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Clinical and radiological features of medullary infarction caused by spontaneous vertebral artery dissection

Stroke & Vascular Neurology 2022年第3期7卷 245-250页

作者： Chun Yu Zhu Zhu Siying Li Yi Xu Wei Yan Xiaocui Kang Yao Li Qiang Dong weijun tang Xiang Han Intensive Care Unit of West Campus Huashan Hospital Fudan UniversityShanghaiChina Department of Neurology University of KentuckyLexingtonKentuckyUSA Department of Anesthesiology Zhongshan Hospital Fudan UniversityShanghaiChina Department of Neurology Fifth People's Hospital of Shanghai Fudan UniversityShanghaiChina Department of Neurology Huashan Hospital Fudan UniversityShanghaiChina Neurology Huashan HospitalState Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina Department of Radiology Huashan Hospital Fudan UniversityShanghaiChina

Background and purpose Medullary infarction(MI)caused by spontaneous vertebral artery dissection(sVAD)is an important type of stroke.It is important to distinguish sVAD from other causes of stroke since the treatment strategies and prognosis were different between them.In this study,we aimed to explore the clinical and radiological features of MI in patients with acute MI caused by sVAD.Methods Patients with acute MI caused by sVAD and non-sVAD in a single tertiary hospital were enrolled from 2010 to 2020.Epidemiologic,clinical and image features were collected and analysed.MI lesions were categorised into three levels rostrocaudally and four arterial groups:anteromedial,anterolateral,lateral and posterior.Results A total of 128 patients with MI were enrolled with 47 cases of sVAD and 81 cases of non-sVAD.Patients with sVAD were younger than those with non-sVAD(med 44 years old vs 58 years old).The sVAD group was less likely to have hypertension(44.68%vs 67.90%;p=0.010)and diabetes(19.15%vs 45.69%;p=0.003),but more likely to have non-sudden onset(27.66%vs 9.87%,p=0.009),minor neck injury(19.15%vs 1.23%;p=0.001)and headache(46.81%vs 7.41%;p=0.000).Vertically,sVAD became more common in caudal medulla than in rostral medulla.Horizontally,the sVAD group was more likely to have lateral MI(91.48%vs 2.96%,p=0.000).In multivariable logistic regression analysis,age,non-sudden onset and headache were independently associated with sVAD with ORs of 0.935(95%CI 0.892 to 0.981,p=0.006),3.507(95%CI 1.060 to 11.599,p=0.040)and 5.426(95%CI 1.673 to 17.599,p=0.005).Conclusion sVAD was not uncommon in patients with MI,especially in patients with lateral MI.Young patients with headache and non-sudden onset should remind clinician the possibility of sVAD.

关键词： dissection headache infarction

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Cobalt-catalyzed asymmetric hydrogenation of ketones:A remarkable additive effect on enantioselectivity

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Chinese Chemical Letters 2021年第3期32卷 1241-1244页

作者： Tian Du Biwen Wang Chao Wang Jianliang Xiao weijun tang Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education School of Chemistry&Chemical EngineeringShaanxi Normal UniversityXi’an 710062China Department of Chemistry University of LiverpoolLiverpoolL697ZDUK

A chiral cobalt pincer complex,when combined with an achiral electron-rich mono-phosphine ligand,catalyzes efficient asymmetric hydrogenation of a wide range of aryl ketones,affording chiral alcohols with high yields and moderate to excellent enantioselectivities(29 examples,up to 93%ee).Notably,the achiral mono-phosphine ligand shows a remarkable effect on the enantioselectivity of the reaction.

关键词： Cobalt Asymmetric hydrogenation Ketones Additive effect Pincer complex

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感音神经性耳聋从肝脾肾瘀论治辨析

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中华中医药杂志 2024年第3期39卷 1333-1336页

作者：潘旭宣伟军唐俊波广西中医药大学南宁530200 广西中医药大学第一临床医学院耳鼻咽喉头颈外科南宁530022

感音神经性耳聋(SNHL)为临床常见慢性病,以听力减退为主要症状,属于中医“耳聋”范畴。宣伟军教授认为本病病机为本虚标实,虚实夹杂,肝失疏泄是发病的始动因素,脾失健运是发病的重要原因,肾精亏虚是发病的根本所在,瘀血滞留是贯穿疾病... 详细信息

感音神经性耳聋(SNHL)为临床常见慢性病,以听力减退为主要症状,属于中医“耳聋”范畴。宣伟军教授认为本病病机为本虚标实,虚实夹杂,肝失疏泄是发病的始动因素,脾失健运是发病的重要原因,肾精亏虚是发病的根本所在,瘀血滞留是贯穿疾病发展的重要病理过程。突发性SNHL治疗以疏肝理气、活血通窍为主,健脾补肾为佐。远期SNHL治疗以健脾补肾、活血通窍为主,疏肝理气为佐。立足于肝脾肾瘀,标本兼施,疗效显著。

关键词：感音神经性耳聋肝脾肾瘀辨证论治理论探讨现代医学

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Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage

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Neuroscience Bulletin 2020年第9期36卷 985-996页

作者： Jiayu Huo Zengxin Qi Sen Chen Qian Wang Xuehai Wu Di Zang Tanikawa Hiromi Jiaxing Tan Lichi Zhang weijun tang Dinggang Shen Institute for Medical Imaging Technology Shanghai Jiao Tong UniversityShanghai 200030China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200030China Neurosurgical Institute of Fudan University Shanghai Clinical Medical Center of NeurosurgeryShanghai Key Laboratory of Brain Function Restoration and Neural RegenerationShanghai 200030China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghai 200030China Department of Radiology Huashan HospitalFudan UniversityShanghai 200030China Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Brain and Cognitive Engineering Korea UniversitySeoul 02841Republic of Korea

Hydrocephalus is often treated with a cerebrospinal fluid shunt(CFS) for excessive amounts of cerebrospinal fluid in the brain.However,it is very difficult to distinguish whether the ventricular enlargement is due to hydrocephalus or other causes,such as brain atrophy after brain damage and surgery.The non-trivial evaluation of the consciousness level,along with a continuous drainage test of the lumbar cistern is thus clinically important before the decision for CFS is made.We studied 32 secondary mild hydrocephalus patients with different consciousness levels,who received T1 and diffusion tensor imaging magnetic resonance scans before and after lumbar cerebrospinal fluid drainage.We applied a novel machine-learning method to find the most discriminative features from the multi-modal neuroimages.Then,we built a regression model to regress the JFK Coma Recovery Scale-Revised(CRS-R) scores to quantify the level of consciousness.The experimental results showed that our method not only approximated the CRS-R scores but also tracked the temporal changes in individual patients.The regression model has high potential for the evaluation of consciousness in clinical practice.

关键词： Hydrocephalus Disorder of consciousness Structural imaging Feature selection Regression

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从麻姑到岳姑:昆嵛山仙道女神的历史嬗变

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民俗研究 2024年第1期 114-123,158,159页

作者：吴欣贾维军烟台大学马克思主义学院山东烟台264005

承接东海仙道文化余绪,唐宋时期昆嵛山麻姑庙宇得以修建;蓬莱清浅、唐臣访姑的故事出现于这一时期庙宇重修的碑刻之中。金元时期全真道教以胶东为基地,以麻姑为资源,弘扬麻姑信仰并将之塑造为“后学仙”和鼓励女性入道的“榜样”;麻姑... 详细信息

承接东海仙道文化余绪,唐宋时期昆嵛山麻姑庙宇得以修建;蓬莱清浅、唐臣访姑的故事出现于这一时期庙宇重修的碑刻之中。金元时期全真道教以胶东为基地,以麻姑为资源,弘扬麻姑信仰并将之塑造为“后学仙”和鼓励女性入道的“榜样”;麻姑乞树、显异助饷的故事也在这一时期得以流传。明清时期尤其是明中期以后,岳姑(碧霞元君)信仰在昆嵛山成为主流,麻姑退居其后;至清末当地人甚至“只知岳姑不知麻姑”。历史长时段视野下,地方士人、民众传承方域文脉的自觉与创造,尤其是全真道教发展过程中因应时势所进行的策略转变,塑造、改变着麻姑、岳姑的形象并推动二姑易位。

关键词：麻姑岳姑昆嵛山历史嬗变

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基于绿色建筑体系的川渝乡土建筑营造技术优化策略研究

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绿色建筑 2024年第2期16卷 29-33,1页

作者：温泉蒋升望唐伟君重庆交通大学重庆400074 重庆市住房与城乡建设委员会重庆400000

川渝地区乡土建筑承载着丰富的地域特色,在环境选择、材料运用、营造方式等方面展现了突出的环保特性,对当代村镇可持续发展和历史文脉传承具有重要价值。因此,建立和完善基于绿色建筑体系的川渝乡土建筑营造技术优化体系显得尤为重要... 详细信息

川渝地区乡土建筑承载着丰富的地域特色,在环境选择、材料运用、营造方式等方面展现了突出的环保特性,对当代村镇可持续发展和历史文脉传承具有重要价值。因此,建立和完善基于绿色建筑体系的川渝乡土建筑营造技术优化体系显得尤为重要。深入剖析了川渝乡土建筑营造技术的绿色特征、优化意义及优化路径,利用AHP分析法构建了相应的评价体系与设计导则,突出节省能源、保护环境等重要指标,提出了一套基于绿色建筑标准的关于功能提升和结构安全性能提升的改造更新策略。以将先进的绿色建筑理念与技术融入乡土建筑实际营造过程,提升其环保性能,为乡村地区的绿色建筑发展提供有力支持。

关键词：绿色建筑体系川渝地区乡土建筑营造技术

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Correlation between iron deposition and Alzheimer's disease In vivo preliminary quantitative study with susceptibility-weighted imaging

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Neural Regeneration Research 2010年第10期5卷 725-728页

作者： Jun Zhang Jianhong Wang Ke Li Daoying Geng Meirong Chen weijun tang Zhenguo Zhao Yuehua Li Shiguo Ma Chenggong Yan Department of Radiology Huashan Hospital Fudan University Shanghai 200040 China Department of Neurology Huashan Hospital Fudan University Shanghai 200040 China Department of Radiology Pudong New Area People's Hospital Shanghai 201200 China Department of Radiology Pudong New Area Hospital of Traditional Chinese Medicine Shanghai 201200 China

BACKGROUND： Studies have demonstrated iron deposition in Alzheimer＇s disease （AD） patients. Therefore, quantitative measurements and tracing of iron deposition are important for early detection and treatment.OBJECTIVE： To quantitatively measure iron deposition in the brain and evaluate the relationship between iron deposition and AD using magnetic susceptibility-weighted imaging. DESIGN, TIME AND SETTING： A case-control study was performed at the Department of Radiology, Huashan Hospital of Fudan University from February to July 2008. PARTICIPANTS： A total of 20 AD patients, comprising 11 males and 9 females, with a mean age of 72.5 years （range, 51-80 years）, and 20 healthy volunteers, comprising 10 males and 10 females, with a mean age of 69.9 years （range, 55-78 years）, were selected. AD was diagnosed according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer Disease and Related Disorders Association criteria.METHODS： Sagittal T2-weighted images were acquired to locate precise positions of the anterior and posterior commissures. The susceptibility-weighted magnetic resonance images were parallel to the anterior-posterior commissural line through the use of a three-dimensional gradient-echo sequence. All participants underwent measurement of corrected phase （CP） value and Mini-Mental State Examination. Pearson correlation coefficients were used to assess the association between CP values and Mini-Mental State Examination results.MAIN OUTCOME MEASURES： CP values of regions of interest in the hippocampal regions were measured on CP images.RESULTS： CP values were significantly reduced in bilateral hippocampal regions of AD patients compared with normal controls （P〈0.01）, but there were no significant differences between left and right CP values （P〉0.05）. The hippocampal mean CP value positively correlated with the Mini-Mental State Examination score in AD patients and normal controls （r= 0.57, P〈0.01）. CONCLUSION： Susceptibility-weighted imaging can be used to measure CP v

关键词： magnetic resonance imaging hippocampus Alzheimer＇s disease neurodegenerative diseases neural regeneration

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White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness

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Neuroscience Bulletin 2018年第4期34卷 668-678页

作者： Xuehai Wu Jiaying Zhang Zaixu Cui weijun tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong Ying Mao Yong He Neurosurgical Department Shanghai Huashan HospitalFudan University State Key Laboratory of Cognitive Neuroscience and Learning IDG/Mc Govern Institute for Brain ResearchBeijing Normal University Centre for Medical Image Computing Department of Computer Science University College London Radiological Department Shanghai Huashan Hospital Fudan University Psychiatry Department Shanghai Huashan Hospital Fudan University Huajia Hospital Shanghai Scientific and Statistical Computing Core National Institute of Mental Health National Institutes of Health Department of Health and Human Services Institute of Mental Health Research University of Ottawa

In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.

关键词： Disorder of consciousness White matter Diffusion tensor imaging Brain injury

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乳腺MRI预测ER^(+)/HER2^(-)乳腺癌21基因检测复发风险评分的价值

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肿瘤影像学 2024年第1期33卷 20-30页

作者：陈阳汤伟顾雅佳彭卫军复旦大学附属肿瘤医院放射诊断科复旦大学上海医学院肿瘤学系上海200032

目的:探究乳腺磁共振成像(magnetic resonance imaging,MRI)影像学特征与21基因检测复发风险评分(recurrence score,RS)的相关性,并建立RS预测模型。方法:收集2017年4月—2019年3月在复旦大学附属肿瘤医院进行21基因检测的雌激素受体(es... 详细信息

目的:探究乳腺磁共振成像(magnetic resonance imaging,MRI)影像学特征与21基因检测复发风险评分(recurrence score,RS)的相关性,并建立RS预测模型。方法:收集2017年4月—2019年3月在复旦大学附属肿瘤医院进行21基因检测的雌激素受体(estrogen receptor,ER)阳性、人表皮生长因子受体2(human epidermal growth factor receptor2,HER2)阴性乳腺癌患者的资料,筛选出有术前MRI检查的患者拟入组。以RS=26分为临界值,将患者分为高危组(RS≥26)与低危组(RS<26)。根据2013版乳腺影像报告和数据系统标准评估患者图像。运用单因素检验比较MRI影像学特征在RS分组间差异,运用多元logistic回归构建RS预测模型。以7∶3比例将患者分为训练组和验证组,使用Pearson相关系数筛选法和递归特征消除法进行特征筛选,运用合成少数类过采样技术法进行重采样,使用4种不同机器学习模型算法构建模型(线性支持向量机、随机森林、决策树和K近邻)。运用受试者工作特征(receiver operating characteristic,ROC)曲线评估模型效能。结果:共入组159例患者(低危组58例,高危组101例)。在临床病理学特征中,孕激素受体(progesterone receptor,PR)表达状态组间差异有统计学意义(P=0.017),低危组PR表达阳性患者占比更高。在MRI影像学特征中,肿块边缘组间差异有统计学意义(P=0.008),低危组肿块多表现为边缘毛刺(64.8%),高危组肿块多表现为边缘不规则(54.7%)。将PR状态和肿块边缘纳入多因素logistic回归模型,PR阳性与PR阴性相比,PR阳性患者复发风险相对低,OR值为0.110(P=0.038);边缘毛刺的肿块与边缘不规则肿块相比,边缘毛刺的肿块复发风险相对低,OR值为0.343(P=0.004)。Logistic回归模型曲线下面积(area under curve,AUC)为0.67,且该模型校准性能良好且具有一定临床实用性。以7∶3划分后,训练组纳入111例患者(低危组34例,高危组77例),验证组纳入48例患者(低危组和高危组均为24例)。4种机器学习模型AUC为0.64~0.69,支持向量机和随机森林模型预测效能相对较高。结论:MRI在评估ER+/HER-乳腺癌患者复发风险方面具有潜在价值。

关键词：乳腺癌磁共振成像 21基因检测复发风险评分

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Multilevel air quality evolution in Shenyang:Impact of elevated point emission reduction

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Journal of Environmental Sciences 2022年第3期34卷 300-310页

作者： Xiaolan Li Guiqian tang Liguang Li weijun Quan Yangfeng Wang Ziqi Zhao Ningwei Liu Ye Hong Yanjun Ma Institute of Atmospheric Environment China Meteorological AdministrationNo.388 Changbai South RoadShenyangLiaoning 110166China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Environmental Meteorology Forecast Center of Beijing-Tianjin-Hebei Beijing 100089China

Visibility observed at different altitudes is favorable to understand the causes of air pol-lution.We conducted 4-years of observations of visibility at 2.8 and 60 m and particulate matter(PM)concentrations from 2015 to 2018 in Shenyang,a provincial city in Northeast China.The results indicated that visibility increased with the increasing height in winter(especially at night),and decreased with height in summer(especially at the daytime).PM concentration exhibited opposite vertical variation to visibility,reflecting that visibility de-grades with the increase of aerosol concentration in the air.The radiosonde meteorological data showed that weak turbulence in the planetary boundary layer(PBL)in winter favored aerosols'accumulation near the surface.Whereas in summer,unstable atmospheric con-ditions,upper-level moister environment,and regional transport of air pollutants resulted in the deterioration of upper-level visibility.Inter-annual variation in the two-level visibility indicated that the upper-level visibility improved more significantly than low-level visibil-ity,much likely due to the reduction in emission of elevated point sources in Shenyang.Our study suggested that strengthening the control of surface non-point emissions is a promis-ing control strategy to improve Shenyang air quality.

关键词： Aerosol pollution Atmospheric visibility Planetary boundary layer Northeast China Vertical evolution

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