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超厚特细砂层中超深地下连续墙的沉渣控制方法研究

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建筑施工 2024年第4期46卷 528-530页

作者：朱韦亮上海市基础工程集团有限公司上海200002

针对在超厚砂层中进行地下连续墙施工时沉渣过厚的问题,以上海轨道交通市域线机场联络线上海浦东国际机场站工程为依托,对超深地下连续墙成槽施工过程中的沉渣控制方法进行研究。通过对沉槽施工过程中的新拌泥浆配比、成槽用时、清基换... 详细信息

针对在超厚砂层中进行地下连续墙施工时沉渣过厚的问题,以上海轨道交通市域线机场联络线上海浦东国际机场站工程为依托,对超深地下连续墙成槽施工过程中的沉渣控制方法进行研究。通过对沉槽施工过程中的新拌泥浆配比、成槽用时、清基换浆用时等各项施工数据进行全过程总结研究,探索出一套超深地下连续墙在超厚砂层中槽段施工沉渣效果控制比较好的方法,以期为后续类似项目提供借鉴。

关键词：超厚砂层超深地下连续墙沉渣控制泥浆配比

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反无人机网捕发射参数误差可行域分析

宇航学报 2024年第5期45卷 711-719页

作者：何举竺伟梁庞兆君赵真杜忠华南京理工大学机械工程学院南京210094 上海宇航系统工程研究所上海201109

针对“低、慢、小”无人机网捕任务存在发射误差问题,基于弹簧质点法和Hertz碰撞理论建立了地面环境下绳网的展开碰撞动力学模型。提出理想工况和非理想工况绳网成功抓捕的判据,通过大量数值仿真分析绳网在给定发射距离、发射角度下牵... 详细信息

针对“低、慢、小”无人机网捕任务存在发射误差问题,基于弹簧质点法和Hertz碰撞理论建立了地面环境下绳网的展开碰撞动力学模型。提出理想工况和非理想工况绳网成功抓捕的判据,通过大量数值仿真分析绳网在给定发射距离、发射角度下牵引体的发射速度误差和发射时间误差可行域;并采用一种带有激光测速机构的绳网地面发射装置验证本文模型的正确性。仿真和地面试验结果表明,在给定发射距离、发射角度下,发射速度和发射时间存在一定误差时绳网仍具有较高的抓捕容错率;仿真结果和试验展开过程基本吻合,验证了所建立的动力学模型的可靠性,对实际抓捕任务具有现实指导意义。

关键词：网捕无人机绳网地面试验发射误差可行域分析

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无人潜航器解算目标运动要素的一种方法

现代电子技术 2024年第9期47卷 173-176页

作者：张严朱伟良程菲海军潜艇学院山东青岛266199

随着计算机技术、人工智能、能源技术的发展,无人潜航器也被应用于军事领域。在分析了无人潜航器水下侦察搜索、反水雷战、水下诱骗战应用的基础上,提出潜艇采用线导方式控制双无人潜航器进行目标运动要素解算的方法,并分别通过图解法... 详细信息

随着计算机技术、人工智能、能源技术的发展,无人潜航器也被应用于军事领域。在分析了无人潜航器水下侦察搜索、反水雷战、水下诱骗战应用的基础上,提出潜艇采用线导方式控制双无人潜航器进行目标运动要素解算的方法,并分别通过图解法和计算法分析了其解算的原理。该方式只需探测目标的方位信息,降低了目标其他要素探测的难度,不仅增加了潜艇的探测距离还利于潜艇隐蔽,这对水下无人潜航器应用具有一定的参考意义。

关键词：无人潜航器目标运动要素线导方位解算图解法

Experimental study on interaction between membrane structures and wind environment

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Earthquake Engineering and Engineering Vibration 2010年第4期9卷 523-532页

作者： Yang Qingshan Wu Yue zhu weiliang School of Civil Engineering Beijing Jiaotong University Beijing 100044 China School of Civil Engineering Harbin Institute of Technology Harbin 150006 China

The interaction between membrane structures and their environment can be either static or dynamic. Static interaction refers to interaction with static air, while dynamic interaction refers to wind and its effects. They can be evaluated by two parameters, added mass and radiation/aerodynamic damping, which are experimentally investigated in this study. The study includes the effects of both the static and dynamic interaction on structural dynamic characteristics, and the relationship between the interaction parameters and the covered area of a membrane structure for the static interaction and the relationship between the interaction parameters and wind direction and speed for the dynamic interaction. Experimental data show that the dynamic interaction is strongly correlated with the structural modes, i.e., the interaction of the symmetric modes is much larger than the anti-synmletric modes; and the influence of the dynamic interaction is significant in wind-induced response analysis and cannot be ignored. In addition, it is concluded that the structural natural frequency is remarkably decreased by this interaction, and the frequency band is significantly broadened.

关键词： membrane structure structure-air/wind interaction added mass aerodynamic damping aero-elastic model

Hybrid transcytosis nanopomegranates for sensitizing breast cancer radiotherapy in deep tumor tissue

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Nano Research 2023年第5期16卷 7260-7268页

作者： Li Wang Liang Xiao Zhengyang Zhao Kai Zhong weiliang zhu Hao Liu Xiaoqiu Li Department of Oncology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China Department of Radiation Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

As a standard cancer treatment method,radiotherapy(RT)has cured or alleviated over half cancer bearing patients worldwide more than 100 ***,the therapeutic outcome is seriously hindered by the resistant tumor microenvironment(TME).Hypoxia is a critical factor of vicious TME that causes radiation resistance owing to the insufficiency of oxygen for DNA damage ***,severe vascular dysfunction and pyknomorphic extracellular matrix(ECM)in deep tumor tissues substantially limit radiosensitizer penetration and oxygen diffusion from vessels into tightly packed tumor *** this study,we develop a hybrid transcytosis nanopomegranate(HTP)with high transcytosis potential in response to TME *** is architected by self-assembly of small CuS and Au nanoparticles(NPs)at normal physiological *** can rapidly collapse to transcytosis NPs(CuS and Au NPs)in TME with cationized surface,which enables excellent transcytosis potential and effectively elevates the penetration of CuS and Au into deep tumor *** the second near-infrared(NIR(II))biowindow laser irradiation,CuS heats the tumor and enhances blood perfusion,eliciting tumor hypoxia alleviation and DNA damage ***,Au NPs enriched in deep tumor tissues effectively sensitize radio-therapeutic *** study provides a new and potential nano-platform to ameliorate tumor hypoxia and sensitize deep tumor tissue radiotherapy.

关键词： breast cancer transcytosis hybrid nanopomegranate hypoxia alleviation radiosensitization

D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1239-1248页

作者： Yulong Shi Xinben Zhang Kaijie Mu Cheng Peng Zhengdan zhu Xiaoyu Wang Yanqing Yang Zhijian Xu weiliang zhu CAS Key Laboratory of Receptor Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China

A highly effective medicine is urgently required to cure coronavirus disease 2019(COVID-19).For the purpose,we developed a molecular docking based webserver,namely D3 Targets-2019-nCoV,with two functions,one is for predicting drug targets for drugs or active compounds observed from clinic or in vitro/in vivo studies,the other is for identifying lead compounds against potential drug targets via *** server has its unique features,(1)the potential target proteins and their different conformations involving in the whole process from virus infection to replication and release were included as many as possible;(2)all the potential ligand-binding sites with volume larger than 200 A^3 on a protein structure were identified for docking;(3)correlation information among some conformations or binding sites was annotated;(4)it is easy to be updated,and is accessible freely to public(https://www.d3 ***/D3 Targets-2019-nCoV/***).Currently,the webserver contains 42 proteins[20 severe acute respiratory syndrome-related coronavirus 2(SARS-CoV-2)encoded proteins and 22 human proteins involved in virus infection,replication and release]with 69 different conformations/structures and 557 potential ligand-binding pockets in *** 6 examples,we demonstrated that the webserver should be useful to medicinal chemists,pharmacologists and clinicians for efficiently discovering or developing effective drugs against the SARS-CoV-2 to cure COVID-19.

关键词： COVID-19 SARS-CoV-2 Target prediction Multi-conformation Multi-site Docking D3Targets-2019-nCoV

A Novel Sarsolenane Diterpene as a PTPIB Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller

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Chinese Journal of Chemistry 2017年第8期35卷 1246-1250页

作者： Linfu Liang Jinan Wang Xiaoxuan Shi Yinghua zhu Jia Li weiliang zhu Heyao Wang Yuewei Guo College of Material Science and Engineering Central South University of Forestry and Technology Changsha Hunan 410004 China State Key Laboratory of Drug Research Shanghai Institute ofMateria Medica Chinese Academy of Sciences Shanghai 201203 China Drug Discovery and Design Center Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

A novel sarsolenane diterpene, named secodihydrosarsolenone （1）, as a minor component was obtained from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller. Its structure was elucidated by detailed spectroscopic analysis. Compound 1 exhibited moderate inhibitory activity （IC50= 13.7 μmol·L^-1） against protein tyrosine phosphatase 1B （PTP1B）, a key target for the treatment of type 2 diabetes, representing the first report of PTP1B inhibitory activity for sarsolenane diterpenes. This discovery promotes computational prediction of binding mode between the enzyme and the metabolite, suggesting a crucial role of the residues Tyr46, Ser216 and Arg221 in the binding action.

关键词： Sarcophyton trocheliophrum sarsolenane structure elucidation PTP1B inhibitory activity binding mode

The open-close mechanism of M2 channel protein in influenza A virus:A computational study on the hydrogen bonds and cation-π interactions among His37 and Trp41

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Science China Chemistry 2008年第8期51卷 768-775页

作者： CHENG JiaGao zhu weiliang WANG YanLi YAN XiuHua LI Zhong TANG Yun JIANG HuaLiang School of Pharmacy East China University of Science and TechnologyShanghai 200237China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Sciences East China University of Science and TechnologyShanghai 200237China

The M2 protein from influenza A virus is a tetrameric ion channel. It was reported that the permeation of the ion channel is correlated with the hydrogen bond network among His37 residues and the cation-π interactions between His37 and Trp41. In the present study,the hydrogen bonding network of 4-methyl-imidazoles was built to mimic the hydrogen bonds between His37 residues,and the cation-π interactions between 4-methyl-imidazolium and indole systems were selected to represent the interac-tions between His37 and Trp41. Then,quantum chemistry calculations at the MP2/6-311G level were carried out to explore the properties of the hydrogen bonds and the cation-π interactions. The calcula-tion results indicate that the binding strength of the N-H···N hydrogen bond between imidazole rings is up to -6.22 kcal·mol-1,and the binding strength of the strongest cation-π interaction is up to -18.8 kcal·mol-1(T-shaped interaction) or -12.3 kcal·mol-1(parallel stacking interaction). Thus,the calcu-lated binding energies indicate that it is possible to control the permeation of the M2 ion channel through the hydrogen bond network and the cation-π interactions by altering the pH values.

关键词： cation-π interaction hydrogen bond noncovalent interaction ab initio calculation M2 protein

Research progress in cation-π interactions

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Science China Chemistry 2008年第8期51卷 709-717页

作者： CHENG JiaGao LUO XiaoMin YAN XiuHua LI Zhong TANG Yun JIANG HuaLiang zhu weiliang School of Pharmacy East China University of Science and TechnologyShanghai 200237China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Sciences East China University of Science and TechnologyShanghai 200237China

Cation-π interaction is a potent intermolecular interaction between a cation and an aromatic system,which has been viewed as a new kind of binding force,as being compared with the classical interactions(e.g. hydrogen bonding,electrostatic and hydrophobic interactions). Cation-π interactions have been observed in a wide range of biological contexts. In this paper,we present an overview of the typical cation-π interactions in biological systems,the experimental and theoretical investigations on cation-π interactions,as well as the research results on cation-π interactions in our group.

关键词： cation-π interaction intermolecular interaction noncovalent interaction