hyperplasia of rough endoplasmic reticulum, ribosomal detachment from the endoplasmic reticulum, and vacuolar degeneration of glial cells in the right frontal lobe of FeCl2-induced PTE rats. With prolonged time injuries became more severe and neuronal apoptosis was observed. Synapses in the hippocampal neuropil significantly increased （primarily type I/excitatory synapses） at day 14 following injury. Type II synapses （inhibitory synapse） were observed in the rat hippocampus at day 30. Cortical neuronal degeneration, apoptosis, glial cell proliferation, and ultrastructural hippocampal changes, in particular changes in type of neuronal synapse, play an important role in PTE onset.

关键词： post-traumatic epilepsy animal model ferrous chloride synapse synaptic plasticity electron microscope electric wire neurodegenerative diseases neural regeneration

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Glioblastoma vaccine tumor therapy research progress

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Chinese Neurosurgical Journal 2022年第2期8卷 128-132页

作者： Tong zhao Chunwang Li Hongliang Ge yuanxiang lin dezhi kang Department of Neurosurgery Neurosurgery Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Fujian Key Laboratory of Precision Medicine for Cancer the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Key Laboratory of Radiation Biology of Fujian higher education institutions the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Clinical Research and Translation Center the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Fujian Institute for brain disorders and brain science the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China

Glioblastoma(GBM)is the most common primary malignancy of the central nervous system in *** prognosis for late-stage glioblastoma(World Health Organization grade IV astrocytic glioma)is very *** treatment options are sought after and evaluated by clinicians and researchers,and remarkable advances have been made in surgical techniques,radiotherapy,and ***,the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few *** has been notable progress in the field of immunotherapy,particularly with the use of tumor vaccines,for treating glioblastoma;especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell ***,the results of the current clinical trials for vaccination are not *** article reviews the progress in the development of vaccines for glioblastoma.

关键词： Glioblastoma Vaccine therapy Immunotherapy Tumor microenvironment Review

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Exosomal circular RNAs inglioma:coexistenceof opportunitiesand challenges forapplication

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Chinese Medical Journal 2022年第13期135卷 1528-1530页

作者： Xiaoyong Chen Jinyuan Chen Yue Chen Honghai You yuanxiang lin Zanyi Wu dezhi kang Chenyu Ding Department of Neurosurgery Neurosurgical Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Ophthalmology The First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina The Graduate School of Fujian Medical University FuzhouFujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated HospitalFujan Medical UniversityFuzhouFujianChina Key Laboratory of Radiation Biology of Fujian Higher Education Instions The First Affiliated HospitalFujian Medical UniversitFuzhouFujianChina Fujian Provincial Insttutes of Brain Disorders and Brain Sciences FuzhouFujianChina Fujian Provincial Clinical Research Center for Neurological Diseases FuzhouFujianChina.

Glioma is the most common primary tumor in the central nervous *** the help of intercellular communication,glioma cells have the ability to survive in the tumor microenvironment(TME)and make it more suitable.

关键词： glioma tumor circular

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Anatomy and surgery of pure neuroendoscopic infratentorial supracerebellar approach for resection of pineal region tumor

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Chinese Neurosurgical Journal 2018年第3期4卷 133-138页

作者： Yuanlong Zhang dezhi kang Changzhen Jiang Xiaorong Yan Zhangya lin yuanxiang lin Xiyue Wu Chenyang Wang Department of Neurosurgery The First Affiliated Hospital Of Fujian Medical UniversityFuzhou 350004China

Background: The pineal region tumors are surrounded by important structures. Neuroendoscopy has been increasingly used at home and abroad. This study is to simulate pure neuroendoscopic infratentorial supracerebellar approach for resection of pineal region tumor from the cadaveric head, and discuss the advantages and safety through this corridor. Methods: The anatomical structure for resection of pineal region tumor was visualized through pure neuroendoscopic infratentorial supracerebellar approach in three cadaveric heads. Three cases with pineal region tumors were retrospectively analyzed and summarized between June 2017 and December 2017. All cases were operated through pure neuroendoscopic infratentorial supracerebellar approach in the first affiliated hospital of Fujian medical university. Results: The anatomical structures of pineal region can be completely visualized by pure neuroendoscopic infratentorial supracerebellar corridor in the cadaveric head. Among the three cases, the first case was total resection, the second case was subtotal resection and the last case was partial resection. The postoperative pathology revealed cavernous hemangioma, germinoma and yolk sac tumor, respectively. The patients were followed-up for 1-6 months and had normal *** KPS (karnofsky performance status) score was 100. Conclusion: The anatomical structure of the pineal region can be completely visualized and the tumor can be safely removed through pure neuroendoscopic infratentorial supracerebellar approach.

关键词： Neuroendoscopy Infratentorial supracerebellar approach Surgery Anatomy Pineal region tumor

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Vagus nerve stimulation for surgical history of complex cerebral arteriovenous malformations combined with multifocal epilepsy-case report

Vagus nerve stimulation for surgical history of complex cere...

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第十六届中国医师协会神经外科医师年会

作者： Feng Wang yuanxiang lin Peisen Yao Xiaofen Huang dezhi kang Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University

objective:Intracranial arteriovenous malformation(AVM) is a rare vascular malformation,AVM comorbid epilepsy is a common clinical condition,and cortical lesions due to AVM are an important cause of *** some special cases,the cortex of these lesions is extremely difficult to treat *** report a case in which vagus nerve stimulation(VNS) was used to treat surgically complex AVM combined multifocal drug-refractory epilepsy(DRE).Case report:A 21-year-old male,who had a combined brain hernia due to left temporal lobe parenchymal hemorrhage at the age of 15 years,underwent a decompression surgery to remove the hematoma,which revealed the presence of AVM in the left temporal lobe,and a parallel malformed vasectomy,which revealed AVM residual and *** epilepsy persists during the period and the seizures increase in *** patient visited our hospital and the comprehensive preoperative findings suggested that the epileptic foci were in the bilateral cerebral *** VNS surgery for ***:At the most recent follow-up,the patient reported being seizure-free for nearly 6 ***:To our knowledge,this report is the only reported use of VNS for the treatment of surgically complex AVM-combined multifocal intractable epilepsy.

关键词： Case report intracranial arteriovenous malformations vagus nerve stimulation intractable epilepsy

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Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors:an operative technique and short-term outcomes of 20 consecutive cases

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Chinese Neurosurgical Journal 2021年第2期7卷 89-97页

作者： Xiaorong Yan Huiqing Wang Cai Li yuanxiang lin lin lin Shinong Zhu Chenyang Wang Zhangya lin Changzhen Jiang dezhi kang Neurosurgery Department The First Affiliated Hospital of Fujian Medical University20#Chazhong RoadFuzhou CityFujian ProvinceChina Neurosurgery Department The First Affiliated Hospital of University of South ChinaHengyang CityHunan ProvinceChina Operation Room The First Affiliated Hospital of Fujian Medical UniversityFuzhou CityFujian ProvinceChina Neurosurgery Department Jinjiang Hospital Jinnan Branch CourtsJinjiang CityFujian ProvinceChina

Background:To present a surgical technique for the treatment of intradural extramedullary(IDEM)tumors by using endoscopically controlled surgery with open hemilaminectomy ***:In this study,20 patients with 22 IDEM tumors were *** endoscopically controlled surgery with open hemilaminectomy was employed to remove the *** related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up ***:All the tumors in 20 patients were well *** clinical symptoms were significantly reduced in all the patients as *** short-term follow-up data showed that there was no tumor recurrence or spinal ***:The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM *** may be an effective surgical method for treating IDEM *** samples and longer follow-up data are needed to verify its long-term effectiveness.

关键词： Endoscopically controlled surgery Open hemilaminectomy Intradural extramedullary tumors

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Altered regional homogeneity of prefrontal cortex in Parkinson's disease with mild cognitive impairment

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Chinese Neurosurgical Journal 2016年第3期2卷 -页

作者： dezhi kang FuXiang Chen FuYong Chen Ying Liu Gang Wu LiangHong Yu yuanxiang lin Department of Neurosurgery The First Affiliated Hospital Fujian Medical University Fuzhou 350005 Fujian Province China Department of Radiology The First Affiliated Hospital Fujian Medical University Fuzhou 350005Fujian Province China Department of Neurology The First Affiliated HospitalFujian Medical University Fuzhou 350005 Fujian Province China

Background:Mild cognitive impairment (MCI) is a common non-motor symptom of early Parkinson's disease (PD),but the neural mechanisms underlying it remain poorly *** aim of the present study was to investigate the characteristics of cognition-related brain activities in the PD patients with ***:The brain fMRIs and cognition tests were acquired in 39 PD patients and 22 healthy controls (HC) from September 2013 to January *** patients were divided into two groups:PD-MCI (n--18) and PD with normal cognition (PDNC,n =19).we used resting state fMRI and a regional homogeneity (ReHo) method to explore patterns of intrinsic brain activity in patients with PD-MCI as compared with PDNC subjects and ***:Compared with the PDNC group,the PD-MCI group exhibited significantly increased ReHo in parts of the prefrontal cortex regions (*** superior frontal gyrus,right middle frontal gyrus and orbitofrontal cortex).Compared to the HC group,a decrease of ReHo value in left thalamus was found in ***,this reduction was not found in the left thalamus of PDNC group,but in the above prefrontal regions (p ＜ 0.05,with Bonferroni correction).Conclusions:These results demonstrate that the ReHo of prefrontal cortex in resting state is changed in PD patients with *** presence of MCI in PD may be attributed to abnormal regional activity in prefrontal cortex regions.

关键词： Parkinson's disease Mild cognitive impairment Resting state fMRI Regional homogeneity Brain activity Prefrontal cortex

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Safety and feasibility of curved lead simultaneously implanted into pedunculopontine nucleus and subthalamic nucleus

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Chinese Medical Journal 2022年第20期135卷 2509-2511页

作者： Wei Wang Xiaoyong Chen Deyuan Chen Yue Chen Lianghong Yu yuanxiang lin dezhi kang Xiangrong Chen Chenyu Ding Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurosurgery Neurosurgical Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350005China Department of Pathology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurosurgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouFujian 362000China

To the Editor:Combined nuclei stimulation may have a synergistic effect on controlling the symptoms of nervous system diseases and improving quality of life.[1]However,increasing of leads may increase costs and complications.[2]Therefore,our study aims to investigate the safety and feasibility of the single curved lead,which can simultaneously reach both subthalamic nucleus(STN)and pedunculopontine nucleus(PPN).

关键词： curved simultaneous synergistic

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