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High strength mullite-bond SiC porous ceramics fabricated by digital light processing

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Journal of Advanced Ceramics 2024年第1期13卷 53-62页

作者： Jian Sun Jingde Zhang Xu Zhang Zihe Li Jianzhang Li Sijie Wei Weibin Zhang weili Wang Guifang Han Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Key Laboratory of Special Functional Aggregated Materials Ministry of EducationShandong UniversityJinan 250100China Materials and Structures Research Centre Department of Mechanical EngineeringUniversity of BathBath BA27AYUK National Engineering Research Centre of Ceramic Matrix Composite Manufacture Technology Xi’an Golden Mountain Ceramic Composites Co.Ltd.Xi’an 710118China School of Physics and Materials Science Changji UniversityChangji 831100China

Fabricating SiC ceramics via the digital light processing(DLP)technology is of great challenge due to strong light absorption and high refractive index of deep-colored SiC powders,which highly differ from those of resin,and thus significantly affect the curing performance of the photosensitive SiC *** this paper,a thin silicon oxide(SiO_(2))layer was in-situ formed on the surface of SiC powders by pre-oxidation *** method was proven to effectively improve the curing ability of SiC *** SiC photosensitive slurry was fabricated with solid content of 55 vol%and viscosity of 7.77 Pa·s(shear rate of 30 s^(−1)).The curing thickness was 50μm with exposure time of only 5 ***,a well-designed sintering additive was added to completely convert low-strength SiO_(2) into mullite reinforcement during *** mullite-bond SiC ceramics were successfully *** flexural strength of SiC ceramics sintered at 1550℃in air reached 97.6 MPa with porosity of 39.2 vol%,as high as those prepared by spark plasma sintering(SPS)techniques.

关键词： digital light processing(DLP) SiC ceramics pre-oxidation mullite-bond SiC mechanical properties

Reservoir Characteristics and Controlling Factors of Silurian Lower Kepingtage Formation in Tahe Area, Tarim Basin, NW China

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Journal of Earth Science 2017年第6期28卷 1135-1144页

作者： Ruohan Liu Zaixing Jiang Ming Wang weili yang Jingxiang Guo Minghao Wu Yi Gao Shanyazi Wei Zhihong Nie Hong He School of Energy Resources China University of Geosciences Beijing 100083 China Institute of Earth Sciences China University of Geosciences Beijing 100083 China Exploration and Production Research Institute SINOPEC Beijing 100083 China Geophysical-China Oilfield Services Limited Tianjin 300451 China PetroChina Coalbed Methane Company Limited Beijing 100028 China

With the breakthrough of exploration in Well TP16-1, the lower Kepingtage Formation becomes a key target for petroleum exploration of deep clastic reservoir in Tahe area. In this paper we focused on the research of the reservoir characteristics and its controlling factors in two sub-member formations（S1k11 and S1k13）. Based on X-ray diffraction, conventional physical properties data（porosity and permeability） and reservoir storage space data（casting thin section and scanning electron microscope）, we determined that the S1k1 Formation belongs to extra-low porosity and permeability reservoir, although the upper S1k13 Formation shows relative better physical characteristic than the lower S1k11 Formation. The development of storage space in the study area is controlled by sedimentary microfacies, diagenesis process. Reservoirs in S1k1 Formation are mainly located in channel（S1k11 sandstones） and sand flat（S1k13 sandstones）. The sand flat sediments with a more coarse grain size compared with the channel. In diagenesis, compaction is the major controlling factor for reducing the porosity, followed by cementation. Dissolution of diagenesis is the major controlling factor in enhancing the reservoir porosities. Compared with channel（S1k11） sandstones, sand flat sandstones（S1k13） have better reservoir quality for its weaker compaction, cementation and stronger dissolution. On the basis of sedimentary characteristics（grain size and subfacies）, physical property（porosity and permeability） and reservoir storage space, we divide the S1k1 reservoir into three categories（I, II and III）. Type I reservoir is high quality reservoir. It is mainly distributed in the south area of S1k11 and S1k13 reservoir. Type II is moderate reservoir. It is located in the middle of S1k11 reservoir and in the north of S1k13 reservoir. Type III is the poor reservoir. It is only located in the north of S1k11 reservoir.

关键词： reservoir characteristics controlling factors reservoir assessment lower Kepingtage Formation Tahe area Tarim Basin

Intensive blood pressure control on arterial stiffness among older patients with hypertension

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Chinese Medical Journal 2024年第9期137卷 1078-1087页

作者： Shuyuan Zhang Yixuan Zhong Shouling Wu Hailei Wu Jun Cai weili Zhang On behalf of the STEP Study Group National Clinical Research Center of Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Central China Subcenter of National Center for Cardiovascular Diseases Henan Cardiovascular Disease CenterFuwai Central-China Cardiovascular HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 450046China 不详

Background:Arterial stiffening increases with age and blood pressure and is associated with cardiovascular disease(CVD),but the relationship between blood pressure lowering and arterial stiffening is still uncertain,especially in older *** study aimed to evaluate the effect of intensive blood pressure treatment on the progression of arterial stiffness and risk of CVD in older patients with ***:The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients(STEP)trial was a multicenter,randomized,controlled trial performed at 42 clinical centers throughout China,and 8511 patients aged 60-80 years with essential hypertension were enrolled and randomly assigned to systolic blood pressure(SBP)target of 110 mmHg to<130 mmHg(intensive treatment)or 130 mmHg to<150 mmHg(standard treatment).Patients underwent repeated examinations of the brachial-ankle pulse wave velocity(baPWV)and ankle-brachial index(ABI)at baseline,and the arterial stiffness was evaluated at the 3-year follow-up.A total of 5339 patients who had twice repeated measurements were included in this *** in arterial stiffness between the intensive and standard treatment groups were analyzed using a multivariate linear regression *** Cox proportional hazard regression model was used to evaluate the effect of intensive treatment on primary CVD ***:The changes in baPWV were 61.5 cm/s(95%confidence interval[CI]:49.8-73.2 cm/s)in the intensive treatment group and 98.4 cm/s(95%CI:86.7-110.1 cm/s)in the standard treatment group(P<0.001).Intensive treatment significantly delayed the progression of arterial stiffness,with an annual change of 23.1 cm·s^(-1)·year-1 vs.36.7 cm·s^(-1)·year^(-1)of baPWV in the intensive and standard treatment groups,*** a median follow-up period of 3.36 years,primary CVD outcomes occurred in 77(2.9%)patients in the intensive treatment group compared with 93(3.5%)in the standard treatment *** tre

关键词： Hypertension Arterial stiffness Cardiovascular disease Older people Blood pressure Pulse wave velocity

Julolidinyl aza-BODIPYs as NIR-Ⅱ fluorophores for the bioimaging of nanocarriers

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3155-3168页

作者： Chang Liu Yifan Cai Zichen Zhang Yi Lu Quangang Zhu Haisheng He Zhongjian Chen weili Zhao Wei Wu Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of MediChinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived ***,its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-Ⅰ(700-900 nm)bioimaging owing to absorption and diffraction by biological tissues and tissue-derived *** study aimed to develop ACQ-based NIR-Ⅱ(1000-1700 nm)probes to further improve the imaging resolution and *** strategy employed is to install highly planar and electron-rich julolidine into the 3,5-position of aza-BODIPY based on the larger substituent *** newly developed probes displayed remarkable photophysical properties,with intense absorption centered at approximately 850 nm and bright emission in the 950-1300 nm *** with the NIR-Ⅰ counterpart P2,the NIR-Ⅱ probes demonstrated superior water sensitivity and quenching ***1 and ACQ6 exhibited more promising ACQ effects with absolute fluorescence quenching at water fractions above 40% and higher quenching stability with less than 2.0% fluorescence reillumination in plasma after 24 h of *** calculations verified that molecular planarity is more important than hydrophobicity for ACQ ***,in vivo and ex vivo reillumination studies revealed less than 2.5% signal interference from prequenched ACQ1,in contrast to 15% for P2.

关键词： 3,5-Julolidinyl Aza-BODIPY Nanocarriers Near-infrared Ⅱ Fluorescence imaging Aggregation-caused quenching Polymeric micelles Polymeric nanoparticles

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美国“远射”项目对未来空战模式影响分析

战术导弹技术 2023年第1期 162-165,182页

作者：杨卫丽程鲤军事科学院国防科技创新研究院北京100071

在军事需求和技术发展背景推动下,美军在空战领域正在探索有人机、无人系统、导弹协同运用理念。通过动向跟踪研究,分析了“远射”(LongShot)项目的发展背景、基本情况及进展,重点揭示了“远射”系统投入使用将带来的空战变革,包括加速... 详细信息

在军事需求和技术发展背景推动下,美军在空战领域正在探索有人机、无人系统、导弹协同运用理念。通过动向跟踪研究,分析了“远射”(LongShot)项目的发展背景、基本情况及进展,重点揭示了“远射”系统投入使用将带来的空战变革,包括加速“忠诚僚机”作战概念实现,推动空战效能倍增,形成有人-无人-导弹协同制空新模式,改变传统空战装备发展思路等。

关键词： “远射”项目无人系统空空导弹制空权有人-无人协同

美退出《中导条约》后陆基中程导弹发展动向分析

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战术导弹技术 2022年第5期 93-98页

作者：杨卫丽李金伦军事科学院国防科技创新研究院北京100071

针对陆基中程导弹后续发展问题,动态跟踪美国经费安排、导弹计划、试验情况、作战运用、军控走势等方面进展,分析美国退出《中导条约》后陆基中程导弹发展新动向、新运用。研究给出:美国陆基中程导弹发展将通过军备发展与军备控制相结... 详细信息

针对陆基中程导弹后续发展问题,动态跟踪美国经费安排、导弹计划、试验情况、作战运用、军控走势等方面进展,分析美国退出《中导条约》后陆基中程导弹发展新动向、新运用。研究给出:美国陆基中程导弹发展将通过军备发展与军备控制相结合方式,一方面聚焦导弹计划适应性改造快速满足近期需要,发展高超声速导弹跨越提升陆基中程打击能力以应对远期威胁;另一方面,借助军控机制实现控制、削弱对手中程导弹发展。同时,重视推进陆基中程导弹作战运用研究,旨在重塑美国在该领域战场主导优势。

关键词：陆基中程导弹陆基弹道导弹陆基巡航导弹高超声速武器国防预算军备控制作战概念

(n,k)-冒泡排序网络的结构连通度和子结构连通度

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山西大学学报(自然科学版) 2022年第2期45卷 332-342页

作者：张国珍杨伟丽山西大学数学科学学院

(n,k)-冒泡排序网络是n维冒泡排序网络的推广,也是分布式系统中著名的网络。连通度是衡量互连网络可靠性和容错性的一个重要参量,结构连通度和子结构连通度是经典连通度的两个推广。文章确定了（n,k）-冒泡排序网络中路P,P,及爪K的结构... 详细信息

(n,k)-冒泡排序网络是n维冒泡排序网络的推广,也是分布式系统中著名的网络。连通度是衡量互连网络可靠性和容错性的一个重要参量,结构连通度和子结构连通度是经典连通度的两个推广。文章确定了（n,k）-冒泡排序网络中路P,P,及爪K的结构连通度和子结构连通度。研究结果可以为（n,k）-冒泡排序网络的容错性度量提供一些新的依据。

关键词： (n,k)-冒泡排序网络结构连通度子结构连通度路爪

应用PDCA循环提高执业医师资格考试通过率的实践研究

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卫生职业教育 2023年第17期41卷 8-10页

作者：杨蔚利兰州大学第一医院/兰州大学第一临床医学院甘肃兰州730000

将兰州大学第一医院(第一临床医学院)作为案例,分析学生在执业医师资格考试中存在的问题及其影响因素,并在分析PDCA循环内涵和特征的基础上,探讨运用PDCA循环提升学生执业医师资格考试通过率的策略。

关键词： PDCA循环执业医师资格考试临床医学

Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis

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Chinese Journal of Natural Medicines 2024年第6期22卷 554-567页

作者： LI Weiming GAO Ming XUE weili LI Xiaoli CHANG Yu ZHANG Kaixin WEN Chenyu ZHANG Mingzhi Department of Oncology Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China

Diffuse large B-cell lymphoma(DLBCL)is characterized by significant treatment *** acid(PA)has shown promising antitumor *** study aims to elucidate the molecular mechanisms by which PA influences DLBCL *** quantified the expression levels of microRNAs(miRNAs),Forkhead box protein O1(FOXO1),and DNA methyltransferase 3A(DNMT3A)in both untreated and PA-treated DLBCL tumors and cell *** were made of cell viability,apoptosis,and autophagy-related protein expression following PA *** analyses among miR-429,DNMT3A,and FOXO1 were conducted using luciferase reporter assays and methylation-specific(MSP)Polymerase chain reaction(PCR).After transfecting the miR-429 inhibitor,negative control(NC)inhibitor,shRNA against DNMT3A(sh-DNMT3A),shRNA negative control(sh-NC),over-expression vector for DNMT3A(oe-DNMT3A),or overexpression negative control(oe-NC),we evaluated the effects of miR-429 and DNMT3A on cell viability,mortality,and autophagy-related protein expression in PA-treated DLBCL cell *** efficacy of PA was also tested in vivo using DLBCL tumor-bearing mouse ***-429 and FOXO1 expression levels were downregulated,whereas DNMT3A was upregulated in DLBCL compared to the control *** treatment was associated with enhanced autophagy,mediated by the upregulation of miR-429 and downregulation of *** luciferase reporter assay and MSP confirmed that miR-429 directly inhibits DNMT3A,thereby reducing FOXO1 *** experiments demonstrated that PA promotes autophagy and inhibits DLBCL progression by upregulating miR-429 and modulating the DNMT3A/FOXO1 *** vivo PA signific-antly reduced the growth of xenografted tumors through its regulatory impact on the miR-429/DNMT3A/FOXO1 *** acid may modulate autophagy and inhibit DLBCL progression by targeting the miR-429/DNMT3A/FOXO1 signaling pathway,suggesting a novel therapeutic target for DLBCL management.

关键词： Palmitic acid Diffuse large B-cell lymphoma MiR-429 DNMT3A FOXO1 Autophagy