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The Judicial Standards Analysis on Abuse of the Right to Apply for Government Information Openness

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The Judicial Standards Analysis on Abuse of the Right to App...

Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis

作者： weijun wu Luwei Zhong School of Public Affairs and Administration University of Electronic Science and Technology of China

In order to protect the right to know of citizens, legal persons and other organizations better and improve the transparency of the work of government departments, citizens, legal persons and other organizations may apply to the relevant departments for access to relevant information in accordance with the regulations on the Decree of Government Information Openness. However, in the process of practice, there is a phenomenon of abuse of the right to apply for public government information. Such applications, which are not aimed at obtaining government information, not only place a burden on the administrative authorities, but also waste limited administrative resources, so there is a need to develop a set of judicial standards for determining the abuse of the right to apply in order to identify them more effectively and to regulate the abuse of the right to apply for information openness.

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Cellular & Molecular Immunology 2019年第8期16卷 694-705页

作者： weijun wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu Department of Pharmacology Shanghai Key Laboratory of Bioactive Small MoleculesSchool of PharmacyFudan UniversityShanghai 201203China State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy Macao University of Science and TechnologyMacaoChina Institute of Arthritis Research Shanghai Academy of Chinese Medical SciencesGuanghua Integrative Medicine Hospital/Shanghai University of T.C.MShanghaiChina Ningbo The 9th Hospital Ningbo 315000China Department of Rheumatology Shanghai Longhua HospitalShanghaiChina Department of Pharmacology National University of SingaporeSingaporeSingapore

Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of *** domain-containing protein 3(JMJD3)is implicated in the immune response and ***,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic *** down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 *** addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone ***,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated ***,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target ***-J4 markedly attenuated the severity of arthritis in CIA *** conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA.

关键词： cystathionine-γ-lyase rheumatoid arthritis Jumonji domain-containing protein 3 Sp-1 Toll like receptor 2

A lysosome-targeted and two-photon excitable iridium（Ⅲ） complex for bimodal phosphorescence imaging of endogenous nitric oxide

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A lysosome-targeted and two-photon excitable iridium（Ⅲ） c...

An acoustic imaging system of migration technique used in borehole

中国化学会第十四届全国生物无机化学学术会议

作者： weijun wu L.Ji Hui.Chao MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University

An iridium（Ⅲ） complex, Ir-BPDA, has been investigated for detceting endogenous NO in nanomolar levels in microphages under two-photon excitation. The complex exhibits an off-on two-photon phosphorescent response and a high sensitivity toward NO, as well as low cytotoxicity and excellent lysosomal localization. Significantly, Ir-BPDA shows very good tolerance to acid pH, which cause low bakground fluorescece under the mild aicd conditions. In addition, the phosphorescence lifetime of Ir-BPDA increases distinctly toward reacting NO that means the complex can be utilized to detecting NO by phosphorescence lifetime microscopy imaging. All in all, the complex Ir-BPDA, is demonstrated as a multifunctional phosphorescence probe for bimodal imaging（two-photon phosphorescent imaging and phosphorescence lifetime imaging） of NO in RAW 264.7 cells and zebrafish.

关键词： Iridium complex Nitric Oxide Two-photon Phosphorescence Lifetime Imaging Lysosome Zebrafish

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Chinese Journal of Acoustics 2008年第3期27卷 231-237页

作者： LIN weijun wu Nan SUN Jian ZHANG Hailan Institute of Acoustics Chinese Academy of Sciences Beijing 100190

In order to detect the damage of casing boreholes, an acoustic imaging method with a two-dimensional ultrasonic array was presented. Each element of the array independently emits down ultrasonic waves, the echoes received by all elements are sampled and transmitted to a computer on ground surface, where the dynamic migration method is used to form a 2 or 3-dimensional image of the situation in the borehole. The numerical simulation and experiment are conducted that demonstrate a high imaging accuracy with a small number of elements used in array. Since the delay circuits used in the traditional phased array imaging system is not needed in this system, and all data process could be completed in a ground system. the complexity and the volume of system in borehole may be significantly simplified, which is critical to the borehole instrument.

关键词： used in numerical simulation imaging system ground surface delay circuits ground system phased array data process

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习近平法治思想中的司法体制改革理论研究

比较法研究 2022年第5期36卷 16-30页

作者：吴卫军电子科技大学法律系

习近平法治思想中的司法改革理论可以从价值论、方法论和本体论三个维度予以理解和把握。价值论主要解决“为何改”的问题,明确了司法体制改革应当以公平正义为最重要目标,坚持以人民为中心,将民众满意度作为衡量改革成效的基本标准;方... 详细信息

习近平法治思想中的司法改革理论可以从价值论、方法论和本体论三个维度予以理解和把握。价值论主要解决“为何改”的问题,明确了司法体制改革应当以公平正义为最重要目标,坚持以人民为中心,将民众满意度作为衡量改革成效的基本标准;方法论主要解决“如何改”的问题,强调了改革应自上而下与自下而上双向互动、整体推进与重点突破有机结合、中国国情与司法规律融汇贯通;本体论则指向“改什么”的问题,突出了司法职权配置改革、司法机构设置改革、司法人员分类管理改革、司法责任制改革及司法职业保障机制改革等重点任务。习近平司法体制改革理论的价值论、方法论和本体论相辅相成、融为一体,形成了完整的理论体系。

关键词：习近平法治思想司法体制改革理论价值论方法论本体论

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贵州晴隆长流“喇叭苗”土话音系

方言 2019年第4期41卷 446-462页

作者：吴伟军贵州师范大学

本文描写贵州晴隆县长流“喇叭苗”土话的语音特点,记录同音字汇。

关键词：湘语长流“喇叭苗”土话语音特点同音字汇

区域企业结构差异对我国货币政策区域效应的影响

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上海金融 2009年第3期 40-43页

作者：吴伟军江西财经大学

本文通过建立回归面板数据模型,证实了企业数量对经济增长有很大的促进作用,然后通过建立SVAR模型,检验了各种规模企业对货币政策的相应作用,结果显示我国中小型企业对货币政策比较敏感,特别是中型企业最为敏感。由于我国区域之间企业... 详细信息

本文通过建立回归面板数据模型,证实了企业数量对经济增长有很大的促进作用,然后通过建立SVAR模型,检验了各种规模企业对货币政策的相应作用,结果显示我国中小型企业对货币政策比较敏感,特别是中型企业最为敏感。由于我国区域之间企业结构存在较大差异,这必然会产生货币政策区域效应。

关键词：企业结构货币政策区域效应

Study on Fishery Ecological Environment and Fish Species Diversity in Yantan Water Area

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Asian Agricultural Research 2015年第9期7卷 81-86页

作者： Yaoquan HAN Anyou HE Li HUANG Jun SHI Dapeng WANG weijun wu Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture Guangxi Academy of Fishery Sciences Guangxi International Business Vocational College

Through analysis on water quality,planktonic organism,fish resources,and fish species diversity in Yantan water area,this paper evaluated current situation of quality of fishery ecological environment in Yantan water area. The survey recorded all 52365 fishes and 1410. 2kg catches obtained by fishermen in half a year,and more than 98% catches are small fishes. The Shannon-Weiner diversity index of Yantan water area is 0. 162,Wilhm improvement index is 1. 814,DG- Findex is 0. 083,and the index of fish species diversity is far lower than other water areas. The average quantity per unit of phytoplankton is 1. 0134 million ind. / L,and the average quantity per unit of organisms is 1. 1151 mg / L. The average quantity per unit of zooplankton is 459. 6 ind. / L,and the average quantity per unit of organisms is 0. 6422 mg / L. Evaluation results indicate that water quality and planktonic organism in Yantan water area are basically normal,but fish resources are increasingly exhausted,fish resource composition is not reasonable,and fish species diversity is extremely low. From the perspective of biomanipulation,it is required to restore fishery ecological environment of reservoir area through restoring normal composition of aquatic organisms.

关键词： Yantan water area Fishery ecological environment F

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid