检索结果-南通市图书馆

Design and application of lysosome-targeted fluorescent probes based on BODIPY molecular structure for the detection of Cys

在线全文

学校读者我要写书评

暂无评论

Design and application of lysosome-targeted fluorescent prob...

The creep behavior of Mg-9Al-1si-1siC composite at elevated temperature

中国化学会·第十六届全国有机合成化学学术研讨会

作者：陶远芳 Jinhua Gao Jian Zhang Xin Ji Yubing si weili Zhao 黄河科技学院 Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan University School of Pharmacy Institutes of Integrative MedicineFudan University Henan Key Laboratory of Nanocompositcs and Applications Institute of Nanostructured Functional MaterialsHuanghe Science and Technology College

Biothiols such as cysteine(Cys),bomocysteine(Hcy) and glutathione(GSH) play vital roles in a wide range of physiological and pathological processes arising from their biological redox chemistry. In addition,biothiols are closely associated with proteolysis in the lysosome w-hich reduces disulphide bonds. Therefore,selective determination of biothiols is of great importance for various investigations in *** this work,we continue to investigate the impact of delicate modulations on the sensing ***,we designed and developed 1,7-dimethyl,3,5-diaryl substituted BODIPY and its conformationally restricted species with meso-arylmercapto moiety(DM-BDP-SAr and DM-BDP-R-SAr) as selective fluorescent probes for ***,the lysosome-target probes(Lyso-S and Lyso-D) based on DM-BDP-SAr carrying one or two morpholinoethoxy moieties were developed(Fig.1).They were able to detect Cys selectively in vitro with low detection *** Lyso-S and Lyso-D localized nicely in lysosomes in living HeLa cells and exhibited red fluorescence for ***,a novel fluorescence quenching mechanism was proposed from the calculations by density functional theory(DFT).The probes may go through intersystem crossing(from singlet excited state to triplet excited state) to result in fluorescence quenchin.

关键词： BODIPY fluorescent probe cysteine lysosome-targeted

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2020年第3期8卷 944-951页

作者： Pengwen Zhou Shaoxiong Zhang Ming Li Hongxia Wang weili Cheng Lifei Wang Hang Li Wei Liang Yiming Liu Shanxi Key Laboratory of Advanced Magnesium based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Southwest Technology and Engineering Research Institute Chongqing 400039China

The creep properties of as-cast Mg-9Al-1si alloy and Mg-9Al-1si-1siC composite were *** results show that Mg-9A1-lsi-lsiC composite performs a better creep resistance than that of Mg-9Al-1si alloy at constant temperature and stress(473 K,70MPa).Besides,the creep behavior of Mg-9Al-1 si-1siC composite at various temperature from 448 K to 498 K and under stresses of 70-90 MPa were systematically *** Mg-9Al-1 si-1siC composite exhibited a stress exponent from 5.5 to 6.9 and the creep activation energy fell within the range of 86-111 kJ/*** results showed that the creep mechanism of Mg-9Al-1si-1siC composite was mainly attributed to the effects of secondary phase strengthening mechanism and dislocation climb mechanism.

关键词： Microstructure Stress exponent n Creep activation energy Q Mg-9Al-1si-1siC composite

Luminescent Properties of Porous si Passivated by Diamond Film and DLC Film

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2004年第2期20卷 145-148页

作者： Linjun WANG, Yiben XIA, weili ZHANG, Minglong ZHANG and Weimin SHISchool of Materials Science & Engineering, Shanghai Univ., Shanghai 201800, China School of Materials Science & Engineering Shanghai Univ. Shanghai 201800 China

Surface passivation methods for porous si (PS) surfaces, i.e., depositing diamond film or diamond-like carbon (DLC) film on PS surfaces, were attempted. Two emission bands, weak blue band and strong red band existed in the PL spectrum of diamond film coated on PS, were discovered by the photoluminescence measurements. The luminescent mechanism and stability were discussed. The results indicated that diamond film may stabilize the PL wavelength and intensity of PS, and therefore could become a promising passivation film of porous si. The PL properties of PS coated by DLC films, including hydrogenated diamond like carbon (DLC:H) film and nitrogen doped DLC film (DLC:N) were also studied in this paper. The DLC films may stabilize the PL of PS, but the photoluminescent intensity was obviously weaker than that of diamond film coated PS.

关键词： Porous si Passivation Diamond film Diamond-like carbon film

Influence of TiO_2 seeding layers on phase composition of lead magnesium niobate-lead titanate thin films prepared by RF magnetron sputtering

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2007年第S1期26卷 205-209页

作者： WANG Junming,LI weili,and FEI Weidong School of Materials Science & Engineering,Harbin Institute of Technology,Harbin 150001,China Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China

The influence of amorphous TiO_2 seeding layers on the phase composition of lead magnesium niobate-lead titanate(0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3,PMN-PT) films deposited on Pt/Ti/siO2/si substrate by RF magnetron sputtering was *** relation between seeding layer thickness and phase composition at different post annealing temperature was observed by *** thickness of amorphous TiO2 seeding layer and post annealing temperature had remarkable effects on PMN-PT film phase *** amorphous seeding layer becomes thick,a new phase of Nb2O5 exists in the *** when the seeding layer thickness is suitable,the film with pure perovskite phase can be attained.

关键词： PMN-PT film amorphous TiO_2 seeding layers RF magnetron sputtering

考虑台风动态路径影响的疏散车辆路径规划研究

在线全文

学校读者我要写书评

暂无评论

中国安全生产科学技术 2023年第12期19卷 156-163页

作者：司上上王维莉王卓周辉上海海事大学物流研究中心上海201306

为了解决强台风灾害下的人群转移安置问题,以2021年第6号台风“烟花”影响下上海市金山区人群转移安置为例,采用ArcGIS空间分析进行集结点选址,以集结点到避难所距离最短为优化目标,考虑疏散需求、避难所容量等约束条件,建立避难所选址... 详细信息

为了解决强台风灾害下的人群转移安置问题,以2021年第6号台风“烟花”影响下上海市金山区人群转移安置为例,采用ArcGIS空间分析进行集结点选址,以集结点到避难所距离最短为优化目标,考虑疏散需求、避难所容量等约束条件,建立避难所选址模型。考虑台风移动路径影响,以疏散车辆行驶距离最短及转移风险最小为优化目标,建立疏散车辆路径规划模型,并设计遗传算法对其进行求解。研究结果表明:该方法能够求出台风路径影响下的车辆路径规划方案。研究结果可为台风灾害下人群转移安置方案提供参考。

关键词：城市交通路径规划遗传算法车辆路径规划人群转移安置

Self-aldol condensation of aldehydes over Lewis acidic rare-earth cations stabilized by zeolites

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2021年第4期42卷 595-605页

作者： Tingting Yan sikai Yao weili Dai Guangjun Wu Naijia Guan Landong Li School of Materials Science and Engineering Nankai UniversityTianjin 300350China Key Laboratory of Advanced Energy Materials Chemistry of the Ministry of Education Nankai UniversityTianjin 300071China

The self-aldol condensation of aldehydes was investigated with rare-earth cations stabilized by[si]Beta zeolites in parallel with bulk rare-earth metal *** catalytic performance was achieved with all Lewis acidic rare-earth cations stabilized by zeolites and yttrium appeared to be the best metal *** to the results of several complementary techniques,i.e.,temperature-programmed surface reactions,in situ diffuse reflectance infrared Fourier transform spectroscopy,ultraviolet-visible diffuse reflectance spectroscopy,the reaction pathway and mechanism of the aldehyde self-aldol condensation over Y/Beta catalyst were studied in more *** functional theory calculations revealed that aldol dehydration was the rate-limiting *** hydroxyl group at the open yttrium site played an important role in stabilizing the transition state of the aldol dimer reducing the energy barrier for its *** acidic Y(Osi)(OH)2 stabilized by zeolites in open configurations were identified as the preferred active sites for the self-aldol condensation of aldehydes.

关键词： Self-aldol condensation Aldehyde Rare-earth cations Zeolite Lewis acid

不同产地雪茄烟叶叶际可培养微生物分离、鉴定及功能研究

在线全文

学校读者我要写书评

暂无评论

河南农业科学 2024年第9期53卷 37-45页

作者：司洪阳阳苇丽崔冰来苗赵铭钦河南农业大学烟草学院河南郑州450002 四川省烟草公司达州市公司四川达州635000

为了明确我国雪茄烟叶叶际可培养微生物种类及功能,以海南省五指山市海烟103和四川省达州市川雪一号经晾制后的雪茄烟叶为试验材料,通过传统的分离纯化方法对雪茄烟叶叶际可培养微生物进行分离,并进行分子鉴定;同时,对所分离微生物的产... 详细信息

为了明确我国雪茄烟叶叶际可培养微生物种类及功能,以海南省五指山市海烟103和四川省达州市川雪一号经晾制后的雪茄烟叶为试验材料,通过传统的分离纯化方法对雪茄烟叶叶际可培养微生物进行分离,并进行分子鉴定;同时,对所分离微生物的产酶和产香能力进行研究。结果表明,从海烟103和川雪一号雪茄烟叶中共分离到52株不同的细菌,这些细菌来自5个不同的科,分别是芽孢杆菌科(Bacillaceae)、动球菌科(Planococcaceae)、欧文菌科(Erwiniaceae)、肠杆菌科(Enterobacteriaceae)和莫拉菌科(Moraxellaceae)。两地雪茄烟叶中的优势菌均为芽孢杆菌科细菌,其中,从海南雪茄烟叶中分离的枯草芽孢杆菌E-11的蛋白酶和果胶酶活性最高,分别为85.02 U/mL和256.71 U/mL。此外,还分离到4株酵母菌,均来自海南烟叶,包括1株毕赤酵母属(Pichia)、1株胶红酵母属(Rhodotorula)、2株德巴利酵母属(Debaryomyces),这些酵母菌不具备产生胞外蛋白酶、果胶酶能力,分离到的毕赤酵母J-2可以代谢产生具有玫瑰花香的2-苯乙醇,在发酵72 h时2-苯乙醇产量最高,为333.81 mg/L。综上,雪茄烟叶中含有丰富的可培养微生物资源,从海烟103中分离的枯草芽孢杆菌E-11和毕赤酵母J-2在降解烟叶大分子物质、增加烟叶香气物质含量方面具有较好的应用前景。

关键词：雪茄烟叶细菌酵母菌分离鉴定功能分析