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Mechanism of action of the bile acid receptor TGR5 in obesity

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Acta Pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： weijun Lun Qihao Yan Xinghua guo Minchuan Zhou Yan Bai Jincan He Hua Cao Qishi Che Jiao guo Zhengquan Su Guangdong Engineering Research Center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan 528458China Guangzhou Rainhome Pharm&Tech Co. Ltd.Science CityGuangzhou 510663China

G protein-coupled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-coupled receptor 5(TGR5)is a member of this family.As a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy consumption,weight loss and blood glucose homeostasis.Recent studies have shown that TGR5 plays an important role in glucose and lipid metabolism disorders such as fatty liver,obesity and diabetes.With the global obesity situation becoming more and more serious,a comprehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge concerning clinical ligand drugs are urgently needed.In this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microscope structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

Plant synthetic epigenomic engineering for crop improvement

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Science China(Life Sciences) 2022年第11期65卷 2191-2204页

作者： Liwen Yang Pingxian Zhang Yifan Wang Guihua Hu weijun guo Xiaofeng Gu Li Pu Biotechnology Research Institute Chinese Academy of Agricultural SciencesBejing 10081China College of Life Science and Technology Huazhong Agriculural UniversityWuhan 430070China

Efforts have been directed to redesign crops with increased yield,stress adaptability,and nutritional value through synthetic biology—the application of engineering principles to biology.A recent expansion in our understanding of how epigenetic mechanisms regulate plant development and stress responses has unveiled a new set of resources that can be harnessed to develop improved crops,thus heralding the promise of“synthetic epigenetics.”In this review,we summarize the latest advances in epigenetic regulation and highlight how innovative sequencing techniques,epigenetic editing,and deep learning-driven predictive tools can rapidly extend these insights.We also proposed the future directions of synthetic epigenetics for the development of engineered smart crops that can actively monitor and respond to internal and external cues throughout their life cycles.

关键词： epigenetics synthetic biology synthetic epigenetics crop improvement

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金银错工艺的发展历史及技艺研究

宝石和宝石学杂志（中英文） 2024年第1期26卷 116-121页

作者：郭卫军北京工业职业技术学院北京100042

金银错工艺在我国有着十分悠久的历史,从商代开始,在青铜器上就已经出现了金银错工艺的运用,经过不断的发展与变革,这一技艺逐渐完善。玉雕金银错工艺是中华民族的瑰宝,金银错嵌宝石工艺的玉器多采用白玉、青白玉、碧玉、墨玉、水晶等材... 详细信息

金银错工艺在我国有着十分悠久的历史,从商代开始,在青铜器上就已经出现了金银错工艺的运用,经过不断的发展与变革,这一技艺逐渐完善。玉雕金银错工艺是中华民族的瑰宝,金银错嵌宝石工艺的玉器多采用白玉、青白玉、碧玉、墨玉、水晶等材质,所表现的图案与被嵌物品构成华美繁复的纹饰。经过打磨的金银散发出绸缎般的光泽,辅以璀璨华美的彩宝与温润大气的和田玉相得益彰。白玉、青白玉主体色泽素雅,青玉、墨玉典雅端庄,配以色泽艳丽的红宝石、蓝宝石及金丝、金片等材料,更显得雍容华贵、高贵典雅。虽然如今金银错工艺的发展并不繁盛,但是依旧能够给当下的设计提供诸多的灵感。本文中笔者探究金银错工艺发展的历史,对其工艺进行具体阐述,并对技艺发展做出展望,希望能够进一步推动其发展和运用。

关键词：金银错工艺发展历史技艺

SMOC:a smart model for open chromatin region prediction in rice genomes

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Journal of Genetics and Genomics 2022年第5期49卷 514-517页

作者： weijun guo Hanqing Liu Yifan Wang Pingxian Zhang Dongwei Li Tuoyu Liu Qian Zhang Liwen Yang Li Pu Jian Tian Xiaofeng Gu Biotechnology Research Institute Chinese Academy of Agriculture SciencesBeijing 100081China College of Life Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China

In eukaryotic genomes, the fundamental unit of chromatin is the nucleosome, which is composed of a histone octamer that contains two copies of each histone, H3, H2A, H2B, and H4 (Bell et al., 2011).Chromatin is wrappe... 详细信息

关键词： smart prediction helical

Integration of high-throughput phenotyping,GWAS,and predictive models reveals the genetic architecture of plant height in maize

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Molecular Plant 2023年第2期16卷 354-373页

作者： Weixuan Wang weijun guo Liang Le Jia Yu Yue Wu Dongwei Li Yifan Wang Huan Wang Xiaoduo Lu Hong Qiao Xiaofeng Gu Jian Tian Chunyi Zhang Li Pu Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China Institute of Molecular Breeding for Maize Qilu Normal UniversityJinan 250200China Institute for Cellular and Molecular Biology The University of Texas at AustinAustinTX 78712USA Department of Molecular Biosciences The University of Texas at AustinAustinTX 78712USA Sanya Institute Hainan Academy of Agricultural SciencesSanya 572000China

Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with i

关键词： phenomics GWAS plant height machine learning prediction maize

基于组合赋权-VIKOR法的山区施工便道方案优选模型

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中南大学学报（自然科学版） 2024年第2期55卷 445-456页

作者：林宇亮左伟俊邢浩郭冬冬中南大学土木工程学院湖南长沙410075 中铁七局集团第四工程有限公司湖北武汉430074

为对山岭地区施工便道方案进行客观、全面、精准评价,结合行业设计规范和相关研究成果,构建山区施工便道方案指标评价体系,提出一种山区施工便道方案优选模型。该模型采用三标度层次分析法和熵权法分别计算评价指标的主、客观权重,基于... 详细信息

为对山岭地区施工便道方案进行客观、全面、精准评价,结合行业设计规范和相关研究成果,构建山区施工便道方案指标评价体系,提出一种山区施工便道方案优选模型。该模型采用三标度层次分析法和熵权法分别计算评价指标的主、客观权重,基于博弈论思想对主、客观权重进行赋权确定综合权重,并运用VIKOR法(多准则妥协解排序法)对山区施工便道方案进行优选。以某高速公路山区施工便道方案比选为工程实例,针对4种施工便道方案进行综合比选,并将本文模型与加权TOPSIS法(优劣解距离法)、灰色加权关联分析法进行对比分析。研究结果表明:3种计算模型得出的最优方案一致,组合赋权的方法克服了单一赋权的缺陷,使指标评价更客观。相比于加权TOPSIS法和灰色加权关联分析法,本文模型能抵御外部因素的干扰,明显地辨别方案之间的差距,得到准确清晰的方案排序,且当评价方案众多时,本文模型能够提供更多方案选择,得到最优化方案。

关键词：道路工程施工便道优选模型博弈论 VIKOR法

Correction to:PRMT6 physically associates with nuclear factor Y to regulate photoperiodic flowering in Arabidopsis

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aBIOTECH 2022年第1期3卷 85-88页

作者： Pingxian Zhang Xiulan Li Yifan Wang weijun guo Sadaruddin Chachar Adeel Riaz Yuke Geng Xiaofeng Gu Liwen Yang Biotechnology Research Institute Chinese Academy of Agricultural ScienceBeijing 100081China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070HubeiChina College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

In this artice Figs.2 and 3 were wrongly numbered;Fig.2 should have been Fig.3 and vice versa as shown below.Moreover,the Fig.3 indications have been revised as shown:the sentence"Next,two transfer DNA(T-DNA)insertion single-mutant prmt6-1(Sail 385_A06)and prmt6-2(Salk 151679C)(Figs.2A;S3)..'has been revised as“Next,two transfer DNA(T-DNA)inser-tion single-mutant prmt6-1(Sail 385_A06)and prmt6-2(Salk 151679C)(Figs.3A;S3..".

关键词： photoperiod revised Arabidopsis

变工况模型下的CCHP设备容量和运行策略优化

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材料与冶金学报 2024年第1期23卷 86-95页

作者：郭子杨张卫军吴琼李卓东北大学冶金学院沈阳110819 南开大学金融学院天津300072

冷热电联产系统(CCHP)运行策略的经济性同时受到能源转换设备模型的准确性和容量合理性的影响.为了实现在变工况条件下CCHP设备容量和运行策略的整体优化,提出了一种新的方法对偶单纯形法-遗传算法(DSM-GA).首先,以能量流动为基础,建立... 详细信息

冷热电联产系统(CCHP)运行策略的经济性同时受到能源转换设备模型的准确性和容量合理性的影响.为了实现在变工况条件下CCHP设备容量和运行策略的整体优化,提出了一种新的方法对偶单纯形法-遗传算法(DSM-GA).首先,以能量流动为基础,建立了能够反映设备性能和负载率之间非线性关系的优化配置模型.其次,构建了用于对比分析不同条件下优化结果的评价指标.最后,以西安某工业园区为场景,用DSM-GA对优化配置模型进行了求解,并对结果进行了分析.研究结果表明:DSM-GA可有效进行变工况条件下设备容量和运行策略的整体优化,且求解速度显著快于常规算法GA的求解速度;所建模型考虑了设备的变工况特性,可以提供更为合理的运行方案;CCHP在原动机热电比与负荷热电比接近时才具有较大优势.

关键词： CCHP 变工况模型整体优化 DSM-GA 热电比

集成式电液制动耐久测试系统中模拟卡钳负载的设计与仿真

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仪表技术与传感器 2024年第1期 64-69页

作者：王炎福范伟军胡晓峰郭斌中国计量大学计量测试工程学院杭州沃镭智能科技股份有限公司

在集成式电液制动系统耐久测试中,对于不同排液量的产品需更换不同的卡钳负载。针对这一问题,设计了缸体容积可调以适应不同需液量的模拟卡钳负载。基于仿真软件AMESim搭建了仿真模型,对其需液量-液压特性进行分析。基于CAN通讯研发了... 详细信息

在集成式电液制动系统耐久测试中,对于不同排液量的产品需更换不同的卡钳负载。针对这一问题,设计了缸体容积可调以适应不同需液量的模拟卡钳负载。基于仿真软件AMESim搭建了仿真模型,对其需液量-液压特性进行分析。基于CAN通讯研发了一套集成式电液制动系统耐久测试系统,对被测产品进行常规制动功和ABS等功能的耐久测试,负载机构通过球阀可以选择模拟卡钳装置或者实车卡钳。实验结果表明模拟卡钳负载可以满足被测产品进行耐久测试,且与卡钳负载对比后相差很小,符合厂商的测试需求。

关键词：模拟卡钳负载仿真模型耐久测试集成式电液制动系统管路系统